Irini Sereti, MD

Senior Investigator- Section Chief
National Institute of Allergy and Infectious Diseases
Bethesda, Maryland, United States

Dr Sereti is the Chief of the HIV Pathogenesis Section in the Laboratory of Immunoregulation at NIAID. After her Internal Medicine training and Chief residency at Northwestern University in Chicago, she completed an infectious disease fellowship at NIAID/NIH and joined the Laboratory of Immunoregulation, initially as a staff clinician, and starting in 2009 as a tenure track investigator receiving tenure in 2015. Her group studies the acute (IRIS) and long-term inflammatory complications of treated HIV and the etiology, prognosis and management of idiopathic CD4 lymphopenia, a rare disorder of low CD4 counts in the absence of HIV. Her previous work on inflammation and lymphopenia has led to new projects on COVID-19 to address the pathogenic mechanisms of inflammation and lymphopenia. Dr Sereti is a physician-scientist with a strong commitment to diversity and equity, excellence in clinical care and mentorship.

Disclosure information not submitted.

Presentation(s):

• Idiopathic CD4 Lymphopenia: A Reappraisal

  Thursday, June 23, 2022
  12:45 PM – 1:10 PM PT

• Autoreactive CD8+ T Cells are Restrained by an Exhaustion-like Program that is Maintained by LAG3

  Thursday, June 23, 2022
  3:00 PM – 3:15 PM PT

• Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus

  Thursday, June 23, 2022
  3:15 PM – 3:30 PM PT

• IL-33 and IL-4 Synergize to Dysregulate TREG Cell Function and Promote Type 2 Responses in RSV-induced Asthma

  Thursday, June 23, 2022
  3:30 PM – 3:45 PM PT

• Multi-omic Profiling in Celiac Disease Reveals Somatic Driver Mutations in Rogue T cell Clones

  Thursday, June 23, 2022
  3:45 PM – 4:00 PM PT

• Single-cell Transcriptomics of Human Alopecia Areata Reveals Clonally Expanded and Activated CD4+ and CD8+ T-cell Populations

  Thursday, June 23, 2022
  4:00 PM – 4:15 PM PT

• Phenotype-based Isolation of Antigen-specific CD4+ T cells in Autoimmunity: A Study of Celiac Disease

  Thursday, June 23, 2022
  4:15 PM – 4:30 PM PT

• Two Sources of Autoreactive T Cells in Patients with FOXP3 Mutations

  Thursday, June 23, 2022
  4:30 PM – 4:45 PM PT

• Understanding the T Cell Repertoire in Autoimmune Diseases Using High-dimensional Single-cell Analysis of Antigen-specific CD4+ and CD8+ T cells

  Thursday, June 23, 2022
  4:45 PM – 5:00 PM PT