Novel Interventions and Targets for the Prevention of Dementia and Frailty: 2021 Editor’s Choice Articles from JGMS

Friday, November 4, 2022

12:00 PM – 1:30 PM ET

Location: 201 CC

CE: 1.5

Chair(s)

LL

Lewis Lipsitz, MD

Director, Marcus Institute for Aging Research
Hinda and Arthur Marcus Institute for Aging Research
Hebrew SeniorLife
Brookline, Massachusetts, United States

Discussant(s)

Beverly Gwen Windham, MD, MHS

Professor
Medicine/Division of Geriatric Medicine
UMMC-The MIND Center
Jackson, Mississippi, United States

Slides

Individual Symposium Abstract First Author(s)

Jeffrey Scherrer, PhD

Vice Chair for Research and Professor
Family and Community Medicine
Saint Louis University School of Medicine
St. Louis, Missouri, United States
Kristen George, PhD, MPH

Assistant Professor
Public Health Sciences
University of California Davis School of Medicine
Daivs, California, United States
AO

Ariela Orkaby, MD, MPH

Geriatrician
New england GRECC (Geriatric Research, Education, and Clinical Center)
VA Boston
Boston, Massachusetts, United States
Justin Golub, MD, MS

Associate Professor
Otolaryngology-Head and Neck Surgery
Columbia University
New York, New York, United States

This symposium will present four 2021 “Editor’s Choice” articles from the Journal of Gerontology Medical Sciences that focus on novel interventions and targets for the prevention of dementia and frailty. Jeffrey Scherrer and colleagues, in their article “Lower Risk for Dementia Following Adult Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination,” examine the links between adult vaccinations and decreased dementia risk. Katharine Brewster, Justin Golub (presenter), and colleagues, in “Age-Related Hearing Loss, Late-Life Depression, and Risk for Incident Dementia in Older Adults,” investigate hearing loss and depression as independent risk factors for eventual conversion to dementia. By understanding these potentially reversible mechanisms for dementia, targets for early interventions could be identified. “Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians’ Health Study,” written by Ariela Orkaby and colleagues, examines the association between long-term aspirin use and frailty, furthering our understanding of the benefits of anti-inflammatory medications even in older adults. Kristen George and coauthors, in their article, “Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Midlife on Late-Life Cognition: Study of Healthy Aging in African Americans,” examine how cardiovascular risk factors early in life may affect late life cognition in Black Americans. Beverly Gwen Windham, the discussant, will highlight commonalities and lessons learned from these studies.

Learning Objectives:

After attending this session, participants will be able to recognize hearing loss and midlife cardiovascular risk factors as important and potentially remediable risk factors for cognitive impairment.
After attending this session, participants will be able to review preliminary data that vaccination may be a novel intervention to prevent dementia.
After attending this session, participants will be able to understand the association between long-term aspirin use and frailty in men, and its potential value to prevent functional decline.

Presentations:

12:00 PM – 1:30 PM ET

Adult Tetanus, Diphtheria, and Pertussis Vaccination and Incident Dementia
Individual Symposium Abstract First Author: Jeffrey Scherrer, PhD – Saint Louis University School of Medicine
12:00 PM – 1:30 PM ET

Impact of Cardiovascular Risk Factors in Adolescence, Young Adulthood, and Mid-Life on Late-Life Cognition
Individual Symposium Abstract First Author: Kristen M. George, PhD, MPH – University of California Davis School of Medicine
12:00 PM – 1:30 PM ET

Association Between Long-Term Aspirin Use and Frailty in Men: The Physicians' Health Study
Individual Symposium Abstract First Author: Ariela R. Orkaby, MD, MPH – VA Boston
12:00 PM – 1:30 PM ET

Age-Related Hearing Loss, Late-Life Depression, and Risk for Incident Dementia in Older Adults
Individual Symposium Abstract First Author: Justin S. Golub, MD, MS – Columbia University