(M1230-12-67) Spray-Dried Inhaled Solid Dispersion of Amodiaquine for Respiratory Disorders

Purpose: One of the most common types of cancer and the main reason for cancer-related mortality is lung cancer. Non-small-cell lung cancer (NSCLC), a diverse group of tumors, accounts for roughly 85 % lung cancer diagnoses. There are rising evidence that repurposed medications work extremely well against many cancers and enable rapid drug development process. In our earlier studies, we have shown feasibility of an antimalarial drug, amodiaquine (AQ) in treating NSCLC. In this study, we developed inhaled solid dispersions of AQ to enable local accumulation in the lungs, and enhanced efficacy against NSCLC. We utilized spray drying for producing solid dispersions which enables quick solvent evaporation and accelerates the conversion of an API-carrier solution into solid API-carrier particles.

Methods: AQ solid dispersions were developed using a spray drier. Mannitol was used as a carrier to prepare solid dispersion. 10% to 50% of the drug load was used with 2% solid content. Drug and carrier weighed in various ratios and dissolved in water. Spray drying was performed on these solutions using one nozzle Buchi Mini Spray Dryer B-290. The operating parameters are:- Aspirator-100%, Inlet temperature-100C, Feed rate-20%. The powder was collected and % yield was calculated for all the formulations. Afterwards, these powders were characterized with DSC, PXRD and calculated drug content of the same.

Results: The appearance of spray dried solid dispersion was yellow in color. % yield was found higher for the formulation with 20% drug load. On the other hand, the % yield was 50% drug load formulation was fairly low, and thus it was not considered in further analysis. The DSC and PXRD data revealed that the formulation was semicrystalline in nature. Morphology studies of solid dispersion will be done with in-vitro deposition studies.

Conclusion: AQ Solid Dispersion was prepared successfully. The formulation will be checked for its Stability and efficacy.




DL:- Drug Load, SD Mannitol:- Spray Dried Mannitol



DL:- Drug Load, SD Mannitol:- Spray Dried Mannitol