Marquette University; Medical College of Wisconsin
The practice in fMRI brain imaging to determine brain activation within a voxel has been to detect a task-related increase in the BOLD signal from baseline. Valuable information about the tissue type contained in a voxel can be found within the baseline of the same data. Different tissue types, gray matter and white matter have different baseline intensity values. It is well known that neurons are in grey matter and thus activation should be in gray matter. This work utilizes both baseline signal and differential signal changes to determine brain activation.
