Professor of Surgery and Microbiology and Immunology, Vice Chair for Research, Department of Surgery
University of Maryland School of Medicine
Baltimore, Maryland, United States
Jonathan Bromberg, MD, PhD is a professor in the Departments of Surgery and Microbiology and Immunology at the University of Maryland School of Medicine. He has been involved continuously in basic cellular and molecular transplant immunology for 30 years and have been continuously funded for the entire time. His basic research has always focused on T cell immunobiology, and for more than 20 years has also focused on issues of migration, trafficking, secondary lymphoid organ structure and function, and lymphatic structure and function, and how these processes and structures influence T cell immunity and T cell tolerance in models of transplantation. He has also maintained an active clinical practice in solid organ transplantation and is thus constantly exposed to the problems of patients and their immune systems, including cellular and humoral rejection, opportunistic infections, chronic viral disease, autoimmune organ failure, and immunosuppression medication side effects.He has had over 60 trainees in my lab, am actively involved in teaching and mentoring. Dr. Bromberg has made seminal discoveries in determining in what anatomic locations tolerance take place and what cellular and molecular processes determine the choice between tolerance and immunity. He demonstrated that proper lymph node function and structure are required for tolerance and that the interaction of lymphocytes and lymphatic endothelium regulate both tolerance and immunity. He has outlined the molecular mechanisms that determine the induction, stimulation, maintenance, and activity of the FoxP3+ CD4+ suppressive regulatory T cells, which are the most critical cells for manipulating immunity and tolerance.
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Wednesday, June 22, 2022
10:45 AM – 11:10 AM PT
