Professor, Section of Endocrinology, Diabetes and Metabolism
Baylor College of Medicine
Houston, Texas, United States
My primary research interest is on understanding abnormalities in energy metabolism, mitochondrial dysfunction and redox biology in aging, and how it contributes to age-associated abnormalities and disease. For the past 2 decades I have conducted translation reseach to investigate mechanisms underlying the deficiency of Glutathione, the most abundant endogenous, intracellular antioxidant. I discovered that impaired synthesis was responsible for glutathione deficiency and developed a novel nutritional approach called GlyNAC to correct glutathione deficiency in humans. Results from studies in aged rodents reveal that GlyNAC supplementation increases length of life by 24% and corrects multiple age-associated defects in the brain, heart, liver, kidneys and muscle. Clinical trials in older adults show that GlyNAC supplementation reverses glutathione deficiency, oxidative stress, mitochondrial dysfunction and aging hallmarks to improve strength, waist circumference, blood pressure and cognition. Overall, these findings and discoveries provide proof-of-concept that GlyNAC supplementation improves healthy aging, and health in aging in humans, and has implications for survival. Ongoing work is focused on understanding the effets of GlyNAC supplementation on age-associated abnormalities in cognition, metabolic syndrome, cardiac, liver and renal health, insulin resistance and diabetes, and sacropenia and physical function, while simultaneously investigating underlying mechanisms at the biochemical, metabolic and molecular level.
Disclosure information not submitted.
Thursday, November 3, 2022
12:00 PM – 1:30 PM ET
Thursday, November 3, 2022
12:00 PM – 1:30 PM ET
Thursday, November 3, 2022
2:00 PM – 3:00 PM ET