Exploring Protein Degrader Drug Delivery Challenges

Tuesday, October 18, 2022

10:30 AM – 11:30 AM ET

Location:360 Stage #1, Exhibit Hall A&B

Presented By

Partner Presentation Speaker(s)

Nathan Bennette, M.S.

Director, Scientific Advisory
Catalent
Sisters, Oregon

Handouts

Description: Targeted protein degraders, and more specifically PROTACs, have the potential to revolutionize the way we design new therapies. Key challenges in the development of PROTACs into orally bioavailable therapies are a result of their unconventional structures and distinctive physicochemical properties. These molecules do not conform to Lipinski’s Rule of 5 for small molecules and often require more complex drug delivery strategies. This presentation will discuss the significant challenges, opportunities, and potential solutions to oral delivery of PROTACs.

Learning Objectives:

• Understand why PROTACs cannot be evaluated through a conventional small molecule lens
• Explore the key physicochemical properties that determine whether a PROTAC is likely to be orally bioavailable
• Discuss rate limiting steps to oral absorption and how enabling technologies may enhance absorption of this class of molecule