Introduction to the Study of Muscle, Mobility, and Aging (SOMMA) and Preliminary Results

Friday, November 4, 2022

10:00 AM – 11:30 AM ET

Location: 245 CC

CE: 1.5

Chair(s)

SC

Steve Cummings, MD (he/him/his)

Senior Scientist
Medicine, Epidemiology and Biostatistics
San Francisco Coordinating Center
San Francisco, California, United States

Slides

Co-Chair(s)

Anne Newman, MD, MPH

Distinguished Professor
Epidemiology
University of Pittsburgh
Pittsburgh, Pennsylvania, United States

Individual Symposium Abstract First Author(s)

SC

Steve Cummings, MD (he/him/his)

Senior Scientist
Medicine, Epidemiology and Biostatistics
San Francisco Coordinating Center
San Francisco, California, United States

Slides
Anne Newman, MD, MPH

Distinguished Professor
Epidemiology
University of Pittsburgh
Pittsburgh, Pennsylvania, United States
TM

Theresa Mau, PhD

Postdoctoral Fellow
California Pacific Medical Center Research Institute
San Francisco Coordinating Center
San Francisco, California, United States
SK

Stephen Kritchevsky, PhD, FGSA

Professor
Sticht Center for Healthy Aging and Alzheimer's Prevention
Wake Forest School of Medicine
Winston Salem, North Carolina, United States
PC

Peggy Cawthon, PhD, MPH

Scientific Director
Department of Epidemiology and Biostatistics
University of California, San Francisco
San Francisco, California, United States

SOMMA is a new cohort study conducted at Wake Forest and University of Pittsburgh, coordinated by the San Francisco Coordinating Center, with management of biological specimens by Adventist Health Research Institute. We aim to discover the biological basis of mobility disability and have collected tissues and measurements for future studies of the biology of human aging. SOMMA has enrolled ~875 older men and women (aged 70 years), and will follow-up participants by phone and in-person every six months for up to three years. An additional cohort of younger adults (aged 30-69) is being enrolled. In this symposium, we will describe the underlying conceptual construct for the study; the baseline characteristics of the cohort; recruitment techniques to enroll participants. We will present preliminary data from ~425 participants, including the association between mitochondrial energetics and muscle function (strength and power); the interrelationship between physical and cognitive measures; and the association of D3Cr muscle mass with strength and walking speed. Finally, we will describe how to obtain data and specimens for analyses and ancillary studies.

Learning Objectives:

After attending this session, participants will be able to describe the design of the SOMMA study
After attending this session, participants will gain an understanding of preliminary data from SOMMA.

Presentations:

10:00 AM – 11:30 AM ET

Introduction to SOMMA: Conceptual Construct and Participant Characteristics
Individual Symposium Abstract First Author: Steve Cummings, MD (he/him/his) – San Francisco Coordinating Center
10:00 AM – 11:30 AM ET

Recruitment of SOMMA Participants: Techniques to Enroll Older Adults in a Complex Study
Individual Symposium Abstract First Author: Anne Newman, MD, MPH – University of Pittsburgh
10:00 AM – 11:30 AM ET

Preliminary SOMMA Data: Mitochondrial Energetics, Leg Power, and Cardiorespiratory Fitness
Individual Symposium Abstract First Author: Theresa Mau, PhD – San Francisco Coordinating Center
10:00 AM – 11:30 AM ET

Preliminary SOMMA Data: Cognitive and Physical Function Relationships in Older Adults
Individual Symposium Abstract First Author: Stephen B. Kritchevsky, PhD, FGSA – Wake Forest School of Medicine
10:00 AM – 11:30 AM ET

Preliminary SOMMA Data: D3Cr Muscle Mass and Strength and Walking Speed in Older Men and Women
Individual Symposium Abstract First Author: Peggy M. Cawthon, PhD, MPH – University of California, San Francisco