249 - Disarming Bacterial Destruction: Toxins as Therapeutic Targets

Saturday, October 22, 2022

1:45 PM – 3:00 PM US ET

Location: 143 ABC

Watch the live stream on the conference website.

All relevant financial disclosures have been mitigated.

Moderator(s)

Anne-Catrin Uhlemann, MD, PhD

Associate Professor of Medicine
Columbia University Irving Medical Center
New York, NY, United States

Disclosure(s): Merck: Grant/Research Support (Ongoing)
Luiz Bermudez, MD

Professor
Oregon State University
Corvallis, OR, United States

Disclosure(s): No financial relationships to disclose

Faculty(s)

Isaac Thomsen, MD MSCI

Associate Professor
Pediatric Infectious Diseases
Vanderbilt University Medical Center
Nashville, Tennessee, United States

Disclosure(s): Horizon Therapeutics: Advisor/Consultant (Ongoing)

Slides
Juliane Bubeck-Wardenburg, MD, PhD

Professor
Washington University School of Medicine in St. Louis

Disclosure(s): No financial relationships to disclose

Slides
Victor Nizet, MD (he/him/his)

Distinguished Professor and Vice Chair
Pediatrics
University of California San Diego
San Diego, CA, United States

Disclosure(s): Cellics Therapeutics: Advisor/Consultant (Ongoing); Clarametyx Biosciences: Advisor/Consultant (Ongoing); Vaxcyte, Inc.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing)

Slides

Disclosure(s):

Anne-Catrin Uhlemann, MD, PhD: Merck: Grant/Research Support (Ongoing)

Luiz Bermudez, MD: No financial relationships to disclose

Isaac Thomsen, MD MSCI: Horizon Therapeutics: Advisor/Consultant (Ongoing)

Juliane Bubeck-Wardenburg, MD, PhD: No financial relationships to disclose

Victor Nizet, MD: Cellics Therapeutics: Advisor/Consultant (Ongoing); Clarametyx Biosciences: Advisor/Consultant (Ongoing); Vaxcyte, Inc.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing)

CME Credits: Maximum of 1.25 hours of AMA PRA Category 1 Credit™
MOC Credits: Maximum of 1.25 hours of MOC Credit
CNE Credits: Maximum of 1.25 hours of ANCC Credit
ACPE Credits: ACPE 1.25 contact hours of pharmacy CE
ACPE Number: JA0007082-0000-22-002-L01-P

Learning Objectives:

At the conclusion of this session, participants will be able to:

evaluate the role of toxin-neutralizing antibodies during S. aureus infection;
describe how the intestinal environment modulates toxin regulation in Bacteroides fragilis;
discuss novel approaches to treat toxin-driven bacterial infections

Presentations:

1:45 PM – 2:10 PM US ET

Toxin-Neutralizing Antibodies in Staphylococcus aureus Infection
Speaker: Isaac Thomsen, MD MSCI – Vanderbilt University Medical Center
2:10 PM – 2:35 PM US ET

Intestinal Environment and Bacterioides fragilis Toxin Regulation
Speaker: Juliane Bubeck-Wardenburg, MD, PhD – Washington University School of Medicine in St. Louis
2:35 PM – 3:00 PM US ET

Repurposing FDA-Approved Drugs and Host Cell Membranes to Treat Toxin-Driven Bacterial Infection and Sepsis
Speaker: Victor Nizet, MD (he/him/his) – University of California San Diego