Professor Purdue University West Lafayette, Indiana
Liquid liquid phase separation (LLPS) is observed when the solution concentration exceeds the amorphous solubility of the drug, leading to the formation of drug-rich nanodroplets. LLPS is frequently observed during dissolution of amorphous solid dispersions (ASD), and is thought to positively contribute to bioavailability in some instances. Herein, we will discuss the phenomenon of LLPS, the link to ASD performance and emerging characterization approaches.
Learning Objectives:
Participants will be able to understand how and why LLPS occurs during drug dissolution of amorphous solid dispersions
Participants will be able to see the impact of LLPS formation on successful drug product development.
Participants will be able to see how formulation parameters (e.g., selection of surfactant, polymer, drug loading,...) will have an impact on LLPS and recrystallization.
