Diagnostic imaging is an integral component for the differential diagnosis. In routine clinical practice there has been a tendency for clinical examinations to become more cursory, largely influenced by increasing demands of time and patient expectations of technological advances. The result may lead to an overreliance on technology for basic clinical diagnosis. The purpose of this session is to provide an introduction or review of basic imaging studies used for the diagnosis of pain related problems. Special attention will also be given to the limitations of such studies and the importance of establishing clinical relevance to their findings. Factors that adversely affect clinical management potentially resulting in failed treatment will be discussed, as well as best practices and clinical pearls when utilizing such studies to help enhance clinical outcomes for treatment.