Stony Brook University
Stony Brook, New York, United States
Dennis K. Galanakis trained in medicine, hematology, and clinical pathology. He founded and directed the blood services at Stony Brook University Medical Center from1980-2020 which included the largest hospital based hemapheresis center in LI. His publications include investigations on fibrinogen structure and function, on familial dysfibrinogenemia, and on soluble fibrin in blood. More recently he defined fibers spontaneously generated by fibrinogen, showed they formed by its soluble fibrin (SF) component, and bound platelets. He isolated SF and identified its physicochemical and functional properties including the presence of des-AA monomers and a smaller population comprising multimeric clusters (old term fibrin/fibrinogen complexes). The clusters displayed a protofibril core, invariably bound to fibers, and accounted for accelerated clot lysis reflecting the known exposure by fibrin self-assembly of binding sites for plasminogen and its activator(s). Additionally, he showed that the innate SF tendency to generate translucent fibers and microclots in blood led to their binding to erythrocytes. This resulted in rouleaux agglutination and accounted for the ensuing accelerated erythrocyte sedimentation (AESR). The effect explains the reported link of AESR to various atherothrombotic and infections including COVID19, and implies that AESR is a thrombosis marker.
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Tuesday, October 18, 2022
10:55 AM – 12:00 PM
Tuesday, October 18, 2022
11:20 AM – 11:40 AM
Tuesday, October 18, 2022
11:40 AM – 12:00 PM