Antecedents, Outcomes, and Correlates of Metabolic Health in Older Age: A Multidisciplinary Perspective

Wednesday, November 2, 2022

12:30 PM – 2:00 PM ET

Location: 238 CC

CE: 1.5

Chair(s)

Johanna Drewelies, PhD

Senior Scientist
Psychology
Humboldt University Berlin
Berlin, Berlin, Germany

Co-Chair(s)

ES

Elisabeth Steinhagen-Thiessen, n/a

Prof.
Endocrinology
Charité - Universitätsmedizin Berlin
Berlin, Berlin, Germany

Discussant(s)

Jeremy Walston, MD

Professor
Division of Geriatric Medicine and Gerontology
Johns Hopkins University
Baltimore, Maryland, United States

Individual Symposium Abstract First Author(s)

SD

Sandra Duezel, Dr.

Dr.
Lifespan Psychology
Max-Planck-Insitute for human developement
Berlin, Berlin, Germany
NB

Nikolaus Buchmann

Dr.
Department of Cardiology
Charité - University Medicine Berlin
Berlin, Berlin, Germany
Rita Kalyani, MD, MHS

Associate Professor of Medicine
Division of Endocrinology, Diabetes, and Metabolism
Johns Hopkins University School of Medicine
Baltimore, Maryland, United States
ID

Ilja Demuth, PhD

Prof.
Medizinische Klinik für Endokrinologie und Stoffwechselmedizin
Charité Universitätsmedizin Berlin
Berlin, Berlin, Germany

Metabolic syndrome (MetS) is a cluster of risk factors for cardiovascular disease associated with reduced physical fitness, higher disease burden, and impaired cognitive functions in late life. Thus investigating antecedents, outcomes and correlates of metabolic health is a priority in order to promote healthier lifestyles and successful aging. This symposium compiles four empirical interdisciplinary studies that examine the role of metabolic health/risk on different timescales. Employing advanced modeling approaches to data obtained in large-scale studies, these reports will shed light on potential antecedents, correlates, and consequences thereof. First, Kalyani and colleagues will report data from the SPRING (Study of Physical Resilience IN Geriatrics) study on the interrelation between metabolic syndrome, glucose intolerance, and physical resilience.Second, Buchmann and colleagues examine the association of the metabolic syndrome and Lipoprotein(a) finding that hormonal aspects and in particular menopausal alterations seem to moderate theassociation between MetS and Lp(a). Third, Demuth and colleagues show how metabolic health is related to specific DNA methylation age acceleration as derived from five different epigenetic clocks, namely PhenoAge, and GrimAge.Fourth, Duezel and colleagues examine the neural correlates of metabolic risk in a sample of older adults finding that lower metabolic risk is linked to greater GMI in the prefrontal cortex. Conjointly, findings demonstrate the multifaceted nature of metabolic risk across adulthood and across different timescales. Walston will critically discuss the contributions from an aging perspective and discuss implications for future research.

Learning Objectives:

After attending this session , participants will gain an overview into the multidimensional perspectives of metabolic risk and its associations with genetic, biological and cognitive health.
After attending this session, participants will lean novel methods e.g. of using continuous latent variable approaches representing the common variance of MetS indicators as a systemic phenomenon in which risk factors are operating on either side of the normal versus pathological divide.
After attending this session, participants will be able to distinguish different time metrics (cross-sectional associations and long-term changes) of investigating how metabolic risk factors are related to outcomes such as health, cognition, and genetics.

Presentations:

12:30 PM – 2:00 PM ET

Associations Among Latent Factors of Metabolic Load, Brain Volume, and Cognition in Healthy Aging
Individual Symposium Abstract First Author: Sandra Duezel, Dr. – Max-Planck-Insitute for human developement
12:30 PM – 2:00 PM ET

Lp(a) and Metabolic Syndrome in Older People
Individual Symposium Abstract First Author: Nikolaus Buchmann – Charité - University Medicine Berlin
12:30 PM – 2:00 PM ET

Metabolic Syndrome, Glucose Intolerance, and Physical Resilience
Individual Symposium Abstract First Author: Rita R. Kalyani, MD, MHS – Johns Hopkins University School of Medicine
12:30 PM – 2:00 PM ET

Relationship Between Metabolic Health and 5 Epigenetic Clocks in the Berlin Aging Study II (BASE-II)
Individual Symposium Abstract First Author: Ilja Demuth, PhD – Charité Universitätsmedizin Berlin