Assistant Professor
University of California, San Francisco
San Francisco, California, United States
I am an Assistant Professor in the Cardiovascular Research Institute and the Department of Physiology at the University of California, San Francisco, and am also affiliated with the Chan Zuckerberg Biohub. My research program is focused on the cell biology of the nucleus. Our work focuses on two major themes: (i) dissecting the functions of the nuclear periphery, and (ii) defining how dynamic spatial and temporal regulation of the nuclear periphery shapes function. I bring an innovative perspective to the nuclear organization field by integrating my cell biology background with dynamic proteomic approaches, which we use as a powerful discovery tool to reveal new biological regulatory mechanisms. For instance, we have used protein turnover measurements and high-resolution microscopy to uncover a novel lysosome-mediated degradation pathway for an unstable nuclear membrane protein (Buchwalter et al., eLife 2019) and to reveal a dramatic shift in protein synthesis regulation in an accelerated aging syndrome (Buchwalter & Hetzer, Nat Comms 2017). We have recently developed methods to quantify cell lifetime, protein lifetime, and protein abundance within a single multiplexed in vivo experiment, which we have used to determine that protein lifetime varies independently of cell lifespan across tissues, indicating that protein lifetime is influenced by both intrinsic and environmental factors(Hasper et al., BioRXiV 2022). We are currently using these approaches to illuminate the mechanisms of “laminopathy” diseases.
Disclosure information not submitted.
Sunday, November 6, 2022
10:00 AM – 11:30 AM ET
Sunday, November 6, 2022
10:00 AM – 11:30 AM ET