(139) Investigation on Primary Management of Community-Acquired Pneumonia at The Emergency Department in Vietnam

Saturday, August 27, 2022

8:00 AM – 6:00 PM CEST

Location: Hall C

Publication Number: 813

Presenting Author(s)

Tien Hoang Tran
– University Medical Center at Ho chi minh city, National Cancer Center Graduate School of Cancer Science and Policy, Ho Chi Minh City, Vietnam

Co-Author(s)

Nhu Quynh Tran
– Department of Pharmacy, Thong Nhat Hospital, Ho Chi Minh City, Vietnam, Vietnam
Trang Nguyen Doan Dang
– Department of Pharmacy, University Medical Center Ho Chi Minh City. Vietnam, Vietnam

Background: Community-acquired pneumonia (CAP) is one of the most common life-threatening infections. Poor adherence to CAP guidelines has been reported in many hospitals, which might be an important cause of unsuccessful treatment outcomes.

Objectives: This study aimed at investigating the bacterial pathogens, the choice of antibiotics, and the rationality of antibiotic indication among patients with CAP at a teaching hospital in Vietnam.

Methods: A cross-sectional study was conducted on 300 patients with CAP who were admitted to the Emergency Department (ED) and subsequently transferred to the Respiratory Department (RD) or the Intensive Care Unit (ICU) at the University Medical Center Ho Chi Minh City from June 2018 to April 2019. Patients died during hospitalization for reasons other than CAP, patients with non-bacterial CAP (viruses, parasites) were excluded from the study. Medical records were reviewed for data analysis including demographics, isolated bacteria, antibiotics indicated, and treatment outcomes. The rationality of antibiotic therapy was assessed based on adherence to CAP guidelines, including the choice of antibiotic, dosing, and route of administration. All data analyses were performed using SPSS 22.0 statistical software.

Results: The most common isolated bacteria were Acinetobacter baumannii (37.7%) and Klebsiella pneumoniae (30.4%). Beta-lactam antibiotics were the most common antimicrobial monotherapy observed (39% in the ED and 42% in clinical departments). The proportions of adherence to antimicrobial practice guidelines at the ED and clinical departments were 64.8% and 64.3%, respectively. Multivariate logistic regression analysis showed that non-adherence to guidelines in clinical departments was associated with a reduction in clinical cure rate (OR = 0.209, 95% CI: 0.061-0.711, p = 0.012).

Conclusions: Results from the study emphasized the importance of adherence to CAP guidelines in clinical settings.