Methods in Pharmacoepidemiology

(277) A Methodology Study to Evaluate External Comparator Arm Study Results Versus Randomised Controlled Trial Results: Multiple Myeloma Case Study

(147) A Comparison of Structured Algorithms for Identifying Men with Metastatic Prostate Cancer Within the Veterans Affairs Health Care System

(156) A Longitudinal Early-Indicator of Overall Survival Based on Prognostic Scores

(286) Adapting Sufficient Component Cause Models to Pharmacoepidemiology: Mapping to Structural Equation Model Equivalents

(141) A Novel Method for Estimating Survival Parameters Under Conditionally Independent Left Truncation

(147) A Review of Algorithms Used to Identify People Who Use Nonmedical or Psychotropic Drugs in Electronic Healthcare Records and Claims Data

(153) A Pragmatic Comparison of Logistic Regression vs. Machine Learning Methods for Propensity Score Estimation

(132) Accounting for Time Trends in Classification Parameters Using the Adaptive Validation Approach

(140) Accuracy and Validity of Reported Opioid Prescription Days' Supply

(152) A Step-By-Step Guide for Causal Study Design When Estimating Treatment Effects Using Real-World Data

(157) Addressing Residual Confounding Using Propensity Score Matching Versus Cardinality Matching

(158) Adapting Sufficient Component Cause Models to Pharmacoepidemiology: Incorporating Continuous Variables

(297) Approaches to The Identification of Ulcerative Colitis Events in a Claims Database

(137) Assessing The Robustness of COVID-19 Vaccine Effectiveness Studies to Bias

(296) Bias Amplification of Unobserved Confounding in Pharmacoepidemiological Studies: There Is No Free Lunch in Restricting the Sample to Those with a Particular Drug Indication

(150) Association of Benzodiazepines, Z-Drugs, Pregabalin and Melatonin with Traffic Accidents

(292) Claims-Based Algorithm to Define Breast Cancer Recurrence in SEER-Medicare Data

(133) Can Machine Learning Models Help Predict Potentially Inappropriate Medication Use in Older Adults? A Population-Based Cohort Study

(131) Changes in Incidence and Characteristics of Juvenile Idiopathic Arthritis Diagnoses from ICD-9-CM to ICD-10-CM

(164) Benzodiazepine Drug-Drug-Drug Interactions and Unintentional Traumatic Injury: Pharmacoepidemiologic Screening to Detect Three-Way Drug Interaction Signals

(161) Bias in Observational Studies on The Effectiveness of Hydroxychloroquine in COVID-19

(138) Comparing Study Designs in Case-Crossover Studies of Chronic Medications Versus Acute Medications in a Systematic Review

(145) Co-Producing a Pharmacoepidemiology Online Knowledge Hub

(171) Concordance Between Subgroup Disproportionality Scores and PRAC Discussions of Subgroup Risk

(153) Data Source Heterogeneity in Multi-Data Base Pharmacoepidemiologic Studies: An ISPE-sponsored Scoping Review

(159) Development and Application of a Claims-Based Frailty Index (CFI): A Systemic Review

(283) Data Lag in a Large Open and Closed Claims Dataset: Navigating the Completeness-Timeliness Tradeoff

(279) Definition of Outcomes and Success Criteria for Healthcare Professional or Patient Surveys Designed to Assess the Effectiveness of Risk Minimization Measures (eRMM)

(142) Diabetes and IBD: Utilization of High Dimensional Propensity Score Methods for Screening and Balancing Risk Factors Between Type 2 Diabetes and Non-Diabetes Population in Risk of IBD Assessment

(179) Developing a Framework for Rapid Analytics: A Self-Controlled Case Series Study Replication

(163) Development and Evaluation of The Algorithm Certainty Tool KIT (ACE-IT) to Evaluate Safety Outcomes Using Electronic Medical Record and Claims-Based Algorithms

(159) Development of a Feasibility and Conceptual Design Framework for Comparative Effectiveness Research

(294) Development and Validation of Elixhauser Summary Comorbidity Score for Use with ICD-10-CM Coded Data Among Older Adults

(284) Development of Real-World Cohorts Using Electronic Health Records (EHR) Supplemented with Administrative Claims Data for Pharmacoepidemiology Studies of Patients with IBD Initiating Biologic Therapy

(155) Discharged Where? The Importance of Understanding Discharge Dispositions When Estimating In-Hospital Mortality

(298) Discrepancies in ICD Codes Used to Identify Three Common Diseases in Cancer Patients in Real-World Settings and Their Implications for Disease Classification in Patients Without Cancer: A Literature Review and Descriptive Study

(287) Distinguishing Death from Disenrollment: Applying a Predictive Algorithm to Reduce Bias in Estimating the Risk of Rehospitalization

(178) EHR Continuity in a Multicenter EHR Data Repository: Potential Implications for Studies Evaluating COVID-19 Therapy

(F) Time Trends in Performance of Different Mortality Data Sources Compared to The National Death Index in The Healthcore Integrated Research Database

(E) Changes in Sensitivity and Positive Predictive Value in Phenotype Algorithms for Myocardial Infarction and Ischemic Stroke Over Time in Multiple Observational Databases

(H) Concordance of Efficacy Data Collected in a Clinical Trial Setting Versus a Registry Study Setting: Example of Use of Real-World Data to Support Drug Regulatory Approval of Abatacept for Acute Graft Versus Host Disease Prophylaxis

(G) Selection of Censoring Schemes for Analyzing Overall Survival in Real-World Data with Linked Mortality Information

(D) The Impact of Longitudinal Data-Completeness of Electronic Health Record (EHR) Data on Prediction Performance of Clinical Risk Scores

(276) Dynamic Relationship Among Immediate Release Fentanyl Use and Cancer Incidence: A Multivariate Time-Series Analysis Using Vector Autoregressive (VAR) Models

(174) Evaluation of Changes in Lung Cancer Care Patterns During The COVID-19 Pandemic

(148) External Validation of a Machine Learning Algorithm to Distinguish Death from Disenrollment in Claims Data

(130) Evaluation of a Cross-School, Student-Led Reading Club on Facilitating Learning in Pharmacoepidemiology - Experience of The Tea & Crêpe Reading Club from Taiwan

(301) Estimation of Years of Life Lost Using Electronic Health Records: Application on Patients with Multiple Myeloma in The SNDS Database

(162) Evaluation of The Case-Time-Control Design to Examine the Association Between Anticancer Drug Use and Acute Kidney Injury

(143) Extending Treatment Effects from a Randomized Trial Using Observational Data

(288) Evaluating The Impact of Electronic Health Record (EHR) Loss to Follow-Up Data in Patients with Atherosclerotic Cardiovascular Disease (ASCVD)

(169) Identification of Obesity and Tobacco Use in Claims Compared to Electronic Health Record (EHR) Data

(172) Impact of Live Attenuated Measles, Mumps and Rubella (MMR) Vaccines on The Risk of Hospitalization with COVID-19 in Children: A Cohort Study of 7 million Children in France

(145) Imputation of Missing Diagnosis Date and Implications for Analyses in Registries: A Simulation Study

(154) Identifying Hospitalizations in Patients with Medicare Supplemental Insurance

(177) Justification for The Acceptance of Uncontrolled Pivotal Trials to Support Marketing Authorisation of Medicines in Europe (1995-2020)

(302) Ignoring Competing Event in Survival Analyses: The Amplitude of The Bias in Kaplan-Meier Estimates Assessed Through Simulations

(165) Length of Lookback Period for The Charlson Comorbidity Index and Prediction of Mortality Among Hip-Fracture Patients in Denmark

(149) Inverse Probability Treatment Weighting Versus Propensity Score Matching in The Sentinel System: A Test Case

(303) Impacts of the COVID-19 Pandemic on Assessment of Progression and Surveillance Bias in Advanced Non-Small Cell Lung Cancer

(166) MINERVA: Metadata for Data Discoverability and Study Replicability in Observational Studies

(150) Multimorbidity Ascertainment in Health Administrative Data and Role of The Time Window

(278) Linking Progression to Lines of Therapy in Triple Class Refractory Multiple Myeloma Patients: Experience from An Oncology Electronic Health Record Database

(134) Methods for Drug Safety Signal Detection Using Routinely Collected Electronic Healthcare Data: A Systematic Review

(180) Patient Satisfaction, Outcomes and Experience Measures Amongst Patients Receiving Propofol: A Patient Reported Outcomes Measure Study

(161) Opportunities and Challenges for Decentralized Clinical Trials: The European Regulators' Perspective

(304) Methodologic Considerations for Emulating Target Trial for Discontinuation of Antidepressant Treatment in Pregnancy

(160) Optimizing Clinicaltrials.gov as a Tool to Evaluate the Potential of Real World (RW) Data Sources for Use as External Comparator Arms

(175) PHARMACOM-EPI: A Framework for Integrating Pharmacometric Modelling into Pharmacoepidemiological Research Using Real-World Data

(300) Novel Recruitment, Data Collection, and Safety Reporting Methods in The Era of COVID-19: Design of a Post-Emergency Use Authorization COVID-19 Vaccination Safety-Surveillance Study

(168) Poor Pain Control and Risk for Anxiety and Sleeping Disorders Among Older Patients with Dementia

(290) Outcome Misclassification: Differences in Hip Fracture Identification Using Administrative Claims Data

(281) Patient Characteristics, Outcomes and Potential for Bias in Oncological Real-World Data Studies with Imaging-Derived Response Endpoints

(176) Quantitative Bias Analysis in Comparative Effectiveness Research: A Cautionary Word

(170) Racial and Ethnic Categories in Propensity Score Analyses: An Application in US Medicare Beneficiaries Initiating DPP4 Inhibitors vs Sulfonylureas

(160) Random Forests Quantile Classifier, a Novel Proposal to Account for Imbalanced Data Sets in The Prediction Model Development: A Feasibility Study Using Retrospective Registry Data of Kawasaki Disease in Japan

(152) Representativeness of the PHARMO Electronic Health Records (EHRs) from Primary Care

(291) Propensity Score-Based Weighting Methods in The Context of Multiple Treatment Options

(280) Remote Trial Elements Reported in Publicly Available Clinical Trial Protocols

(173) Safety-Related Drug Label Changes After Large Cardiometabolic Trials. A Review of European Public Assessment Reports

(141) Scalable Feature Engineering from Electronic Free Text Notes to Supplement Confounding Adjustment of Claims-Based Pharmacoepidemiologic Studies

(162) Selective Sampling: A Novel Approach to Simulating Biased Samples for Methods Research

(285) Risk Factor Identification Using Machine Learning and High-Dimensional Hospital Data to Inform Propensity and Disease Risk Score Models: An Applied Example in Hemostasis-Related Surgical Complications

(157) Standardizing to Specific Target Populations in Distributed Networks: A Proof of Concept

(158) The Autopsy of a Failed Instrumental Variable: Plasmode Simulation as a Tool to Assess Unconfoundedness of an IV

(148) The Effect of Continuous Use of Antidepressants, with or Without Anticholinergic Properties, for At Least 4 Months Versus No Treatment on The Incidence of Dementia: A Target Trial Emulation

(128) The State of Use and Utility of Negative Controls in Pharmacoepidemiologic Studies

(155) The Data Analysis and Real-World Interrogation Network (DARWIN EU®): A Federated Network of Data Sources and Services in the European Union

(139) The Use of Electronic Health Records During The COVID-19 (C19) Pandemic: What Impact for Observational Studies Not Assessing COVID-19?

(146) Trajectories of Severity Pattern Among Patients with Systemic Lupus Erythematosus: A Retrospective Cohort Study

(144) Treatment Effects of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in People Underrepresented from The ONTARGET Trial: Analysis of Routinely Collected Data Using Trial Replication Methods

(127) Trends in The Incidence of Immunologic and Oncologic Diseases Before and During COVID-19 Pandemic in the US

(126) Use of a Potential Outcomes Framework to Simulate Bias Due to Unidirectional Treatment Switching in Real World Studies

(149) Two Component Claims-Based Algorithm to Identify Heart Failure Ejection Fraction Phenotypes

(167) Updated Core Competencies in Pharmacoepidemiology to Inform Contemporary Curricula and Training for Academia, Government, and Industry

(151) Use of Patient Profiles to Validate Acute Myocardial Infarction in Claims Data

(154) Utilization and Timing of Z3A Codes in Pregnancy to Estimate Gestational Age Using Administrative Claims

(136) Validation of an Algorithm for Unusual Site Thrombosis with Thrombocytopenia Syndrome (TTS) Within Electronic Health Records (EHRs)

(135) Validation of an Algorithm to Identify Venous Thromboembolism (VTE) in Health Insurance Claims Data Among Patients with Rheumatoid Arthritis

(143) Validation of a Case-Finding Algorithm for Endometrial Cancer Using ICD10 Diagnostic Codes in Insurance Claims

(144) Validation of Diagnostic Codes to Identify Carbon Monoxide Poisoning in Taiwan's Claim Data

(142) Validation of Safety Outcomes in Routinely Collected Data: Lessons Learned from a Multinational Post-Approval Safety Study

(151) Validation of Medical Code Lists for Defining Mental Health Conditions with Primary Care Data: A Mixed Qualitative and Quantitative Study

(146) Validation of New Medication User Definitions in Single-Specialty EHR Data

(129) Validity of Adverse Clinical Outcomes in Routine Health Data for COVID-19 Vaccines and Therapies

(293) Use of a Rate-Based Sequence Symmetry Analysis to Assess Recurring Adverse Drug Events

(299) Utilization of Pharmacokinetic/Pharmacodynamics Modeling in Pharmacoepidemiologic Studies: A Systematic Review on Anti-Arrhythmic and Glucose-Lowering Medicines

(305) Validating The Standardized and ICD-9 Code of Type 2 Diabetes Mellitus in a Saudi Common Data Model

(282) Validation to Estimate Sensitivity Along with Positive Predictive Value: A Case Study

(289) Validity of An Electronic Health Record (EHR) and Claims-Derived Proxy Measure of Multiple Sclerosis (MS) Disability