(70) Antimicrobial Use in Sweden During The COVID-19 Pandemic: Prescription Filling and Inpatient Care Requisition Patterns

Sunday, August 28, 2022

8:00 AM – 1:45 PM CEST

Location: Hall C

Publication Number: 1115

Presenting Author(s)

Aya Nakitanda
– Karolinska Institutet, Stockholm, Stockholms l�n, Sweden

Co-Author(s)

Pär Karlsson
– Statistician, Centre for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Lukas Löfling
– Section for Epidemiology and Prevention, Department of Research, Cancer Registry of Norway, Norway
Carolyn E. Cesta, PhD
– PhD, Karolinska Institutet, Stockholm, Sweden
Ingvild Odsbu
– Researcher, Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Oslo, Norway

Background: Increased and inappropriate antimicrobial use are the key drivers of the emergence of antimicrobial resistance, and there have been widespread concerns around potential antimicrobial misuse, overuse and their consequences during the COVID-19 pandemic. A better understanding of the impact of the pandemic on antimicrobial use is warranted, particularly in light of the resurgence of COVID-19 cases since the summer of 2020.

Objectives: To describe trends in antimicrobial prescription fills and hospital requisitions in Sweden during 2020 against those of preceding years.

Methods: A descriptive study using population-based data from the Swedish Prescribed Drug Register and the Swedish e-Health Agency. The weekly number of prescriptions filled, and the total volume sold to inpatient care institutions in defined daily doses (DDDs), per 1000 inhabitants for systemic antibacterials (Anatomical therapeutic chemical therapeutic subgroup J01 excluding J01XX), antimycotics (J02), antivirals (J05) and antiprotozoals (P01) were computed and assessed from time series graphs. A time series linear regression with ordinary least squares (OLS) estimation was used to model 2015-2019 data and predict the expected number of prescriptions filled and volumes sold in DDDs per 1000 inhabitants during 2020 with 95% confidence limits.

Results: From mid-March 2020, the weekly rate of antibiotic and antiprotozoal prescriptions filled plummeted to unprecedentedly low levels for the rest of the year; while unprecedentedly high numbers of antiviral prescriptions were filled weekly between mid-February and mid-March 2020. There was a net reduction in annual dispensing of antibiotics by 17%; of antiprotozoals by 21%; and of antivirals by 0.3% during 2020 compared to 2019. Inpatient care requisitions of antiprotozoals and antibiotics surged to 6-year highs during March 2020, resulting in a 127% increase in DDDs of antiprotozoals sold from 2019. The volume of antibiotics and antivirals sold to inpatient care institutions in 2020 decreased by 3% and 13% compared to 2019, respectively.

Conclusions: The overall decline in antimicrobial prescriptions filled in Sweden during 2020 were in part, collateral dividends of the COVID-19 pandemic.