The COVID-19 pandemic has created one of the greatest chaos worldwide since 2020. Many countries are significantly impacted, especially developing countries in the Middle East and North Africa (MENA) region. In this project, we investigate how the COVID-19 pandemic in MENA countries is affected by cultural factors as well as other factors including population and life expectancy. Our research found that each cultural factor such as power distance, individualism, and uncertainty avoidance significantly influences total cases per million without considering population density and life expectancy. Combining them together, the impact is less significant. Similar results can be found when population density and life expectancy are present. Among these two variables, only life expectancy is significantly positively associated with total cases per million. For total deaths per million, only power distance is negatively associated with it with a slight significance. In terms of adding population density and life expectance factors into consideration, the results are quite similar.