(267) Hospitalizations After COVID-19 Vaccination: Self-Reported Patient Characteristics

Sunday, August 28, 2022

8:00 AM – 1:45 PM CEST

Location: Hall C

Publication Number: 1312

Presenting Author(s)

Matthew W. Reynolds, PhD, FISPE
– Vice President, Real World Evidence, IQVIA , Grasonville, Maryland, United States

Co-Author(s)

Kendall B. Knuth
– IQVIA , Raleigh, North Carolina, United States
Yiqiong Xie
– Milpitas, California, United States
Emma Brinkley
– IQVIA, Durham, NC, United States
Tom Kwon
– IQVIA, United States
Christina Mack, FISPE
– IQVIA , UNC-Chapel Hill, Chapel Hill, North Carolina, United States
Nancy A. Dreyer, PhD, MPH, FISPE, Fellow DIA
– Chief Scientific Officer, Dreyer Strategies LLC, Newton, Massachusetts, United States

Background: While recent publications have shown effectiveness of vaccines in the real-world setting, an understanding of vaccine side effects that result in hospitalizations remains unclear.

Objectives: To describe characteristics of vaccinated COVID-19 participants who are enrolled in a direct-to-community COVID-19 registry and reported hospitalization due to vaccine side effects.

Methods: Social media outlets were used to enroll over 37,000 adult volunteers who believed they had been exposed to or tested positive for COVID-19, and/or received a COVID-19 vaccine (www.helpstopCOVID19.com). Out of 7,744 vaccinated, we characterize participants who received at least one dose of a COVID-19 vaccine (J&J, Pfizer, or Moderna), and reported a hospitalization due to vaccine side effects from surveys collected between March 19 - July 15, 2021. Demographics and duration of hospitalization are described for these participants.

Results: Twenty-two out of 7,744 participants vaccinated reported having been hospitalized after vaccination and attributed this hospitalization to COVID-19 vaccine side effects. Twenty (91%) of patients were female; 7 (32%) were over 60 years old. These 22 participants reported 24 hospitalizations as follows: 13 hospitalizations after first dose, and 11 hospitalizations after second dose, with 2 participants reported hospitalization both after first dose and after second dose. Mean duration of hospital stays was 7.0 (sd: 7.37) days for first dose and 6.4(sd: 8.77) days for second dose among the 13 participants who received Pfizer vaccine, 3.3(3.21) days for first dose and 4.0(1.00) days for second dose among the 6 participants who received Moderna, and 2.3(0.58) days among the 3 participants who received J&J.

Conclusions: This real-world evidence of hospitalization due to vaccine side effects is informative and provides unique information about characteristics of the hospitalizations.