(39) Associations Between Oral Diseases and Chronic Diseases Modified by Trajectories of Lifestyle Behaviors: A Nationwide Population-Based Study in Korea

Friday, August 26, 2022

8:00 AM – 6:00 PM CEST

Location: Hall C

Publication Number: 370

Presenting Author(s)

Ji-Yeob Choi
– Seoul National University College of Medicine, Seoul, South Korea

Co-Author(s)

Jaseung Choi
– Seoul National University College of Medicine, Jongno-gu, South Korea
Seokyung Hahn
– Institute of Health Policy and Management, Medical Research Center, Seoul National University, Korea, Republic of Korea
Hee-Kyung Park
– Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Korea, Republic of Korea
Seo-Young Park
– Sungkyunkwan University, Republic of Korea

Background: Lifestyle behaviors that can reduce inflammatory responses may be expected to reduce the risk of chronic diseases from oral disease.

Objectives: This study identified associations of oral diseases with the risk of diabetes and cardiovascular diseases (CVD) and examined which trajectory of lifestyle could reduce the risk of these diseases.

Methods: This study was conducted in population-based retrospective study from the Korean National Health Insurance Service-Health Screening cohort with adults aged 45 or more years. ‘Dental caries and pulpitis’ and ‘Gingivitis and periodontitis’ were defined and entered as time-dependent variables in a Cox proportional hazard model with diabetes and CVD. Smoking, alcohol drinking, and exercise were repeatedly assessed and latent classes mixed models identified the trajectories of lifestyle which is used as stratification variables in the time-dependent analysis.

Results: The risk of diabetes was significantly higher in those with ‘dental caries and pulpitis’ in men (HR = 1.04, 95% CI: 1.00–1.06). The risk of diabetes (HR = 1.14, 95% CI: 1.11–1.16) and CVD (HR = 1.06, 95% CI: 1.02–1.10 in men, HR = 1.12, 95% CI: 1.08–1.15 in women) were significantly higher in those with ‘gingivitis and periodontitis’. The elevated risk of diabetes was reduced in those who stopped drinking alcohol in men (HR = 0.90, 95% CI=0.83-0.96).

Conclusions: Our findings suggest that the risk of diabetes in those with oral diseases were decreased when they stop alcohol drinking. Therefore, these results can be used to prevent chronic disease through oral disease management and lifestyle intervention.