The outcome of pathogenic infections in mosquitoes is often defined by the mosquito responses to infection and the range of multipartite interactions that occur with other microbes. While the mosquito immune system is at the interface of much of the microbial interactions with the mosquito host, microbe-microbe interactions can also influence the outcome of pathogenic infections. Increasing our understanding of mosquito-microbe interactions can facilitate the development of novel biological control strategies. This presentation will describe multipartite interactions that occur between the mosquito, symbiotic microbes, and pathogens, with a focus on entomopathogenic microbes evaluated for mosquito control.