(190) Health Related Quality of Life in HIV Patients: A Decennial Data Systematic Review and Meta-Analysis

Saturday, August 27, 2022

8:00 AM – 6:00 PM CEST

Location: Hall C

Publication Number: 864

Presenting Author(s)

Balaji Sathyanarayana Gupta, MPharm
– JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Academy of Higher Education & Research, Mysuru, Karnataka, India

Co-Author(s)

Tenzin Thinley
– 1. Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru – 570015, India
Rahul Krishna Puvvada
– 2. Department of Physiology, Anatomy and Microbiology, College of Science Health and Engineering, La Trobe University, Australia, Australia
Ramesh Madhan, PhD
– Professor, JSS College of Pharmacy, Mysore, India

Background: Assessing the Health-Related Quality of Life (HRQOL) in Human Immunodeficiency Virus (HIV) patients is important for evaluating the effect of disease and measures the influence of intervention to improve the quality of life in HIV patients.

Objectives: To systematically review and assess the HRQOL in HIV patients

Methods: Randomized control trials assessing the HRQOL in HIV patients published in PubMed, Scopus and Google Scholar and records from Jan 2010-Dec 2020 were considered. The retrieved records were screened by two authors independently. Cochrane collaboration’s tool to assess the risk of bias and meta-analysis was performed using Review Manager Software (RevMan 5.4.1).

Results: From 2842 studies, 36 and 4 studies were included in qualitative and meta-analysis, respectively. The overall standard mean difference in QOL of two studies with yoga intervention was 3.20 (95% CI:-1.55,7.95), P=0.19. The difference in the quality of life in the psychological and social domains of the yoga group was 2.81 (95% CI: -2.00,9.62) and 6.62 (95% CI: 5.48,7.75), respectively. The HRQOL from two studies that reported the intervention of the rehabilitation group with the control group was statistically not significant (P=0.94). However, the physical domain of both studies was statistically significant (P=0.04).

Conclusions: Yoga and Rehabilitation had shown significant positive outcomes in the HRQOL. Although few interventions had shown beneficial effects in the HRQOL, the results were not significant due to the heterogeneity of studies. Therefore, more studies are to be conducted on similar outcome parameters to assess the quality of life among HIV patients.