Associate Professor
UCSF, Dept. of Laboratory Medicine
San Francisco, California, United States
Dr. Ari Molofsky is an MD/PhD Clinical Pathologist and Immunologist and Associate Professor of Laboratory Medicine at UCSF. Dr. Molofsky’s research goals are to understand the regulation and function of tissue-resident lymphocytes to define novel pathways that can be targeted in diverse human diseases, including obesity/type 2 diabetes, allergic pathologies (asthma, allergy), and neuropsychiatric disease. They are particularly focused on type-2 immune-associated lymphocytes, including type 2 innate lymphoid cells (ILC2), Th2 cells, and subsets of regulatory T (Treg) cells, and the ‘niche’ stromal cells and signals involved in their regulation. These tissue resident immune cells are early organizers of tissue remodeling and first responders during tissue damage and infection, positioning them as key mediators of tissue health and disease. The Molofsky lab has defined an adventitial ILC2 niche surround larger vessels and other boundary structures in multiple tissues, including lung, liver, adipose tissue, and brain. They are using multi-modal approaches such as 3D quantitative imaging, single cell transcriptomics, and cytokine reporters to dissect these critical immune-microenvironment interactions.
Disclosure information not submitted.
Friday, June 24, 2022
3:20 PM – 3:45 PM PT
