Serial Two-Photon Plus: Translating Ex Vivo to In Vivo Imaging

Monday, October 17, 2022

2:00 PM – 3:00 PM ET

Location:360 Stage #4, Exhibit Hall A&B

Presented By

Tech Spotlight Speaker(s)

Stefan Linehan, MS

VP of Operations and Development
TissueVision Inc.
Newton, Massachusetts

Handouts

Description: When the FDA requests more information from pre-clinical models to assess safety related issues identified in clinical studies, what modality do you turn to? Naturally, ex vivo imaging provides high resolution content to answer such questions, but conventionally lacks translatability to the clinic. TissueVision’s novel Serial Two-Photon Plus platform provides a solution to span the gap between ex vivo and in vivo translational data evaluation. The resulting ex vivo 3D models can be integrated back to the pre-clinical in vivo 3D data, creating a translational bridge to the clinical in vivo imaging.

Learning Objectives:

Understand lack of translation between in-vivo imaging (typically 3D) and high resolution ex-vivo imaging (typically 2D).
Identify what tools are required to fill this gap and provide better translational data for the clinic.
Understand how Serial Two-Photon Plus imaging patches the gap by producing high resolution ex vivo 3D models to integrate back to the preclinical in vivo 3D data.