This course will provide an overview of emerging genomic applications to explore the genetic architecture of age-related cognitive decline. Topics will include genome-wide association studies on cognition, ongoing collaborative initiatives to incorporate whole genome and whole exome sequencing into studies of cognition, and applications in the areas of resistance and resilience to Alzheimer’s disease. Finally, the course will highlight methods to incorporate sex as a biological variable into such genomic analyses, and emerging evidence of sex-specific genetic effects that contribute to cognitive aging and cognitive impairment.
Learning Objectives:
Articulate the importance of data harmonization for genomic analysis
Describe common genetic drivers of cognitive performance in older adulthood
Explain the contribution of sex and gender differences to the genetic architecture of cognitive performance
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