Co-processed HPMC–mannitol: A directly compressible excipient for controlled release

Monday, October 17, 2022

2:00 PM – 3:00 PM ET

Location:360 Stage #2, Exhibit Hall A&B

Presented By

Tech Spotlight Speaker(s)

Talles Ernica, MS

Global Pharma Technical Developer
Roquette America Inc.
Lower Gwynned, Pennsylvania

Description: Controlled release dosage forms deliver an effective dose of the active pharmaceutical ingredient over a prolonged duration, which is particularly advantageous to maintain a constant plasma drug concentration within the therapeutic window. In this work, HPMC is co-processed with mannitol via fluid bed spray granulation to confer improved flowability and good tabletability. The developed excipient demonstrated excellent controlled release performance for drugs over a wide range of aqueous solubilities, and reduced dose dumping risk.

Learning Objectives:

Introduction to controlled release technology
Understanding the key performance attributes of a directly compressible, controlled release excipient
Understanding the benefits of co-processing HPMC and mannitol on product performance.