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Associate Professor of Medicine
Johns Hopkins School of Medicine
Dr. Balagopal is an Associate Professor of Medicine in the Division of Infectious Diseases, and a member of the Center for Viral Hepatitis Research at Johns Hopkins University. He attended MIT for his undergraduate studies and received his medical degree from the Mount Sinai School of Medicine. He completed his residency and chief residency in internal medicine at the Yale-New Haven Hospital. He worked as a post-doctoral fellow in the lab of Dr. Larry Schlesinger at the Ohio State University studying macrophage biology and innate immune sensing. He then completed a clinical and research fellowship at Johns Hopkins University under the mentorship of Dr. Dave Thomas and Dr. Stuart Ray, conducting translational research in HIV/HCV co-infection. After joining the faculty in 2009, Dr. Balagopal has provided care of patients with HCV, HBV, and HIV in his longitudinal care clinic.
Dr. Balagopal’s lab has been focused on developing high-resolution techniques for the detection and quantification of viruses in human tissues (hepatitis C virus [HCV], hepatitis B [HBV], and HIV-1). Using novel approaches, his lab quantified HCV and HBV replication intermediates in single hepatocytes from liver tissues taken from people who were chronically infected. In HBV, his lab has contributed to the description of transcriptional regulation of HBV covalently closed circular DNA (cccDNA) in people taking antivirals. Most recently, his lab developed tools to uncover the source of hepatitis B surface antigen (HBsAg), either cccDNA or integrated HBV DNA. He has also characterized HIV infection in tissue resident macrophages (liver macrophages or Kupffer cells) taken from people who were virologically suppressed with antiretrovirals. In parallel, his lab focuses on physiologic and pathologic innate immune responses to viral infections in relevant human tissues, including characterizing microbial translocation and immune activation in HIV/HCV co-infected people.
I do not have any relevant financial / non-financial relationships with any proprietary interests.
Friday, October 21, 2022
3:15 PM – 4:30 PM US ET
Friday, October 21, 2022
3:15 PM – 3:40 PM US ET