(73) Persistence and Adherence to Antihypertensive Drugs in The Participants of Social Health Insurance Attending a Primary Care Clinic in Banjarmasin, Indonesia

Sunday, August 28, 2022

8:00 AM – 1:45 PM CEST

Location: Hall C

Publication Number: 1118

Presenting Author(s)

Alfi Yasmina
– School of Medicine Lambung Mangkurat University, Banjarmasin, Kalimantan Selatan, Indonesia

Co-Author(s)

Haura Maulida Rahmatika
– Medicine Study Program, Faculty of Medicine, Universitas Lambung Mangkurat, Indonesia
Farida Heriyani
– Department of Public Health, Faculty of Medicine, Universitas Lambung Mangkurat, Indonesia
Djallalluddin Djallalluddin
– Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat, Indonesia
Hendra Wana Nur’amin
– Department of Pharmacology, Faculty of Medicine, Universitas Lambung Mangkurat, Indonesia

Background: Hypertensive patients should be persistent and adherent when using antihypertensive drugs.

Objectives: This study aimed to determine persistence and adherence to antihypertensive treatments in Indonesian Social Health Insurance (BPJS) participants attending a primary care clinic, based on types and classes of antihypertensives, as well as patient characteristics.

Methods: This study used retrospective cohort design conducted on secondary data from outpatient back-referral program for hypertensive patients who were BPJS participants attending a primary care clinic in Banjarmasin during 2020. Persistence was measured by calculating the gap between prescriptions with 15 days cutoff, and adherence was measured with Medication Posession Ratio (MPR). Persistence was analysed with survival analysis, while difference in adherence was tested by Mann-Whitney and Kruskal-Wallis tests.

Results: A total of 154 patients were included in this study, consisted of mostly females (55.8%) and 50% of the patients were ≥ 60 years. Most patients had comorbidities (69.5%), started with a monotherapy drug (90.9%), with calcium antagonists (46.8%) and angiotensin receptor blockers (33.8%) were used the most. During 2020, the proportion of patients who persistently used antihypertensives was 20.1% with a median persistence of 210 days (95%CI 18.32-230.68). Adherence to antihypertensive treatments was indicated by MPR mean of 72.12±22.08%. There were no significant differences between patient persistence and adherence based on types and classes of antihypertensives, age, gender, and comorbidities (p > 0.05).

Conclusions: It was concluded that persistence and adherence to antihypertensive treatments in BPJS participants attending a primary care clinic in Banjarmasin were poor, and type and classes of antihypertensives, as well as patient characteristics were not significantly affected the persistence and adherence to antihypertensive treatments. Other factors associated with the persistence and adherence need to be investigated to improve the treatment of these patients.