185 - Promise and Perils of New Beta-Lactam Agents

Friday, October 21, 2022

3:15 PM – 4:30 PM US ET

Location: 152 AB

Watch the live stream on the conference website.

All relevant financial disclosures have been mitigated.

Moderator(s)

Yohei Doi, MD, PHD

Professor of Medicine
Division of Infectious Diseases
University of Pittsburgh
Pittsburgh, PA, United States

Disclosure(s): bioMerieux Inc.: Advisor/Consultant (Ongoing); Chugai: Advisor/Consultant (Terminated); Entasis Pharmaceuticals: Grant/Research Support (Ongoing); FujiFilm: Advisor/Consultant (Ongoing); Gilead Sciences Inc.: Advisor/Consultant (Ongoing); GlaxoSmithKline (GSK): Advisor/Consultant (Ongoing); Meiji Seika Pharma Co., Ltd.: Advisor/Consultant (Ongoing); MSD Japan: Advisor/Consultant (Terminated); Shionogi & Co.,Ltd.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing)
Ryan Shields, PharmD, MS

Associate Professor of Medicine
Medicine
University of Pittsburgh
Pittsburgh, Pennsylvania, United States

Disclosure(s): No financial relationships to disclose

Faculty(s)

Marguerite Monogue, PharmD

Pharmacist
Pharmacy
University of Texas Southwestern Medical Center
Dallas, TX, United States

Disclosure(s): Merck & Co., Inc.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing); Shionogi & Co., Ltd.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing), Honoraria (Ongoing); Wolters-Kluwer: Advisor/Consultant (Ongoing)

Slides
Rachel Powers, PhD

Professor of Chemistry
Grand Valley State University
Allendale, MI, United States

Disclosure(s): No financial relationships to disclose

Slides
Jennifer Dien Bard, PhD, D(ABMM), FIDSA

Director, Clinical Microbiology and Virology; Professor of Pathology (Clinical Scholar)
Department of Pathology and Laboratory Medicine
Children's Hospital Los Angeles; University of Southern California
Los Angeles, CA, United States

Disclosure(s): Abbott Molecular: Grant/Research Support (Ongoing); bioMeriuex/BioFire: Advisor/Consultant (Ongoing); GenMark Diagnostics: Advisor/Consultant (Ongoing); Luminex: Grant/Research Support (Ongoing); Qiagen: Advisor/Consultant (Ongoing)

Slides

Disclosure(s):

Yohei Doi, MD, PHD: bioMerieux Inc.: Advisor/Consultant (Ongoing); Chugai: Advisor/Consultant (Terminated); Entasis Pharmaceuticals: Grant/Research Support (Ongoing); FujiFilm: Advisor/Consultant (Ongoing); Gilead Sciences Inc.: Advisor/Consultant (Ongoing); GlaxoSmithKline (GSK): Advisor/Consultant (Ongoing); Meiji Seika Pharma Co., Ltd.: Advisor/Consultant (Ongoing); MSD Japan: Advisor/Consultant (Terminated); Shionogi & Co.,Ltd.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing)

Ryan K. Shields, PharmD, MS: No financial relationships to disclose

Marguerite Monogue, PharmD: Merck & Co., Inc.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing); Shionogi & Co., Ltd.: Advisor/Consultant (Ongoing), Grant/Research Support (Ongoing), Honoraria (Ongoing); Wolters-Kluwer: Advisor/Consultant (Ongoing)

Rachel Powers, PhD: No financial relationships to disclose

Jennifer Dien Bard, PhD, D(ABMM), FIDSA: Abbott Molecular: Grant/Research Support (Ongoing); bioMeriuex/BioFire: Advisor/Consultant (Ongoing); GenMark Diagnostics: Advisor/Consultant (Ongoing); Luminex: Grant/Research Support (Ongoing); Qiagen: Advisor/Consultant (Ongoing)

CME Credits: Maximum of 1.25 hours of AMA PRA Category 1 Credit™
MOC Credits: Maximum of 1.25 hours of MOC Credit
CNE Credits: Maximum of 1.25 hours of ANCC Credit
ACPE Credits: ACPE 1.25 contact hours of pharmacy CE
ACPE Number: JA0007082-0000-22-002-L01-P

Learning Objectives:

At the conclusion of this session, participants will be able to:

explain how gram-negative bacteria are evolving to resist novel beta-lactam agents;
identify mechanistic basis of beta-lactamase-mediated resistance to new agents;
discuss considerations in the clinical microbiology laboratory

Presentations:

3:15 PM – 3:40 PM US ET

Resistance to New Bl/blis - Overview
Speaker: Marguerite Monogue, PharmD – University of Texas Southwestern Medical Center
3:40 PM – 4:05 PM US ET

Evolution of Beta-Lactamases Against New Bl/blis
Speaker: Rachel Powers, PhD – Grand Valley State University
4:05 PM – 4:30 PM US ET

Considerations in the Micro Lab
Speaker: Jennifer Dien Bard, PhD, D(ABMM), FIDSA – Children's Hospital Los Angeles; University of Southern California