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W1
Aryl Hydrocarbon Receptor Activity is Required Downstream IL-10 Signaling to Promote Regulatory Functions in Human Dendritic Cells

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W2
Conventional and Unconventional T-Cell Sources of IL-17A and IL-17F in Psoriatic Arthritis

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W3
Anti-CD45RC Antibody Immunotherapy Prevents and Treats Experimental Autoimmune Poly Endocrinopathy Candidiasis Ectodermal Dystrophy Syndrome

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W4
Tolerogenic Dendritic Cells Engineered with a Lentiviral Vector Encoding for IL-10 and Antigen Control T Cell Responses to Pathogenic Antigens

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W5
Human Aging, Autoimmunity, and Palmitate: The Fatty Acid Palmitate Induces Human B Cell Metabolic Reprograming and Autoimmunity in Aging and Obesity

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W8
The B Cell Repertoire in Multiple Sclerosis Reveals Molecular Mimicry between EBV EBNA1 and GlialCAM

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W9
Glucose Metabolism Controls Human γδ-T Cell-mediated Tumor Immunosurveillance in Diabetes Through AMPK Pathway

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Th1
Clinical Grade CD8+T Regulatory Cells Moving Forward in Human Transplantation

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Th5
Spatial Whole Transcriptome Analysis of Human Kidney Histological Structures using Digital Spatial Profiling

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Th6
A CXCR4/PLC-mediated Cell Survival Pathway is Involved in Steroid Resistance of B-acute Lymphoblastic Leukemia

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Th7
Vitamin D Modulates Th2 Response by Mediating T Regulatory Cells in Allergic Conjunctivitis

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Tu4
Molecular Signature of Myeloid Cells during Ischemia-Reperfusion Injury in Human Liver Transplantation

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Tu5
Serum IL-6 and PTX3 Predict Severe Outcome from Covid-19 in Ambulatory Subjects

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Tu6
Identification of Novel DRB1*01:01-restricted T Cell Epitopes in Rheumatoid Arthritis

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Tu9
IL-6 Targeted Therapies Directed to Cytokine or Cytokine Receptor Blockade Drive Distinct Alterations in T Cell Function.

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W10
Intrathecal CD8+CD20+ T Cells in Primary Progressive Multiple Sclerosis

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W11
Combination of ImmTOR Tolerogenic Nanoparticles and IL-2 Mutein Induces Massive Expansion of Antigen-specific Regulatory T Cells

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W13
Vedolizumab Reduces Dendritic Cells and Naïve Lymphocytes in the Colon Mucosa

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W17
Immune Remodelling in Advanced Adenocarcinoma by a CD40L-MUC1 Vaccine

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W19
MHC-deficient CD8+ Tregs as Universally Compatible Cell Therapy

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W21
Reemergence of Pathogenic B Cell Clones in Autoimmune Myasthenia Gravis Tollowing B Cell Depletion Therapy

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W22
Kv1.3−/− Mice Do Not Develop CIA: A Novel Target with Small Molecules for Autoimmune Arthritis

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W23
Sex Differences in NK Cells Mediated by the X-linked Epigenetic Regulator UTX

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W24
Interferon Gamma Induction of TH1-like Tregs Dampens Anti-viral Responses

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W26
Serum Levels of IgG Antibodies Against Oxidized LDL and Atherogenic Indices in HIV-1-infected Patients Treated with Protease Inhibitors

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W28
A SLIT3 Deficiency Promotes M1 Macrophage Polarization and Inflammation

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W30
Underlying T Cell Receptor Methylation Defects in Type 1 Diabetes Associated with Quantitative Defects

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W32
Therapeutic Effects of Anti-IFNg Therapy in a Spontaneous Mouse Model of Myositis

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W35
Exaggerated Inflammatory Response During Acute Lung Injury: Role of Mitochondrial ROS and NLRP3 Inflammasome

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W36
Plasma Levels of the MiR-193b/365a Cluster in Combination with Clinical Parameters Predict Response to Lactococcus Lactis-based Antigen-specific Combination Therapy

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W37
JAK Inhibition in a Patient with a STAT1 Gain-of-function Variant Reveals STAT1 Dysregulation as a Common Feature of Aplastic Anemia

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W38
Antigen-driven Ocular Immune Responses Distinguish Granulomatous and Non-granulomatous Uveitis

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W39
Identification of a Transcription Factor Network that Regulates Anti-TNF Mediated IL-10 Expression by Human CD4+ T-Cells

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W43
Combined Germline and Somatic FADD Mutations as a New Cause of Autoimmune Lymphoproliferative Syndrome

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W44
An Automated Approach to High-Content Cytometric Immune Profiling of Human PBMC and Blood Samples

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W47
Immunometabolism Effect of Follicular Helper T Cells in Systemic Lupus Erythematosus

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W49
Brain-homing Monocytes Identified in Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are Immunosuppressive

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W50
A Dysregulated CXCR3+CCR6+ Adaptive Immune Rheostat Exists in Patients with Active Enthesitis-related Arthritis

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W56
Evaluation of GPER Activation Pathways Associated with Migration and Invasion in LNCaP Cells

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W58
Transcriptomic Comparison of Pediatric Acute Myeloid Leukemia Cells Sensitive or Resistant to Engineered Tr1-like Cell Mediated Killing

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W59
Deep Biology Approach for Development of Novel Therapeutics for Autoimmunity and Inflammation

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W60
Racial and Ethnic Disparities in Detection of Donor-Specific HLA Antibodies

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W61
Expression of TNFR2 and CD29 Define a Highly Suppressive Subset of Human CD8+ T Regulatory Cells

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W62
Osteosarcoma Tumorigenesis is Affected by Macrophage Behavior in 3D Engineered Bone Marrow Model

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W63
DiSiR: A Software Framework to Identify Ligand-receptor Interactions at Subunit Level from Single-cell RNA-sequencing Data

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W64
Association of rs763361 C>T and rs727088 G>A SNPs of DNAM-1 with CRP Levels and BASDAI Index in Ankylosing Spondylitis Patients

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W65
Longitudinal Dynamics of SARS-CoV-2 Specific Cellular Immunity to Different Vaccination Schemes

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W66
Association of CTLA-4 (AT)n Genetic Variants in Basal Cell Carcinoma and Squamous Cell Carcinoma in Patients from Western Mexico

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W67
Novel Therapy with Neddylation Inhibitor Delays the Progression of Disease in Pre-Diabetic Non-Obese Diabetic Mice by Restoring Endogenous Treg Function

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W68
Human CD4+CD25+ Regulatory T Cells Deficient of CD226 Demonstrate Increased Purity and Lineage Stability Following Ex Vivo Expansion for Adoptive Treg Therapies

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W69
Effect of Chronic Exposure to Abrocitinib on Immune Homeostasis in Mice

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W70
SARS-CoV-2 Rapid Antigen Kit Efficacy in Comparison with Quant Studio 12 PCR Poster

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W71
SARS-CoV-2 Neutralizing Antibody Presence in Infected and Vaccinated Patients

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W74
The Tumor Suppressor APC Regulates T Lymphocytes Migration: Insights from Familial Polyposis Patients

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W75
A 10-Month Period Evaluation of Cellular Responses After ChAdOx1-nCoV-19 and BNT162b2 Vaccinations

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W78
Autoimmunity Risk Loci Tagged to CIITA and MHC Class II Impact CD8+ T Cell and Monocyte HLA-DR Expression

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W79
A Hypermorphic Variant in CARD11 Leads to A Novel Inflammatory and Immune Regulation Disorder

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W81
Mass Cytometry to Define Healthy Immunotypes

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W87
A Versatile New Monoclonal Antibody for Elucidating Human TMPRSS2 Expression and Function

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W88
IL-21 is a Key Regulator of Chronic Germinal Centers in Autoimmune Settings

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W90
CSF Inflammatory and Neuroaxonal Damage Biomarkers in COVID-19 Associated Encephalopathy and Encephalitis

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W93
Selective Induction of Cell Death in Human M1 Macrophages by Smac Mimetics is Mediated by cIAP-2 and RIPK-1/3 Through the Activation of mTORC

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W94
Herpes Simplex Virus Type 1 Modulation of Neutral Lipid Metabolism in Dendritic Cells Affects the Function of These Cells

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W95
Targeting Cholesterol Metabolism as a Novel Immune Checkpoint in Viral Infections and Cancer

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Th10
Effect of Cigarette Smoke on Immune Response to Pollen Allergen in the Lung

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Th14
Crosstalk Between Alloimmunity and Ischemia-Reperfusion Injury in Human Liver Transplantation

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Th16
Effects of Cytomegalovirus on T Cell Differentiation in Two Distinct Immunosuppressed Populations

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Th18
Long Term Expanded Purified Allospecific Tr1 Cells Maintain a Suppressive Phenotype and Function in the Presence of Inflammatory Cytokines and Express a Chemokine Receptor Profile Involved in Allograft Tolerance.

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Th19
Regulation of Antigen Presenting Cells by Retinal Pigment Epithelial Cells

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Th20
An Academic BCMA-directed CAR-T Therapy (ARI0002h) with Fractionated and Booster Dose in Patients with Relapsed/Refractory Multiple Myeloma: First Data About Efficacy and Safety

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Th25
IL-33 and IL-4 Synergize to Dysregulate TREG Cell Function and Promote Type 2 Responses in RSV-induced Asthma

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Th26
CRISPR-Mediated Deletion of PD1 to Enhance the Efficacy of Human CAR Tregs

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Th30
Use of Ex Vivo Lung Perfusion to Study the Immune Response to Influenza Viral Challenge in Human Lung

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Th32
A Case of μ Heavy and λ Light Chain Amyloidosis in a Patient with Bi-clonal (IgM κ and λ ) Gammopathy Successfully Treated with Daratumumab

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Th33
Developing Islet Antigen-Specific Regulatory T Cell For Therapy in Type 1 Diabetes

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Th34
Performance Comparison of the Spectral Signature, Spillover Spreading Matrix, and Data Unmixing Quality Between the Spectral Cytek Aurora and the Spectral BD FACS Symphony A5 SE by a 35-Color Human Broad Immunophenotyping Panel

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Th37
Clonally Expanded CD8 T Cells Are Recruited to the CSF in Neurosarcoidosis Through the Chemokine Receptors CXCR3 and CXCR4

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Th38
A Novel Ultrasensitive Assay Enables Measurement of IL-11 in Fibrosing Disease Patients and Healthy Donor Samples

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Th39
The Role of Chimeric Antigen Receptor (CAR) Versus Endogenous Co-stimulation in the Function of Alloantigen-specific Tregs

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Th40
Profound abnormalities in thymic epithelial cells in Rag1 mutant mice: implications for immune reconstitution after stem cell transplantation

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Th41
The Therapeutic Potential of Hematopoietic Stem Cell IL-1RA Gene Therapy for the Treatment of Hereditary IL-1-mediated Autoinflammatory Syndromes

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Th42
Next-generation Immunostimulatory Antibody-drug Conjugate (iADC) Combines Direct Tumor Killing and Innate Immune Stimulation to Provide Protective Anti-Tumor Immunity

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Th45
Autoreactive CD8+ T Cells are Restrained by an Exhaustion-like Program that is Maintained by LAG3

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Th46
Calibrating T Cell ‘Help’ by Antigen Cross-linking as a Universal Vaccine Platform Against Rapidly Evolving Pathogenic Viruses

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Th47
Single Cell and Spatially Resolved Analysis of Tissues by Integrated RNA and Protein Multi-omics Identifies Novel Tumour-infiltrating Lymphocyte Phenotypes

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Th49
Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus

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Th50
Elucidating Inflammation-induced Cell Fate Decisions in Primary Human Tregs

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Th51
High Compliance of Oral Immunotherapy and Improvement of Health-related Quality of Life in a Long-term Follow-up for Food Allergy Study

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Th52
Childhood Idiopathic Nephrotic Syndrome is Characterized by Antigen-Experienced B-Cell Responses and Diminished Immunoregulation that are Differentially Targeted by Distinct Immunosuppressive Treatments

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Th54
Pre-existing Cardiothoracic Comorbidity and Lung Disease in Still's

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Th55
Impaired T Cell Mitochondrial Function and Metabolic Shifts in Glycolysis Characterize Axial Spondylarthritis

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Th56
A Novel Multiplex Digital PCR Method Offering Rapid Quantitation of Donor and Recipient DNA After Transplantation

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Th59
Investigating the Immune Basis of Green Tea Induced Liver Injury in Healthy Donors Expressing HLA-B*35:01

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Th60
High Salivary IgA-coating Levels of the Oral Microbiota in Patients with Systemic Lupus Erythematosus (SLE)

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Th61
The Tolerogenic Effects of IL-2 on T Regulatory Cells (Tregs) are TGF-β Dependent

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Th62
Bioengineering Probiotic Yeast to Secrete Anti-Proinflammatory Cytokine Antibodies for Resolving Gut Inflammation

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Th63
Non-Conventional CD8+IL-13+ T Cells in Refractory Atopic Dermatitis Patients

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Th64
Renal Allograft Rejection: New Paradigms in T Cell Reactivity Revealed by Single Cell RNAseq Analysis

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Th69
Oral Mucosal Breaks Trigger Unique Systemic Immune Responses that Mediate Rheumatoid Arthritis

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Th72
Engineering of Alpha/Beta Selective IL-2 Muteins for Antigen Activated T cells in Solid Tumors

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Th73
Pilot Study of a Novel Anti-CD5 Antibody-drug Conjugate for Combined Peripheral and Thymic Lymphocyte Depletion in a Cynomolgus Macaque Model

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Th74
Ex vivo Fold Expansion of Human Regulatory T Cells Negatively Correlates with Preservation of Beta Cell Function in Adolescent T1D subjects

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Th75
Reduced CD8 T Cell Exhaustion in DR4 Risk Subjects is Selectively Augmented with Abatacept in RA

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Th76
The Effect of TRPV1+ Neuron-derived Neuropeptides on Cytokine Production of Th1 and Th17 Cells

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Th77
Postnatal Depletion of Maternal Cells Shifts Splenic NK and CD8+ T Cell Profiles Toward Mature and Activated Phenotypes

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Th80
The Role of Mucosal-Associated Invariant T (MAIT) Cells in Glioblastoma Immunity

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Th84
Leveraging the OASIS Resource to Query LEAP GWAS Results in an Unbiased or Targeted Fashion

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Th89
Increased Intrathecal Activity of Follicular Helper T Cells in Patients with Relapsing-Remitting Multiple Sclerosis

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Th97
Utilization of a Clinical Data Research Network to Improve Identification of Systemic Lupus International Collaborating Clinics Classification Criteria Attributes in Patients with Systemic Lupus Erythematosus

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Th99
Multi-omic Profiling in Celiac Disease Reveals Somatic Driver Mutations in Rogue T Cell Clones

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Tu11
High-Dimensional Immunophenotyping Reveals Altered Regulatory T Cell Fitness Between Inactive and Active Disease in Juvenile Idiopathic Arthritis

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Tu12
An In Silico Analysis to Predict the Function of Genes Associated with Type 1 Diabetes, Systemic Lupus Erythematosus, and Juvenile Idiopathic Arthritis in Colombian Patients

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Tu14
Functional and Molecular Characterization of Th2 Cell Subsets in Type 1 Diabetes

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Tu15
Elevated anti-PEG Antibody Levels Amongst Covid-19 Vaccinated Donors

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Tu18
Targeted PD-1 Agonists as localized Immune Suppressants against Skin Autoimmune and Inflammatory Diseases

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Tu19
Multi-parametric Interrogation of the Systemic Lupus Erythematosus (SLE) Immunome Reveals Multiple Derangements

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Tu20
Chimerism and Bidirectional Alloresponses in Patients Receiving Lung Transplantation

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Tu21
Monitoring of Naturally Acquired and Vaccine-induced SARS-CoV-2 Specific Cellular Immune Responses

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Tu31
Development of Proliferating Cell Nuclear Antigen Autoantibodies with Manifestation of Graft Versus Host Disease after Peripheral Blood Stem Cell Transplantation

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Tu35
Single-cell Transcriptomic Analysis of Peripheral Blood Reveals the Disparate Subsets of Innate Immune Cells in Kidney Transplant Recipient with BK Virus Infection

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Tu36
SARS-CoV-2-specific T Cells in Unexposed Adults Display Broad Trafficking Potential and Cross-react with Commensal Antigens

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Tu38
CLEC5A and TLR2 are Critical in SARS-CoV-2-induced Immunothrombosis and Lung Inflammation

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Tu40
Humoral Response to Heterologous Prime-boost Vaccination with CoronaVac and BNT162b2 in Healthy Individuals and Solid Organ Transplant Recipients

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Tu41
KIR+CD8+ T Cells Target Pathogenic T Cells and are Active in Autoimmune Diseases and COVID-19

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Tu42
JAK Inhibitor Ruxolitinib Prevents Autoimmune Diabetes in Non-Obese Diabetes Mice through Inhibition of the JAK-STAT Pathway in Multiple Cell Types

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Tu43
NaCl Exposure Results in Increased Expression and Processing of IL-1β in Meniere's Disease Patients

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Tu44
Immunotherapy Using IL-34 for the Treatment of GvHD and Solid Organ Rejection: Strategies for its Optimisation

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Tu45
Isocaloric Ketogenic Diet Modulates NLRP3 Inflammasome of Macrophages via β-hydroxybutyrate and Fibroblast Growth Factor 21 in Humans

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Tu46
Quantitative Analysis of SARS-CoV-2 Antibody Titer After the 3rd Dose of COVID-19 Vaccination

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Tu48
Naïve Arthritogenic SKG T Cells have a Defect in Anergy and a Repertoire Pruned by Superantigen

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Tu49
Multi-OMICs Analysis of Metabolites, Proteins, and Histone Modifications During Human Macrophage Polarization Reveals Novel Regulatory Pathways

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Tu51
Pim1 Positively Regulates Interferon Production by Interacting with IRF3

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Tu52
NKG2D Co-stimulation Differentially Reprograms CD8 T Cells for Enhanced Memory Formation and Homeostasis in Mouse Prostate Tumors

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Tu53
Rapid Waning and Unique Response Kinetics of Humoral and Cellular Immune Responses to SARS-CoV-2 Vaccination in Patients on Immunomodulatory Drugs

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Tu56
Analysis of Antigen-Specific Cellular and Humoral Immune Response in COVID-19 Patients

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Tu57
Genotype-Phenotype Correlation of T cell Subtypes Reveals Senescent and Cytotoxic Genes in Alzheimer’s Disease

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Tu59
Multicohort Meta-Analysis of Bronchial Epithelial Cells Classifies Asthma from Healthy Subjects and Identifies Pathways in Asthma

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Tu62
Impaired TIGIT Expression on B Cells Drives Circulating Tfh Cell Expansion in Multiple Sclerosis

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Tu71
Synthekines: A Novel Platform for Combinatorial Engineering of Cytokine Receptor Agonists

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Tu74
CD3+CD56+ Cells in Cervical Cancer Patients: Evaluation of Immune Checkpoint Expression

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Tu76
A Robust, Xeno- and Feeder-Free Culture System for Expansion of Human Peripheral Blood NK Cells

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Tu77
Selective CD226 Knockout on Regulatory T Cells Reduces Diabetes in Female Non-obese Diabetic Mice

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Tu79
Searching for Environmental Triggers of Juvenile Dermatomyositis Using Antibody Profiling Technology

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Tu80
Discovery of T Cell Receptors for Adoptive T Cell Therapy Against Solid Tumors

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Tu81
Multiplexed Single-cell Analysis Reveals Dysfunctional CD8+ CD103+ T Cells and Negatively Prognostic CD38+ Regulatory T Cells in Human Colorectal Cancer

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Tu82
Detecting Alloreactive T Cells in Transplant Recipients with a Trogocytosis Assay

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Tu83
Anti-TIGIT Antibodies Promote Immune Activation in Combination with Immunotherapeutic Agents

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Tu84
Diverse Functional Profiles of Individual Human Gamma Delta T and iNKT Cells Revealed With a 32 Color Intracellular Cytokine Staining Spectral Flow Cytometry Panel

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Tu85
Long-term Impact of Atopy in Kidney Transplantation

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Tu86
Rescuing Antitumor Responses Mediated by Immune Checkpoint Inhibition Through Jak Inhibition

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Tu91
Evaluation of Indirect Immunofluorescent Assays for LGI1 Antibody Detection in Patients with Anti-LGI1 Encephalitis

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Tu92
TLR-4 Agonist Induces IFN-gamma Production Selectively in Pro-inflammatory Human M1 Macrophages Through the PI3K-mTOR and JNK-MAPK Activated p70S6K Pathway

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Tu96
Epitope Profiling of COVID-19 Convalescent Plasma and Vaccine Elicited Antibodies

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Tu98
Development of a Classification Criteria-based Polygenic Risk Score for Systemic Lupus Erythematosus

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W103
IRF5 Regulation of CD4+ T Cell Metabolism Controls CD40L Expression

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W112
B Cell Subsets as Severity-associated Signatures in COVID-19 Patients

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W113
Identification of Conserved Detrimental Host Immune Response Predicts Severity of Bacterial and Viral Infections

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W118
Ex vivo Production Of Immunotherapeutic NK Cells From Cord Blood Or Mobilized Peripheral Blood CD34+ Cells Using Notch Ligand Delta-Like 4 Culture System

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W119
Neurofilament Light Chain Levels as a Potential Biomarker of Immune effector Cell-Associated Neurotoxicity Syndrome (ICANS) in Patients Treated with CAR T Cell Therapy

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W121
Modulating Innate Immune Signaling with Nanomaterials to Drive Antigen-Specific Tolerance

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W122
Developing Trajectories of Immunosenescence in Diverse Adults

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W125
SARS-CoV-2 Antibody Kinetics in Healthcare Workers in Northern Metropolitan Barcelona

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W131
Altered Innate and Adaptive Immune Landscape in Pediatric Patients with Glycogen Storage Disease 1b

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W143
Dynamic Peripheral Immune Proteins in Extremely Premature Infants

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W150
Natural Killer Cells may be Functionally Altered due to Simulated Microgravity Exposure

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W155
Integrating Spatial Transcriptomics and Single-Cell RNA Sequencing to Spatially Characterize Human Lymphatic Tissue

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W157
Segregating the Regional Effects of Aging and Blood Immune Factors on Age Related Brain Athrophy

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W161
Genome-wide Prioritization of Autoimmune Disease-associated Genetic Variants in T Cells Identifies a Risk Variant that Elicits Effector T Cell Differentiation

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W164
Aging and Autoimmunity: Down Syndrome Gives a Master Class

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W166
Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome can cause Secondary Hemophagocytic Lymphohistiocytosis with a Unique Immune and Genetic Profile

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W167
CRISPR-based Functional Genomics in Primary Human T Cell Subsets Decode Cis and Trans Regulation of the CD28, CTLA4, and ICOS Costimulatory Locus

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W170
TMEM176B is a Target to Control Pathogenic Inflammasome Activation in Obesity

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W173
Rosnilimab, a Novel PD-1 Agonist Monoclonal Antibody, Demonstrated Modulation of Peripheral T Cell Activity and Reduction of Circulating PD-1high Expressing CD4 and CD8 T Cells in a Phase 1 Healthy Volunteer Clinical Trial

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W175
Immunological Profiles of HIV-infected and Uninfected Patients Admitted with COVID-19 in Tshwane

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W179
Platelet Activation Through TRPC6 Mediates Cystic Fibrosis Lung Inflammation and Injury

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W184
CGC+ CD4+ T Cells are Cytomegalovirus Specific Cells that are Biomarkers of Cardiometabolic Disease Risk in Persons with HIV

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W185
Fc Structure and Function of Antibodies Elicited by COVID-19 mRNA Vaccine and Infection

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Th104
GPCR19 Agonist (HY209) Regulates P2X7 Ion Channel-mediated NLRP3 Inflammasomal Activation and Ameliorates Atopic Dermatitis in Mice

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Th108
T Cell Cross Reactivity Between Viral and Self-peptides in the Coronary Atherosclerotic Plaque

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Th111
Metastatic melanoma (MM) patients with stable disease display reduced Mo-MDSCs levels in peripheral blood

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Th115
Barcode Enabled Antigen Mapping (BEAM) Enables Next-Generation Systems Immunology Analysis of the Post-COVID-19 Immune Landscape

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Th122
Mutation of a Single Critical Region in the IgV of Butyrophilin 3 Reveals That One Chain Functions as a Sensor and the Other as a Ligand for the Sensing of Prenyl Pyrophosphates by Vγ2Vδ2 T Cells: Implications for Cancer Immunotherapy

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Th127
Engineered Single Amino Acid Substitutions Protect Therapeutic Cells From CD123 Targeted Immunotherapy in vitro

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Th135
Biomarkers of Disease Outcome in Lassa Fever

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Th139
Engineering Optimized Autoreactive T Cells for the Study of Type 1 Diabetes Pathogenesis

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Th140
CAR-T Cells Mediated B Cell Depletion in EAE-induced Disease

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Th142
Evaluation of the MAPK and PI3K Signaling Pathways in Cancer Stem Cells Isolated from Prostate Cancer Tumor Tissues, a Preliminary Study

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Th144
Single Cell Analysis Reveals Altered Regulatory T Cells in Neonates with Necrotizing Enterocolitis

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Th146
Chimeric Antigen Receptor Regulatory T Cells (CAR-Tregs) Provide Significantly Greater Modulation of Alloimmune Responses than Alternative Alloantigen-Specific Treg Strategies

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Th154
Diminished Vδ2+ γδ T cell Cytokine Production and Degranulation Following in vitro Malaria Exposure

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Th159
A Nine-Gene Blood-Based Signature Meets the World Health Organization (WHO) Target Product Profiles for Diagnosis of Active Tuberculosis and Predicting Progression from Latent to Active Disease

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Th162
Commensal Myeloid Crosstalk in Neonatal Skin Regulates Long-term Cutaneous Type 17 Inflammation

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Th163
The Minor Allele of a Single Nucleotide Polymorphism in SH2B3 Promotes CD8+ T Cell IFNg Production, Hypertension Development, and Renal Damage

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Th165
Induction of a T Cell Intrinsic DNA Damage and Repair Response is Associated with Clinical Response to PD-1 Blockade

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Th168
Differentiation of Human iPSc into Functional Thymic Organoids for in vitro T Cell Generation and Cell Therapy

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Th169
Detection and Clonal Dynamics of Alloreactive T Cells in a Kidney Transplant Recipient Experiencing Acute Rejection After Immune Checkpoint Inhibitor Therapy

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Th171
Gain of Function Mutation in SKAP2 Leading to Autoimmune Diabetes

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Th177
Understanding the T Cell Repertoire in Autoimmune Diseases Using High-dimensional Single-cell Analysis of Antigen-specific CD4+ and CD8+ T Cells

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Th178
The CDKN2A Deletion Influences the Establishment of the Tumor Immune Microenvironment of Pancreatic Ductal Adenocarcinoma

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Th181
AMT-126: A Novel Oral GI-selective Fusion Protein Delivering IL-22 to Support Mucosal Homeostasis and Epithelial Barrier Integrity

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Th182
High-Throughput B Cell Epitope Determination by Next-Generation Sequencing

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Th183
Two Sources of Autoreactive T Cells in Patients with FOXP3 Mutations

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Tu100
A Pathogenic Th17/CD38+ Macrophage Feedback Loop Drives Inflammatory Arthritis Through TNFa

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Tu101
A Novel Organotypic Model of Skin Rejection

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Tu105
A Screening Platform for Drug Effects on Vaccine Responses Using Human Tonsil Immune Organoids

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Tu106
Phenotype-based Isolation of Antigen-specific CD4+ T Cells in Autoimmunity: A Study of Celiac Disease

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Tu107
Increased Monocyte Activity in Patients with Primary Progressive Multiple Sclerosis

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Tu108
Immunogenicity Induced by Full Academic CD19 Chimeric Antigen Receptor (ARI0001) in Patients Recruited into the CART-BE-01 Clinical Trial

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Tu109
SQZ® TAC Cell Therapy Platform Induces Antigen Specific T-regs and Prevents Onset of Type 1 Diabetes in Adoptive Transfer Models

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Tu110
Understanding Neuro-Immune Interactions in Multiple Sclerosis Brain by Single Nucleus Profiling

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Tu111
Severity of SARS-CoV-2 Infection is Linked to Double Negative (CD27- IgD-) B Cell Subsets Numbers

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Tu114
Prediction of HLA Genotypes from Single-cell Transcriptome Data

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Tu116
Bac Transgenic Overexpression Mice Recapitulate the Immunologic Role of Exonic Variants of APOL1

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Tu117
Deep Molecular Comparison Between Lymphoid Progenitor Cells Differentiated from CB or mPB CD34+ Hematopoietic Stem Cells Cultivated on Notch Ligand DLL4 Through a Clinically Compatible Culture Procedure

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Tu120
Spatial Whole Transcriptome Profiling of the Tumor Microenvironment in FFPE Prostate Carcinoma using the Visium Platform

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Tu123
IL-23 Signaling Induces Autoimmune Disease Genes in Mucosal-associated Invariant T (MAIT) Cells

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Tu126
Efficacy and Safety of mRNA SARS-CoV-2 Vaccination in Hematopoietic Stem Cell Transplant Recipients: Single Centre Experience

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Tu128
Enhanced Function of Vaccine Dendritic Cells from Obese Donor upon Inhibition of Lipid Metabolism

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Tu130
Central Nervous System-specific Chimeric Antigen Receptor Regulatory T Cells for the Therapy of Multiple Sclerosis

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Tu132
Induction of Antigen-Specific Immune Tolerance in Type 1 Diabetes by Antigen-Expressing Red Cell Therapeutics

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Tu133
Mass Cytometry Demonstrates an Extrafollicular T and B cell Signature that Correlates with Disease Activity in Pediatric Lupus Nephritis

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Tu134
High CD96 Expression Marks an IL-22 Producing CD4 T cell Population Reduced in Lupus Patients

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Tu136
Intravenous Ofatumumab Treatment of Multiple Sclerosis and Related Disorders: An Observational Study

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Tu137
Allogenic and Autologous Stem Cell Transplant (SCT) Recipients have Detectable Levels of SARS-CoV-2 Antigen-specific T Cells One Month After mRNA Vaccination

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Tu138
Sequence Similarity Between SARS-CoV-2 Nucleocapsid and CNS Proteins Provides Mechanistic Insight into Viral Neuropathogenesis Following Infection

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Tu141
Correlation of GPER with GLI1 and GLI3 in Tumor and Stromal Tissue with Different Prognosis Groups of Patients with Prostate Cancer

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Tu145
STAT3 Gain-of-function Variants and T Cell-mediated Inflammation

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Tu147
Regulatory T Cell Functional Dynamics During The Response To PD-1 Blockade

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Tu149
Plasma from Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) Induces Increased BBB Permeability Through Disruption of Tight Junction Proteins

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Tu150
Autoantibodies to Perilipin-1 Define a Subset of Acquired Generalized Lipodystrophy

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Tu151
GAD65 Mediated Inflammatory Immune Response In HLA-DR3/DQ2+ Type 1 Diabetes Patients

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Tu152
Senescence Associated DNA Damage in Lymph Node and Synovial Tissue Biopsies of Early Rheumatoid Arthritis Patients

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Tu153
Comprehensive Analysis of the Immune Landscape in the Peripheral Blood of Advanced Melanoma Patients Reveals Chronic Activation of Differentiated Cytolytic Cell Subsets

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Tu156
A GATA3 Frameshift Mutation Alters DNA-binding Causing Loss of Th2 Polarization in a Patient with Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia Syndrome

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Tu158
TNFα-producing CD4+ T Cells Dominate the SARS-CoV-2-specific T Cell Response in COVID-19 Outpatients and are Associated with Durable Antibodies

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Tu228
Comprehensive assessment of SARS-CoV-2 antibodies after COVID-19 infection and vaccination (BNT162b2 or ChAdOx1 nCoV-19) using multiplex bead assay

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Tu229
Two-dimensional Materials for Biomedical Applications: MXenes Immune Profiling

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