Inflammation, Inflammatory Triggers and Anti-inflammatory Approaches: Key Regulators Impacting Autoimmunity, Cancer and Transplantation

Description:
Advances in our understanding of mechanisms involved in the inflammatory process have revolutionized our opportunity to treat patients and to better inform about transplant rejection, autoimmune diseases and cancer. This session will highlight new approaches exploring inflammation, major drivers of inflammation and ways to alter disease progression. Specially, our speakers will share new ways to utilize T-reg cells in autoimmune disease, explore the archetypes in the tumor microenvironment and their impact on anti-tumor immune strategies, and identify mechanisms for immune-protection and overriding T cell tolerance in transplantation. Finally, our two Societies will showcase lectures highlighting how these themes overlap and apply to autoimmune disease, cancer and transplantation.

Co-Chairs:
Barbara Detrick, PhD
The Johns Hopkins University

Elaine Reed, PhD
University of California, Los Angeles

Program Agenda:
1:00pm - 1:05pm
Introduction
Barbara Detrick, PhD
The John Hopkins University

1:05pm - 1:45pm
Next Frontier in Autoimmune Disorders: Manipulating T-regs in the Management of Type 1 Diabetes
Qizhi Tang, PhD
University of California, San Francisco

1:45pm - 2:25pm
Modulating Donor Mitochondrial Fusion/Fission Delivers Immunoprotective Effects in Cardiac Transplantation
Satish N. Nadig, MD
Northwestern University

2:25pm - 3:05pm
Regulating Inflammation in the Tumor Microenvironment and Uncovering Strategies to Promote Anti-tumor Immunity
Alexis Combes, PhD
University of California, San Francisco

3:30pm - 4:10pm
Pregnancy-induced Humoral Sensitization Overrides T Cell Tolerance to Fetus-matched Allografts
Anita Chong, PhD
University of Chicago

4:15pm - 5:00pm
Final Questions and Closing Remarks
Elaine Reed, PhD
University of California, Los Angeles