Prologue: Current Status and Gaps in Predicting the Food Effect

Tuesday, October 18, 2022

8:30 AM – 9:00 AM ET

Location:253 C

Prologue Speaker(s)

Xinyuan Zhang, PhD

Director
Daiichi Sankyo, Inc.
Basking Ridge, New Jersey

The utility of physiologically based pharmacokinetic modeling for food effect prediction has been discussed extensively in the scientific community. There were successful cases and cases where the model could not predict the observed food effect. Decision trees and recommendations have been proposed to improve model predictive performance. In this prestation, we will review the recent advancement and gaps in predicting the food effect and discuss what can be done with the current PBPK models.

Learning Objectives:

Upon completion, participant will be able to understand the mechanisms involved in the effects of food on pharmacokinetics.
Upon completion, participant will be able to understand how physiologically based pharmacokinetic (PBPK) modeling and simulation can be used to predict the effects of food on pharmacokinetics.
Upon completion, participant will be able to understand the current gaps in predicting the effects of food on pharmacokinetics.