The Importance of Immune Homeostasis in Ocular Inflammatory Disease
Tuesday, June 21, 2022
8:00 AM – 12:00 PM PT
Location: Salons 3/4
Organized By
Description: Maintenance of the ocular structures and cells that allow for precise visual function necessitates a fine balance of many intricate, redundant mechanisms to maintain immune homeostasis of the eye. A broad range of disorders can arise when this fine balance is disrupted, ranging from frank uveitis to viral infections, inappropriate post-operative inflammation, diabetic retinopathy, and even age-related macular degeneration. In order to better understand various diseases’ pathogenesis, it is first essential to understand what ocular components, local systemic lymphoid tissues, and also systemic lymphoid tissues or mechanisms help maintain immune homeostasis. It is then important to consider how response to an inciting event such as trauma or infection occurs by this network. Finally, it is of great importance to then learn how these mechanisms can be harnessed to effectively re-establish immune homeostasis of the eye to prevent the potentially blinding consequences. We plan to organize a symposium to cover these topics in an arc with a combination of basic science lectures and translational studies to look at mechanisms, and ultimately potential therapeutics for ocular inflammatory conditions.
Co-Chairs: Phoebe Lin, MD, PhD Casey Eye Institute, Oregon Health & Science University
Lynn Hassman, MD, PhD Washington University
Program Agenda: 8:00am - 8:05am Introduction Lynn Hassman, MD, PhD Washington University
Maintaining Immune Homeostasis in the Eye and Elsewhere
8:05am - 8:25am Immune Surveillance of Ocular Antigens During Homeostasis Jamie Walsh, MD, PhD Washington University
8:25am - 8:45am Neuropeptide Regulation of Immune Privilege in the Eye Andrew Taylor, PhD Boston University
8:45am - 9:05am The Immunobiology of Tissue Tregs Jarish Cohen, MD, PhD University of California, San Francisco
Disrupting Immune Homeostasis
9:05am - 9:25am Biomarkers in Non-infectious Uveitis Shilpa Kodati, MD National Eye Institute, NIH
9:25am - 9:45am Proteomic Biomarkers of Inflammatory Eye Disease Vinit Mahajan, MD, PhD Stanford University
9:45am - 10:05am Distinct Immunologic Mechanisms Activate CD4 T Cells in Uveitis Lynn Hassman, MD, PhD Washington University
Targeting Re-establishment of Immune Homeostasis
10:30am - 10:50am Immunological Lessons from a Monogenic Immune Dysregulation Disorder Erica Schmitt, MD, PhD Washington University
10:50am - 11:10am Altering the Intestinal Microbiota to Re-establish Intestinal Immune Homeostasis to Treat Uveitis Phoebe Lin, MD, PhD Casey Eye Institute, Oregon Health & Science University
Panelist Talks
11:10am - 11:20am Pathogenic T Cells and Lessons from the Accelerating Medicine Partnerships Project Deepak Rao, MD, PhD Brigham and Women's Hospital
11:20am - 11:30am Germline Genetic Contribution to Cancer Immune Responsiveness David Bedognetti, PhD Sidra Medicine
11:30am - 11:40am Current and Future Status of Clinical Trials in Uveitis Nisha Acharya, MD University of California, San Francisco
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