This course will address which migraineurs need prevention and why. We will discuss pharmacological treatment as well as neuromodulating devices, supplements, and lifestyle interventions. Migraine treatment has evolved dramatically in the past 5 years and because of this, migraine patients have experienced better outcomes with less side effects. It is important to look at what our prevention outcome goals are and how we can track them. Even though older treatments were fraught with tolerability issues and patient compliance, it is important to understand these therapies. There is a rating system for migraine prevention medicines which is formulated by scientific data. We will address older therapeutic agents, their clinical data, and how to utilize the information. In the past several years there have been lightening changes to our preventative treatments which include Botulinum toxin for chronic migraine as well as the advent of monoclonal antibodies to CGRP and GPANTS in the prevention of migraines. Lastly, we will address the use of neuromodulating devices as part of the migraine treatment spectrum.