Mark D. Hicar, MD/PhD

Associate Professor
University at Buffalo

Disclosure(s): No financial relationships to disclose

Mark Daniel Hicar, Associate Professor, University at Buffalo and Oishe's Children's Hospital
The focus of my research career is antibody discovery against infectious agents. I have used a variety of techniques to discover human antibodies, including cloning antibodies from survivors of the 1918 influenza pandemic. I have active research program on antibodies against HIV, Kawasaki disease, Alzheimer's and Multisystem Inflammatory Syndrome in Children (MIS-C). These anti-HIV antibodies were isolated using single B cell cultures after separation by flow cytometry. In our current projects, we are cloning paired heavy and light chain genes from plasmablasts and using advanced genomics for diseases such as COVID-19, MIS-C, Alzheimer's, and Kawasaki disease.

Poster(s):

• 493 - Defining background shared antibody sequences between unrelated healthy individuals (public clonotypes) to support future studies on specific infectious disease related conditions.
  Thursday, October 20, 2022

  12:15 PM – 1:30 PM US ET

• 503 - Lack of coronary aneurysms during Kawasaki Disease (KD) correlates with higher levels of autoantibodies to both full form and spliced variant of immune regulator EDIL-3 (Del-1)
  Thursday, October 20, 2022

  12:15 PM – 1:30 PM US ET