Formulation and Delivery
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Christopher Worrall, PhD
Atropisomeric Diaryl Ethers
University of Manchester, UK
Helsinki, Uusimaa, Finland
Advanced nanoparticle engineering technology can produce excipient-free crystalline API nanoparticles. This enables poorly soluble molecules in the pharmaceutical pipeline to progress into clinical development by increasing their rate of dissolution and thus improving their bioavailability without the need for additional excipients. It also opens up huge possibilities for novel drug delivery improvements and approaches. The incorporation of a sparse-data AI based platform into the workflow predicts the outcomes of such nanoparticle generation experiments. This presentation will give an introduction to this leading technology and present a case study in which in-silico predictions were confirmed experimentally. Subsequent formulation aspects will demonstrate incorporation of nanoformed material into a thermoresponsive hydrogel formulation outperforming nanomilled API based formulations by a factor of x5 and allowing a more facile production process. This innovation has now enabled this product to progress towards clinical development.