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Please note that while there are no virtual sessions at EB 2022, registrants may log in to access virtual posters March 25 to May 5, 2022.
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Poster Schedule
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Sunday, April 3, 2022
9:00 AM – 4:00 PM
APS GI hormones, peptides and receptors Poster Session
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9:00 AM – 4:00 PM
480 Cardiovascular Biology
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9:00 AM – 4:00 PM
Active learning in the molecular life sciences II
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9:00 AM – 4:00 PM
Allosterism and Biased Ligands
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9:00 AM – 4:00 PM
Anatomy Education
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9:00 AM – 4:00 PM
Anatomy Education: Clinical Based Approaches
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9:00 AM – 4:00 PM
Anatomy Education: Technology-Assisted Learning
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9:00 AM – 4:00 PM
Anatomy: Cardiovascular
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9:00 AM – 4:00 PM
Anatomy: Ethics
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9:00 AM – 4:00 PM
Anatomy: Outreach
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9:00 AM – 4:00 PM
Antibiotic resistance I
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9:00 AM – 4:00 PM
APS Adaptations to chronic exercise in health and disease Poster Session
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9:00 AM – 4:00 PM
APS Alcoholic and nonalcoholic fatty liver diseases Poster Session
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9:00 AM – 4:00 PM
APS Angiogenesis/Microvascular Remodeling/Injury & Repair Poster Session
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9:00 AM – 4:00 PM
APS Astrocyte and Neuroglial Interactions Poster Session
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9:00 AM – 4:00 PM
APS Autonomic and Respiratory Interactions Poster Session
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9:00 AM – 4:00 PM
APS Autonomic Balance: Sympathetic and Parasympathetic Poster Session
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9:00 AM – 4:00 PM
APS Blood Pressure Regulation Poster Session
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9:00 AM – 4:00 PM
APS Blood-Brain Barrier, Brain Blood Flow and Metabolism Poster Session
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9:00 AM – 4:00 PM
APS Bone Cell Physiology and Signaling Poster Session
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9:00 AM – 4:00 PM
APS Brain Development and Aging Poster Session
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9:00 AM – 4:00 PM
APS Cardiac and skeletal muscle contraction: regulation and biophysics of contraction Poster Session
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9:00 AM – 4:00 PM
APS Cardiac Function and Dynamics Poster Session
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9:00 AM – 4:00 PM
APS Cardiac muscle; physiology and metabolism in health and disease Poster Session
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9:00 AM – 4:00 PM
APS Cardiovascular and Exercise Endocrinology Poster Session
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9:00 AM – 4:00 PM
APS Cell Physiology: Emerging Topics Concepts, and Methods Poster Session
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9:00 AM – 4:00 PM
APS Cellular Mechanisms of Contractility and Excitability Poster Session
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9:00 AM – 4:00 PM
APS Cellular Signaling and Transduction Poster Session
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9:00 AM – 4:00 PM
APS Central Nervous System: Other Poster Session
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9:00 AM – 4:00 PM
APS Central Regulation of Autonomic Control: Brain Stem Poster Session
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9:00 AM – 4:00 PM
APS Central Regulation of Autonomic Control: CNS Poster Session
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9:00 AM – 4:00 PM
APS Central Regulation of Body Fluid Homeostasis Poster Session
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9:00 AM – 4:00 PM
APS Central Regulation of Food Intake and Body Weight Poster Session
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9:00 AM – 4:00 PM
APS Cerebral Circulation Poster Session
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9:00 AM – 4:00 PM
APS Cognition and Behavior Poster Session
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9:00 AM – 4:00 PM
APS Control of breathing: chemoreception Poster Session
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9:00 AM – 4:00 PM
APS Control of breathing: development Poster Session
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9:00 AM – 4:00 PM
APS Control of breathing: respiratory motoneurons and muscles Poster Session
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9:00 AM – 4:00 PM
APS Control of breathing: rhythm generation and pattern formation Poster Session
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9:00 AM – 4:00 PM
APS Diabetes and the Kidney Poster Session
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9:00 AM – 4:00 PM
APS Diabetes, Insulin Resistance and Obesity Poster Session
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9:00 AM – 4:00 PM
APS Dysfunctional Gut-Brain Axis in Cardiometabolic Diseases Poster Session
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9:00 AM – 4:00 PM
APS Effects of diet on GI and liver physiology Poster Session
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9:00 AM – 4:00 PM
APS Endothelial Cell Biology in Health and Disease Poster Session
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9:00 AM – 4:00 PM
APS Enteric Nervous System, Digestion and Metabolic Function Poster Session
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9:00 AM – 4:00 PM
APS Environmental stress: hypoxia, gravity, hyperbaria, blood volume Poster Session
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9:00 AM – 4:00 PM
APS Epithelial Transport Group I Poster Session
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9:00 AM – 4:00 PM
APS Exercise and Autonomic Regulation of Cardiovascular Function Poster Session
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9:00 AM – 4:00 PM
APS Exosomes, Ectosomes, and Microvesicles Poster Session
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9:00 AM – 4:00 PM
APS Extracellular Matrix and Cytoskeleton Poster Session
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9:00 AM – 4:00 PM
APS Functional-Omics: Genomics, Transcriptomics, Proteomics and Metabolomics Poster Session
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9:00 AM – 4:00 PM
APS Genetics, Genomics, Gene Expression, and Epigenetics in Health and Diseases Poster Session
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9:00 AM – 4:00 PM
APS Gut-brain axis Poster Session
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9:00 AM – 4:00 PM
APS History of Physiology Poster Session
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9:00 AM – 4:00 PM
APS Hot Topics in Nutrition Physiology Poster Session
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9:00 AM – 4:00 PM
APS Inflammation, Immune System and Autonomic Regulation Poster Session
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9:00 AM – 4:00 PM
APS Inflammation/Leukocyte-Endothelium Interactions Poster Session
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9:00 AM – 4:00 PM
APS Ischemia-Reperfusion/Free Radical Biology Poster Session
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9:00 AM – 4:00 PM
APS Kidney in hypertension Poster Session
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9:00 AM – 4:00 PM
APS Liver physiology and pathophysiology Poster Session
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9:00 AM – 4:00 PM
APS Lung Biology: Aerodigestion Poster Session
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9:00 AM – 4:00 PM
APS Lung Biology: Airway Epithelial Cell Biology Poster Session
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9:00 AM – 4:00 PM
APS Lung Biology: Airway Responsiveness and Smooth Muscle Cell Biology Poster Session
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9:00 AM – 4:00 PM
APS Lung Biology: Alveolar Epithelial Cell Biology Poster Session
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9:00 AM – 4:00 PM
APS Lymphatic Function Poster Session
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9:00 AM – 4:00 PM
APS Microbiome and Cell Signaling Poster Session
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9:00 AM – 4:00 PM
APS Micronutrient Regulation of Health and Chronic Disease Poster Session
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9:00 AM – 4:00 PM
APS microRNAs in Health and Disease Poster Session
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9:00 AM – 4:00 PM
APS Microvascular Flow Regulation/Oxygen Delivery/Networks Poster Session
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9:00 AM – 4:00 PM
APS Microvascular Mechanics/Hemodynamics/Rheology Poster Session
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9:00 AM – 4:00 PM
APS Mitochondrial biology in endocrinology and metabolism Poster Session
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9:00 AM – 4:00 PM
APS Molecular Mechanisms of Cellular Signaling and Transduction Poster Session
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9:00 AM – 4:00 PM
APS NCAR New Investigator Awards Poster Session
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9:00 AM – 4:00 PM
APS Neuroendocrinology/Neuroimmunology Poster Session
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9:00 AM – 4:00 PM
APS Neuroexcitability, Neurotransmission and Neuroplasticity Poster Session
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9:00 AM – 4:00 PM
APS Neuroinflammation/Neuroprotection/Schemia Poster Session
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9:00 AM – 4:00 PM
APS Neurotransmission and Signaling Molecules Poster Session
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9:00 AM – 4:00 PM
APS Non-Coding RNA: miRNA, siRNA and Long ncRNA Poster Session
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9:00 AM – 4:00 PM
APS Nutrient and Metabolite Signaling Poster Session
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9:00 AM – 4:00 PM
APS Nutrient metabolism in the gut Poster Session
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9:00 AM – 4:00 PM
APS Nutrition and Body Composition Poster Session
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9:00 AM – 4:00 PM
APS Permeability/Fluid & Solute Exchange/Glycocalyx Poster Session
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9:00 AM – 4:00 PM
APS Polycystic Kidney Disease Poster Session
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9:00 AM – 4:00 PM
APS Renal pathology and toxicology Poster Session
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9:00 AM – 4:00 PM
APS Sex differences in blood pressure and fluid volume homeostasis
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9:00 AM – 4:00 PM
APS Sex differences in physiological responses to exercise/environmental stressors Poster Session
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9:00 AM – 4:00 PM
APS Skeletal muscle; physiology and metabolism in health and disease Poster Session
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9:00 AM – 4:00 PM
APS Sympathetic and Parasympathetic Regulation in Disease Poster Session
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9:00 AM – 4:00 PM
APS Systems Biology, Computational Modeling and Bioinformatics Poster Session
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9:00 AM – 4:00 PM
APS Teaching, Learning and Testing in the Biological and Biomedical Sciences I Poster Session
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9:00 AM – 4:00 PM
APS The Role of Bioactive Compounds in Health and Chronic Disease Poster Session
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9:00 AM – 4:00 PM
APS Tissue-Microvessel Interactions/Extracellular Matrix Poster Session
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9:00 AM – 4:00 PM
APS Translational physiology in water and electrolyte homeostasis research
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9:00 AM – 4:00 PM
APS Vascular Ion Channels Poster Session
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9:00 AM – 4:00 PM
ASIP Poster Viewing - Lymphatic and Vascular Pathobiology
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9:00 AM – 4:00 PM
ASIP Poster Viewing - Molecular and Cellular Pathobiology of Liver Diseases
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9:00 AM – 4:00 PM
ASIP Poster Viewing - Mucosal and Epithelial Pathobiology
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9:00 AM – 4:00 PM
ASIP Poster Viewing - Ocular Pathobiology
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9:00 AM – 4:00 PM
ASIP Poster Viewing - Pathobiology of Infectious Diseases
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9:00 AM – 4:00 PM
Bacteria and parasites: from microbiome to antibiotics
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9:00 AM – 4:00 PM
BMB education and professional development I
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9:00 AM – 4:00 PM
Cancer signaling and therapeutics I
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9:00 AM – 4:00 PM
Cannabinoids
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9:00 AM – 4:00 PM
Cardiovascular Pharmacology I
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9:00 AM – 4:00 PM
Cell Biology
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9:00 AM – 4:00 PM
Chemical biology, drug discovery and bioanalytical methods I
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9:00 AM – 4:00 PM
Chromatin structure, remodeling and gene expression I
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9:00 AM – 4:00 PM
COVID-19 Clinical Presentation and Pharmacology Integration
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9:00 AM – 4:00 PM
CYP Enzymes: Structure, Function and Regulation
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9:00 AM – 4:00 PM
Development & Growth
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9:00 AM – 4:00 PM
Diabetes, obesity and metabolic syndrome I
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9:00 AM – 4:00 PM
DNA polymerases, telomerase, replicases and replisomes I
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9:00 AM – 4:00 PM
Drug Discovery and Development - General I
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9:00 AM – 4:00 PM
Drug screening and development I
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9:00 AM – 4:00 PM
Drug Targets in Cancer
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9:00 AM – 4:00 PM
Education Adaptations During COVID-19
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9:00 AM – 4:00 PM
Enzyme chemistry and catalysis I
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9:00 AM – 4:00 PM
Enzyme mechanisms, kinetics and energetics I
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9:00 AM – 4:00 PM
G proteins and small GTPases I
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9:00 AM – 4:00 PM
Gastrointestinal Pharmacology
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9:00 AM – 4:00 PM
Glycans and glycobiology
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9:00 AM – 4:00 PM
Immune signaling I
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9:00 AM – 4:00 PM
Interdisciplinary/translational science (SEBM)
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9:00 AM – 4:00 PM
Intrinsically disordered proteins, prions and amyloids I
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9:00 AM – 4:00 PM
Lipids and inflammation
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9:00 AM – 4:00 PM
Lipids and membranes I
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9:00 AM – 4:00 PM
Mechanisms and regulation of protein synthesis and dynamics
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9:00 AM – 4:00 PM
Membrane proteins, lipid interactions, and lipid domains I
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9:00 AM – 4:00 PM
Mental Health
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9:00 AM – 4:00 PM
Metabolism and bioenergetics I
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9:00 AM – 4:00 PM
Metabolism and cancer I
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9:00 AM – 4:00 PM
Metabolomics
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9:00 AM – 4:00 PM
Nanotechnology
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9:00 AM – 4:00 PM
Non-coding RNAs I
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9:00 AM – 4:00 PM
Opioids I
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9:00 AM – 4:00 PM
Organ Toxicology
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9:00 AM – 4:00 PM
Pharmacokinetics and Modeling
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9:00 AM – 4:00 PM
Proteasomes: structure and regulation
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9:00 AM – 4:00 PM
Protein folding and chaperones I
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9:00 AM – 4:00 PM
Protein interactions and binding I
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9:00 AM – 4:00 PM
Protein kinases and phosphatases I
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9:00 AM – 4:00 PM
Protein structure and biophysics I
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9:00 AM – 4:00 PM
Protein synthesis, structure, modifications and interactions I
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9:00 AM – 4:00 PM
Protein turnover, misfolding, aggregation and degradation I
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9:00 AM – 4:00 PM
Protein-small molecule interactions I
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9:00 AM – 4:00 PM
RNA binding proteins I
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9:00 AM – 4:00 PM
RNA: processing, transport, and regulatory mechanisms I
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9:00 AM – 4:00 PM
Service learning initiatives, community involvement and context dependent biochemistry instruction
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9:00 AM – 4:00 PM
Signal transduction and cellular regulation I
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9:00 AM – 4:00 PM
Stimulants I
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9:00 AM – 4:00 PM
Structural dynamics of enzymes and multienzyme complexes
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9:00 AM – 4:00 PM
Transcriptional mechanisms, regulation and RNA polymerases I
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9:00 AM – 4:00 PM
Translational Models
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9:00 AM – 4:00 PM
Tumor suppressors and tumor drivers I
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9:00 AM – 4:00 PM
Vascular Pharmacology I
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9:00 AM – 4:00 PM
Vesicle trafficking and cargo
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9:00 AM – 4:00 PM
(584.8) Does Dietary Methionine Alter Perivascular Adipose Tissue Function?
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10:00 AM – 12:00 PM
(530.1) Impact of a Spiral Learning Strategy on the Integration of Pharmacology Content in a Pre-clerkship Osteopathic Medical
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10:00 AM – 12:00 PM
(530.2) Reflections on COVID: Comparison of Teaching Methods and Outcomes for Virtual vs In-Person Preclinical Integrated Medical School Pharmacology Education
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10:00 AM – 12:00 PM
(530.3) Second Year Medical Students Perceive In-person Pathophysiology and Pharmacology Case-Based Sessions Promote Learning More Effectively than Zoom
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10:00 AM – 12:00 PM
(530.4) Repurposing Immunopharmacology to Inculcate Pharmacist’s Professional Identity Formation in a Doctor of Pharmacy Program
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10:00 AM – 12:00 PM
(530.5) The COVID-19 Pandemic and Its Effects on Student Performance in Medical Pharmacology
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10:00 AM – 12:00 PM
(531.1) Understanding patient-level immune response to COVID-19 can inform treatment options
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10:00 AM – 12:00 PM
(531.2) The Impact of Secondary Bacterial Infections in COVID-19 Patients on Mortality and the Immune Response in the State of Arizona
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10:00 AM – 12:00 PM
(531.3) Characteristics and Outcomes of Patients Presenting to Rural or Urban Emergency Departments with COVID-19.
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10:00 AM – 12:00 PM
(531.4) Multisite Clinical Utilization of Antibiotics among Hospitalized Patients with COVID-19
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10:00 AM – 12:00 PM
(532.1) Acute Low Dose Cannabidiol Treatment Boosts Social Interaction Preference in Male Mice
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10:00 AM – 12:00 PM
(532.2) Acute, Chronic, and Prenatal Exposure to Cannabidiol (CBD) Differentially Affects Anxiety and Successful Birthrate in Mice
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10:00 AM – 12:00 PM
(532.3) Endocannabinoid regulation of behavior in response to negative affective states associated with alcohol abstinence
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10:00 AM – 12:00 PM
(532.4) Nicotine and THC Effects on Rodents
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10:00 AM – 12:00 PM
(532.5) Effects of Cannabinoid Agonists and Antagonists in Rats Discriminating Fentanyl
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10:00 AM – 12:00 PM
(532.6) The Effects of Sex on CB1 Expression in Male and Female Mice After Morphine Treatment
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10:00 AM – 12:00 PM
(532.7) Effects of Increasing Endocannabinoid 2-AG Tone on Sensorimotor Gating and Anxiety-like behavior
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10:00 AM – 12:00 PM
(532.8) Arachidonyl-2- Chlorethylamide alters the Gene Expression of Renin Angiotensin System Components in Primary Cultures of Astrocytes
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10:00 AM – 12:00 PM
(532.9) Sex-Differences in Acute Cannabinoid Response and Tolerance as a Function of Mouse Strain
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10:00 AM – 12:00 PM
(533.1) Physiological Effects of Binary Mixtures of Common Bath Salt Constituents: Studies with MDPV, Methylone, and Caffeine in Rats
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10:00 AM – 12:00 PM
(533.2) A role for BD2-selective BET inhibitors in cocaine-seeking behaviors
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10:00 AM – 12:00 PM
(533.3) Diurnal Variation in Motivation, Cocaine Value, and In Vivo Dopamine Release
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10:00 AM – 12:00 PM
(533.4) Methamphetamine-Induced Proteomic Changes Within the Neuroinflammatory TLR4 Pathway Persist After Long-Term Self-Administration in Rats
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10:00 AM – 12:00 PM
(533.5) The Impact of HIV Infection in Cocaine Seeking Behaviors
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10:00 AM – 12:00 PM
(533.6) Role of Neuregulin 3-ErbB4 Signaling in a Murine Model of Co-Morbid Nicotine Dependence and Schizophrenia
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10:00 AM – 12:00 PM
(533.7) Localizing circuits of cocaine contextual memories
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10:00 AM – 12:00 PM
(533.8) Intermittent Cocaine Self-Administration but not Passive Cocaine Infusions Reduces H-Current in Putative Dopaminergic Neurons of the Ventral Tegmental Area
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10:00 AM – 12:00 PM
(533.9) Sex Differences in Cocaine Self-Administration Behavior in Rats
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10:00 AM – 12:00 PM
(534.1) Role of Pharmacological Modulation of Tonic Inhibition in Hippocampal Sharp Wave Ripples Amplitude and Place Cell Firing Dynamics.
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10:00 AM – 12:00 PM
(534.2) Effects of RTI-567 on the Neuropeptide S System
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10:00 AM – 12:00 PM
(534.3) Does clozapine affect the discriminative stimulus effects of food deprivation in rats trained to discriminate between 2 and 22 hours food deprivation?
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10:00 AM – 12:00 PM
(534.4) CB2 Receptor Potentiation Mediates Antipsychotic-like Efficacy in Mice
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10:00 AM – 12:00 PM
(534.5) Effects of the Mouse Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors
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10:00 AM – 12:00 PM
(534.6) Estradiol Promotes Social Stress Susceptibility in Female Rats in a Region- and CRF-Specific Manner
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10:00 AM – 12:00 PM
(534.7) Probabilistic Reinforcement Schedules in Neuropsychiatric Medications Development
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10:00 AM – 12:00 PM
(534.8) Activation of the Central Medial Thalamic Afferent to the Orbitofrontal Cortex Contributes to Successful Reversal Learning
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10:00 AM – 12:00 PM
(534.9) Role of CRF1 and CRF2 receptors in the lateral hypothalamus in anxiogenic response evoked by acute and repeated restraint stress in rats
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10:00 AM – 12:00 PM
(535.1) Reinforcing Effects of Fentanyl and a Fentanyl Analog Found in Illicit Drug Markets
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10:00 AM – 12:00 PM
(535.2) Irreversible and noncompetitive mu opioid receptor agonists
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10:00 AM – 12:00 PM
(535.3) Gabapentinoids Attenuate Naloxone Reversal of Heroin-Induced Ventilatory Depression
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10:00 AM – 12:00 PM
(535.4) BET proteins as novel epigenetic targets for the treatment of Opioid Use Disorder
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10:00 AM – 12:00 PM
(535.5) Morphine Aggravates Inflammatory, Behavioral, and Hippocampal Structural Deficits in Septic Rats
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10:00 AM – 12:00 PM
(535.6) Effects of oxycodone self-administration on sleep duration and quality in male and female rats
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10:00 AM – 12:00 PM
(535.7) Methadone disrupts early synaptic development in human cortical organoids
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10:00 AM – 12:00 PM
(535.8) The Effects of Activation and Blockade of Delta Opioid Receptors on the Acquisition of Responding for an Opioid-Associated Stimulus
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10:00 AM – 12:00 PM
(535.9) Pharmacodynamics and Pharmacokinetics of the Non-Fentanyl Synthetic Opioid, Isotonitazene, in Male Rats
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10:00 AM – 12:00 PM
(536.1) Investigating Drivers for M1 Muscarinic Acetylcholine Receptor-Mediated Adverse Events by M1 Positive Allosteric Modulators
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10:00 AM – 12:00 PM
(536.2) Structure–Activity Relationships of a Negative Allosteric Modulator of the D3 Dopamine Receptor and Investigation of its Binding Site
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10:00 AM – 12:00 PM
(536.3) Differential Regulation of Inflammatory Responses Following 5-HT2 Receptor Activation in Pulmonary Tissues
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10:00 AM – 12:00 PM
(536.4) Beta-agonist Profiling Reveals Novel Biased Signaling Phenotypes for the Beta 2-adrenergic Receptor with Implications in the Treatment of Asthma
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10:00 AM – 12:00 PM
(536.5) Design and Development of Site Specific Null Allosteric Ligands for γ-Aminobutyric Acid Type A Receptor as Reversal Agents for General Anesthesia
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10:00 AM – 12:00 PM
(536.6) Multiple roles of β-Arrestin2 in initiating and sustaining D3R-mediated ERK1/2 phosphorylation by G protein-biased and unbiased D3R agonists
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10:00 AM – 12:00 PM
(536.7) Discovery of Balanced and Novel G Protein Biased Agonists for the Orphan Receptor GPR52
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10:00 AM – 12:00 PM
(536.8) Ligand-Dependent Reversal Kinetics of Mu Opioid Receptor Agonists by the Novel Antagonist, Methocinnamox
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10:00 AM – 12:00 PM
(537.1) Mechanisms of Orthosteric Agonist and Allosteric Modulator Activity at mGlu7
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10:00 AM – 12:00 PM
(537.2) Integrated Quantum Mechanical and Machine Learning Methods Enable Scalable and General pKa Prediction for Pharmacokinetic Modeling
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10:00 AM – 12:00 PM
(537.3) A novel allosteric PDE4B inhibitor T2409 improves mild cognitive impairment: involvement of cAMP related anti-inflammatory pathway
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10:00 AM – 12:00 PM
(537.4) Engineered Nanoparticles as Potential Therapeutics for Acute Myeloid Leukemia
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10:00 AM – 12:00 PM
(537.5) Development and validation of a novel UPLC-MS/MS method for the simultaneous quantification of mycophenolic mofetil and its major metabolites in rat plasma and liver S9 hydrolysis assay in rats
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10:00 AM – 12:00 PM
(537.6) Analgesic and Antinociceptive Effects of (2R,6R)-hydroxynorketamine (HNK) in Mice
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10:00 AM – 12:00 PM
(537.7) A New Family of Subnanomolar inhibitors of Soluble Epoxide Hydrolase
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10:00 AM – 12:00 PM
(537.8) RXFP2 Small Molecule Agonists: Potential Therapeutics for Osteoporosis
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10:00 AM – 12:00 PM
(537.9) Targeting 5-HT1A Receptors to Correct Perineuronal Net and Social Behavioral Deficits in Fmr1 Knockout Mice, a Model of Fragile X Syndrome
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10:00 AM – 12:00 PM
(538.1) A multiplex model in a Drosophila identifies novel gene-environment interactions: A step towards personalized medicine
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10:00 AM – 12:00 PM
(538.2) Dithiolethiones D3T and ACDT Protect Against Ferroptosis Induced by Erastin and RSL3
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10:00 AM – 12:00 PM
(538.3) Cardiovascular and core temperature responses to acute organophosphate intoxication in rats
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10:00 AM – 12:00 PM
(538.4) Exposure to the Brominated Flame Retardant Hexabromocyclododecane Results in Systemic Changes in Polyunsaturated Fatty Acid Metabolism Within Phospholipids of Mice
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10:00 AM – 12:00 PM
(538.5) Secreted Proteins, Lipids and Low-Molecular-Weight Metabolites as Early Biomarkers of Human Proximal Tubular Cell Exposure to Nephrotoxic Agents
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10:00 AM – 12:00 PM
(538.6) Mechanism of Phosgene Oxime Induced Skin Toxicity in C57BL/6 Mouse Model
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10:00 AM – 12:00 PM
(538.7) Elucidating the Role of the NRF2 pathway in Nitrogen Mustard Induced Toxicity in Mouse Epidermal Skin Cells
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10:00 AM – 12:00 PM
(538.8) Inflammatory cytokines analysis in C57BL/6 mouse skin after dermal exposure with chemical threat agent phosgene oxime
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10:00 AM – 12:00 PM
(538.9) Single-Cell Proteomic Profiling of Hepatocytes Reveals Heterogeneous Responses to Hepatotoxic Drugs Nevirapine, Efavirenz, and Acetaminophen
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10:00 AM – 12:00 PM
(539.1) Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding
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10:00 AM – 12:00 PM
(539.2) Direct and Sequential Bioactivation of Pemigatinib to a Reactive Iminium Ion Intermediate Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A
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10:00 AM – 12:00 PM
(539.3) Metabolism of Benzalkonium Chloride by CYP-Mediated ω-Oxidation and C-C Cleavage Followed by β-Oxidation in Humans
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10:00 AM – 12:00 PM
(539.4) Induction of Cytochrome P450 (CYP) 1A2 and CYP3A Influences Sunitinib Metabolism and Bioactivation in Primary Human Hepatocytes
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10:00 AM – 12:00 PM
(539.5) Protein/protein interactions in the human cytochrome P450 system
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10:00 AM – 12:00 PM
(539.6) Role of the Proximal Region of CYP1A2 in the heteromeric P450 complex with POR and Cytochrome-b5
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10:00 AM – 12:00 PM
(539.7) Utilization of CYP3A-Specific Inhibitors to Study Cytochrome P450 CYP3A7 Activity in Neonatal Human Liver Microsomes
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10:00 AM – 12:00 PM
(539.8) CYP1A1 and CYP1A2 Form Distinct Protein Complexes with NADPH-cytochrome P450 Reductase, Cytochrome b5, and Heme Oxygenase-1
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10:00 AM – 12:00 PM
(539.9) Steroid-Derived Isonitriles are Potent Cytochrome P450 Ligands that Should Enable Solution NMR as a Structural Technique to Probe P450 Dynamics
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10:00 AM – 12:00 PM
(540.1) Proteomics-informed physiologically-based pharmacokinetic (PBPK) modeling revealed differential effects of UGT2B17 variability on the pharmacokinetics of diclofenac following intravenous and oral administration
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10:00 AM – 12:00 PM
(540.2) Physiologically Based Pharmacokinetic (PBPK) Modelling to Predict Breast Milk Exposure of Valproic Acid
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10:00 AM – 12:00 PM
(540.3) A novel integrated pharmacokinetic-pharmacodynamic model for the determination of in vivo synergism of combination therapy
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10:00 AM – 12:00 PM
(540.4) Investigation of Diazepam Sequential Metabolism with Hepatocytes via a Microfluidic Device
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10:00 AM – 12:00 PM
(540.5) Poor and variable oral bioavailability of dimethandrolone (DMA), an investigational male hormonal contraceptive, is likely associated with UGT2B17 mediated first-pass metabolism
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10:00 AM – 12:00 PM
(540.6) Mechanisms of Transplacental Transfer of (-)-∆ 9-Tetrahydrocannabinol (THC) in the Human Dual Cotyledon, Dual Perfusion, Placenta Model
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10:00 AM – 12:00 PM
(540.7) Assessing the Effect of Organic Anion Transporter Inhibition on Circulating Pyridoxic Acid, an Endogenous Transporter Biomarker, using Physiologically-based Pharmacokinetic Modeling
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10:00 AM – 12:00 PM
(540.8) AI/ML-driven simulation of the skin retention of opioid analgesics following topical administration in normal skin and cutaneous lesions lt;/p"gt;
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10:00 AM – 12:00 PM
(540.9) Determining the Relationship Between Clofazimine Gastrointestinal Levels and anti-Cryptosporidium Efficacy in Mice
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10:00 AM – 12:00 PM
(541.1) Inhibition of Core Binding Factor Transcriptional Complex Provides a Novel Pharmacological Target for Osteosarcoma
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10:00 AM – 12:00 PM
(541.2) Inhibition of PRMT5 Disrupts Cell Cycle Progression and DNA Damage Signaling, Revealing a Potential Novel Combination Therapy for Pancreatic Cancer
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10:00 AM – 12:00 PM
(541.3) An Antagonist of KSR1-Driven Adaptive Resistance to Clinical RAS-MAPK Inhibitors
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10:00 AM – 12:00 PM
(541.4) ADGRF1 promotes tumorigenesis via the activation of STAT3 pathway in HER2+ and triple-negative breast cancers
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10:00 AM – 12:00 PM
(541.5) The role of master regulators such as HMGA1, SOX9, FOXA1 in the development of triple-negative breast cancer
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10:00 AM – 12:00 PM
(541.6) Jadomycin B Acts Synergistically with NSAIDs to Produce Cytotoxic Effects in Human Breast Cancer Cells in vitro
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10:00 AM – 12:00 PM
(541.7) Knockdown and Inhibition of Spleen Tyrosine Kinase Decreases mTORC1 Activity and Enhances Lysosomal Biogenesis and Autolysosomal Maturation in Pancreatic Cancer Cell Lines
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10:00 AM – 12:00 PM
(541.8) Periprostatic Adipose Tissue Thromboinflammation Drives Early Prostatic Neoplastic Alterations in a Rat Model of Mild Metabolic Dysfunction
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10:00 AM – 12:00 PM
(541.9) Decoupling the Transcriptional and Translational Roles of Core Binding Factor Beta to Identify Novel Therapeutic Targets in Osteosarcoma
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10:00 AM – 12:00 PM
(542.1) Role of S-nitrosoglutathione reductase (GSNOR) Dysregulation and Nitrosative Stress in Heart Failure With Preserved Ejection Fraction
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10:00 AM – 12:00 PM
(542.2) Compromised endothelial progenitor cell exosomal communication with endothelial cells in hypertension ischemia conditions
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10:00 AM – 12:00 PM
(542.3) Mitochondrial GRK2 is a Novel Regulator of Cardiac Energetics
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10:00 AM – 12:00 PM
(542.4) Myeloid Expressed Epidermal Growth Factor Receptor (EGFR) is Critical to Heart Homeostasis and Limits Adverse Outcomes Following Ischemic Attack
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10:00 AM – 12:00 PM
(542.5) Statins stimulate voltage-gated Ca2+ channels in arterial smooth muscle cells to induce rapid vasoconstriction in resistance-size cerebral arteries
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10:00 AM – 12:00 PM
(542.6) VX-745 Inhibits Smooth Muscle Cell p38 Mitogen-Activated Protein Kinase Alpha (MAPKα) and Heat-Shock Protein 27 (Hsp27) Phosphorylation to Induce Vasodilation in Resistance Mesenteric Arteries
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10:00 AM – 12:00 PM
(542.7) H2S Therapy Improves Diastolic Dysfunction and Exercise Capacity in Two-Hit Murine Model of Heart Failure with Preserved Ejection Fraction
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10:00 AM – 12:00 PM
(542.8) Novel HM12, A Selective Inhibitor of L-/T-type Calcium Channels, Averts Doxorubicin Cardiotoxicity in Male Wistar Rats
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10:00 AM – 12:00 PM
(542.9) Consequent Endotoxemia Relieves Abnormalities in Renal Vasoconstriction and AT1/ACE/ACE2 Signaling in Preeclamptic Offspring: Roles of Sex and Antenatal Ang 1-7 Therapy
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10:00 AM – 12:00 PM
(543.1) Reduction of Reactive Oxygen Species by a Growth Hormone-Releasing Hormone Antagonist in Endothelial Cells
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10:00 AM – 12:00 PM
(543.2) Activation of Endothelial Potassium Channels Lowers Pulmonary Arterial Pressure in Pulmonary Hypertension
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10:00 AM – 12:00 PM
(543.3) Dapagliflozin Stimulates Smooth Muscle Cell Voltage-Gated K+ Channels KV7 to Induce Vasodilation in Resistance Mesenteric Arteries
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10:00 AM – 12:00 PM
(543.4) Interactions between β3-adrenergic receptors and bFGF-induced effects in rat aortic smooth muscle cells
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10:00 AM – 12:00 PM
(543.5) Nitric oxide synthase inhibitor is an effective therapy for ischemia-reperfusion injury in mice
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10:00 AM – 12:00 PM
(543.6) β-catenin C-terminal Domain/Sphingosine-1-Phosphate Receptor 1 Axis is a Potential Therapeutic Target in Vascular Remodeling
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10:00 AM – 12:00 PM
(543.7) Evaluation of the effects of mild aerobic exercise and Losartan treatment on aortic endothelial function in a mouse model of Marfan syndrome
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10:00 AM – 12:00 PM
(543.8) Effect of the General Inhibitor of Nitric Oxide Synthase (L-NAME) On Cardiac and Aortic Function and Structure in A Mouse Model of Marfan Syndrome-Associated Aortic Aneurysm
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10:00 AM – 12:00 PM
(543.9) Activation of APJ Receptors by CMF-019, but not Apelin, Causes Endothelium-Dependent Relaxation of Spontaneously Hypertensive Rat Coronary Arteries
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10:00 AM – 12:00 PM
(544.1) MAL-pharmacodynamics theory based small-size experimental-design and analysis, in vitro, in animals and in clinical trial, with bioinformatics algorithm, for automated computer simulation to achieve quantitative/digital/indexed conclusions
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10:00 AM – 12:00 PM
(544.2) Interactions of a high-fat Western diet and crystalline silica inhalation on airway epithelial ion transport and airway reactivity
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10:00 AM – 12:00 PM
(544.3) A Novel Method for Measuring Lung Metabolism of Precision-cut Lung Slices
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10:00 AM – 12:00 PM
(544.4) A Non-Human Primate Model of Carfentanil Overdose: Preventing Renarcotization with Superior Countermeasures
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10:00 AM – 12:00 PM
(544.5) Development of the Göttingen Minipig Model: GB and GF Toxicity
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10:00 AM – 12:00 PM
(544.6) Emerging Microbiome Genetic Engineering Technology for Stable Levodopa Delivery in Parkinson’s Disease
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10:00 AM – 12:00 PM
(544.7) Early Interventions for Toxicant Ocular Injury May Need to be Toxicant-Specific
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10:00 AM – 12:00 PM
(545.1) Comparison of the Safety and Efficacy of Tofacitinib and Fingolimod in TNBS-Induced Colitis Model in Adult Zebrafish: The Role of Myd88/NF-κB/TNF-α Signaling Pathway
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10:00 AM – 12:00 PM
(545.2) Angiotensin-(1-7) Restores Gut Barrier Integrity and Ameliorates Systemic Inflammation in Aging
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10:00 AM – 12:00 PM
(545.3) A Novel Oral Glutamate Carboxypeptidase II Inhibitor for the Treatment of Inflammatory Bowel Disease
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10:00 AM – 12:00 PM
(545.4) Effects of Electrical Spinal Cord Stimulation on the Activity of the Hypothalamic-Pituitary-Adrenocortical System and the Sensitivity of the Gastric Mucosa to Ulcerogenic Stimuli
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10:00 AM – 12:00 PM
(545.5) Pharmacological Preconditioning by Corticotropin Releasing Factor (CRF) or ACTH Protects the Gastric Mucosa against Ulcerogenic Action of Indomethacin through Involvement of Glucocorticoids
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10:00 AM – 12:00 PM
(545.6) Effect of Heparin on the Formation and the Healing of Kissing Gastric Ulcers in Rats
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10:00 AM – 12:00 PM
(545.7) GUCY2C-Enriched Intestinal Neuropod Cells Modulate Visceral Pain
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10:00 AM – 12:00 PM
(545.8) Pentadecapeptide BPC 157 Anti-Ulcer Effect After Stomach Perforation also Opposed the Intracranial Hypertension (Superior Sagittal Sinus), Portal and Caval Hypertension and Aortal Hypotension
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10:00 AM – 12:00 PM
(545.9) Repeated Treadmill Running Attenuates Indomethacin-caused Gastric Injury in Rats with Streptozotocin-induced Diabetes
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10:00 AM – 12:00 PM
(915.1) Benztropine Reduces Reacquisition of Alcohol Self-Administration in Rats with Stress History: Role of FKBP5
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10:00 AM – 12:00 PM
(915.2) Investigation of the Role of Wnt/Delta-Catenin Signaling in Regulating Opioid Pain Relief After Heat Shock Protein 90 Inhibition
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10:00 AM – 12:00 PM
(915.3) Effect of Bacopa Monnieri and Memantine in LPS-induced neuronal toxicity
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10:00 AM – 12:00 PM
(915.4) Anti-Epileptic Drug and Teratogen Valproic Acid Induces Microglial Cell Death in a Valproic Acid Murine Model of Autism
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10:00 AM – 12:00 PM
(915.5) Activation of a novel α2AAR-spinophilin-cofilin axis determines the effect of α2 adrenergic drugs on fear memory reconsolidation
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10:00 AM – 12:00 PM
(915.6) 5HTR1E receptor interacts with Neurotrophic factor-α1 and serotonin to activate two distinct signaling pathways
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10:00 AM – 12:00 PM
(915.7) Cellular redox regulation by the neuronal glutamate and cysteine transporter, EAAT3
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10:00 AM – 12:00 PM
(915.8) Inhibition of prelimbic cortical inputs to the patch compartment of striatum reduces habitual methamphetamine self-administration
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10:00 AM – 12:00 PM
(915.9) Modulatory role of 17α-estradiol (non-feminizing estrogen) on 6-OHDA-induced Parkinsonism in ovariectomized rats
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10:00 AM – 12:00 PM
(916.1) CUIDAME: a pharmacology and nutrition education program for ESPOL workers with Chronic Illnesses
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10:00 AM – 12:00 PM
(916.2) Riding a VeSPha in the classroom: A Versatile Simulation tool for effective didactic illustration of Pharmacodynamic concepts
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10:00 AM – 12:00 PM
(533.10) RTI-263, a biased NPS receptor agonist that retains anxiolytic effect, attenuates cocaine-seeking behavior in rats
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10:00 AM – 12:00 PM
(533.11) Dopamine Receptor Antagonist-Induced Elevation of the Compulsion Zone Results in Differential Effects on Cocaine Self-Administration and Lever-Pressing Behavior
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10:00 AM – 12:00 PM
(533.12) Structure-activity Relation of Halogenated 2,5-Dimethoxyamphetamines Compared to their α‑Desmethyl (2C) Analogues
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10:00 AM – 12:00 PM
(533.13) Isoform-selective PI3-kinase Inhibition Confers Partial Resilience to Cocaine Cessation-induced Anxiety-like Behavior
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10:00 AM – 12:00 PM
(534.10) Impulsive behavior induced by Dopamine D3 receptor agonist treatment in Parkinson’s disease is mediated by β-arrestin
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10:00 AM – 12:00 PM
(534.11) Biomolecular Assessment and Assay of Kisspeptin, Oxytocin and Melatonin in Female Depressed Patients on Antidepressant Therapy: A Comparative Study
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10:00 AM – 12:00 PM
(534.12) Expression of Key Modulators of Serotonergic Neurotransmission after Chronic Metformin Treatment
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10:00 AM – 12:00 PM
(534.13) Examination of the behavioral effects of ketamine in Sprague-Dawley and Wistar Kyoto rats
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10:00 AM – 12:00 PM
(534.14) Reduction of Postoperative Cognitive Deficits in Aged Mice by Chronic Intermittent Propofol
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10:00 AM – 12:00 PM
(534.15) Pharmacological Manipulation of Microglia Regulates Social Stress Susceptibility Among Females in a Region-Specific Manner
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10:00 AM – 12:00 PM
(534.16) Immune Phenotypes of Oligodendroglial-Lineage Cells in MDD and in Response to Chronic Stress-Induced Microglial Inflammation
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10:00 AM – 12:00 PM
(534.17) Loss of Rbm12, a Genetic Risk Factor for Psychosis, Leads to Hyperactivated GPCR/cAMP Signaling Pathway
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10:00 AM – 12:00 PM
(534.18) STREStrogen: The Dichotomous Role of Estrous Cycle on Anxiety-like Behavior is Dependent upon Stress History
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10:00 AM – 12:00 PM
(535.10) Investigating the neuroinflammatory regulation of social stress-induced anxiety and opioid seeking between the sexes
Favorite
10:00 AM – 12:00 PM
(535.11) Interactions between Fentanyl and 2,5-dimethoxy-4-methylamphetamine (DOM), a 5-HT2A Receptor Agonist, in Rhesus Monkeys Responding under a Food Versus Drug Choice Procedure
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10:00 AM – 12:00 PM
(535.12) Detection of Mu-Opioid Receptors in SH-SY5Y Human Neuroblastoma Cells by Flow Cytometry
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10:00 AM – 12:00 PM
(535.13) Role of Neuromedin S-expressing Ventral Tegmental Area Neurons in Morphine Behavior
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10:00 AM – 12:00 PM
(535.14) Positive Allosteric Modulation of the Mu Opioid Receptor
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10:00 AM – 12:00 PM
(535.15) Fentanyl-Induced Sleep Disruption in C57BL/6J (B6) Mice is not Secondary to Increased Motor Activity or Hypothermia
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10:00 AM – 12:00 PM
(536.10) Loss of Biased Signaling Specificity of the Angiotensin II Type 1 Receptor in Overexpressed Systems
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10:00 AM – 12:00 PM
(536.11) In Silico Identification of a β2 Adrenergic Receptor Allosteric Site that Selectively Augments Canonical β2AR-Gs Signaling and Function
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10:00 AM – 12:00 PM
(536.12) Phosphorylation barcode ensembles encoded by biased CXCR3 agonists direct non-redundant chemokine signaling
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10:00 AM – 12:00 PM
(537.10) Characterization and Chemical Optimization of the D2 Dopamine Receptor-Selective Antagonist, ML321, Identifies Lead Compounds for the Clinical Treatment of Neuropsychiatric Disorders
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10:00 AM – 12:00 PM
(537.11) Soluble Epoxide Hydrolase Inhibitors: Design, Synthesis, in vitro Profiling and in vivo Evaluation in Murine Models of Pain.
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10:00 AM – 12:00 PM
(537.12) Glycosylated Sulfonylurea (2DGs) Modulates Insulin - dependent and Insulin - independent Signaling Pathways via PI3K and P38 MAPK in L6 Skeletal Muscle Cell Line
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10:00 AM – 12:00 PM
(537.13) Hepatoprotective Effects of Astragaloside IV and Formononetin Against Oxidative Injury
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10:00 AM – 12:00 PM
(537.14) Structure activity relationship of 3-methylcytidine-5’-α,β-methylenediphosphates as CD73 inhibitors
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10:00 AM – 12:00 PM
(537.15) Novel Anosmia-Inducing Compounds for Environmentally Friendly Mosquito Vector Control: Structural Determinants of ORco Ligands Antagonizing Odorant Receptor Function
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10:00 AM – 12:00 PM
(537.16) Structural Analysis of the Interaction of Pyrazole and Benzimidazole Core Compounds with PfATP4
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10:00 AM – 12:00 PM
(537.17) USP Potency Adjusted Bovine Mucosal Heparins are Comparable to Porcine Mucosal Heparin and May be Interchangeable for Anticoagulation
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10:00 AM – 12:00 PM
(537.18) Small molecule inhibitors of human RGS2 developed by structure based drug design approach
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10:00 AM – 12:00 PM
(537.19) Novel Treatment Option for Rheumatoid Arthritis through Bone-Targeted Delivery of Novokinin
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10:00 AM – 12:00 PM
(537.20) Effects of a Recombinant Humanized Anti-Cocaine Monoclonal Antibody on the Metabolism and Distribution of Cocaine In Vitro and in Mice
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10:00 AM – 12:00 PM
(537.21) Multivalent Vaccine Strategies against Polydrug Use in Opioid Use Disorders
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10:00 AM – 12:00 PM
(537.22) Pharmacology and pharmacokinetics of fentanyl toxicity reversal by anti-fentanyl monoclonal antibodies in combination with naloxone
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10:00 AM – 12:00 PM
(537.23) Design of Experiment (DOE) for Optimization of PLGA Nanoparticles
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10:00 AM – 12:00 PM
(537.24) The characteristics of metformin nanoliposomes
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10:00 AM – 12:00 PM
(537.25) Structure Activity Relationship and Biological Evaluation of Small Molecule Antagonists for G-Protein Coupled Receptor Associated with Neuropathic Pain
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10:00 AM – 12:00 PM
(538.10) Cytotoxicity in Human Kidney HK-2 Cells of the Flavoring Aldehydes Cinnamaldehyde and Vanillin
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10:00 AM – 12:00 PM
(538.11) Effects of Senescent Human Endothelial Cells on Neuronal Viability and Neurite Outgrowth Are Not IL-8- or Serpin E1-Dependent
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10:00 AM – 12:00 PM
(539.10) Loss of protein stability and function caused by a single point mutation (P228L) in the Cytochrome P450 Oxidoreductase
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10:00 AM – 12:00 PM
(539.11) Profiling the Cytochrome P450 2J2 Active Site
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10:00 AM – 12:00 PM
(539.12) Impact of Interindividual Variability in CYP3A Activity on Ibrutinib and Venetoclax Metabolism In Vitro
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10:00 AM – 12:00 PM
(539.13) The development of an intestinal microphysiological system to model oral drug disposition
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10:00 AM – 12:00 PM
(540.10) Superior Pharmacokinetic Profile of an Innovative, Next Generation Curcumin Formula
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10:00 AM – 12:00 PM
(540.11) Intestinal P-glycoprotein (P-gp) Contribution to Talinolol Pharmacokinetics in Human
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10:00 AM – 12:00 PM
(540.12) Green Tea Alters Bile Acid Micellar Solubility of Raloxifene
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10:00 AM – 12:00 PM
(540.13) Pharmacokinetics and distribution of cathine and cathinone in rats
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10:00 AM – 12:00 PM
(541.10) CRISPR/Cas9 with Homology-Directed Repair Effectively Silences the Human Topoisomerase IIα Intron-19 5 Splice Site and Results in Etoposide Resistance in Human Leukemia K562 Cells
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10:00 AM – 12:00 PM
(541.11) Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide
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10:00 AM – 12:00 PM
(541.12) Implication of integrins in eptifibatide interference with platelet stimulation of ovarian cancer
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10:00 AM – 12:00 PM
(541.13) Diabetic Triple Negative Breast Cancer: Polyamine Enzymes, Ornithine decarboxylase and Spermine oxidase as Potential Targets
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10:00 AM – 12:00 PM
(541.14) Response of Osteosarcoma Cell Lines to a Novel CHD1L Inhibitor
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10:00 AM – 12:00 PM
(541.15) Combined Inhibition of the Ataxia-telangiectasia mutated and Rad3-related Pathway and the G9a Methyltransferase Synergize to Reduce Pancreatic Cancer Cell Growth
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10:00 AM – 12:00 PM
(541.16) Effect of CaS/DMSO dispersions in the cytoskeleton and focal adhesion points of human skin adherent benign and melanoma cells
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10:00 AM – 12:00 PM
(541.17) Knockout of the a4 isoform of the V-ATPase subunit a reduces tumor growth and metastasis in vivo
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10:00 AM – 12:00 PM
(541.18) Nuclear Location Bias of HCAR1 Drives Cancer Malignancy by Multiple Routes
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10:00 AM – 12:00 PM
(542.10) Development of an Automated, High-Throughput Assay to Detect Angiotensin AT2-Receptor Agonistic Activity by Nitric Oxide Measurement In Vitro
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10:00 AM – 12:00 PM
(543.10) Tracking and Inhibiting Atypical Vascular Inflammation
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10:00 AM – 12:00 PM
(545.10) Influences of Housing Environment on Functional State of the Body after Action of Ulcerogenic Stressor
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10:00 AM – 12:00 PM
(915.10) The Single Dose Cocaine Reinstatement of Lever-Pressing Behavior in Rats is Explained by The Compulsion Zone Theory
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10:00 AM – 12:00 PM
(915.11) Eating a high fat or ketogenic diet increases sensitivity of rats to methamphetamine-induced locomotion
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10:00 AM – 12:00 PM
(915.12) Neurotrophic and Adrenergic Mechanisms Contribute to the Anti-Allodynic Efficacy of the Kratom Alkaloid Mitragynine Against Chemotherapy-Induced Peripheral Neuropathy
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10:00 AM – 12:00 PM
(915.13) “A Method for Touchscreen-Based Oral Self-Administration of Oxycodone in Mice”
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10:00 AM – 12:00 PM
(915.14) Establishing Olfactory Based Learning and Memory Protocol in Kabuki Syndrome Mice
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10:00 AM – 12:00 PM
(915.15) Cues Associated with Social Defeat Stress Recruit CRF in the Nucleus Accumbens and Invigorate Drug-Seeking following Abstinence from Cocaine
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10:15 AM
(584.4) Essential Amino Acid Regulation of Protein Turnover to Support Skeletal Muscle Health with Age
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10:15 AM – 12:15 PM
584 APS Macronutrient regulation of health and chronic disease Poster Session
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10:15 AM – 12:15 PM
(474.1) Clinical Communication Skills Training in Third- and Fourth-Year Medical Students: A Qualitative Study
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10:15 AM – 12:15 PM
(474.2) Assessment of the Impact of Student Role on Performance during Reciprocal Peer Teaching in Human Gross Anatomy, Who Benefits?
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10:15 AM – 12:15 PM
(474.3) Q&A: What exactly do students need to learn anatomy? Finely designed dissection videos!
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10:15 AM – 12:15 PM
(474.4) An Exploration of Metacognitive Practices in Gross Anatomy Educators
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10:15 AM – 12:15 PM
(474.5) Learning from the Past: A Five-Year Analysis of the Exam Preparations of Students Repeating an Integrated Medical Anatomy Course
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10:15 AM – 12:15 PM
(474.6) The Utility of Anatomical Diagrams Shared on Social Media
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10:15 AM – 12:15 PM
(474.7) Anatomy: A research-led science with evidence-based teaching
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10:15 AM – 12:15 PM
(474.8) Transitioning from In Person to Online Human Anatomy: Student Perspectives from the COVID-19 Pandemic
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10:15 AM – 12:15 PM
(474.9) Students Perception of the Anatomy Educational Environment at Regional Medical Campuses (RMC) and Main Campus
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10:15 AM – 12:15 PM
(475.1) Obesity Stigma in Anatomy and Osteopathic Manipulative Medicine
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10:15 AM – 12:15 PM
(476.1) Increased Interest in Anatomical Donation As A Result of Positive Media Coverage
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10:15 AM – 12:15 PM
(477.1) Flipping the Anatomy Classroom with Clinical Cases and Teamwork at a Large Medical School
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10:15 AM – 12:15 PM
(477.2) Embalming and Maintenance of a Pliable Cadaver Over a Two-Year Period for Clinical Procedure Learning
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10:15 AM – 12:15 PM
(478.1) Design Principles for VanVR APP: a Virtual Anatomy Lab
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10:15 AM – 12:15 PM
(478.2) Brave New E-World: Medical Students’ Preferences for and Usage of Electronic Learning Resources during Two Different Phases of Their Education
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10:15 AM – 12:15 PM
(478.3) 3D Printed Schematic Model for Extraocular Muscles teaching
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10:15 AM – 12:15 PM
(478.4) Best Practices and Student Preferences for Implementing iPads into an Occupational Therapy Anatomy Laboratory
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10:15 AM – 12:15 PM
(478.5) An Online Magnetic Resonance Imaging Approach Using Augmented Reality Visualizations for Introducing Students to Their “Silent Teachers”
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10:15 AM – 12:15 PM
(478.6) The Efficacy of Digital Media in Teaching Anatomy During the COVID-19 Pandemic
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10:15 AM – 12:15 PM
(478.7) Enriching Anatomy Learning with Virtual Reality Clinical Scenarios
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10:15 AM – 12:15 PM
(478.8) Reviving Microscopy in Paramedical Anatomy Courses Using Web-based Virtual Microscopy and Interactive Exercises
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10:15 AM – 12:15 PM
(478.9) Integration of Virtual Three- Dimensional (3D) Anatomy Platforms with Cadaveric Prosections in the Teaching of Cardiac Anatomy
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10:15 AM – 12:15 PM
(479.1) AGE-RELATED CHANGES IN THE STRUCTURE OF THE CAVOTRICUSPID ISTHMUS IN AN EAST AFRICAN POPULATION
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10:15 AM – 12:15 PM
(479.2) Methods for studying the ductus venosus in animals
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10:15 AM – 12:15 PM
(479.3) Anatomical and topographic features of lymphatic outflow of the heart in an Anglo-Nubian goat
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10:15 AM – 12:15 PM
(479.4) Histological features of the mitral valve in Anglo-Nubian goats
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10:15 AM – 12:15 PM
(479.5) Bilateral angio-radiography of volumetric organs and structures
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10:15 AM – 12:15 PM
(479.6) A Cadaveric Study of Intercostal Neurovascular Bundle Variation in Intercostal Spaces: Chest Tube Insertion Approaches
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10:15 AM – 12:15 PM
(479.7) A Retrospective Medical History Based on Cadaveric Dissection
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10:15 AM – 12:15 PM
(479.8) Nearest Neighbor Density Analysis of the Stellate Ganglia
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10:15 AM – 12:15 PM
(479.9) Case Study: Exploring a Variation of Partial Anomalous Pulmonary Venous Return of the Right Upper Pulmonary Vein into the Cephalic Portion of the SVC Causing a Left-to-Right Shunt in a 56-year-old Asian Female
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10:15 AM – 12:15 PM
(480.1) Revealing Leptin and Adiponectin Involvement in Endothelial Cell Response to Disturbed Flow
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10:15 AM – 12:15 PM
(480.2) Abdominal Aortic Aneurysm and Plasminogen Activator Inhibitor 1: Correlation in the Context of Type 2 Diabetes
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10:15 AM – 12:15 PM
(480.3) Pyrazole Reduces the Effects of Oxidative Stress in Cardiomyocytes Induced by Rotenone and Doxorubicin lt;/p"gt;
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10:15 AM – 12:15 PM
(480.4) A rare pediatric case report: Salvage transcatheter closure of atrial septal defect before parent-to-offspring living-donor liver transplantation
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10:15 AM – 12:15 PM
(480.5) Case Analysis of a Unique RIII-C Single Coronary Artery with Type IV Dual LAD and Right-Dominant Triple PDA
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10:15 AM – 12:15 PM
(480.6) Anatomical changes of the internal jugular vein with Trendelenburg position and head rotation. Evidence for a safer catheterization
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10:15 AM – 12:15 PM
(480.7) Determining the Association Between Density of Muscarinic Acetylcholine Receptor M3 in Myocardium and Tunica Media of Coronary Vasculature and Self-Reported Disease States
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10:15 AM – 12:15 PM
(480.8) Arteria Lusoria and its relation to Dysphagia Lusoria. A systematic review
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10:15 AM – 12:15 PM
(480.9) Metabolic Profile in Neonatal Pig Hearts
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10:15 AM – 12:15 PM
(481.1) Telocytes within the Ligamentum Arteriosum: An Ultrastructural Evidence
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10:15 AM – 12:15 PM
(481.2) ARHGAP29 Regulates Keratinocyte Migration through the RhoA/ROCK Pathway
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10:15 AM – 12:15 PM
(481.3) Microautophagy catabolizes lipid droplets in liver hepatocytes via the small GTPase Rab5 and is connected to alcoholic fatty liver
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10:15 AM – 12:15 PM
(481.4) Investigating the Effects of IRF6 on Focal Adhesions in Keratinocytes
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10:15 AM – 12:15 PM
(481.5) Selection of culture media for chicken PGC long-term cultivation
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10:15 AM – 12:15 PM
(481.7) Diacerein attenuates 1,2-dimethylhydrazine induced colon cancer progression in rats: Modulation of IL-6/STAT3/ lncRNA HOTAIR pathway
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10:15 AM – 12:15 PM
(481.8) PP2A and LRP-1 targeted protection of human retinal pigment epithelial cells
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10:15 AM – 12:15 PM
(481.9) Effects of Antiviral Nucleoside Analogues on the Maintenance of the Mitochondrial Genome
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10:15 AM – 12:15 PM
(482.1) Reference chart for transverse cerebellar diameter in developing fetuses according to their gestational age in Indian population
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10:15 AM – 12:15 PM
(482.2) Developing A Reference Charts for Foetal Biometry in Indian Population to Predict Growth & Development of Foetus.
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10:15 AM – 12:15 PM
(482.3) Effects of spliceosomal mutations on brain patterning and morphogenesis
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10:15 AM – 12:15 PM
(482.4) Facial dysmorphologies in genetic disorders: exploring the ancestry component in a Colombian population
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10:15 AM – 12:15 PM
(482.5) Dose dependent effects of green tea extracts in the skeletal development of a Down syndrome mouse model
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10:15 AM – 12:15 PM
(482.6) Radiography Suggests a Fibrous Tubular Sleeve Distal to a Cartilaginous Anlage in a Limb with ‘Absent Fibular’ Represents a Traction
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10:15 AM – 12:15 PM
(482.7) Developmental Morphospace of Embryonic Brain and Face Growth in the Chicken (Gallus gallus)
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10:15 AM – 12:15 PM
(482.8) Meckel’s Cartilage and Mandibles: Effects of the Fgfr2 C342Y mutation on development of the lower jaw in a Crouzon syndrome mouse model
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10:15 AM – 12:15 PM
(546.1) Characterizing the Correlation Between Angiogenesis and Osteogenesis In Vivo Using Multicontrast Functional Imaging in a Calvarial Defect Model
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10:15 AM – 12:15 PM
(546.2) Which Comes First: Angiogenesis or Myogenesis Following Punch Biopsy Injury?
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10:15 AM – 12:15 PM
(546.3) FOXM1 Promotes Intestinal Vascular Endothelial Cell Proliferation and Protects Neonatal Mice against Necrotizing Enterocolitis
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10:15 AM – 12:15 PM
(546.4) Modeling Structural Adaptation and Pruning of Blood Vessels Connected in Parallel: Implications for Control of Capillary Density
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10:15 AM – 12:15 PM
(546.5) Investigating a Ligand-receptor Role for Glutathione in Angiogenesis
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10:15 AM – 12:15 PM
(546.6) Chemotherapy, Microvascular Function, and Angiogenesis - a Longitudinal Study
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10:15 AM – 12:15 PM
(546.7) The Role of CD44v6 in Vascular Rarefaction and Left Ventricular Diastolic Dysfunction in HFpEF
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10:15 AM – 12:15 PM
(546.8) Skeletal Muscle Injury is Sufficient for Angiogenesis but Myofiber Regeneration is Required for Restoring Microvascular Integrity
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10:15 AM – 12:15 PM
(546.9) A machine-learned microvasculature optimizes physiological insulin secretion in a vascularized pancreas-chip
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10:15 AM – 12:15 PM
(547.1) Effects of Acetate on Mesenteric Lymphatic Pump Function
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10:15 AM – 12:15 PM
(547.2) Prolonged Exposure to Intestinal Edemagenic Stress Decreases Mesenteric Lymphatic Contractility
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10:15 AM – 12:15 PM
(547.3) Ethanol-Induced Lymphatic Endothelial Cell Permeability: Role of Prox-1 and Vascular Endothelial Growth Factors
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10:15 AM – 12:15 PM
(547.4) In Vitro Irradiation of Lymphatic Vessels Enhances Lymphatic Pump Function
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10:15 AM – 12:15 PM
(547.5) Discerning the role of IP3R1 activation by Gq/G11 signaling in murine lymphatic collecting vessel pacemaking
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10:15 AM – 12:15 PM
(547.6) Obesity-Induced Lymphatic Valve Dysfunction
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10:15 AM – 12:15 PM
(548.1) Theoretical Model of Extracellular Potassium Diffusion as a Signaling Mechanism in Neurovascular Coupling
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10:15 AM – 12:15 PM
(548.2) Quantifying Longitudinal Network Geometry Alterations in Rat Skeletal Microvasculature Subject to Ischemia
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10:15 AM – 12:15 PM
(548.3) Application of a Second-Order Control-Systems Model to Investigate Effects of Impaired Capillary Signalling in Skeletal Muscle on Regulation of Capillary Blood Flow Velocity and Tissue Oxygenation
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10:15 AM – 12:15 PM
(548.4) Development of thin-film micro-outlet devices for spatially constraining local O2 perturbations to capillaries
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10:15 AM – 12:15 PM
(548.5) Effect of increased ventilation during feeding on broiler breeder biochemical, enzymatical, and electrolytes parameters
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10:15 AM – 12:15 PM
(548.6) Autocrine P2X4 receptor activation in RBCs drives oxygen-dependent hyperemic responses in mouse skeletal muscle capillaries
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10:15 AM – 12:15 PM
(548.7) The Regulatory Role of miR-21 in Coronary Microcirculation
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10:15 AM – 12:15 PM
(548.8) Vascular myogenic control of tibial bone blood flow in young healthy individuals
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10:15 AM – 12:15 PM
(548.9) Clamping Skeletal Muscle PO2 Eliminates Hyperinsulinemic Microvascular Blood Flow Response
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10:15 AM – 12:15 PM
(549.1) Measurement of Cerebrovascular Hemodynamics in Awake Freely Behaving Mice
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10:15 AM – 12:15 PM
(549.2) Substrate Stiffness Modulates Normal and Diabetic Coronary Smooth Muscle Cell Stiffness
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10:15 AM – 12:15 PM
(549.3) Estimation of Shear Stress Heterogeneity along Capillary Segments in Angiogenic Rat Mesenteric Microvascular Networks
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10:15 AM – 12:15 PM
(550.1) Inhibition of Peroxiredoxin 6 PLA2 Activity Decreases Oxidative Stress and the Severity of Acute Lung Injury in the Mouse Cecal Ligation and Puncture Model
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10:15 AM – 12:15 PM
(550.2) Promoting the Resolution of Thromboinflammation
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10:15 AM – 12:15 PM
(550.3) Myristic Acid-Trans-Activator of Transcription Dual Conjugation Improves Intracellular Delivery of Protein Kinase C Beta II Peptide Inhibitor Cargo in Isolated Rat Polymorphonuclear Leukocytes
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10:15 AM – 12:15 PM
(551.1) Cardioprotective effects of redox regulator MnTnBuOE-2-PyP 5+ in myocardial ischemia/reperfusion injury
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10:15 AM – 12:15 PM
(551.2) A Novel Technique to Reduce Kidney Injury by Maintaining Na/K Pump Functions Using Electric Energy
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10:15 AM – 12:15 PM
(551.3) Evans Blue Dye Interferes with Gating for Certain Fluorochrome-Conjugated Antibodies Using Flow Cytometry in the Ischemic Rat Heart
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10:15 AM – 12:15 PM
(552.1) Cell-free Hemoglobin-Oxidized LDL Axis Contributes to Microvascular Endothelial Barrier Dysfunction and Poor Outcomes During Sepsis
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10:15 AM – 12:15 PM
(552.2) The Loss of Endothelial Glycocalyx in Diabetic Retinopathy
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10:15 AM – 12:15 PM
(552.3) Extension of the isogravimetric method for the determination of the capillary filtration coefficient CFC
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10:15 AM – 12:15 PM
(552.4) Proteomic Analysis of Control and Disrupted Endothelial Monolayers
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10:15 AM – 12:15 PM
(552.6) SMAD3 is a Mediator of TGF-β -induced Barrier Dysfunction and Hyperpermeability in Microvascular Endothelial Cells
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10:15 AM – 12:15 PM
(552.7) Andrographolide-Mediated Protection of Barrier Integrity and Permeability is Mediated Through NLRP3 Inflammasome Inhibition in Blood-Brain Barrier Endothelial Cells
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10:15 AM – 12:15 PM
(553.1) Ossified Particles in the Peripheral Circulation of Young and Old male Fischer-344 Rats following Bone Marrow Ablation and Interleukin-1 Receptor Antagonism
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10:15 AM – 12:15 PM
(554.1) Role of Potassium Channel Function and Long-term Exercise Training in Soleus Resistance Arterioles
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10:15 AM – 12:15 PM
(554.2) Obesity Differentially Effects Visceral vs. Subcutaneous Adipose Arteries: Role of Shear Activated Kir2.1 and Alterations to the Glycocalyx in Mediating Endothelial Dysfunction
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10:15 AM – 12:15 PM
(554.3) Spironolactone prevents L-type CaV1.2 potentiation and chronic vasoconstriction during diabetic hyperglycemia
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10:15 AM – 12:15 PM
(554.4) A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation
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10:15 AM – 12:15 PM
(554.5) Vasodilators stimulate SK3 channel anterograde trafficking in endothelial cells to elicit vasodilation
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10:15 AM – 12:15 PM
(554.7) Endothelial inwardly rectifying potassium channels regulates receptor-mediated vasodilation via PI3K/Akt/eNOS signal pathway
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10:15 AM – 12:15 PM
(554.8) TNFα signaling impairs endothelial calcium signaling and elevates blood pressure in obesity
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10:15 AM – 12:15 PM
(554.9) Integrated redox sensitivity of vascular Kv1 channels
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10:15 AM – 12:15 PM
(555.1) Middle Cerebral Artery Pulsatility Index is Elevated in Chronic Kidney Disease
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10:15 AM – 12:15 PM
(555.2) Constrictor Responses of Cerebral Resistance Arterioles Preserved in Male and Female Rats Exposed to Prenatal Alcohol
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10:15 AM – 12:15 PM
(555.3) Impaired mechanotransduction of small cerebral arteries after traumatic brain injury. Role of arachidonic acid pathway dysfunction
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10:15 AM – 12:15 PM
(555.4) A dual potassium channelopathy underlies small vessel disease of the brain in a mouse model of Alzheimers Disease
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10:15 AM – 12:15 PM
(555.5) Loss of Ca2+ spark-to-BK channel coupling impairs cerebral autoregulation in hypertension.
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10:15 AM – 12:15 PM
(555.6) Characterization of cerebral arteries function and structure in a mouse model of Marfan syndrome: effects of exercise and Losartan treatment
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10:15 AM – 12:15 PM
(555.7) Dantrolene Significantly Improves Cerebral Blood Flow In Diabetic Rats With Cerebral Vasospasms
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10:15 AM – 12:15 PM
(555.8) Chronic Stress Accelerates the Progression of Cerebrovascular Dysfunction with Alzheimers Disease
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10:15 AM – 12:15 PM
(555.9) Global Toll-like Receptor 4 Knockout Prevents Cerebrovascular Dysfunction Associated with Chronic Stress
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10:15 AM – 12:15 PM
(556.1) The effect of novel second generation prebiotics (levan of β-[2,6]-glycosidic linkages) on the cardiovascular system in obesity
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10:15 AM – 12:15 PM
(556.2) Endothelial Cell Heterogeneity Between Conduit and Resistance Mesenteric Arteries
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10:15 AM – 12:15 PM
(556.3) The Effect of Tauroursodeoxycholic Acid (TUDCA) Treatment on Pregnancy Outcomes and Uterine Artery Function in a Rat Model of Advanced Maternal Age
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10:15 AM – 12:15 PM
(556.4) Calcium Signaling in Trauma: Increased Intracellular Calcium Flux in the Severely Injured
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10:15 AM – 12:15 PM
(556.5) The Role of Adipocyte-derived Extracellular Vesicles in Diabetes-associated Endothelial Dysfunction
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10:15 AM – 12:15 PM
(556.6) Endothelial Function Does Not Show Signs of Impairment in Young Athletes At Two Months Post-Covid-19 Infection
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10:15 AM – 12:15 PM
(556.7) The Role of PER-1, ET-1 Axis in Regulating Endothelial Cell Function
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10:15 AM – 12:15 PM
(556.8) Galectin-3 Regulates Oxidant Stress in Obesity
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10:15 AM – 12:15 PM
(556.9) Canagliflozin Regulates Human Endothelial Cell Function: Role of Heme Oxygenase-1
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10:15 AM – 12:15 PM
(557.1) Study on changes of cardiac function and peripheral vascular resistance in elderly patients with hypertension
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10:15 AM – 12:15 PM
(557.2) Enhanced Cerebral Blood Flow and Hemodynamic Status with an Alternative Left Ventricle Chest Compression Position during Cardiopulmonary Resuscitation in Swine
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10:15 AM – 12:15 PM
(557.3) Activation of the Soluble Guanylate Cyclase Increases 26S Proteasome Activities and Protects against Proteotoxicity in Cardiomyocytes
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10:15 AM – 12:15 PM
(557.4) Cardiomyocyte-specific deletion of Med13 & Med13L results in dysregulated gene expression and lethal systolic heart failure
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10:15 AM – 12:15 PM
(557.5) The Effect of Sildenafil on Atrial Natriuretic Peptide Level in Rats Treated with Monocrotaline
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10:15 AM – 12:15 PM
(557.6) Machine Learning to Identify Regional and Segmental Dysfunction during Type 2 Diabetes Mellitus Progression
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10:15 AM – 12:15 PM
(557.7) Investigating the Therapeutic Potential of Cdk8 Small Molecule Inhibitors to Prevent Pathological Cardiac Remodeling and Heart Failure
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10:15 AM – 12:15 PM
(557.8) Mutation in the 5SL Region of Collagen I mRNA Attenuates Diastolic Dysfunction in Male, but not Female, Mice Following 28 Weeks of Feeding a High Fat High Sucrose Diet
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10:15 AM – 12:15 PM
(557.9) Cardiovascular reactivity to and recovery from cold face test
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10:15 AM – 12:15 PM
(558.1) Sexual Dimorphism in Response to Vitamins B3, B9 and B12, Used in Combination, in a Mice Model of Heart Failure Induced by Pressure Overload
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10:15 AM – 12:15 PM
(558.2) Does Metabolism Regulate Cardiac Repair in the Regeneration Competent Axolotl Salamander?
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10:15 AM – 12:15 PM
(558.3) MED12 is a Transcriptional Mediator of Cardiac Contractile Function
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10:15 AM – 12:15 PM
(558.4) A New Method to Analyse Myocardial Substrate Metabolism and Mitochondrial Function in Intact Cardiac Tissue Slices
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10:15 AM – 12:15 PM
(558.5) The Ketogenic Diet Impairs Mitochondrial Function in Hearts of Male and Female Mice
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10:15 AM – 12:15 PM
(558.6) 3D mitochondrial remodeling during postnatal heart development
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10:15 AM – 12:15 PM
(558.7) Mama and papa of the early spontaneous electrical activity of the embryo sinoatrial node
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10:15 AM – 12:15 PM
(559.1) Developmental Regulation of Sarcomere Branching in Cardiomyocytes
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10:15 AM – 12:15 PM
(559.2) Decreased Contraction Rate, Altered Calcium Transients, and Increased Proliferation seen in Patient-specific iPSC-CMs Modeling Ebstein’s Anomaly and Left Ventricular Noncompaction
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10:15 AM – 12:15 PM
(560.1) The Role of Scleraxis in Inducing Vascular Stiffness
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10:15 AM – 12:15 PM
(560.2) PPARγ Deacetylation: A Novel Therapeutic Strategy to Mitigate Arterial Stiffness in Obese Male Mice
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10:15 AM – 12:15 PM
(560.3) The Effect of Amiloride (10mg) on the Blood Pressure Response to Ischemic Exercise: Preliminary Observations
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10:15 AM – 12:15 PM
(560.4) Effect of Self-Reported Anxiety Levels on Blood Pressure Responses to Slow Breathing
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10:15 AM – 12:15 PM
(560.5) Acute Intermittent Hypoxia Improves Orthostatic Tolerance in Chronic but not Acute Spinal Cord Injured Rats
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10:15 AM – 12:15 PM
(560.6) Conditional deletion of the glucocorticoid receptor in vascular smooth muscle disrupts the circadian rhythm of vascular reactivity and reduces blood pressure
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10:15 AM – 12:15 PM
(560.7) Indole-3-propionic Acid, Bacterial Metabolite of Tryptophan, Increases Blood Pressure in Normotensive and Hypertensive Rats
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10:15 AM – 12:15 PM
(560.8) Objectively Assessed Habitual Sleep Duration Is Associated with Peripheral and Central Blood Pressure in Non-Hypertensive Young Adults
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10:15 AM – 12:15 PM
(560.9) Impact of COVID-19 on Ambulatory Daytime and Nighttime Blood Pressure in Young Otherwise Healthy Adults
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10:15 AM – 12:15 PM
(561.1) Post-Pubertal Testosterone Implants Induce Hypertension in Female-to-Male Trans-Sex Rat Model
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10:15 AM – 12:15 PM
(561.2) Single Prolonged Stress Alters Vasopressin and Orexin System Expression in Sprague Dawley Rats
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10:15 AM – 12:15 PM
(561.3) Sex Differences in Insulin Sensitivity and Glomerular Function in African Green Monkeys
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10:15 AM – 12:15 PM
(562.1) Agomelatine Ameliorates Obesity-Induced Kidney Injury through the Inhibition of Renal Fibrosis and Improvement of Impaired Autophagy
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10:15 AM – 12:15 PM
(562.2) Effect of adrenalectomy and insulin resistance on non-shivering thermogenesis in the corpulent rat
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10:15 AM – 12:15 PM
(562.3) Chitosan Oligosaccharide Ameliorates Kidney Injury by Improving Intestinal Barrier Dysfunction and Lipid Metabolism in Obese-insulin Resistant Rats
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10:15 AM – 12:15 PM
(562.4) Mother with Obesity Induced by High-Fat Diet Impaired Autophagic Process and Induced Renal Lipid Accumulation in the Offspring
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10:15 AM – 12:15 PM
(562.5) Endothelial (Dys)function in Women With Androgen Excess Polycystic Ovary Syndrome: Effects of Body Composition and Ethinyl Estradiol Supplementation
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10:15 AM – 12:15 PM
(562.6) Progesterone Treatment Attenuates Body Weight Gain, Adiposity and Glycaemic Metabolism Damage in Obese Female Mice
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10:15 AM – 12:15 PM
(562.7) "Effects of Metformin on Attenuating Renal Dysfunction Through the Modulation of AMPK/PPARα Dependent Pathways in Obese Rats"
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10:15 AM – 12:15 PM
(562.8) Deletion of Myostatin Resolves Myosteatosis and Improves Angiogenesis in Obese Mice
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10:15 AM – 12:15 PM
(562.9) D4 dopamine receptors regulate Insulin sensitivity via activation of renal insulin receptors in mice
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10:15 AM – 12:15 PM
(563.1) Loss of Cingulin-like 1 in Dahl Salt-Sensitive Rats Leads to Reduced Renal Injury and Blood Pressure
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10:15 AM – 12:15 PM
(563.2) Loss of Clcn6 Alters Expression of Nearby Regulatory Blood Pressure Genes but Does Not Affect High Salt Induced Mortality in Dahl Salt-Sensitive Rats
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10:15 AM – 12:15 PM
(563.3) TLR4 Promotes ER stress and Unfolded Protein Response in Hypertension-Induced Kidney Injury
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10:15 AM – 12:15 PM
(563.4) Renal Pathophysiological Changes During Chronic Metabolic Acidosis Associated Increased Blood Pressure
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10:15 AM – 12:15 PM
(563.5) Effect of SGLT2 Inhibition on the Development of Salt-sensitive Hypertension, RAAS, and Sodium Channels and Transporters in Dahl SS Rats
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10:15 AM – 12:15 PM
(563.6) MicroRNA-195 regulates blood pressure by inhibiting NKCC2A
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10:15 AM – 12:15 PM
(563.7) Interaction between CD81 and NCC is associated with LPS induced preeclampsia
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10:15 AM – 12:15 PM
(563.8) Proximal Tubule-Specific Transgenic Overexpression of Peroxisome Proliferator-Activated Receptor Alpha Prevents the Development of Hypertension in Dahl Salt-Sensitive Rats
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10:15 AM – 12:15 PM
(563.9) Mice with Brain-Specific Deletion of Hsd11b2 have an impaired renal vascular and tubular response to high salt intake
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10:15 AM – 12:15 PM
(564.1) REDD1 deletion prevents the development of renal dysfunction in diabetic mice
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10:15 AM – 12:15 PM
(564.2) Exaggerated Store-Operated Calcium Entry: A Mechanism for High Glucose-induced Podocyte Injury and Mitochondria Damage
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10:15 AM – 12:15 PM
(564.3) A novel compound AD021 attenuates renal fibrosis by inhibiting transforming growth factor-β1 in renal proximal tubule epithelial cells
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10:15 AM – 12:15 PM
(564.4) Mitochondrial-derived ROS Contribute to the Development of Hypertensive-Diabetic Kidney Injury
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10:15 AM – 12:15 PM
(564.5) Urotensin II receptor knockout alleviates streptozotocin-induced hyperglucagonemia and diabetic kidney disease
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10:15 AM – 12:15 PM
(564.6) A Newly Synthesized Specific PDE5a Inhibitor LW1646 Attenuated Lipid-Induced Kidney Injuries through Inhibiting Endoplasmic Reticulum Stress
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10:15 AM – 12:15 PM
(564.7) Investigating the influence of the gut microbiome on diabetic renal disease
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10:15 AM – 12:15 PM
(564.8) FABP1: A Potential Biomarker for Nephropathy in Type II Diabetes
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10:15 AM – 12:15 PM
(564.9) Glucosidase Inhibitor Alleviates Inflammation and Fibrosis in Type-1 Diabetic Kidney
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10:15 AM – 12:15 PM
(565.1) Afferent Renal Nerve Activity is Proportionately Increased with Cystic Progression in a Preclinical Model of Autosomal Recessive Polycystic Kidney Disease
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10:15 AM – 12:15 PM
(566.1) Vascular Endothelial Growth Factor is Augmented in the Kidney with Chronic Partial Ureteral Obstruction and Further Stimulated by Lipopolysaccharide
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10:15 AM – 12:15 PM
(566.2) Nigella Sativa Can Reverse Statin-Induced Renal Injury in Rats: An Ultrastructural Study
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10:15 AM – 12:15 PM
(566.3) Sensitivity to Iron-Mediated Pro-Inflammatory Signaling in NZBWF1 Mice, a Model of Systemic Lupus Erythematosus
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10:15 AM – 12:15 PM
(566.4) Nephrology Patients Exhibit Frequent Depression Without Neurological Deficits
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10:15 AM – 12:15 PM
(566.5) Application of Scanning Ion Conductance Microscopy in the Studies of Podocytes Morphological Changes
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10:15 AM – 12:15 PM
(566.6) Imaging of Corticosteroids in Mouse Kidney Using Mass Spectrometry
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10:15 AM – 12:15 PM
(567.1) Variation in ORF3a Protein of SARS-CoV-2 Decreases The Severity of Host Cell Damage
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10:15 AM – 12:15 PM
(567.2) Ablation of PRAK exacerbates the mitochondria dysfunction in C2C12 myoblasts exposed to palmitate stress
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10:15 AM – 12:15 PM
(567.3) Antagonism of Na,K-ATPase signaling by pNaKtide can attenuate systemic inflammatory response in murine sepsis model induced by cecal ligation and puncture
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10:15 AM – 12:15 PM
(567.5) Endothelial Regulation of Microvascular Growth and Stability by Ang-Tie and VEGF Signaling Pathways: A Mechanistic Computational Systems Biology Model
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10:15 AM – 12:15 PM
(567.6) PAR2, not PAR1, regulates endothelium-dependent vascular tone in resistance arteries
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10:15 AM – 12:15 PM
(567.7) Mechanosensitive Responses of Resident Alveolar
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10:15 AM – 12:15 PM
(567.8) Calcium-dependent signaling via gap junctions drives RhoA/ROCK activation during collective cell migration
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10:15 AM – 12:15 PM
(567.9) Key Facilitator Proteins that Mediate Sarcolemma Membrane Repair have Potential as Therapeutics for Muscle Disease and Injury
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10:15 AM – 12:15 PM
(568.1) Characterizing the influence of Toxoplasma infection on opioid receptor expression using human neuroblastoma cells (SKNSH)
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10:15 AM – 12:15 PM
(568.2) The Effects of Lavendustin-A on Peripheral Nerve Degeneration in Hyperglycemic Danio rerio
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10:15 AM – 12:15 PM
(568.3) Photodynamic Activation of Cholecystokinin 1 Receptor Is Evolutionarily Conserved
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10:15 AM – 12:15 PM
(568.4) STING mediates Pulmonary Hypertension through VEGF but independent of type I interferon signaling
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10:15 AM – 12:15 PM
(568.5) Different modes of Piezo1 Ca2+ signaling in principal and intercalated cells of the collecting duct
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10:15 AM – 12:15 PM
(568.6) Tacrolimus induces ligand independent TGFβ receptor signaling to promote renal fibrosis
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10:15 AM – 12:15 PM
(569.1) Origin of the Term "Isotonic"
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10:15 AM – 12:15 PM
(569.2) A Resolution for the Inconsistency in the Definitions of Tonicity
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10:15 AM – 12:15 PM
(569.3) Resolutions to the Problems Caused by Introducing both Osmolarity and Effective Osmolarity
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10:15 AM – 12:15 PM
(569.4) Intracellular Sphingosine-1-Phosphate is Involved in Lung Cancer Cells Proliferation
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10:15 AM – 12:15 PM
(569.5) Age-Associated Changes in Autophagy in Peripheral Blood Mononuclear Cells following Maximal Exercise: Preliminary Observations
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10:15 AM – 12:15 PM
(569.6) Cellular Senescence and the Associated Secretome Contribute to Age-Related Vascular Dysfunction
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10:15 AM – 12:15 PM
(569.7) BAFF 60-mer binding to BAFF receptor 3 utilizes the NF-κB1 signaling pathway to hyperactivate B cells
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10:15 AM – 12:15 PM
(570.1) Evaluating the Effects of Chondroitin Sulfate and Hyaluronic Acid in Modifying the Properties of Collagen-Based Matrices
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10:15 AM – 12:15 PM
(570.2) PGE receptor EP4 signaling increased hyaluronan-vesican complex in abdominal aortic aneurysm
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10:15 AM – 12:15 PM
(571.1) The beneficial effect of SCFAs on the cardiovascular system during hypertension
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10:15 AM – 12:15 PM
(572.1) Impaired vertebral development following hyperglycemic induction and recovery in Danio rerio
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10:15 AM – 12:15 PM
(572.2) Role of the Phosphate Transport Facilitator XPR1 in Bone Homeostasis and Phosphate-Dependent FGF23 Secretion
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10:15 AM – 12:15 PM
(573.1) Targeting Diabetic Cardiomyopathy: LncRNA Kcnq1ot1 Rescues Mitochondrial ATP Synthase via Sponging of MiR-378a-5p
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10:15 AM – 12:15 PM
(573.2) miR-133a Mitigates Ferroptosis by Attenuating Fatty Acid Metabolism in the Diabetic Heart
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10:15 AM – 12:15 PM
(573.3) microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury
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10:15 AM – 12:15 PM
(573.4) Single-Nucleotide Polymorphisms Inside MicroRNA Target Sites: Influence in Hepatocellular Carcinoma Risk
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10:15 AM – 12:15 PM
(573.5) Antisense oligonucleotides (ASO) to increase progranulin production in frontotemporal dementia
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10:15 AM – 12:15 PM
(574.1) Dissecting the Component Parts of the Excitation-Contraction Coupling Machinery in Drosophila melanogaster
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10:15 AM – 12:15 PM
(575.1) Glial cell-Derived, but Not Neuron-Derived, Extracellular Vesicles May Serve as Novel Biomarkers of Acute Sport-Related Concussion
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10:15 AM – 12:15 PM
(575.2) Circulating Exosomal Proteins are linked to Neuropathogenesis in SIV-infected Rhesus Macaque: A Proteomic Approach
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10:15 AM – 12:15 PM
(575.3) Investigating the Effect of Small Extracellular Vesicles at Varying Concentrations on Wound Healing
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10:15 AM – 12:15 PM
(575.4) Obese Animal Serum Derived Vesicles Alter Gene Expression in C2C12 Myotubes
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10:15 AM – 12:15 PM
(575.5) Neutrophil-Derived Microvesicles Enhance Pulmonary Vascular Inflammation via a Toll-like Receptor 4 Signaling-Dependent Mechanism
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10:15 AM – 12:15 PM
(575.6) Investigating the Application of Size-Exclusion Chromatography to Purify Bacterial Extracellular Vesicles
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10:15 AM – 12:15 PM
(575.7) Development of Myotropic Extracellular Vesicles for Targeted Delivery of Therapeutics to Skeletal Muscle
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10:15 AM – 12:15 PM
(575.8) A Mouse Model Tracking Cardiac Exosomes Spatially and Temporally
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10:15 AM – 12:15 PM
(575.9) Evaluation of extracellular vesicle isolation and detection repeatability from cell cultures, biofluids, and mammalian tissues
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10:15 AM – 12:15 PM
(576.1) Fats and Sugars Recruit Distinct Gut-Brain Circuits To Control Food Intake And Reward
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10:15 AM – 12:15 PM
(576.2) Iron Deficiency And Overload Attenuate Inflammatory Response and Modulate Metabolism in Alveolar Macrophage in Vitro
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10:15 AM – 12:15 PM
(576.3) Intestinal Zip14 ablation dysregulates tight junction protein expression, inflammatory genes and lncRNAs in intestinal epithelial cells and enteroids
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10:15 AM – 12:15 PM
(576.4) Glucose Availability Regulates Sestrin3 Binding to Hexokinase2 to Affect Glucose-induced mTORC1 Activation
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10:15 AM – 12:15 PM
(576.5) Dietary Protein Quality Influences Liver Circadian Rhythms in a GCN2-dependent Manner
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10:15 AM – 12:15 PM
(576.6) RGS4 Mediates Catecholaminergic Inhibition of Short-Chain Fatty Acid Receptor FFAR3 Signaling & Function in Cardiomyocytes
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10:15 AM – 12:15 PM
(577.1) Cortistatin Inhibits Intestinal Ion Secretion via Activating the Somatostatin-2 Receptor in the Submucosal Neurons of the Mouse Colon
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10:15 AM – 12:15 PM
(577.2) Topographical Organization and Morphology of Substance-P Axons in the Flat-Mounts of the Mouse Whole Stomach
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10:15 AM – 12:15 PM
(577.3) Topographical Organization and Morphology of Calcitonin Gene-Related Peptide (CGRP) Axons in the Flat-Mounts of Whole Mouse Stomach
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10:15 AM – 12:15 PM
(577.4) Spinal Afferent Innervation of the Rat Stomach: Anterograde Tracing
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10:15 AM – 12:15 PM
(577.5) Human Milk Oligosaccharide L-N-Tetraose Activates GPR35 on Vagal Afferent Neurons In Vitro and Reduces High Fat Diet-Induced Obesity in Male Mice
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10:15 AM – 12:15 PM
(578.1) Excitation of Vagal Afferent Neurons by Fecal Supernatant from Inflammatory Bowel Disease Patients
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10:15 AM – 12:15 PM
(578.2) Ciprofloxacin Permanently Accelerates Gastrointestinal Transit in a Rodent Model of Fluoroquinolones Associated Disability
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10:15 AM – 12:15 PM
(578.3) GPR55-Dependent Excitation of Dorsal Root Ganglion Neurons by Lysophosphatidylcholine
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10:15 AM – 12:15 PM
(578.4) SPARC: Sex difference in colorectal afferent sensitization in zymosan-induced visceral hypersensitivity as revealed by high-throughput GCaMP recordings in thoracolumbar and lumbosacral DRG
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10:15 AM – 12:15 PM
(579.1) Acipimox Induces the Hepatic Accumulation of Long-Chain Diacylglycerides and Triglycerides in Severely Burned Sprague Dawley Rats
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10:15 AM – 12:15 PM
(579.2) Sex Differences in Vascular Endothelial Function After Liver Transplant
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10:15 AM – 12:15 PM
(579.3) The Role of the Optic Atrophy 1 (OPA1) Protein in Drug-Induced Liver Injury
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10:15 AM – 12:15 PM
(579.4) The Composition of Bile Acids under Fatty Liver Model in Chicken
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10:15 AM – 12:15 PM
(579.5) Feeding Coconut Oil Reduces Fatty Acid Oxidation and Exacerbates Steatosis in the Liver of Neonatal Pigs
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10:15 AM – 12:15 PM
(579.6) Localization of Orphan GPCRs within the Liver
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10:15 AM – 12:15 PM
(579.7) Phosphoglycerate Mutase 5 Expression Modulates Hepatocellular Steatosis
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10:15 AM – 12:15 PM
(579.8) Liver-specific Deletion Of Small Heterodimer Partner Alters Enterohepatic Bile Acid Levels And Promotes Bile Acid-Mediated Proliferation In Male Mice
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10:15 AM – 12:15 PM
(579.9) Ablation of Na+/H+ exchanger-3 prevents tissue iron loading in the Hfe mouse model of hereditary hemochromatosis
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10:15 AM – 12:15 PM
(580.1) Bile acid-mediated activation of brown fat protects from alcohol-induced steatosis and liver injury
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10:15 AM – 12:15 PM
(580.2) Altered Mitochondrial Dynamics in Hepatocytes Induces Nonalcoholic Fatty Liver Disease Progression
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10:15 AM – 12:15 PM
(580.3) A Mechanistic Role for RECK in the Regulation of Hepatocellular Inflammation
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10:15 AM – 12:15 PM
(580.4) The (pro)renin receptor antagonist, PRO20, attenuates high fat diet induced hepatic steatosis and fibrosis in non-alcoholic fatty liver disease (NAFLD)
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10:15 AM – 12:15 PM
(580.5) Susceptibility of Hepatic ProgenitoInhibition by acetazolamide of reactivated carbonic anhydrase activity in a receptor protein tyrosine phosphatase γ (RPTPγ) mutantr Cells to Lipotoxicity as Contributor for Impaired Liver Regeneration and Disease Advancement In Pediatric Nonalcoholic Fatty Liver Disease (PNAFLD)
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10:15 AM – 12:15 PM
(580.6) Characterizing Hepatic Inflammation upon SGLT2 Inhibition in Diabetic TallyHo Mice
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10:15 AM – 12:15 PM
(581.1) Functional MYO5B Loss Alters Lipid Metabolic Pathways in Intestinal Progenitor Cells
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10:15 AM – 12:15 PM
(581.2) Cellular Iron Imbalance Alters Metabolite Profile in Gut Epithelial Cells
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10:15 AM – 12:15 PM
(581.3) Microbial metabolite mitigates arsenic induced oxidative stress, inflammation, and barrier dysfunction in gut epithelia
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10:15 AM – 12:15 PM
(582.1) LPS transport during fat absorption is inhibited in caveolin-1 knockout murine jejunum
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10:15 AM – 12:15 PM
(582.2) Nutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease
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10:15 AM – 12:15 PM
(582.3) Regulation of the Nuclear Bile Acid Receptor, Farnesoid X Receptor, by the Omega-3 Polyunsaturated Fatty Acid, Alpha-Linolenic Acid, in Colonic Epithelial Cells
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10:15 AM – 12:15 PM
(582.4) Hyperacetylation of Toll-like receptor 4 (TLR4): a potential factor contributing to non-alcoholic liver disease (NAFLD), a silent killer in obesity
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10:15 AM – 12:15 PM
(582.5) Alpha-ketoglutarate promotes goblet cell differentiation and alters metabolome in a mouse model of colitis
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10:15 AM – 12:15 PM
(583.1) Phenolic Extract(s) from Wild Blueberries promote(s) wound healing via vascularization
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10:15 AM – 12:15 PM
(583.2) Yo-Yo Diet Has Adverse Effects on Cardiac Function and Insulin Sensitivity in Female Fischer Rats
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10:15 AM – 12:15 PM
(583.3) Intestinal Dmt1 is Required for Iron Loading in Mice Modeling β-Thalassemia Intermedia
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10:15 AM – 12:15 PM
(583.4) Valproic acid regulates sodium-dependent vitamin C transporter-2 (SVCT-2) functional expression in neuronal cells
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10:15 AM – 12:15 PM
(583.5) Dietary curcumin regulates hepatic cellular senescence in aged mice via p38-MAPK activation pathway
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10:15 AM – 12:15 PM
(583.6) Dose and Time Dependent Effect of Dietary Blueberries on Diabetic Vasculature is Associated with Gut Microbes
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10:15 AM – 12:15 PM
(583.7) Role of Taste Receptor Gene Variations (SNPs) on Diet Quality in Adolescent Females
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10:15 AM – 12:15 PM
(583.8) Low Sodium Supply in Early Life Causes Growth Restriction and Programs Long-Term Changes in Energy Homeostasis
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10:15 AM – 12:15 PM
(583.9) Longevity Effects of DMSO-Solubilized Rapamycin and Other Compounds in y w Male Drosophila melanogaster
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10:15 AM – 12:15 PM
(584.1) Impact of Krill Oil Supplementation on Neuroinflammation and Spatial Memory in Aged Rats
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10:15 AM – 12:15 PM
(584.2) Hepatic Lipidomic Analysis of Dietary Different Type of Fats and Fructose Interactions in the Pathogenesis of Nonalcoholic Fatty Liver Diseases
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10:15 AM – 12:15 PM
(584.3) Postprandial Responses of Energy Substrates in Dogs Fed High Fat- vs High Protein-Low Carbohydrate Ketogenic Foods Relative to a High Carbohydrate Food
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10:15 AM – 12:15 PM
(584.5) The Effect of Protein Supplementation During Time Restricted Feeding in Overweight and Obese Adults
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10:15 AM – 12:15 PM
(584.6) Understanding the endocrine response to macronutrients in the context of a ketogenic diet
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10:15 AM – 12:15 PM
(584.7) Rapamycin Suppresses Penile NADPH Oxidase Activity to Preserve Erectile Function in Mice Fed a Western Style High-Fat, High-Sucrose Diet
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10:15 AM – 12:15 PM
(585.1) Establishing Dietary Iron Requirements for Mouse and Rat Models of Hereditary Hemochromatosis
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10:15 AM – 12:15 PM
(585.2) Development of a Vitamin A Deficient (VAD) Songbird
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10:15 AM – 12:15 PM
(585.3) The Role of Vitamin D and Platelet Aggregation in Patients with Hypertension
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10:15 AM – 12:15 PM
(585.4) Urinary Potassium Excretion Inversely Correlates with Diastolic Blood Pressure Variability in Healthy Normotensive Adults
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10:15 AM – 12:15 PM
(586.1) Probiotic Effect on SARS-CoV2 Immunity Is Associated to Type-1 Interferons: A Post-Hoc Analysis of a Randomized, Placebo-Controlled Trial
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10:15 AM – 12:15 PM
(586.2) A Randomized Controlled Trial of Dietary Supplementation with Prunes (Dried Plums) on Inflammatory Markers in Postmenopausal Women
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10:15 AM – 12:15 PM
(586.3) Black ginseng ameliorates cellular senescence via p53/p21 pathway
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10:15 AM – 12:15 PM
(587.1) Moderate-to-Vigorous Physical Activity and Time-Restricted Eating are Predictors of Fat Mass Loss in Overweight and Obese Females Following an Eight-Week Exercise and Dietary Intervention
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10:15 AM – 12:15 PM
(587.2) Improving Emotional Well-Being and Cardio-Metabolic Health with Continuous Glucose Monitoring
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10:15 AM – 12:15 PM
(587.3) One-Year Comparison of Body Composition in a Cohort of Patients with Multiple Myeloma
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10:15 AM – 12:15 PM
(588.1) Housing Temperature Alters Energy Expenditure and Adipose Tissue Bioenergetics in Mice
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10:15 AM – 12:15 PM
(588.2) Metabolic and Cardiac Manifestations in a Mouse Model of Genetic Mitochondrial Hepatopathy Without Obesity: Evidence for a Sexual Dimorphism
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10:15 AM – 12:15 PM
(588.3) Activation of Lysophosphatidic Acid Receptor 3 Promotes Mitochondrial Homeostasis in aged cells
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10:15 AM – 12:15 PM
(588.4) Evidence of Mitochondrial Impairment in a Mouse Model of Down Syndrome
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10:15 AM – 12:15 PM
(588.5) Maternal Western-style diet and obesity during pregnancy reduces mitochondrial Complex I-linked oxidative capacity in tandem with decreased oxidative stress in skeletal muscle of adolescent Japanese macaque offspring
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10:15 AM – 12:15 PM
(588.6) Aging Female Offspring Exposed to Maternal Hyperandrogenemia have Increased Renal Mitochondrial Content and Decreased Mitochondrial Reactive Oxygen Species
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10:15 AM – 12:15 PM
(588.7) The Loss of Drp1 Improves Skeletal Muscle Insulin Action in Primary Myotubes Derived from Humans with Severe Obesity
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10:15 AM – 12:15 PM
(588.8) Alcohol intoxication stimulates antioxidant gene expression in skeletal muscle in a time dependent manner
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10:15 AM – 12:15 PM
(588.9) Localized Heat Therapy Improves Mitochondrial Respiratory Capacity but Not Fat Oxidation in Human Skeletal Muscle
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10:15 AM – 12:15 PM
(589.1) Synthetic Cannabidiol Reduced Body Mass and Visceral Adiposity but Not Blood Pressure in Rats With Advanced Metabolic Syndrome
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10:15 AM – 12:15 PM
(589.2) Exogenous thyroxine increases GLUT4 translocation to the membrane in cardiomyocytes in insulin resistant OLETF rats Dora A Mendez1, Jose G. Soñanez-Organis2, Guillermo Vasquez-Anaya1, Daisuke Nakano3, Akira Nishiyama3, Rudy M Ortiz1 1Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA 2Division of Science and Engineering, Department of Chemical Biological and Agropecuary Sciences, University of Sonora, Lazaro Cardenas 100, Colonia, Campus Navojoa, Francisco Villa, 85890 Navojoa, SON, Mexico 3Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan
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10:15 AM – 12:15 PM
(589.3) Effect of Short-Term Estradiol Exposure on Endothelin-B Receptor-Mediated Vasodilation in Postmenopausal Women
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10:15 AM – 12:15 PM
(589.4) Genetic Background in the Rat Impacts Metabolic Outcomes of Post-wean BPF Exposure
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10:15 AM – 12:15 PM
(589.5) Lactic metabolism and swimming. Comparison between freestyle swimming and swimming with fins in french athletes
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10:15 AM – 12:15 PM
(589.6) Glucocorticoids differentially regulate the skeletal muscle transcriptome in response to acute aerobic exercise at distinct times of day
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10:15 AM – 12:15 PM
(589.7) Comparison of Intermittent Fasting and Voluntary Wheel Running on Mental and Physical Fatigue in High-Fat-induced Obese and Non-obese Rats
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10:15 AM – 12:15 PM
(590.1) Prefrontal-medullary circuit activation attenuates stress reactivity
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10:15 AM – 12:15 PM
(590.2) Sex differences in cortical-hypothalamic circuitry mediating cardiovascular disease risk
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10:15 AM – 12:15 PM
(590.3) Neurosteroid Role in the Integration of Olfactory Immune Responses in Rainbow Trout (Oncorhynchus Mykiss)
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10:15 AM – 12:15 PM
(590.4) Lineage Tracking and Differentiation of Neuro 2A cells (N2a) upon exposure to Dopamine, Monosodium Glutamate and Corticosterone
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10:15 AM – 12:15 PM
(590.5) Hypoxia Regulates Endothelin-1 Production and Microglial Cell Activation
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10:15 AM – 12:15 PM
(590.6) Nandrolone Use During Adolescence Increases Cocaine Sensitization And Impairs Reproductive Function In Adult Female Rats
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10:15 AM – 12:15 PM
(590.7) Thyroid Supplementation Reverses the Abnormal Social and Oxytocin Phenotype Produced by Developmental Exposure to PBDEs in a Sex-Dependent Manner
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10:15 AM – 12:15 PM
(591.1) Insulin Signaling Suppresses Autophagy in Astrocytes
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10:15 AM – 12:15 PM
(591.2) The Role of Astroglial xCT in Mitigating Cue-Induced Amphetamine-Seeking
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10:15 AM – 12:15 PM
(591.3) Astrocyte Reactivity in Female Rats with Persistent Low Back Pain Following Spinal Mobilization
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10:15 AM – 12:15 PM
(591.4) Phrenic Motor Neuron Fractalkine Expression After Intermittent Hypoxia and Spinal Cord Injury
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10:15 AM – 12:15 PM
(591.5) ADAR Dysfunction in Brain Aging and Alzheimers Disease
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10:15 AM – 12:15 PM
(591.6) Dual role of low frequency magnetic field on neuroinflammation induced dendritic trimming and memory impairment on rat model of sporadic Alzheimer’s disease
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10:15 AM – 12:15 PM
(591.7) Cocaine affects astrocyte activation and iNOS expression
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10:15 AM – 12:15 PM
(592.1) Prodromal Physiologic Changes During Copper Sulfate-Induced Nausea and Vomiting: Potential Use of Intestinal EMG Recordings as a Marker for Nausea
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10:15 AM – 12:15 PM
(592.2) Distribution of c-Fos Labeling Elicited by Intragastric Copper Sulfate: Comparison with Labeling Induced by Galvanic Vestibular Stimulation
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10:15 AM – 12:15 PM
(592.3) Evaluation of Hypothalamic Neural Stem Cell Niche – Implications on Obesity-Induced Sympathoexcitation
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10:15 AM – 12:15 PM
(592.4) Intake of High Fat Diet leads to Over-expression of CD36, QRFP and QRFPr in the Gustatory Neural Circuit
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10:15 AM – 12:15 PM
(593.1) Bile Duct Ligation Changes the Inhibitory Control of Vasopressin Neurons in Male Rats
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10:15 AM – 12:15 PM
(593.2) Spatial Transcriptomics Reveal Potential Sex Differences in Gene Expression of the Supraoptic Nucleus
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10:15 AM – 12:15 PM
(594.1) Effects of Toxicants on Blood-Brain Barrier Function in Resilient Versus Non-resilient Mice
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10:15 AM – 12:15 PM
(594.2) SARS-CoV-2 Spike Protein Enhances Toxicant-Induced Blood-Brain Barrier Dysfunction
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10:15 AM – 12:15 PM
(594.3) Brain endothelial cell barrier function is compromised by autophagy depletion
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10:15 AM – 12:15 PM
(594.4) LPS-induced endotoxemia promotes blood-brain barrier permeability via TSP1-dependent TGFβ1 activation
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10:15 AM – 12:15 PM
(595.1) Investigating the impact of 14-3-3 protein knockout on excitability of hippocampal CA1 pyramidal neurons
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10:15 AM – 12:15 PM
(595.2) Activation and fine-tuning of Ca2+-dependent slow afterhyperpolarizations by Ca2+-handling organelles in vasopressin magnocellular neurosecretory neurons
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10:15 AM – 12:15 PM
(595.3) Chronic Intermittent Hypoxia Alters Chloride Gradients in Median Preoptic Nucleus (MnPO) Neurons of Rats: Comparing ClopHensorN and Perforated Patch Recording
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10:15 AM – 12:15 PM
(595.4) Advanced Technology or Manual Skills: Evidence That The Accuracy of Corticospinal Responsiveness Is Not Ameliorated by Neuronavigation
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10:15 AM – 12:15 PM
(595.5) Cannabinoid Receptor-Mediated Synaptic Signaling and Neural Plasticity in Central Olfactory Neurons
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10:15 AM – 12:15 PM
(595.6) The Braking KV1/D-type Potassium Channels Regulate the Excitability of Bronchopulmonary Vagal Afferent Nerves
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10:15 AM – 12:15 PM
(595.7) Role of the Dopamine Subtype 1 Receptor (D1R) Modulation of the Ih Current in Rhythmic Spinal Mammalian Motor Networks
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10:15 AM – 12:15 PM
(595.8) Hyperpolarization-Activated Current Shows Excitatory Effect on Fictive Locomotion in the Neonatal Mouse Under Hyperdopaminergic Conditions
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10:15 AM – 12:15 PM
(595.9) The effects of temperature changes on the mammalian spinal locomotor CPG network and the role of TRP channels in functional compensation
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10:15 AM – 12:15 PM
(596.1) Biodistribution and Efficacy of an NF-κB-Targeted Biologic for Therapy of Ischemic Stroke
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10:15 AM – 12:15 PM
(596.2) Investigating the temperature-dependent and independent neuroprotective effects of cyclohexyladenosine in SH-SY5Y neurons undergoing oxygen glucose deprivation
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10:15 AM – 12:15 PM
(596.3) Genetic profiling of the hippocampus during peripheral chronic inflammatory pain
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10:15 AM – 12:15 PM
(597.1) Modulatory capacity correlates with dietary diversity in three species of decapod crustaceans
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10:15 AM – 12:15 PM
(597.2) The GluN2A Subunit of the NMDA Receptor Modulates the Rate of Functional Maturation in Parvalbumin-positive Interneurons
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10:15 AM – 12:15 PM
(598.1) Brain Malformations in C57BL/6 Mice Affect Seizure Onset
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10:15 AM – 12:15 PM
(598.2) AT1R-mediated neurodegeneration is part of the etiology of hypertension-associated cognitive impairment
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10:15 AM – 12:15 PM
(598.3) Study on exosome proteomics related to Parkinsons disease
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10:15 AM – 12:15 PM
(598.4) Perinatal High Fat Diet Decreases Oxytocinergic Innervation to the Brainstem
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10:15 AM – 12:15 PM
(599.1) Effects of pituitary hormones deficiency from the specific pituitary lobes on learning, memory and survival behavior in the Wistar rat
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10:15 AM – 12:15 PM
(599.2) Dietary influences on closed-head traumatic brain injury in a pediatric rodent model
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10:15 AM – 12:15 PM
(599.3) Bioactive Steroid Marinobufagenin in a Mouse Model of Early-Stage Alzheimers Disease
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10:15 AM – 12:15 PM
(599.4) Effect of COVID-19 on the Mental Health of College Students
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10:15 AM – 12:15 PM
(599.5) Rescuing Behavioral Impairment after Doxorubicin Chemotherapy in Rats
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10:15 AM – 12:15 PM
(599.6) Acute And Chronic Learning Impairment Following Seizures In Larval Zebrafish
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10:15 AM – 12:15 PM
(599.7) Ciprofloxacin May Cause an Anxiety-like Phenotype in a Rodent Model of Fluoroquinolone Associated Disability
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10:15 AM – 12:15 PM
(599.8) In utero exposure to dietary emulsifier alters the behavioral activity in offspring
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10:15 AM – 12:15 PM
(599.9) Possible Short-Term Memory Loss of Adult Drosophila With Applied Ultrasonic Waves
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10:15 AM – 12:15 PM
(600.1) Central and Systemic Effects of Subdiaphragmatic Vagus Nerve Stimulation during the Development of Hypertension in the SHR
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10:15 AM – 12:15 PM
(600.2) Butyrate supplementation rescues sex-specific deficits in respiratory plasticity and mean arterial pressure in adult offspring exposed to gestational intermittent hypoxia
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10:15 AM – 12:15 PM
(601.1) Cardiovascular and autonomic profiles in offspring of fructose fed parents: role of anti-inflammatory cholinergic reflex and exercise training
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10:15 AM – 12:15 PM
(601.2) Enalapril associated with combined training is more effective in reducing SBP and improve baroreflex sensitivity than drug therapies alone in hypertensive rats
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10:15 AM – 12:15 PM
(601.3) Exercise Training Upregulates SK+ Channel Function in the Hypothalamic Paraventricular Nucleus (PVN) of Animals
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10:15 AM – 12:15 PM
(602.1) Brain Structural and Functional Connectivity in Collegiate Endurance Athletes
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10:15 AM – 12:15 PM
(602.2) Nitric Oxide-dependent Cutaneous Vasodilation is not Altered in Adults Following SARS-CoV-2 Infection
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10:15 AM – 12:15 PM
(602.3) Aerobic Fitness as a Predictor of Conduit, Resistance and, Microvascular Arterial Function
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10:15 AM – 12:15 PM
(602.4) Run for Your Life: A Meta-Analysis of the Effects of Exercise Intensity on Cardiovascular Outcomes in a Rat Model of Hypertension
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10:15 AM – 12:15 PM
(602.5) High-intensity Interval Training Combined With Blood-flow Restriction Predominantly Alters Anaerobic Capacity in Endurance-trained Athletes
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10:15 AM – 12:15 PM
(602.6) The Training-Induced Increase in Critical Power Is Strongly Related to Changes in Vascular Function in Young Adults
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10:15 AM – 12:15 PM
(602.7) High-Resistance Inspiratory Muscle Strength Training-Associated Increases in Exercise Tolerance in Midlife/Older Adults are Related to Circulating Acylcarnitines
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10:15 AM – 12:15 PM
(602.8) Determining the role of ATF4 in the regulation of mitochondrial remodeling during myotube differentiation and contractile activity
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10:15 AM – 12:15 PM
(602.9) Resistance Training Enhances Muscle Function and Hemorheological Properties in Middle-aged Obese Women
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10:15 AM – 12:15 PM
(603.1) Cardiac baroreflex sensitivity and heart rate variability are lower in humans with high affinity hemoglobin compared to typical affinity hemoglobin
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10:15 AM – 12:15 PM
(603.2) Effect of Cyclooxygenase Inhibitor on Hypoxia Stimulated Cerebral Blood Flow Using Arterial Spin Labeling Magnetic Resonance
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10:15 AM – 12:15 PM
(603.3) Complex Cognitive Functions and Neurovascular Coupling are Protected by Carbon Dioxide during Hypoxia
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10:15 AM – 12:15 PM
(603.4) Lower-limb venous function in hypoxia and hyperoxia: effect of healthy ageing
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10:15 AM – 12:15 PM
(603.5) Generation of isofemale lines from hypoxia tolerant Drosophila melanogaster population
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10:15 AM – 12:15 PM
(603.6) Effects of Simulated Long Duration Spaceflight on Erectile Function
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10:15 AM – 12:15 PM
(603.7) CNS O2 toxicity and Seizure Genesis: Hyperbaric radio telemetric recordings of activity in the motor cortex and dorsal medulla oblongata or cerebellum during exposure to hyperbaric O2 ± CO2 in freely behaving Sprague-Dawley rats
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10:15 AM – 12:15 PM
(603.8) Mitigation of CNS oxygen toxicity seizures: evaluating the neuroprotective effects of L-NAME versus Mitoquinone during exposure to 5 ATA O2 in freely behaving Sprague-Dawley rats
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10:15 AM – 12:15 PM
(603.9) Effect of Prolonged High-Altitude Exposure on Heart Rate Response to Central Sleep Apnea
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10:15 AM – 12:15 PM
(604.1) Hypoxic Vasodilation is Augmented During the High versus Low Estrogen Phase of the Menstrual and Oral Hormonal Contraceptive Pill Cycle
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10:15 AM – 12:15 PM
(604.2) Glomerular Filtration Rate Reserve During Mild Passive Heat Stress Does Not Differ Between Younger Men and Women
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10:15 AM – 12:15 PM
(604.3) Endothelial Sensitivity to Exercise-Induced Shear Rate in Pre- and Post-Menopausal Females and in Males
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10:15 AM – 12:15 PM
(604.4) Renal Vascular Resistance Does Not Differ Between Younger Men and Women
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10:15 AM – 12:15 PM
(604.5) The Influence of Androgen Receptors on Muscle Repair and Hypertrophy
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10:15 AM – 12:15 PM
(604.6) Sex Differences in ROS Production and SOD Activity Following Induced Inflammation
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10:15 AM – 12:15 PM
(604.7) Estrogen-mediated signaling mechanisms regulate voluntary running behavior in rats
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10:15 AM – 12:15 PM
(604.8) Repeated Restraint Stress Alters Small Conductance Calcium-activated Potassium Channel (SK) Expression in Rat Basolateral Amygdala Neurons in Sex-dependent Manner
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10:15 AM – 12:15 PM
(604.9) Heat Stress Increases Mitochondrial Complex I Capacity in Female Pigs but Favors Reliance on Complex II in Males
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10:15 AM – 12:15 PM
(605.1) Development and characterization of an aging rat model of sustained Gulf War Illness
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10:15 AM – 12:15 PM
(605.2) Epigenetic Evidence for Distinct Contributions of Resident and Acquired Myonuclei During Long-Term Exercise Adaptation Using Timed In Vivo Myonuclear Labeling
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10:15 AM – 12:15 PM
(605.3) Is the Use of Oral Contraceptive Beneficial to Female Athletes in the Prevention of Anterior Cruciate Ligament Injury?
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10:15 AM – 12:15 PM
(605.4) Effects of Vitamin D Supplementation on Overload-Induced Muscle Growth and Function in Mice
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10:15 AM – 12:15 PM
(605.5) Hyperbaric Oxygen Therapy Following Cervical Spinal Cord Injury Increases BDNF/TrkB Signaling in Diaphragm Muscle
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10:15 AM – 12:15 PM
(605.6) The Effect of Glucose Administration on Yes-associated Protein (YAP) Activity in Healthy and Cachectic Mouse Muscles
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10:15 AM – 12:15 PM
(605.7) Skeletal Muscle Deoxygenation Amplitude, Rather Than Splenic Emptying Contributes to Higher V̇O2 max. During Supine Cycling in Healthy Active Men
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10:15 AM – 12:15 PM
(605.8) NOR-1 Knockdown Reduces Mitochondrial Function in C2C12 Myotubes
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10:15 AM – 12:15 PM
(605.9) Oxygen Consumption Rates Between Skeletal Muscle Cells Derived From Young and Old Human Donors Elucidate Mitochondrial Dysfunction
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10:15 AM – 12:15 PM
(606.1) Cardiomyocyte-specific deletion of sarcoglycan-δ leads to dilated cardiomyopathy, autonomic dysfunction, and exaggerated stress-induced cardiovascular reactivity
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10:15 AM – 12:15 PM
(606.3) Hypertension Precedes Changes in Afferent Renal Nerve Activity and Renal Dysfunction in DOCA-Salt Rat Model
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10:15 AM – 12:15 PM
(606.4) Implementation of tissue clearing and 3-dimensional volumetric imaging approaches for visualization of anatomical structures in autonomic nuclei
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10:15 AM – 12:15 PM
(607.1) Autonomic Responses to Acute Hyperoxia are Impaired in Patients with Peripheral Artery Disease
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10:15 AM – 12:15 PM
(607.2) Overproduction of reactive oxygen species in cardiac vagal postganglionic neurons contributes to myocardial infarction-induced lethal ventricular arrhythmias in type 2 diabetes mellitus
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10:15 AM – 12:15 PM
(607.3) Cardiac Baroreflex Sensitivity and Heart Rate Variability Following COVID-19 in Young Adults
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10:15 AM – 12:15 PM
(607.4) Sympathetic Responses to Chemoreflex Stress in Lean Women with Polycystic Ovary Syndrome
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10:15 AM – 12:15 PM
(607.5) Application of Physiological Autonomic Activity Tracking GUI and Computational Algorithms for Measuring Persistent Vagal Nerve Dysfunction After Recovery from SARS-CoV-2 Infection
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10:15 AM – 12:15 PM
(608.1) Electroacupuncture Decreases Chronic Inflammation, Sympathetic Activities, and Blood Pressure in Dahl Salt-Sensitive Hypertensive Rats
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10:15 AM – 12:15 PM
(608.2) The Effect of Transcutaneous Vagus Nerve Stimulation on Heart Rate Variability during Paced Breathing
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10:15 AM – 12:15 PM
(608.3) Correlation between heart rate variability and polysomnography-derived scores of severities for obstructive sleep apnea
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10:15 AM – 12:15 PM
(608.4) The Impact of Levels of Religious Belief and Practices on Heart Rate Variability
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10:15 AM – 12:15 PM
(608.5) The Effect of Meditation on Heart Rate Variability
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10:15 AM – 12:15 PM
(608.6) Method for Measuring Cervical Vagus Nerve Activity in Conscious and Freely Moving Rats
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10:15 AM – 12:15 PM
(608.7) The Effects of Acute Cannabidiol on Autonomic Balance
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10:15 AM – 12:15 PM
(608.8) Topographical Mapping of Catecholaminergic Axon Distribution and Morphology in the Flat-Mounts of the Mouse Heart
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10:15 AM – 12:15 PM
(608.9) Topographical Distribution and Morphology of CGRP-IR Axons in the Flat-Mounts of Whole Mouse and Rat Hearts
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10:15 AM – 12:15 PM
(609.1) Unilateral Vagotomy Blunts Cardiorespiratory Responses to Vagal Afferent Stimulation and Nucleus Tractus Solitarii (NTS) Glutamate Microinjection
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10:15 AM – 12:15 PM
(609.2) Long-term hypercapnia does not alter Galanin immunoreactivity in mouse brain respiratory and chemoreceptor regions
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10:15 AM – 12:15 PM
(609.3) A 3D Anatomical and Molecular Map of Cardiac Vagal Motoneurons
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10:15 AM – 12:15 PM
(609.4) Altered GABAergic neurotransmission at the nucleus tractus solitarii following Hindlimb Unloading
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10:15 AM – 12:15 PM
(609.5) GABAA δ receptors in vagal motor neurons play a role in the influence of high fat diet on cardiac function
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10:15 AM – 12:15 PM
(609.6) Dysfunctional Nrf2-Keap1 redox signaling in the RVLM is linked to obesity-induced sympathoexcitation
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10:15 AM – 12:15 PM
(609.7) Elimination of Senescent Cells Attenuates Obesity-Induced Increase in Sympathetic Nerve Activity
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10:15 AM – 12:15 PM
(609.8) The activation of C1 neurons during REM sleep is dependent on the arterial baroreflex
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10:15 AM – 12:15 PM
(609.9) High Fat Diet-Induced Neuroplasticity in Cardiac-Projecting Dorsal Motor Nucleus of the Vagus (DMV) Motoreurons
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10:15 AM – 12:15 PM
(610.1) Hypoglycemia: Control of counter-regulatory hormone secretion by the brain
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10:15 AM – 12:15 PM
(610.2) Oxytocin and corticotropin-releasing hormone augment synaptic activity in the nTS of rats subjected to chronic intermittent hypoxia
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10:15 AM – 12:15 PM
(610.3) OVLT Lesion attenuates hypertension and polydipsia in 2-kidney, 1-clip hypertensive Rats
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10:15 AM – 12:15 PM
(610.4) Angiotensin-II, insulin, and NELL2 involvement in forebrain synaptic circuit modifications during hypertension
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10:15 AM – 12:15 PM
(610.5) Gastrointestinal mechanosensation affects the activity of prefrontal cortical neurons mediating social behavior in mice
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10:15 AM – 12:15 PM
(611.1) Role of medullary cardiorespiratory neurons on the maintenance of altered sleep function in heart failure
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10:15 AM – 12:15 PM
(611.2) Cardiorespiratory Coupling Response to Chest Wall Strapping in Chronic Obstructive Pulmonary Disease
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10:15 AM – 12:15 PM
(611.3) The rostral brainstems pivotal role in swallow-breathing coordination
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10:15 AM – 12:15 PM
(611.4) Roles of Nav1.9 in inflammatory Mediator-induced Activation of Vagal C-fibers Innervating Mouse Lungs
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10:15 AM – 12:15 PM
(611.5) The Cardiorespiratory Coupling as a Background for Blood Pressure Decrease
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10:15 AM – 12:15 PM
(611.6) Reactive medullary astrocytes are associated with RVLM neuroinflammation in heart failure rats
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10:15 AM – 12:15 PM
(611.7) Activation of Cold-Sensitive Afferents Inhibits Aberrant Irritant-evoked Cardiopulmonary Reflexes in the Spontaneously Hypertensive (SH) Rat
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10:15 AM – 12:15 PM
(612.1) Neurochemical Profile of Enteric Neurons in the Submucosal Plexuses of Pig vs. Human Colon
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10:15 AM – 12:15 PM
(613.1) Baroreflex Activation Contributes to the Progression of the Systemic Inflammatory Response in Unanesthetized Rats
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10:15 AM – 12:15 PM
(613.2) Vagus Nerve Sensory Neurons Respond Distinctly to Specific Inflammatory Mediators
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10:15 AM – 12:15 PM
(613.3) F11 dorsal root ganglion nociceptor neurons release calcitonin gene related peptide in response to pathogen associated molecular patterns
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10:15 AM – 12:15 PM
(613.4) Optogenetic stimulation of cholinergic neuronal endings in the celiac-superior mesenteric ganglion complex suppresses inflammation in murine endotoxemia
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10:15 AM – 12:15 PM
(613.5) Non-invasive, Spatiotemporal Characterization of Muscle Activation Patterns from Vagus Nerve Stimulation in Human Subjects
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10:15 AM – 12:15 PM
(613.6) A Foundation for the Neural Control of Viral Fever
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10:15 AM – 12:15 PM
(613.7) Alcohol Dysregulates CD4 T Cell Mitochondrial Homeostasis
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10:15 AM – 12:15 PM
(613.8) Protective Effects of Pegylated Choline Acetyltransferase in a Murine Model of DSS Colitis
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10:15 AM – 12:15 PM
(613.9) Electrical Stimulation of the Dorsal Motor Nucleus of the Vagus Attenuates Serum Pro-Inflammatory Cytokine Levels in Murine Models of Endotoxemia and Sepsis
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10:15 AM – 12:15 PM
(614.1) Activation of Kir4.1/Kir5.1 of DCT is essential for acute calcineurin-inhibition-induced stimulation of NCC
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10:15 AM – 12:15 PM
(614.2) WNK bodies are multikinase complexes that facilitate NCC activation during hypokalemia
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10:15 AM – 12:15 PM
(614.3) DCT-specific COP9 Signalosome Deletion Activates the WNK4-NCC Pathway and Mimics Familial Hyperkalemic Hypertension
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10:15 AM – 12:15 PM
(614.4) The E3 ubiquitin-protein ligase Nedd4-2 regulates the sodium chloride cotransporter (NCC) but is not required for a potassium-induced reduction of NCC expression
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10:15 AM – 12:15 PM
(614.5) KS-WNK1 is Required to Translate the Response to Extreme Changes in Potassium Ingestion to NCC Activity and Expression
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10:15 AM – 12:15 PM
(614.6) Kidney and Gut Microbiome Crosstalk in Response to High Dietary Potassium
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10:15 AM – 12:15 PM
(614.7) Sodium Status Modulates the Effects of Aldosterone on Renal Transporter Expression and Tubular Remodeling
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10:15 AM – 12:15 PM
(614.8) Interrogation of Novel Aldosterone-induced Genes Associated With Acute Stimulation Of ENaC In Primary Collecting Duct Cells
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10:15 AM – 12:15 PM
(614.9) Bile acids directly bind and allosterically regulate the epithelial sodium channel
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10:15 AM – 12:15 PM
(615.1) Roles of GABAergic and Glutamatergic Prebötzinger Complex Circuits in Opioid-Induced Respiratory Depression
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10:15 AM – 12:15 PM
(615.2) Opioid inhibition of projection-specific, respiratory-related pontomedullary neurons
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10:15 AM – 12:15 PM
(615.3) Tac1-expressing cells in the pre-Bötzinger complex are potential targets to prevent opioid-induced respiratory depression
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10:15 AM – 12:15 PM
(615.4) Plausible presynaptic effects of opioids on pontine inspiratory circuits: New insights from a joint neural biomechanical model
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10:15 AM – 12:15 PM
(615.5) Potential presynaptic effects of opioids on medullary inspiratory circuits: New insights from a joint neural biomechanical model
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10:15 AM – 12:15 PM
(615.6) Activation of Brainstem mu-Opioid Receptors (mORs) Increases Respiratory-Related Motor Burst Amplitude in Neonatal Rat Brainstem-Spinal Cord Preparations
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10:15 AM – 12:15 PM
(615.7) Distributed latent dynamics underlie breathing control in the brainstem during normal breathing, OIRD, and gasping
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10:15 AM – 12:15 PM
(615.9) Chemogenetic activation of glutamatergic preBötzinger Complex neurons increases breathing in mice
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10:15 AM – 12:15 PM
(616.1) 5-HT7 receptors expressed in the mouse parafacial region are not required for respiratory chemosensitivity
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10:15 AM – 12:15 PM
(616.2) Effect of Mild Acidosis on CA2+ Signaling in Rat Carotid Body Chemoreceptor Cells: Role of CAV, ASIC, and Task
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10:15 AM – 12:15 PM
(616.3) Melanin-Concentrating Hormone (MCH) Decreases the Hypercapnic Ventilatory Response by Acting in the Lateral Hypothalamic Area (LHA)
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10:15 AM – 12:15 PM
(616.4) Loop gain is Increased and the Arousal Threshold is Decreased in Caucasian Compared to African American Males with Obstructive Sleep Apnea
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10:15 AM – 12:15 PM
(616.5) Nicotine withdrawal after chronic exposure in adulthood blunts the ventilatory response to hypoxia in rats
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10:15 AM – 12:15 PM
(616.6) Reduced expression of SOD2 in the Retrotrapezoid nucleus is associated with enhanced ventilatory chemoreception: implications for breathing disorders in heart failure
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10:15 AM – 12:15 PM
(616.7) Acute and Chronic Effects of Seizures on Cardiorespiratory Control in the SSKcnj16-/- Rat
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10:15 AM – 12:15 PM
(617.1) GABAergic and Glycinergic Synaptic Transmission in Respiratory-Controlling Kolliker-Fuse Neurons in Female and Male Rett Syndrome Mice
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10:15 AM – 12:15 PM
(617.2) Postnatal Development of the Purinergic Signaling System in the preBötzinger Complex; Implications for the Hypoxic Ventilatory Response
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10:15 AM – 12:15 PM
(617.3) Changes in oxygen and carbon dioxide in umbilical cord arterial blood before and after the first breath of a newborn to explore the mechanisms of respiratory regulation
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10:15 AM – 12:15 PM
(617.5) The effect of brain serotonin deficiency on breathing during sleep is magnified by age
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10:15 AM – 12:15 PM
(617.6) Neonatal ventilatory changes in the control of breathing in a hyperoxia-induced mouse model of bronchopulmonary dysplasia
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10:15 AM – 12:15 PM
(617.7) Chronic, episodic developmental nicotine exposure alters GABAergic synaptic transmission to hypoglossal motor neurons at a critical developmental age in rats
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10:15 AM – 12:15 PM
(618.1) Postnatal Phrenic Motor Neuron and Diaphragm Maturation in the Mouse
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10:15 AM – 12:15 PM
(618.2) Effects of postnatal maturation on muscarinic acetylcholine receptor distribution in hypoglossal motorneurons
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10:15 AM – 12:15 PM
(618.3) Characterizing the Contribution of Muscarinic Receptor Subtypes to Inspiratory Bursting Activity at Hypoglossal Motor Neurons of CD1 Mice
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10:15 AM – 12:15 PM
(618.4) Acute Respiratory Muscle Fatigue in Patients with Obesity Following Peak Aerobic Exercise
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10:15 AM – 12:15 PM
(618.5) Force and Shortening Velocity are Reduced in 24-month Fischer 344 Rats
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10:15 AM – 12:15 PM
(618.6) Fiber Type Differences in SDHmax and Mitochondrial Volume Density between Diaphragm and Tibialis Anterior Muscles
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10:15 AM – 12:15 PM
(618.7) Induction of Autophagy in Motor Neurons with Lanthionine Ketenamine Analogs
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10:15 AM – 12:15 PM
(618.8) Age-Related Autophagy Impairment in Cervical and Lumbar Motor Neurons
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10:15 AM – 12:15 PM
(619.1) Loss of Club Cell Creb Mitigates IL-1B–mediated Muco-obstructive Phenotypes in Male Murine Airways
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10:15 AM – 12:15 PM
(619.2) PDE4 Inhibitor Reverses Alcohol Impairment of CFTR Function and Protects Against Bacterial Pneumonia
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10:15 AM – 12:15 PM
(619.3) Sex differences in lung inflammation and microbiome profiles in asthmatic mice exposed to ambient ozone
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10:15 AM – 12:15 PM
(620.1) TNFα Reduces the Maximum Respiratory Capacity of Mitochondria in Human Airway Smooth Muscle Cells
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10:15 AM – 12:15 PM
(620.2) Kisspeptin Reduces Airway Hyperreactivity and Remodeling in Asthmatic Ovariectomized Mice
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10:15 AM – 12:15 PM
(620.3) TNFα Mediated Endoplasmic Reticulum Stress Promotes Differential Phosphorylation of DRP1 and Mitochondrial Fragmentation in Human Airway Smooth Muscle Cells
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10:15 AM – 12:15 PM
(620.4) Single Cell Assessment of Mitochondrial Function
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10:15 AM – 12:15 PM
(620.5) Inhibiting Actin Polymerization Increases Tension Cost in Porcine Airway Smooth Muscle
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10:15 AM – 12:15 PM
(620.6) Elucidating the Bitter Taste Signaling Paradox in Airway Smooth Muscle Relaxation
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10:15 AM – 12:15 PM
(621.1) Autophagic activity in response to nanoparticle exposure of A549 cells
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10:15 AM – 12:15 PM
(621.2) L-Citrulline Attenuates Inflammation Induced Phenotypic Changes in Neonatal Rat Alveolar Type 1 Cells
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10:15 AM – 12:15 PM
(621.3) Alternative Chloride Channels are Increased in the CFTR-/- Rat Airway
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10:15 AM – 12:15 PM
(621.4) Sigmar1 Deficiency Results in Pulmonary Fibrosis Associated with Increased Pulmonary Inflammation and Surfactant Protein Levels in Mice Lung
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10:15 AM – 12:15 PM
(621.5) The Ying and the Yang: Compensatory UPR Signaling Responses Observed In An In-Vitro Model Expressing Clinical Mutant Surfactant Protein C Isoforms
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10:15 AM – 12:15 PM
(621.6) Nonselective Cation Channels Maintain Alveolar Fluid Clearance After Exposure to Toxins from Respiratory Pathogens
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10:15 AM – 12:15 PM
(621.7) Identification of alveolar proteins associated with claudin-18 using BioID
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10:15 AM – 12:15 PM
(621.8) Influenza A Virus Causes Shedding of the Alveolar Epithelial Glycocalyx through Activation of Sheddases
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10:15 AM – 12:15 PM
(622.1) Development of an FM interferential electrical stimulator for swallowing rehabilitation
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10:15 AM – 12:15 PM
(622.2) Global Dysphagia Scale Detects Swallowing Disorder Following a Clinical Dose of Buprenorphine
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10:15 AM – 12:15 PM
(622.3) Targeted Electrical Stimulation of the Superior Laryngeal Nerve – A Potential Treatment for Dysphagia in ALS
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10:15 AM – 12:15 PM
(622.4) Swallowing Kinematics in Rats Treated with Low Dose Chemotherapy Concurrently with Fractionated Radiation
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10:15 AM – 12:15 PM
(622.5) The 5-HT1A Agonist 8-OH-DPAT Enhances Submental Laryngeal Elevator EMG Amplitude During Swallow
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10:15 AM – 12:15 PM
(622.6) 3D Hyolingual Kinematics Reveal New Insights Into the Biomechanical and Neural Control of Chewing and Swallowing in Macaque Primates
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10:15 AM – 12:15 PM
(622.7) The laryngeal adductor reflex (LAR) is modulated by the serotonin 5-HT1A agonist 8-OH-DPAT
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10:15 AM – 12:15 PM
(623.1) Exploration of Cytochrome P450 Structure and Function in In Silico Assays for Toxicity
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10:15 AM – 12:15 PM
(623.2) dkNET Hypothesis Center: A Hub for FAIR Data, Online Resources and Hypothesis Generation
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10:15 AM – 12:15 PM
(624.1) LncRNAs imported into mitochondria possess distinct features stratified by machine learning that promote interaction with the mitochondrial import protein PNPase
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10:15 AM – 12:15 PM
(624.2) RNA Interference Via shRNA Decreases the Number of Transcripts of Scn8a in Glutamatergic Interneurons in the preBötC
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10:15 AM – 12:15 PM
(624.3) The Role Lnc-RHL in Hepatic Cell Lineage Decisions and Proliferation in HepaRG Cells
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10:15 AM – 12:15 PM
(624.4) Identification of microRNA Targets in colorectal cancer through Data Sequencing
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10:15 AM – 12:15 PM
(624.5) Signaling Pathways Associated with miR-106b mediated Radioresistance in the Treatment of Colorectal Cancer
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10:15 AM – 12:15 PM
(624.6) Ovarian Hormone-Dependent miR-146b-5p Regulation of Plasminogen Activator Inhibitor-1 in Renal Epithelial Cells
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10:15 AM – 12:15 PM
(625.1) Phosphoproteomic profiling of skeletal muscle twitch torque potentiation in ovarian hormone deficient female mice
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10:15 AM – 12:15 PM
(625.2) Comparative Analysis of Annexin A1 (ANXA1) Protein Expression in Different Cancer Types
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10:15 AM – 12:15 PM
(625.3) Transcriptomic and metabolic profiling of Tolvaptan treated Autosomal dominant polycystic kidney disease (ADPKD) patient
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10:15 AM – 12:15 PM
(625.4) Using targeted LC-MS/MS-based metabolomics to measure a broad constellation of bile acids/salts in disorders of human health
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10:15 AM – 12:15 PM
(625.5) Specificity of Antibodies for the Identification of Annexin 1 (ANXA1) Protein in Various Types of Cancer
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10:15 AM – 12:15 PM
(625.6) Metabolomic Kidney Input and Output Analyses in Salt-Sensitive Hypertension
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10:15 AM – 12:15 PM
(625.7) Subcellular Protein Expression of Annexin A1 (ANXA1) in Different Types of Cancer
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10:15 AM – 12:15 PM
(625.8) Metabolomic responses in brain endothelial cells (CLU-512-hCMEC/D) to Angiotensin II and Angiotensin 1-7
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10:15 AM – 12:15 PM
(625.9) Keratinocyte-associated Protein 3 May Participate in the Stress Response to Impact Adiposity
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10:15 AM – 12:15 PM
(626.1) Hybrid Rat Diversity Program (HRDP): A rat resource for mapping complex traits
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10:15 AM – 12:15 PM
(626.2) Functional Annotation and Cross-study Comparison of DNA Methylation Regions uniquely associated with 24-hour Blood Pressure Phenotypes in African Americans
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10:15 AM – 12:15 PM
(626.3) Inhibiting ADAM10-MMP14 Complex Blocks Cystogenesis of Kidney Epithelial Cells
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10:15 AM – 12:15 PM
(626.4) Single-Cell Reconstruction of Cellular Heterogeneity of Congenital Heart Disease
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10:15 AM – 12:15 PM
(626.5) Vitamin D Regulates Natriuretic Peptide Receptor-A Gene Expression via Modulation of Histone Deacetylases and DNA Methyltransferase Activity
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10:15 AM – 12:15 PM
(626.6) Use Of Weighted Gene Coexpression Network Analysis To Identify Connectivity Between Gut And Brain Gene Expression
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10:15 AM – 12:15 PM
(627.1) Polyethylene glycol-20 ameliorates tissue ischemia and improves renal function following traumatic shock
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10:15 AM – 12:15 PM
(627.2) Plasma Concentrations of Trace Elements Selenium and Cobalt During and After Coronary Artery Bypass Grafting Surgery
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10:15 AM – 12:15 PM
(627.3) Iatrogenic dehydration drives organic osmolyte production in critical COVID-19
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10:15 AM – 12:15 PM
(627.4) Change in Metabolomic Profile Associated with an Average Increase in Plain Water Intake of gt;+1 L/day, Sustained over 4 Weeks, in Healthy Young Men with Initial Total Water Intake below 2 L/day
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10:15 AM – 12:15 PM
(627.5) Vasopressin, Cortisol, and Osmotic Regulation in Non-hospitalized SARS-CoV-2 Infected Patients
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10:15 AM – 12:15 PM
(627.6) COVID-19 Increases Markers of Endothelial Damage in Normotensive Pregnant Women
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10:15 AM – 12:15 PM
(627.7) Exacerbated Vascular Inflammation Following Traumatic Hemorrhage in Obese Rats
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10:15 AM – 12:15 PM
(627.8) Effects of extremity trauma on physiological responses and survival to hemorrhage in conscious rats
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10:15 AM – 12:15 PM
(628.1) The Lighter Side of Aviation Medicine during World War 2: Aero Medical Training Cartoons
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10:15 AM – 12:15 PM
(628.2) The Lighter Side of Aviation Medicine during World War 2: Aviation Gremlins
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10:15 AM – 12:15 PM
(629.1) Teaching Essay Writing: When Good Intentions Lead to Bad Outcomes
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10:15 AM – 12:15 PM
(629.2) Dissecting the language of physiology students
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10:15 AM – 12:15 PM
(629.3) Journaling as an effective tool to promote metacognition and enhance study methods in a pharmacology course, during and after the pandemic
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10:15 AM – 12:15 PM
(629.4) Intentional Innovation in Educational Technology and Media to Promote Students’ Holistic Development
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10:15 AM – 12:15 PM
(629.5) Using A Simulation to Improve Learning Outcomes In An Undergraduate Determinants of Health Course
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10:15 AM – 12:15 PM
(629.6) The Use of Guided Versus Partially Complete Non-guided Note Sets on the Development of Notetaking Skills and Academic Behaviors in a Health Science Professional Degree Program: Student Perspectives
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10:15 AM – 12:15 PM
(629.7) The Disconnect in the Use and Purpose of the Syllabus Between Faculty and Students is REAL
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10:15 AM – 12:15 PM
(629.8) The Research-Intensive Community Model has the Necessary Properties for Successful Propagation at Research-Extensive Universities
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10:15 AM – 12:15 PM
(629.9) A CURE for What Ails You: Relating Current Events to New Research in a Course-Based Undergraduate Research Experience (CURE) in Physiology
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10:15 AM – 12:15 PM
(630.1) Soft silicone-based neural interface to modulate bladder function: chronic studies in awake behaving cats
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10:15 AM – 12:15 PM
(630.2) The Effects of Exercise Training with Oral Intake of Lactate on Hippocampal Neurogenesis and Neurotrophic Factors in Mice
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10:15 AM – 12:15 PM
(630.3) Acute Hypernatremia Increases Functional Connectivity of Sodium Sensing Regions in the Brain
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10:15 AM – 12:15 PM
(474.10) Life-Long Learning of Leonardo da Vinci: Exploration of Cardiovascular Anatomy
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10:15 AM – 12:15 PM
(474.11) Assessing Attitudes About Returning to In-person Learning Among Physician Assistant Students Using Q Methodology
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10:15 AM – 12:15 PM
(474.12) Student Perspectives of Threshold Concepts in Undergraduate Medical Education for Understanding the Structure and Function of the Human Body
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10:15 AM – 12:15 PM
(474.13) The Impact of Distance and Social Isolation on Brain Morphology, Neural Coupling, Social Connectedness, and Immediacy: Implications for Online Learning
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10:15 AM – 12:15 PM
(474.14) Assessing the Effect of Restudying Anatomy with Flashcards versus Handouts in Study Groups Equalized by Memory Test Scores
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10:15 AM – 12:15 PM
(474.15) Experiential factors affecting the empathy of students in their pre-clinical year(s) of 21 universities
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10:15 AM – 12:15 PM
(474.16) Different Perceptions on Body Donation for Anatomical Teaching in Brazil: a Cross-Sectional Study
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10:15 AM – 12:15 PM
(474.17) An Introduction to Anatomic Knowledge in Pre-Hispanic Mesoamerica
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10:15 AM – 12:15 PM
(474.18) Embalming Procedures and Laboratory Practices for Cadaver-Based Learning
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10:15 AM – 12:15 PM
(474.19) Sentiment Analysis Machine Learning Model Congruence: A Case Study Using Neuroscience Module Evaluations
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10:15 AM – 12:15 PM
(474.20) Remembering Our Past: Teaching the History of Anatomy at Indiana University
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10:15 AM – 12:15 PM
(474.21) Investigating the Contributions of Human Body Donors in the United States
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10:15 AM – 12:15 PM
(474.22) The Visible Ape Project: a free, comprehensive, web-based anatomical atlas designed to raise public awareness about apes
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10:15 AM – 12:15 PM
(474.23) Leave it to the Learners … Student Perspectives on the Effectiveness of Prosection and Dissection
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10:15 AM – 12:15 PM
(474.24) Knowledge of anatomical variants in teachers of private universities in Santiago de Chile
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10:15 AM – 12:15 PM
(474.25) Decline of gross anatomy in medical education. I. Independent learning and need for assessment of effects of curricular change on medical practice
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10:15 AM – 12:15 PM
(474.26) Investigating the Status of Whole-Body Donation Across the United States of America
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10:15 AM – 12:15 PM
(474.27) Training Gross Anatomy Educators: Success of a Radiology Focused Continuing Education Course
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10:15 AM – 12:15 PM
(474.28) Using Q-Methodology to Evaluate Student Perceptions of Online Anatomy in the Time of COVID-19
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10:15 AM – 12:15 PM
(474.29) Medical School Culture Influences How Students Think About Gross Anatomy Lab
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10:15 AM – 12:15 PM
(474.30) Qualitative Analysis of Autism Spectrum Disorder Student Body Language and Teacher Pedagogical Techniques while Scanning for Frontal Lobe Activation Using fNIRS
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10:15 AM – 12:15 PM
(474.31) Physical Therapy Student Knowledge Retention from a Remotely Taught Anatomy Course
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10:15 AM – 12:15 PM
(474.32) Using A Community of Inquiry in the Design of Histology Curriculum for First Year Medical Students
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10:15 AM – 12:15 PM
(474.33) Osteopathic Medical Student Study Skills for Clinical Anatomy
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10:15 AM – 12:15 PM
(474.34) Needs Assessment of Essential Anatomy: A Perspective from Anesthesiology, Emergency Medicine, ObGyn and Orthopedics Resident
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10:15 AM – 12:15 PM
(474.35) Summing up 10 years in a new medical school: Per aspera ad astra
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10:15 AM – 12:15 PM
(474.36) The Dissection Experience of Orthopedic Resident: A Comparison between Soft-Preservation and Formalin-Fixation Embalming Techniques
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10:15 AM – 12:15 PM
(474.37) Understanding a Facial Bypass Found in a Medical Donor
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10:15 AM – 12:15 PM
(474.38) Determining the Time Management Techniques and Study Strategies of Master’s Students Enrolled in a Graduate Gross Anatomy Course: a Pilot Study
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10:15 AM – 12:15 PM
(474.39) Retroaortic Left Renal Vein: An Incidental Finding During Cadaver Dissection
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10:15 AM – 12:15 PM
(474.40) Anomalous Origin of the Left Vertebral Artery from the Aortic Arch: A Case Report
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10:15 AM – 12:15 PM
(474.41) An Accessory Muscle of the Pectoral Region
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10:15 AM – 12:15 PM
(474.42) Horseshoe Kidney with Surplus Renal Arteries, Veins, and Roots of the Ureters
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10:15 AM – 12:15 PM
(474.43) Qualitative analysis of the role of teacher rapport on autism spectrum disorder student engagement while scanning for frontal lobe activation using fNIRS
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10:15 AM – 12:15 PM
(474.44) Cadaveric Clinical Integration: Integration of Basic Science and Medical Science
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10:15 AM – 12:15 PM
(474.45) Anatomical Gift Programs Continue to Meet Donor Demands of Anatomy Educators During the COVID-19 Pandemic: Here’s How
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10:15 AM – 12:15 PM
(474.46) Pathology Encountered During Cadaver Dissection Provides an Opportunity for Case-based Learning
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10:15 AM – 12:15 PM
(474.47) Retention of Physical Therapy students in relation to Human Anatomy failure in a private university in Santiago, Chile
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10:15 AM – 12:15 PM
(474.48) Analysis of Gross Anatomy Educational References Used by Anatomy Graduate Students
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10:15 AM – 12:15 PM
(474.49) A Community of Medical Educators Coming together to lend an “Anatomical” Hand: Showing the Value of an In-Person Anatomy Lab based Curriculum
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10:15 AM – 12:15 PM
(474.50) How Do Physical Therapists Perceive Anatomy Education?
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10:15 AM – 12:15 PM
(474.51) Enhanced confidence and ultrasound-performance skills of medical students: A comparative study with and without prior videographic ultrasound exposure
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10:15 AM – 12:15 PM
(474.52) Recipe for Success: Correlates of Student Performance in Human Gross Anatomy
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10:15 AM – 12:15 PM
(474.53) Gross Anatomical Knowledge Loss in Fourth-Year Nursing Students
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10:15 AM – 12:15 PM
(478.10) Tele-Ultrasound: Virtual Hands-on Medical Education for Novice Users Utilizing FAST & Carpal Tunnel Models, Pilot Study
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10:15 AM – 12:15 PM
(478.11) Augmented and Virtual Reality in Anatomical Education and its Evaluation: Quality Matters
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10:15 AM – 12:15 PM
(478.12) Mobile Gyro Control for Intuitive Manipulation of Virtual Anatomy Specimens
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10:15 AM – 12:15 PM
(478.13) What Makes a Good Anatomy E-module? A Quantitative and Qualitative Evaluation of Occupational Therapy Introductory Anatomy E-modules
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10:15 AM – 12:15 PM
(478.14) The Development and Evaluation of Online Neuroanatomy Resources for OT Students
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10:15 AM – 12:15 PM
(478.15) Evaluating Cybersickness in Virtual 3D Models for Anatomy Learning
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10:15 AM – 12:15 PM
(478.16) Virtual Reality, Autostereoscopy, and Physical Models for Learning Anatomy: Performance Comparisons
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10:15 AM – 12:15 PM
(478.17) Minigames for Teaching the Cardiovascular System to Students of Human Anatomy
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10:15 AM – 12:15 PM
(478.18) Learning Anatomy in a developing country under COVID-19 lockdown measures: How did the learners perceive it?
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10:15 AM – 12:15 PM
(478.19) Evaluating Autostereoscopy (AlioscopyTM) Use for Anatomy Education
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10:15 AM – 12:15 PM
(478.20) The Cognitive Load of Learning Anatomy in a Virtual World
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10:15 AM – 12:15 PM
(478.21) A Workflow for Digitizing Anatomical Specimens by Combining Photogrammetry and 3D Scanning
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10:15 AM – 12:15 PM
(478.22) Role of Digital Media in Enhancing Anatomical Education: A Survey Study Focused on the Cranial Cavity and Its Contents
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10:15 AM – 12:15 PM
(478.23) The Pedagogical Analysis of Digital Media Utilization in the Anatomical Sciences: An Innovative Approach to Teaching the Cadaveric Dissection and Anatomy of the Heart
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10:15 AM – 12:15 PM
(478.24) Student created quizzes to reinforce critical information and highlight deficits for both the students and instructor
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10:15 AM – 12:15 PM
(478.25) Integrating Basic and Clinical Sciences for Medical Undergraduate Students to Enrich Learning
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10:15 AM – 12:15 PM
(480.10) Increased Glycolysis and ATP Production Are Not Prerequisites for Cardiomyocytes Cell Cycle Induction
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10:15 AM – 12:15 PM
(480.11) Morphometrical Description of the Left Ventricular Summit Vascular Triangle
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10:15 AM – 12:15 PM
(480.12) Heat Stress More Negatively Impacts Cardiac Muscle Mitochondria in Female Versus Male Pigs
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10:15 AM – 12:15 PM
(480.13) Ligamentum Arteriosum: An Innervated and Contractile Muscular Structure
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10:15 AM – 12:15 PM
(480.14) Cardiac structure and function relates to body composition and metabolic profiles in high spinal cord injury
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10:15 AM – 12:15 PM
(482.10) The role of cytoskeleton regulators in embryonic facial morphogenesis
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10:15 AM – 12:15 PM
(482.11) Investigating the effects of the marine drug Manzamine-A related to craniofacial development in vitro
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10:15 AM – 12:15 PM
(482.12) Small Brains, Small Skulls: Effect of Cortex Specific Overexpression of BAF170 on the Mouse Cranium
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10:15 AM – 12:15 PM
(482.13) Postnatal endocranial volume growth in Galago moholi
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10:15 AM – 12:15 PM
(482.14) Cortex Specific Overexpression of BAF170 and Growth of the Cranial Base, Cranial Vault, and Facial Skeleton in Mice
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10:15 AM – 12:15 PM
(482.15) Exploring the Distribution and Orientation of Cell Proliferation as Drivers of Mouse Facial Development
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10:15 AM – 12:15 PM
(482.16) Deletion of Sf3b4 in Neural Crest Cells Encapsulates the Variable Expressivity of Craniofacial Abnormalities Observed in Nager and Rodriguez Syndrome Patients
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10:15 AM – 12:15 PM
(482.17) Discerning a Potential Link between MEMO1’s Role in Vascular, Bone, and Craniofacial Development.
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10:15 AM – 12:15 PM
(482.18) Differential Effects of the Fgfr2c C342Y Mutation on Developing Cranial Cartilage
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10:15 AM – 12:15 PM
(482.19) Mechanical Properties of Embryonic Mouse Cartilage and Bone
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10:15 AM – 12:15 PM
(482.20) Arhgap29 is Required for Proper Palatogenesis and its Loss in Ectodermal-Derived Cells Results in a Kinked Tail Phenotype
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10:15 AM – 12:15 PM
(482.21) Left - Right Asymmetry of the Jugular Foramen in Multisuture Syndromic Craniosynostosis
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10:15 AM – 12:15 PM
(482.22) Investigating Zmym2 and Zmym4 as Putative Six1 Co-Factors
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10:15 AM – 12:15 PM
(482.23) Tissue Interaction in Pharyngeal Arches
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10:15 AM – 12:15 PM
(482.24) Differential regulation of IGF-1 pathway and accelerated bone elongation in pre-obese juvenile mice
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10:15 AM – 12:15 PM
(482.25) Differential Regulation of Lhx9 Expression in Mouse and Chicken Limbs
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10:15 AM – 12:15 PM
(482.26) The effect of disease-causing DVL1 mutations on chondrogenesis in chicken limb mesenchyme
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10:15 AM – 12:15 PM
(482.27) The Role of Sox9 in Regulating Joint Development through a Gdf5 Enhancer
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10:15 AM – 12:15 PM
(482.28) Regulation of LIM homeodomain 2 (Lhx2) in the distal limb bud during patterning and development
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10:15 AM – 12:15 PM
(482.29) An E-Box Binding Site is Sufficient for ZPA Regulatory Sequence (ZRS) Activity in the Limb
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10:15 AM – 12:15 PM
(482.30) LHX2 Regulates Shh Expression in the Limb Independent of the ZPA Regulatory Sequence
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10:15 AM – 12:15 PM
(482.31) Neural Crest-Specific Elp1 Deletion Disrupts Trigeminal Ganglion Development in a Model of Familial Dysautonomia
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10:15 AM – 12:15 PM
(482.32) Elucidating the Role of N-cadherin during Trigeminal Gangliogenesis
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10:15 AM – 12:15 PM
(482.33) Elp1-Mediated Mechanisms Underlying Trigeminal Ganglion Development
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10:15 AM – 12:15 PM
(482.34) Expression of Neural Crest Specifiers During the Two Waves of Trunk NCC Migration in Turtle Embryos
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10:15 AM – 12:15 PM
(482.35) Late Gestation Exposure to PolyI:C-Induced Maternal Immune Activation Results in Sex-Dependent Antiviral Responses in Rat Placenta
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10:15 AM – 12:15 PM
(482.36) Mammalian testes utilize multiple modalities to moderate spermatogonial responsiveness to retinoic acid
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10:15 AM – 12:15 PM
(482.37) The role of Kisspeptin, KISS1 and KISS1R genes in primary female infertility: a case-control study of a Nigerian population
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10:15 AM – 12:15 PM
(482.38) Neuronal Activity Differentially Regulates KCC2 Protein Expression at Distinct Neuronal Maturation Stages
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10:15 AM – 12:15 PM
(482.39) Regulation of Vacuolar H+ ATPase Subunit Expression in the Mouse Brain by Developmental Stage and pH Changes
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10:15 AM – 12:15 PM
(482.40) Finasteride induces Epigenetic Modulation of LSP1: A Gene implicated in Neutrophil Actin Dysfunction disease
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10:15 AM – 12:15 PM
(482.41) emx2 is Required for Nephron Segment Development in the Zebrafish Pronephros
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10:15 AM – 12:15 PM
(482.42) Delineating the role of gldc in nephron patterning during kidney development
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10:15 AM – 12:15 PM
(482.43) How to Make a Vampire: Part II. Getting Ready to Feed
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10:15 AM – 12:15 PM
(546.10) Spatiotemporal and Multicellular Intravital Microscopy Analysis during Cardiac Injury and Repair
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10:15 AM – 12:15 PM
(548.10) Electro-metabolic signaling in heart: how local blood flow is regulated
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10:15 AM – 12:15 PM
(548.11) Conducted Capillary Signaling Enables Oxygen Responses in Skeletal Muscle Independent of Metabolite Production
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10:15 AM – 12:15 PM
(548.12) A theoretical model for flow regulation in the cerebral cortex: role of penetrating arterioles
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10:15 AM – 12:15 PM
(548.13) Drag Reducing Polymers Improves Microvascular Perfusion After Extracorporeal Circulation
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10:15 AM – 12:15 PM
(548.14) Blood Flow Heterogeneity and Oxygenation in the Lung: Effect of the Hypoxic Pulmonary Vasoconstriction Response Curve
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10:15 AM – 12:15 PM
(548.15) Chloride Intracellular Channel Protein 1 (CLIC1) Inhibitor (IAA94) Decreases Contractile Force in Rat Uterine Arteries
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10:15 AM – 12:15 PM
(554.10) Role of the High-Conductance Calcium-Activated Potassium Chanel in first order mesenteric artery of hypercaloric diet rat model
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10:15 AM – 12:15 PM
(554.11) Metabolic Syndrome and SIRT1 Mutation Impair Ca2+ Channels in Coronary Smooth Muscle Cells of Ossabaw Miniature Swine
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10:15 AM – 12:15 PM
(554.12) Loss of SR-PM Contact Sites May Contribute to The Development of Hypertension in Spontaneously Hypertensive Rats
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10:15 AM – 12:15 PM
(555.10) On the Regulation of Regional Cerebral Blood Flow during Hypoxic and Hypercapnic Exercise in Humans
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10:15 AM – 12:15 PM
(555.11) Post-menopausal Cerebral Microvascular Alterations in a Mouse Model of Alzheimer’s Disease
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10:15 AM – 12:15 PM
(555.12) OxLDL Mediates Brain Vascular Smooth Muscle Cell LOX-1 Splicing, Oxidative Stress, and Inflammation Following Ischemic-like Injury
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10:15 AM – 12:15 PM
(555.13) Cerebrovascular Carbon Dioxide Reactivity with Hyperoxia and Hypoxia in Humans with Treated Hypertension
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10:15 AM – 12:15 PM
(555.14) Middle-Aged and Older Adults with Greater White Matter Hyperintensity Burden Display Attenuated Blood Pressure and Cerebral Blood Velocity Responses During Orthostatic Tilt
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10:15 AM – 12:15 PM
(555.15) Assessment by Multi-Distance Hyperspectral NIRS of Changes in the Oxidation State of Cytochrome C Oxidase (oxCCO) to Carotid Artery Compressions
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10:15 AM – 12:15 PM
(555.16) Bilateral Nephrectomy Impairs Cerebral Oxygen Delivery After Acute Hemodilution Anemia in Rats
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10:15 AM – 12:15 PM
(555.17) The Influence of Sleep Duration on Cerebrovascular Reactivity
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10:15 AM – 12:15 PM
(555.18) Effect of Hyperinsulinemia on Cerebral Autoregulation and Myogenic Control of Cerebral Blood Flow in Healthy Young Adults
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10:15 AM – 12:15 PM
(555.19) Intracranial Cerebrovascular Reactivity by Traditional and Novel Methods in Young, Middle, and Old Aged Healthy Males and Females
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10:15 AM – 12:15 PM
(555.20) Effect of Arterial Stiffness and Cerebral Pulsatility on Hippocampal Tissue Integrity in Healthy Adults
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10:15 AM – 12:15 PM
(555.21) A Pilot Study to Investigate the Effect of Hypercapnia Training on Cerebrovascular Reactivity in Healthy Adults
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10:15 AM – 12:15 PM
(555.22) Analysis of Cerebrovascular Architecture in Experimental Models of Hypertension and Chronic Neuroendocrine Stress
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10:15 AM – 12:15 PM
(555.23) The Impact of Aging on the Association between Aortic Stiffness and Cerebral Pulsatility Index
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10:15 AM – 12:15 PM
(555.24) Exercise and Hypercapnia Differentially Modify Ratios of Extracranial and Intracranial Pulsatility
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10:15 AM – 12:15 PM
(555.25) Acute Antioxidant and Cytoprotective Effects of Caffeine in the Model of Neurovascular Injury by Oxidative Stress
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10:15 AM – 12:15 PM
(555.26) Central Command Related Changes in Anterior Cerebral Artery Blood Velocity and Prefrontal Oxygenation at the Onset of Moderate Voluntary Hand-Grip Exercise
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10:15 AM – 12:15 PM
(555.27) The Cold Receptor TRPM8 Mediates the Antioxidant and Cytoprotective Effects of Mild Hypothermia in Cerebral Endothelial Cells During Inflammation
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10:15 AM – 12:15 PM
(555.28) The Effects of Transcutaneous Vagal Nerve Stimulation on Dynamic Cerebral Autoregulation
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10:15 AM – 12:15 PM
(555.29) The impact of cyclooxygenase inhibition with ketorolac on regional cerebral perfusion in healthy adults
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10:15 AM – 12:15 PM
(555.30) Reduced microvascular expression of ADAM17 contributes to cognitive impairment in Alzheimers disease model, APP/PS1 mice
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10:15 AM – 12:15 PM
(555.31) ATP Attenuates α1-Adrenergic and Peptidergic Vasocontraction in Isolated Porcine Cerebral Arteries
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10:15 AM – 12:15 PM
(555.32) Differential Expression Profile of Sphingosine-1-Phosphate Receptors in Human Brain Vascular Smooth Muscle and Endothelial Cells Following Hypoxia Plus Glucose Deprivation
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10:15 AM – 12:15 PM
(556.10) Loss of Endothelial Cell RIPK3 Leads to Increased Vascular Permeability Following Intestinal Ischemia-Reperfusion Injury
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10:15 AM – 12:15 PM
(556.11) Laminar Shear Stress Enhances Cytosolic PINK1 Expression: Increased Mitophagic Sensitivity Toward Mitochondrial Dysfunction
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10:15 AM – 12:15 PM
(556.12) Advanced Maternal Age Impairs Uterine Artery Remodelling in the Pregnant Rat
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10:15 AM – 12:15 PM
(556.13) Actin-Fence Enhancement Protects against Extra-Pulmonary Infection of Pseudomonas Aeruginosa
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10:15 AM – 12:15 PM
(556.14) EB3 inhibitor increases chromatin accessibility and reprograms neovascular endothelial cells
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10:15 AM – 12:15 PM
(556.15) Intercellular Ca2+ waves propagate by regenerative IP3-induced IP3 release
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10:15 AM – 12:15 PM
(556.16) Mechanical stretch-driven ROS generation stimulates endothelin production in neonatal pig renal epithelial and vascular endothelial cells
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10:15 AM – 12:15 PM
(556.17) Endothelial cell specific knockout of caveolin-1 attenuates AngII/BAPN-induced vascular remodeling in mice
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10:15 AM – 12:15 PM
(556.18) Cell-Free Hemoglobin Increases Leukocyte Adhesion and Mitochondrial Oxidative Damage in the Pulmonary Microvascular Endothelium
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10:15 AM – 12:15 PM
(556.19) Vascular Function and Sugar Sweetened Beverage Consumption in Hispanic and Non-Hispanic Males
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10:15 AM – 12:15 PM
(556.20) Toll-like Receptor 4 Mediates Histone Subunit H3-induced Endothelial Dysfunction in Human Lung Endothelium
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10:15 AM – 12:15 PM
(556.21) Moderate Intensity Exercise-Induced Shear Stress Upregulates eNOS mRNA Expression
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10:15 AM – 12:15 PM
(556.22) Weight Gain, Fibroblast Growth Factor-23, and Vascular Function in Liver Transplant Recipients
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10:15 AM – 12:15 PM
(556.23) Mice Deficient in Endothelial Cell-Selective Adhesion Molecule Develop Vascular Endothelial and Left Ventricle Diastolic Dysfunction
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10:15 AM – 12:15 PM
(556.24) Exercise-Induced Shear Stress Upregulates eNOS Protein in vitro
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10:15 AM – 12:15 PM
(556.25) GPR68 Inhibition with a Novel Group of Ogremorphin Inhibitors Upregulate Endothelial Barrier Function and Protect Against Bacterial Pathogens or Acidosis-induced Inflammation in Lung Endothelium
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10:15 AM – 12:15 PM
(556.26) Glutamine Counteracts Glucose-Mediated Human Endothelial Cell Dysfunction
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10:15 AM – 12:15 PM
(556.27) A Cell Permeant Phosphopeptide Mimetic Of Niban Restores Endothelial Function And Inhibits p38 MAPK Activation After IL-1β Induced Vascular Injury
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10:15 AM – 12:15 PM
(556.28) Exercise Training Alleviates Alzheimer’s Disease-Associated Aortic Endothelial Dysfunction
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10:15 AM – 12:15 PM
(556.29) Higher Levels of Shear Stress Downregulate Endothelin-1 mRNA Expression
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10:15 AM – 12:15 PM
(556.30) Glutathione Regulates Endothelial Cell Function and VEGFR2 Signaling
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10:15 AM – 12:15 PM
(556.31) Apohemoglobin-haptoglobin (Apohb-Hp) Complex as a Vasculo-protective Agent in Hypoxia Induced Vaso-occlusion in Sickle Cell Disease
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10:15 AM – 12:15 PM
(557.10) Left Ventricular Systolic-Diastolic Coupling: Insight from Magnetic Resonance Dobutamine Stress
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10:15 AM – 12:15 PM
(557.11) Heart Rate Fragmentation in Rats with Streptozotocin-induced Diabetes
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10:15 AM – 12:15 PM
(557.12) Synchronous biventricular pressure-volume loops in rodents using a closed-chest approach
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10:15 AM – 12:15 PM
(557.13) Binge drinking-like behavior in juvenile rats causes long-lasting cardiorespiratory dysfunction that persists until adulthood
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10:15 AM – 12:15 PM
(557.14) Correlation of Cardiovascular Function and Hemodynamic Parameters with Gender and BMI in Healthy Subjects
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10:15 AM – 12:15 PM
(557.15) Blood Pressure Lowering Effect of Electro-Acupuncture in Middle-aged and Elderly Patients with Mild to Moderate Hypertension: Does Inflammation Play a Role
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10:15 AM – 12:15 PM
(557.16) A New High-Speed Biaxial Testing System for Rodent Myocardium Viscoelastic Measurement under Dynamic Loadings
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10:15 AM – 12:15 PM
(557.17) Stretch-induced Myocardial Injury and Inflammation After Transient Vasopressin-Mediated Left Ventricular Pressure Overload in Swine
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10:15 AM – 12:15 PM
(557.18) Minocycline Blunts Isoproterenol-Induced Cardiac Hypertrophy
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10:15 AM – 12:15 PM
(557.19) Hemodynamic Determinants of Cardiac Interoception
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10:15 AM – 12:15 PM
(557.20) Perinatal nicotine exposure alters development of cardiac performance
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10:15 AM – 12:15 PM
(557.21) Preservation of Right Ventricular Contractility After Transient Phenylephrine-Induced Pressure Overload in Swine
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10:15 AM – 12:15 PM
(557.22) Effect of a single individualized precise constant power exercise on pulse wave in patients with new-onset chronic disease
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10:15 AM – 12:15 PM
(557.24) Stress relaxation behavior of left ventricular myocardium in mice
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10:15 AM – 12:15 PM
(560.10) Peroxiredoxin-4 Interacts with Dopamine D5 Receptor to Reduce Endoplasmic Reticulum Stress
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10:15 AM – 12:15 PM
(560.11) A Preliminary Report on the Variation of Respiratory Blood Pressure during Sleep in Normal Subjects
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10:15 AM – 12:15 PM
(560.12) A low salt diet increases blood pressure in mice with selective deletion of the dopamine D2 receptor in the renal proximal tubule.
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10:15 AM – 12:15 PM
(560.13) Inhibition of the Hippo Pathway Prevents Arterial Stiffness and Hypertension in Vascular Smooth Muscle Cell Specific Kdm6a Knockout Mice
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10:15 AM – 12:15 PM
(560.14) Characterization and Ischemic Response of Telecytes in the Mouse Renal Medulla
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10:15 AM – 12:15 PM
(560.15) Adipose-derived human soluble (pro)renin receptor causes resistance to Losartan treatment in high-fat diet male and female mice
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10:15 AM – 12:15 PM
(562.10) Differential Expression of Microglial BDNF in Response to Acute Hyperglycemia and Hypoxia
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10:15 AM – 12:15 PM
(562.11) Ameliorative potential of D-Ribose-L-Cysteine in male Wistar rats with metabolic syndrome
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10:15 AM – 12:15 PM
(562.12) Study of Insulin Resistance with Female Liver Androgen Receptor Knock-Out Mice (Liv-AKRO) on a High Fructose Diet
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10:15 AM – 12:15 PM
(562.13) Association between indices of cardiac repolarization, adiposity and metabolic syndrome. The Polish Norwegian Study (PONS)
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10:15 AM – 12:15 PM
(562.14) Inhibition of Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Attenuates BCKA Induced Suppression of Insulin-Stimulated Glucose Uptake in Muscle Cells
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10:15 AM – 12:15 PM
(562.15) GPR75 Deficiency Protects Against High-Fat Diet Induced Obesity
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10:15 AM – 12:15 PM
(562.16) Hyperglycemia and Obesity Play a Different Role in the Pathogenesis of Colitis in Diabetic Mice
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10:15 AM – 12:15 PM
(562.17) Heart Rate Fragmentation in Patients with Type 2 Diabetes Mellitus
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10:15 AM – 12:15 PM
(562.18) Nicotine Treatment Resulted in Decreased Protein Expression of Prorenin and Soluble Prorenin Receptor in 3T3-L1 cells
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10:15 AM – 12:15 PM
(562.19) PGC1α Overexpression Protects against Cardio-Metabolic Disease and Skeletal Muscle Dysfunction in a Type 2 Diabetic Mouse Model
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10:15 AM – 12:15 PM
(562.20) Relationship Between Periodontal Disease and Glycemic Control in Pediatric Patients with Type 2 Diabetes Mellitus
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10:15 AM – 12:15 PM
(562.21) Hypoglycosylated Follistatin-Like 1 Attenuates the Loss of Coronary and Cerebral Vascular Functional Capacity in Ossabaw Swine with Cardiometabolic Heart Failure with Reduced Ejection Fraction
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10:15 AM – 12:15 PM
(563.10) Therapeutic effects of L-lysine in Dahl SS rats, a Model of Salt-Induced Hypertension
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10:15 AM – 12:15 PM
(563.11) The IFNγ-PDL1 Pathway Enhances the Interaction Between CD8+ T Cells and Distal Convoluted Tubules to Promote Salt-Sensitive Hypertension
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10:15 AM – 12:15 PM
(563.12) A Role for the Adrenal Clock in Aldosterone Regulation and Renal Excretory Function
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10:15 AM – 12:15 PM
(563.13) Low Blood Pressure is Independent of Plasma Renin in the Bmal1 Knockout Rat
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10:15 AM – 12:15 PM
(563.14) Protective Role of Angiotensin II type 2 receptor (AT2R) in High Salt Diet-Induced Low Molecular Weight Proteinuria and Loss of Megalin in the Kidney
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10:15 AM – 12:15 PM
(563.15) Global PER1 knockout Dahl Salt Sensitive rats show increased expression of renal Edn1 mRNA and Endothelin-1 peptide
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10:15 AM – 12:15 PM
(563.16) Renal Afferent Nerves Regulate Salt Appetite in DOCA Hypertensive Rats
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10:15 AM – 12:15 PM
(564.10) Calcium-Dependent Dual Oxidase 2 is a Novel Source of Reactive Oxygen Species Implicated in Glomerular Mesangial Cell Fibrotic Response to Angiotensin II and Glucose
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10:15 AM – 12:15 PM
(564.11) Dietary Empagliflozin Regulates Angiotensin Converting Enzyme 2 (ACE2) and Transmembrane Serine Protease 2 (TMPRSS2) in Kidney Cortex of Mice
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10:15 AM – 12:15 PM
(564.12) Novel Role of Dual Oxidase 2 as a Mediator of Podocyte Injury in the Diabetic Environment
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10:15 AM – 12:15 PM
(567.10) Very Low-Density Lipoprotein (VLDL) Signals Through Sphingosine-1-Phosphate Receptor 1, Upon Binding to VLDL Receptor, to Induce Aldosterone Synthesis and Secretion in Human Adrenocortical Cells
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10:15 AM – 12:15 PM
(567.11) Phospholipase D2 Loss Impairs Low Salt-Induced Increases in Steroidogenic Gene Expression with No Effect on Serum Aldosterone Levels
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10:15 AM – 12:15 PM
(567.12) Sexual Dimorphic Regulation of MicroRNAs Alters Sodium Transport in the Kidney Distal Nephron
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10:15 AM – 12:15 PM
(567.13) Selective blockade of AT1R and B1R modulates the expression of ACE2 ubiquitination partners
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10:15 AM – 12:15 PM
(567.15) Regulation of PITX2 and ABCB1 in oncogenic multidrug resistance by tumorigenic HIF2 in VHL-deficient renal cancer cells
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10:15 AM – 12:15 PM
(567.16) Mapping myocyte microdomains with optogenetic cAMP signaling
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10:15 AM – 12:15 PM
(567.17) The role of ABCC4 in pigment granule migration in RPE of mice
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10:15 AM – 12:15 PM
(567.18) N-cadherin signaling stabilizes occludin tight junction via PI3K p110β signaling
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10:15 AM – 12:15 PM
(583.10) Dietary Impacts on Changes in Diversity and Abundance of the Murine Microbiome During Progression and Treatment of Cancer
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10:15 AM – 12:15 PM
(583.11) High fat diet disrupts diurnal interactions between small intestinal host innate immune factor REG3γ and gut microbiota resulting in metabolic dysfunction
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10:15 AM – 12:15 PM
(583.12) Rapamycin Supplementation: Effect on Longevity in Drosophila melanogaster
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10:15 AM – 12:15 PM
(583.13) Correlation between Intermittent Fasting and Mental and Physical Fatigue in High-fat-induced Obese and Non-obese Rats
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10:15 AM – 12:15 PM
(588.10) The Effect of Lipolysis Inhibitor Acipimox on Brown Adipose Tissue Bioenergetics and Uncoupling Protein Abundance in Severely Burned Rats
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10:15 AM – 12:15 PM
(588.11) Adult-Onset Exercise Improves Mitochondria Efficiency of the Heart in Female Offspring Born from Dams Fed a High-Fat and a High-Sucrose Diet
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10:15 AM – 12:15 PM
(595.10) NMDA receptor modulation in protracted ethanol withdrawal
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10:15 AM – 12:15 PM
(595.11) Intermittent Cocaine Self-Administration Infusions Increases Subthreshold Activity in Putative Dopaminergic Neurons of The Ventral Tegmental Area
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10:15 AM – 12:15 PM
(595.12) Perinatal High Fat Diet and Acute Stress alters the Chloride Gradient in Dorsal Motor Nucleus of the Vagus Neurons Controlling Gastric Function
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10:15 AM – 12:15 PM
(599.10) Temporal and Region-Specific Tau Protein Hyper-Phosphorylation in the Brain Coincides with the Development of Impaired Baroreflex Control of Arterial Pressure and Spatial Learning in Male Obese Zucker Rats
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10:15 AM – 12:15 PM
(599.11) Estrogen-Mediated Mechanisms of Social Stress Susceptibility within the Central Amygdala
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10:15 AM – 12:15 PM
(599.12) C. elegans Attraction Learning in casy-1 Mutants
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10:15 AM – 12:15 PM
(599.13) Role of locus coeruleus expressing angiotensin type 1 receptors (AT1R) neurons in fear learning and stress-induced anxiety
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10:15 AM – 12:15 PM
(602.10) MOTS-c protein expression increases following aerobic exercise training and remains elevated during detraining
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10:15 AM – 12:15 PM
(602.11) Contribution of Genetic Background to Vascular Adaptation to Exercise Training Based on Critical Speed of Different Intensities
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10:15 AM – 12:15 PM
(602.12) Exercise Training Attenuates Radiation-Induced Impairments in Endothelium-Dependent Vasodilation of Coronary Arterioles in Rats
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10:15 AM – 12:15 PM
(602.13) Response to Endurance Training Using Critical Speed: Influence of Genetic Background and Exercise Intensity
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10:15 AM – 12:15 PM
(602.14) Structured, Progressive Exercise Training Improves Cardiovascular Psychophysiological Outcomes in Young Adult Women with a History of Adverse Childhood Experiences
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10:15 AM – 12:15 PM
(602.15) MitoQ supplementation improves oxygen uptake kinetic by reduced reactive oxygen species levels and altered expression of miR-155 and miR-181b
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10:15 AM – 12:15 PM
(603.10) Resistance Breathing and Sympathetic Nerve Activity During Simulated Hemorrhage in Humans
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10:15 AM – 12:15 PM
(603.11) Energy Balance and Muscular Power Alterations Following Repeated 4-Hour Exercise Dives
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10:15 AM – 12:15 PM
(603.12) HPT- Axis Activation During Cold Head Out Water Immersion is Not Modified by Moderate Hypoxia
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10:15 AM – 12:15 PM
(603.13) Identifying Predictive Markers of CNS Oxygen Toxicity and Ketone Ester Effects on Latency to Seizure and Antioxidant Capacity
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10:15 AM – 12:15 PM
(603.14) Acute Elevations in Apnea-Induced Spleen Contraction Provoked by Thermoneutral Head Out Water Immersion
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10:15 AM – 12:15 PM
(603.15) Oxygen Dose: A new perspective
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10:15 AM – 12:15 PM
(603.16) Cardiovascular Responses to Mild Lower Body Negative Pressure during Spaceflight
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10:15 AM – 12:15 PM
(603.17) The Impact of Long-Duration Exposure to Microgravity and Galactic Cosmic Radiation on Corpus Cavernosum Function
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10:15 AM – 12:15 PM
(603.18) Effects of Sustained Hypobaric Hypoxia on Amplitude of Forced Hemodynamic Oscillations During Central Hypovolemia
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10:15 AM – 12:15 PM
(603.19) Acute Impact of JUUL Electronic Cigarette use on Cerebral Vascular Vasodilator Responsiveness
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10:15 AM – 12:15 PM
(603.20) The Use of Low-Dose Radiation Pre-Treatments as a Potential Countermeasure to Galactic Cosmic Radiation Exposure
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10:15 AM – 12:15 PM
(603.21) Countermeasure Analysis for Galactic Cosmic Radiation Induced Damage
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10:15 AM – 12:15 PM
(604.10) Sex differences in lipopolysaccharide-induced cytokine secretion in skeletal muscle
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10:15 AM – 12:15 PM
(604.11) Examining Vascular Responses to Passive Movement in Premenopausal Females: Comparisons Across Sex and Menstrual Cycle Phase
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10:15 AM – 12:15 PM
(604.12) Exercise Capacity Mediated by the Gut Microbiome
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10:15 AM – 12:15 PM
(604.13) Cutaneous Microvascular Endothelial Function: Effects of Sex and Menopause Stage
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10:15 AM – 12:15 PM
(605.10) Effects of neutral sphingomyelinase activation associated factor (Nsmaf) gene knock-down on myogenesis in murine C2C12 myoblast
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10:15 AM – 12:15 PM
(605.11) Skeletal Muscle Dysfunction in Experimental Pulmonary Hypertension Kosmas Kosmas1,2, Zoe Michael2,3, Fotios Spyropoulos1,2, Jeffrey Widrick2,4, Ravi Jasuja2, Aimilia Papathanasiou1,2, Helen Christou 1,2 1 Department of Pediatric Newborn Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA 2 Harvard Medical School, Boston, MA 02215, USA 3 Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02215, USA 4 Department of Genetics, Boston Children’s Hospital, Boston, MA 02215, USA
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10:15 AM – 12:15 PM
(605.12) Med12 is Essential for Skeletal Muscle Development
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10:15 AM – 12:15 PM
(605.13) Prior Alcohol Use does not Enhance Skeletal Muscle Atrophy and Force Decrements Induced by Cancer Cachexia
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10:15 AM – 12:15 PM
(605.14) Neuromuscular Synapse Dynamics in Aged and Injured Skeletal Muscle
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10:15 AM – 12:15 PM
(605.15) A prospective clinical study on the mechanisms underlying Critical Illness Myopathy – A time-course approach
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10:15 AM – 12:15 PM
(605.16) Electrical Stimulated Glut4 Trafficking Reduces Critical Illness-Associated Muscle Wasting
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10:15 AM – 12:15 PM
(605.17) Using an HDAC Inhibitor to Alter Muscle Growth in Fetal Pigs
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10:15 AM – 12:15 PM
(605.18) Age-dependent differences in the ventilator-induced diaphragm dysfunction (VIDD): A multi-omics study
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10:15 AM – 12:15 PM
(605.19) Physiological Changes in Response to Skeletal Muscle Specific High Expression of mu-Crystallin Following High and Low-Fat Diets
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10:15 AM – 12:15 PM
(605.20) The Differential Contribution of TRIM72/MG53 Protein Domains in Plasma Membrane Repair
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10:15 AM – 12:15 PM
(605.21) Changes to the Skeletal Muscle Gene Expression Signature in Response to Nutrient and/or Mechanical Stimuli
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10:15 AM – 12:15 PM
(605.22) Fatty Gastrocnemius Muscle: A Case Report
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10:15 AM – 12:15 PM
(605.23) Accumulation of Intramyocellular Acetylcarnitine is Associated with Glycolytic ATP Production In Vivo During Incremental Contractions in Human Skeletal Muscle
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10:15 AM – 12:15 PM
(605.24) Skeletal Muscle Mitochondrial Capacity in Patients with Statin-Associated Muscle Symptoms (SAMS)
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10:15 AM – 12:15 PM
(605.25) The Optimized Quantum Dots Mediated Thermometry Reveals the Efficiency of Myosin Extracted from Muscle Mini Bundles
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10:15 AM – 12:15 PM
(605.26) Non-acidotic hypercapnia limits the loss of diaphragm force at single fiber level in mechanically ventilated rats for 5 days
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10:15 AM – 12:15 PM
(605.27) Exploiting exercise and mTOR enhanced protein synthesis to augment mRNA vaccine translation
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10:15 AM – 12:15 PM
(605.28) Neuregulin-1β promotes myoblast differentiation and is anti-cachexic in respiratory muscles of post-infarcted swine
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10:15 AM – 12:15 PM
(605.29) MYTHO: A novel regulator of autophagy and skeletal muscle health
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10:15 AM – 12:15 PM
(605.30) Brain-derived Neurotrophic Factor in Duchenne Muscular Dystrophy Myopathy
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10:15 AM – 12:15 PM
(605.31) Lysine deacetylases (KDACs) regulate PKCõ phosphorylation in response to muscle atrophy
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10:15 AM – 12:15 PM
(605.32) Impact of Heat Therapy on Skeletal Muscle Mass and Function in A Mouse Model of Duchenne Muscular Dystrophy
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10:15 AM – 12:15 PM
(605.33) An Exercise-Driven, Insulin-Independent Glucose Uptake Pathway in Contracting Skeletal Muscle
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10:15 AM – 12:15 PM
(605.34) An Exercise Mimetic Blunts Influenza-Induced Mortality in Middle Aged and Obese Mice
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10:15 AM – 12:15 PM
(605.35) Expression profiles of protein markers regulating the mitochondrial lifecycle in skeletal muscle of acute spinal cord transected rats
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10:15 AM – 12:15 PM
(605.36) Effects of a novel AMP-mimicking prodrug on AMPK and mTORC1 activity in C2C12 cells
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10:15 AM – 12:15 PM
(605.37) Mechanistic Insights into the Role of TRIM28 in the Regulation of Skeletal Muscle Size
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10:15 AM – 12:15 PM
(605.38) PRMT5 regulates lipid metabolism in skeletal muscle via epigenetic suppression of Pnpla2
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10:15 AM – 12:15 PM
(605.39) Characterization of the Three Dimensional Genome in Human Skeletal Muscle Progenitor Cells
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10:15 AM – 12:15 PM
(605.40) Impact of cell-free hemoglobin on oxygen pressure dynamics in muscles comprised primarily of fast-twitch fibers
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10:15 AM – 12:15 PM
(605.41) Lectin Biomarker Development in a Mouse Model of GNE Myopathy
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10:15 AM – 12:15 PM
(608.10) Heart Rate Variability Parameters Indicate Altered Autonomic Tone in Patients with COVID-19
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10:15 AM – 12:15 PM
(608.11) Reliability of Heart Rate Variability during Polysomnographic Sleep
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10:15 AM – 12:15 PM
(609.10) Deletion of Prorenin Receptor in the Rostral Ventrolateral Medulla Results in Biphasic and Sex-Dependent Pressor Responses in Deoxycorticosterone Acetate-salt Hypertension
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10:15 AM – 12:15 PM
(613.10) Central Activation of the Cholinergic Anti-Inflammatory Pathway Improves Outcome in a Murine Model of Systemic Lupus Erythematosus
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10:15 AM – 12:15 PM
(613.11) Novel Therapeutics Modulate Cardiac Leukocyte Populations Following Myocardial Infarction
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10:15 AM – 12:15 PM
(614.10) Activation by Cleavage of the Epithelial Na+ Channel α and γ Subunits Independently Coevolved with the Vertebrate Terrestrial Migration
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10:15 AM – 12:15 PM
(614.11) Regulation of BK channel expression by Paraoxonase 3
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10:15 AM – 12:15 PM
(614.12) HDAC3 Inhibition Improved Urinary Concentrating Defect in Hypokalemia by Promoting AQP2 Transcription
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10:15 AM – 12:15 PM
(614.13) Genetic Deletion of the Prostaglandin EP4 Receptor in the Kidney Tubule of Adult Male Mice Has Mild Impact on Kidney Water Handling
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10:15 AM – 12:15 PM
(614.14) Forty-five Vasopressin-Regulated Phosphoproteins Involved in Control of Collecting Duct Water Transport
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10:15 AM – 12:15 PM
(614.15) Proteomic analysis of urinary exosomes from patients with lithium-induced nephrogenic diabetes insipidus
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10:15 AM – 12:15 PM
(614.16) Membrane phosphoinositides and renal epithelial cell polarity determination in the Xenopus pronephros in vivo
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10:15 AM – 12:15 PM
(614.17) Immunohistochemical localization of receptor protein tyrosine phosphatase γ in mouse renal proximal tubule, thick ascending limb and distal convoluted tubule
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10:15 AM – 12:15 PM
(614.18) SGLT2 Inhibitor Effects on Proximal Tubule Cell Function
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10:15 AM – 12:15 PM
(614.19) The Role of MUC1 in Lactation-Associated Bone Mineral Conservation
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10:15 AM – 12:15 PM
(614.20) Gentamicin induces calciuresis by blocking TRPV5
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10:15 AM – 12:15 PM
(614.21) Characterization and application of a novel immortalized murine thick ascending limb (imTAL) cell line to investigate the role of myosin II motor proteins Myh9 and Myh10 in TAL cargo transport
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10:15 AM – 12:15 PM
(614.22) Inhibition of Na+/H+ exchanger-3 (NHE3) results in hyperphosphatemia without major alterations in Ca2+ homeostasis
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10:15 AM – 12:15 PM
(614.23) Generation and characterization of thick ascending limb specific knockout of NHE3 mouse model
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10:15 AM – 12:15 PM
(615.10) The Role of the Ih Current in Rhythmic Stability of the PreBötzinger Complex
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10:15 AM – 12:15 PM
(615.11) A Closed Loop Feature Detection Platform for Automated Neonate Cardio-Respiratory Measurements and Data Analysis
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10:15 AM – 12:15 PM
(615.12) An Automated Respiratory Data Pipeline for Waveform Characteristic Analysis
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10:15 AM – 12:15 PM
(629.10) The DeBakey Executive Research Leadership Program Bridges the Depth of Experienced Leaders with the Breadth of Emerging Leaders
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10:15 AM – 12:15 PM
(629.11) The trepidatious return to in-person instruction during the COVID-19 pandemic: valuable lessons applied from online teaching using Lt in the face-to-face classroom
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10:15 AM – 12:15 PM
(629.12) Reporting COVID-19 Cases within Kleberg County
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10:15 AM – 12:15 PM
(629.13) Improved student performance in cardiovascular physiology despite the pandemic, class size increase and switching to a pass/fail grading system
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10:15 AM – 12:15 PM
(629.14) Network mapping of asynchronous student interactions in online discussion boards
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10:15 AM – 12:15 PM
(629.15) The benefits of incorporating active learning into online, asynchronous coursework in dental physiology
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10:15 AM – 12:15 PM
(629.16) Reflections on a Plague Academic Year: A Multiyear Comparison of Student Engagement, Investment, and Performance in Undergraduate Physiology Courses During the COVID-19 Pandemic
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10:15 AM – 12:15 PM
(629.17) Its Not Fair: Remote Students Report Feeling Disadvantaged in a Hybrid Clinical Physiology Course
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10:15 AM – 12:15 PM
(629.18) Using Google Tools to Increase Student Learning, Engagement, and Collaboration in Remote, Hybrid, and In-person Courses
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10:15 AM – 12:15 PM
(629.19) Survey and Analysis of Virtual vs. In-Person Biology Teaching Labs
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10:15 AM – 12:15 PM
(629.20) Seeing and Understanding the Light: Student-Built Fluorescence Microscopes for Dynamic Calcium Imaging in the Undergraduate Physiology Lab Class
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10:15 AM – 12:15 PM
(629.21) Clinical Decision-Making in Endocrine Physiology: Induced Hypoglycemia in Dogs
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10:15 AM – 12:15 PM
(629.22) Microvascular anatomy and physiology laboratory class using the Australian cane toad
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11:45 AM – 12:45 PM
(525.1) P2X7 inhibition prevents mitochondrial stress caused by alcohol and e-cigarette exposure in primary vascular endothelial cells and restores barrier function
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11:45 AM – 12:45 PM
(525.2) Hydrostatic Pressure Controls Angiogenesis through Endothelial YAP1 during Lung Regeneration
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11:45 AM – 12:45 PM
(525.3) Involvement of Lysyl Oxidase in the Pathogenesis of Arterial Stiffness in Chronic Kidney Disease
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11:45 AM – 12:45 PM
(525.4) Molecular and cellular pathogenesis of endothelial lining in atrial fibrillation
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11:45 AM – 12:45 PM
(525.5) The Effect of Endomucin on Cell Surface Receptor Signaling Is Specific for Vascular Endothelial Growth Factor Receptor 2
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11:45 AM – 12:45 PM
(525.6) Targeting Neuropilin-2 in Lymphatic Malformation
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11:45 AM – 12:45 PM
(525.7) LncRNA Xist Participates in Signaling Pathways Related to Pulmonary Arterial Hypertension and its Comorbidities
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11:45 AM – 12:45 PM
(525.8) FXR1 Decreases Blood Pressure by Regulating Vascular Contractility
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11:45 AM – 12:45 PM
(525.9) IL-6 Signaling is Required for LPS-induced Barrier Function Loss
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11:45 AM – 12:45 PM
(526.1) Investigating the therapeutic efficacy of a novel mTORC1 inhibitor, RMC-6272, on liver tumors with b-catenin activation
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11:45 AM – 12:45 PM
(526.2) Acquisition of a Senescence-like Phenotype in Neurons Contributing to the Pathogenesis of Hepatic Encephalopathy Due to Chronic Liver Disease
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11:45 AM – 12:45 PM
(526.3) Liver Proteomic Profile in Mice on a High-Fat Diet: Modulation with Anti-Tumor Intervention
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11:45 AM – 12:45 PM
(526.4) Spatial transcriptomics reveals differences among genetic models of disruption in the Wnt-beta-catenin signaling in hepatocytes
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11:45 AM – 12:45 PM
(526.5) Differential responses of receptor tyrosine kinases C-Met and EGFR in mice
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11:45 AM – 12:45 PM
(526.6) The role of CGPR - receptor antagonist in the plastic process on the hepatopathies with toxical genesis
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11:45 AM – 12:45 PM
(526.7) Prospects of transient elastography’ using in the veterinary hepatology
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11:45 AM – 12:45 PM
(526.8) The new in the enteral dysbiosis correction intensified by heavy metals and mycotoxins
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11:45 AM – 12:45 PM
(526.9) The gut-liver axis in the liver’s disease: the pathophysiological basic of dysbiosis and hepatopathy’s pharmacorrection
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11:45 AM – 12:45 PM
(527.1) Direct effects of anti-inflammatory medication on barrier function in intestinal epithelial cells
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11:45 AM – 12:45 PM
(527.2) Claudin-23 Strengthens the Colonic Epithelial Barrier by Regulating Claudin-3 and -4 proteins in the Tight Junction Plasma Membrane
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11:45 AM – 12:45 PM
(527.3) Butyrate Analogues Mimicking Hypoxia by the Chemical Stabilization of Hypoxia Inducible Factor (HIF)
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11:45 AM – 12:45 PM
(527.4) Proteasomes in the Cells of the Ocular Surface in Health and Disease
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11:45 AM – 12:45 PM
(527.5) Klebsiella pneumoniae utilizes intestinal mucus to increase fitness in the gastrointestinal tract
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11:45 AM – 12:45 PM
(527.6) Role of Oral Microbiota Biofilms in Recurrent Tonsillitis and Sleep-Disordered Breathing in Children
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11:45 AM – 12:45 PM
(527.7) The Interplay Between Enteric Tuft Cell Responses and Giardia Colonization
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11:45 AM – 12:45 PM
(527.8) Colonic Goblet Cells Produce Augmented Levels of Pro-inflammatory Cytokines due to Metabolically Stressful MUC2 Mucin Biosynthesis
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11:45 AM – 12:45 PM
(527.9) ASIP Poster Viewing - Mucosal and Epithelial Pathobiology
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11:45 AM – 12:45 PM
(528.1) Contrasting Metabolic Profiles of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition (EMT)
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11:45 AM – 12:45 PM
(528.2) Mitochondrial Transplantation as a Novel Therapeutic for Retinal Metabolic Dysfunction-Driven Disease
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11:45 AM – 12:45 PM
(528.3) Potential Mechanisms of NUR77-Mediated Signaling in the Aging Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
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11:45 AM – 12:45 PM
(528.4) Microglia Prevent the Loss of Visual Function in the Aging Retina by Maintaining the Health of Retinal Pigment Epithelial Cells
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11:45 AM – 12:45 PM
(529.1) Safety and efficacy of currently used COVID-19 vaccines: Results of a pilot survey
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11:45 AM – 12:45 PM
(529.2) Vitamin D Status and its Associations with Cytokines and Chemokines in Arab Adults Screened for COVID-19
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11:45 AM – 12:45 PM
(529.3) Capturing Coronaviruses: Comparison of Recovery Methods for Infectious Coronaviruses From Environmental Surfaces
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11:45 AM – 12:45 PM
(529.4) COVID-19: Implications Regarding the Properties and Behaviors of the Coronavirus Disease
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11:45 AM – 12:45 PM
(529.5) Detection of Genomic Variations of SARS-CoV-2 on the S-Gene in the Orange County, CA Population
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11:45 AM – 12:45 PM
(529.6) Determining the Stability of Human Betacoronavirus OC43 on Different Surfaces
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11:45 AM – 12:45 PM
(529.7) Mathematical Modeling of Protracted HCMV Replication using Genome Substrates and Protein Temporal Profiles
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11:45 AM – 12:45 PM
(529.8) Adjuvants for inactivated vaccine against Avibacterium paragallinarum
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11:45 AM – 12:45 PM
(529.9) Corynebacterium pseudotuberculosis goat lymphadenitis and mastitis
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11:45 AM – 12:45 PM
(910.1) Sex-differences and cell type-specific alterations in brain Bcl2 expression after transient focal cerebral ischemia in aged mice
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11:45 AM – 12:45 PM
(910.2) Efficacy of post-injury anti-miR-181a and anti-miR-200c intravenous treatment in protection against experimental stroke in aged mice
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11:45 AM – 12:45 PM
(911.1) Epigenetic Age Acceleration as a Risk Predictor of Hepatocellular Carcinoma
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11:45 AM – 12:45 PM
(911.2) FoxO1 Promotes Liver Fibrosis through TGF-β1 mediated Hepatic Stellate Cell Activation
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11:45 AM – 12:45 PM
(913.1) Prevention at Full Steam - Can Steam Inhalation Stop the Contagion of Sars-Cov 2?
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11:45 AM – 12:45 PM
(913.2) Epitope Profiling Reveals the Antibody Immune Response Difference Between COVID-19 Infected and Vaccinated
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11:45 AM – 12:45 PM
(914.1) Early Life Stress Induced Hypothalamic–Pituitary–Adrenal (HPA) Axis Dysfunction Promotes Chronicity of Experimental Colitis in Mice
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11:45 AM – 12:45 PM
(914.2) Effects of Viral Infection on Endothelial Activation and Barrier Function
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11:45 AM – 12:45 PM
(914.3) Vaping /E-liquid Exposure Causes Dysregulation of Neutrophil Extracellular Trap formation
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11:45 AM – 12:45 PM
(525.10) The internal elastic lamina of resistance arteries facilitates vasodilation
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11:45 AM – 12:45 PM
(525.11) Understanding the Impact of Endothelial Cd36 in the Progression of Dyslipidemia-induced Dysfunction
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11:45 AM – 12:45 PM
(525.12) Soluble VE-cadherin disrupts endothelial barrier function via VE-PTP/RhoA signalling
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11:45 AM – 12:45 PM
(525.13) IL-33/ST2L Signaling Regulate Blood-Retinal Barrier Integrity via Affecting Cadherin-Catenin Adheren Junction Complex
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11:45 AM – 12:45 PM
(525.14) VCAM1 regulates Fra1/JunB mediated IL-8 expression and pathological retinal neovascularization in a murine model of oxygen-induced retinopathy
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11:45 AM – 12:45 PM
(525.15) IL-19 Regulates Atherosclerotic Plaque Progression via Lymphangiogenesis
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11:45 AM – 12:45 PM
(525.16) Oxidative Stress Biomarkers in Patients with End Stage Renal Disease
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11:45 AM – 12:45 PM
(525.17) Vascular and glomerular vs. proximal tubular components in calcineurin inhibitor-related nephrotoxicity
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11:45 AM – 12:45 PM
(526.10) Deconvolution of Bulk RNAseq Data from Human Liver Samples Reveals a Metabolic Switch in Periportal Hepatocytes in Alcoholic Hepatitis
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11:45 AM – 12:45 PM
(526.11) Mast Cells Contribute to Hepatic Neurokinin1 Receptor Signaling, Subsequent Biliary Damage and Peribiliary Fibrosis Via TGF-β1 Signaling in MDR2-/- Mouse Model of Primary Scelrosing Cholangitis
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11:45 AM – 12:45 PM
(526.12) Toxic form of steatosis in dairy cows (clinical, hematological and histological data)
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11:45 AM – 12:45 PM
(526.13) MicroRNA Drivers for Regenerative Capacity in Liver Transplantation
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11:45 AM – 12:45 PM
(526.14) Hepatocyte β-catenin is regulated by endothelial cell-derived Wnt2 and Wnt9b to govern liver metabolic zonation and regeneration
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11:45 AM – 12:45 PM
(526.15) Integrating Single Cell RNAseq and Computational Modeling to Infer Hepatocyte Metabolic Functionalities during Liver Regeneration
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11:45 AM – 12:45 PM
(526.16) Modulation of miR-21 can reprogram the TGF-β signaling pathway to alter HSC phenotype in vitro
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11:45 AM – 12:45 PM
(526.17) Pharmacological Evaluation of Beta-Hydroxifosphocarnitine in No-Alcoholic Esteatohepatitis Induced in Rats
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11:45 AM – 12:45 PM
(526.18) Gene expression correlation analysis of livers undergoing normothermic machine perfusion identifies interactions between donor demographics and liver function
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11:45 AM – 12:45 PM
(529.10) Comparative evaluation of methods for determining sensitivity to colistin in E. coli isolates
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11:45 AM – 12:45 PM
(529.11) Phenotypical resistance profile of Stenotrophomonas maltophilia insolated from farm amimals
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11:45 AM – 12:45 PM
(529.12) Aspects of Mannheimia haemolytica cryopreservation
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11:45 AM – 12:45 PM
(529.13) Benefit of Circadian Clocks in Adaptive Immunity And Vaccination Responses
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12:45 PM – 2:00 PM
(483.1) DNA Polymerase-Parental DNA Interaction is Essential for Helicase-Polymerase Coupling in Bacteriophage T7 DNA Replication
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12:45 PM – 2:00 PM
(483.2) Implications of DNA Polymerase Gamma in the Repair of the Mitochondrial Genome
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12:45 PM – 2:00 PM
(483.3) Structures of LIG1 engaging with mutagenic mismatches inserted by polβ in base excision repair
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12:45 PM – 2:00 PM
(483.4) Unique DNA Polymerase kappa Interactome Suggests Novel Cellular Functions
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12:45 PM – 2:00 PM
(483.5) Processing of DNA Clamp Loader Subunit DnaX Is Important in the Absence of Caulobacter Cell Division Inhibitors
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12:45 PM – 2:00 PM
(483.6) Single-Molecule Analysis of in vivo DNA Replication Origin Licensing Stoichiometry
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12:45 PM – 2:00 PM
(483.7) Deletion of Ch. IV Telomeres via Genetic Engineering of a Circular Chromosome in the Budding Yeast S. cerevisiae
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12:45 PM – 2:00 PM
(483.8) Role of key protein residues involved in DinB DNA damage specificity: an in silico study
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12:45 PM – 2:00 PM
(483.9) A biochemistry platform to incorporate replication forks, DNA lesions, and nucleosome arrays to single-molecule experiments
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12:45 PM – 2:00 PM
(484.1) Nucleolar function is regulated by the mitochondrial protein sulfite oxidase (SUOX)
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12:45 PM – 2:00 PM
(484.2) Immunofluorescent and Immunohistochemical (Colorimetric) Characterization of B-DNA, Z-DNA and G4-Quadruplex DNA in Human Tissues Demonstrating the Spatial Genomic Organization of Different DNA Structures: Genomesorganizomics
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12:45 PM – 2:00 PM
(484.3) Investigating the Transition of the Core Centromeric Nucleosome Complex from Interphase to Mitosis using Chemical Biology Tools
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12:45 PM – 2:00 PM
(484.4) Measurement of UHRF1 and UHRF2 Interaction With Nucleosomes
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12:45 PM – 2:00 PM
(484.5) Identifying Genes with Consistently Noisy Expression in S. cerevisiae
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12:45 PM – 2:00 PM
(484.6) PROTECTION OF TELOMERES 1b Modulates Cellular ROS and Chromatin Structure in Arabidopsis thaliana
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12:45 PM – 2:00 PM
(484.7) The stretch region within the TTD domain of UHRF2 is a disordered region
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12:45 PM – 2:00 PM
(484.8) To ChIP, or to CUT, that is the question: Comparative Evaluation of NextGen Methodologies for Studying the genome-wide distribution of Histone H3 Lysine 9 di-methyl mark in pancreatic cells
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12:45 PM – 2:00 PM
(484.9) Transcriptional Landscape Established by the Euchromatic Histone-lysine N-methyltransferase Pathway During Pancreas Ontogenesis and Pancreatitis
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12:45 PM – 2:00 PM
(485.1) DANCR acetylated-KLF5 induces cisplatin resistance in triple-negative breast cancer by inhibiting the transcription of p27Kip1
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12:45 PM – 2:00 PM
(485.2) Kinetic networks identify key regulatory nodes and transcription factor functions in early adipogenesis
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12:45 PM – 2:00 PM
(485.3) Spt5-nucleic acid interactions are directly involved in promoter proximal pausing of RNA polymerase II
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12:45 PM – 2:00 PM
(485.4) The Shape of Silence: A Role for the Nuclear Envelope in Transcriptional Regulation
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12:45 PM – 2:00 PM
(485.5) The Codependent Expression of Yeast RNA Polymerase I Rpa34/Rpa49 Heterodimer Subcomplex
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12:45 PM – 2:00 PM
(485.6) Genotoxic Stress Globally Downregulates Transcription in Budding Yeast
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12:45 PM – 2:00 PM
(485.7) Characterization of Fly POLR1D Mutations in a Clinically Relevant Residue Associated with Treacher Collins Syndrome (TCS)
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12:45 PM – 2:00 PM
(485.8) Eukaryotic RNA Polymerase ⍺-like Subunits Heterodimerize by Distinct Interaction Mechanisms
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12:45 PM – 2:00 PM
(485.9) Developing RNA-Seq and ChIP-Seq Pipelines on an Oxford Nanopore Technologies Platform to Study Notch1 Transcriptional Dynamics
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12:45 PM – 2:00 PM
(486.1) The NuA4 Acetyltransferase, Acetylation of Histone H4 and the H2A.Z Variant Histone are Required for Appropriate RNA Splicing in Saccharomyces cerevisiae
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12:45 PM – 2:00 PM
(486.2) A Novel Connection Between [PSI+] Prion Formation and RNA Splicing in Saccharomyces cerevisiae
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12:45 PM – 2:00 PM
(486.3) SUMO Regulates Histone mRNA Processing and Polyadenylation
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12:45 PM – 2:00 PM
(486.4) Thermodynamic analysis of SL1 1x2 internal loop in SARS-CoV-2
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12:45 PM – 2:00 PM
(486.5) The Effects of Ribosomal Proteins uS2, uS3, and uS4 on Transcription
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12:45 PM – 2:00 PM
(486.6) Computational and Genetic Exploration of RNA-binding FinO-domain Structures
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12:45 PM – 2:00 PM
(486.7) Structural characterization of the Long Non-Coding RNA SChLAP1
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12:45 PM – 2:00 PM
(486.8) Med13 Plays a Dual Role in Promoting P-Body Assembly
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12:45 PM – 2:00 PM
(486.9) Searching for Novel sRNA-Binding Proteins in Chlamydia trachomatis
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12:45 PM – 2:00 PM
(487.1) Interplay between TPR nucleoporin and TREX-2 complex in mRNA export
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12:45 PM – 2:00 PM
(487.2) Phosphorylation-specific recruitment of human SCAF6 to RNA polymerase II during transcription regulation
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12:45 PM – 2:00 PM
(487.3) Harness RNA-binding protein HuR to boost Anti-PD-1 Immunotherapy in immunologically cold tumors
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12:45 PM – 2:00 PM
(487.4) Biochemical Characterization of the Sexually Dimorphic Helicases DDX3X and DDX3Y
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12:45 PM – 2:00 PM
(487.5) The Role of SARS-CoV Nonstructural Protein 1 in Cytoplasmic Stress Granule Formation
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12:45 PM – 2:00 PM
(487.6) Nucleolin’s Role in the Biogenesis of Pri-miRNA 16 by the Microprocessor Complex: An In silico Approach
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12:45 PM – 2:00 PM
(487.7) Antisense Molecules Designed to Target SARS-CoV-2 are Nontoxic to the Host in a Murine Model
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12:45 PM – 2:00 PM
(488.1) RNA Modifications Destabilize a Pyrimidine-Motif RNA●DNA-DNA Triple Helix
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12:45 PM – 2:00 PM
(488.2) Circulating MicroRNAs in Canine Congestive Heart Failure – Why Exosomes?
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12:45 PM – 2:00 PM
(488.3) Determining The mRNA Which microRNA-379-5p Inhibitor Is Targeting in Human Lung A549 Cells
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12:45 PM – 2:00 PM
(488.4) Mutational analysis of the oligomerization domain of the HERV-K Rec protein
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12:45 PM – 2:00 PM
(488.5) Characterization and Modeling of Conserved RNA Elements Within the Human Coronavirus OC43 5’ UTR
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12:45 PM – 2:00 PM
(488.6) Identification and Characterization of Small Regulatory RNA in Streptococcus
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12:45 PM – 2:00 PM
(488.7) Multi-assay profiling of diminazene library reveals predictive bidirectional modulation of MALAT1 triplex stability in vitro
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12:45 PM – 2:00 PM
(488.8) The potential role of microRNA as bio markers in canine congestive heart failure
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12:45 PM – 2:00 PM
(488.9) Structural studies of regulatory elements in the RNA transcript for streptolysin S associated gene A (sagA) in group A Streptococcus
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12:45 PM – 2:00 PM
(489.1) Inhibiting the Interaction Between von Willebrand Factor and Collagen Using Novel Peptides to Prevent Thrombosis Initiation
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12:45 PM – 2:00 PM
(489.2) Predicting Protein Function and Orientation on a Gold Nanoparticle Surface Using a Residue-Based Affinity Scale
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12:45 PM – 2:00 PM
(489.3) Engineering Prophylactic Biosynthesis of an Antituberculosis Antibiotic
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12:45 PM – 2:00 PM
(489.4) Modelling the Applications of CRISPR-Cas9 for Treating Sickle Cell Disease
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12:45 PM – 2:00 PM
(489.5) The role of PETase in Breaking Down Polyethylene Plastics
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12:45 PM – 2:00 PM
(489.6) Investigating CTLA-4 binding to generate novel small-molecule inhibitor
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12:45 PM – 2:00 PM
(489.7) Parkinsons Disease
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12:45 PM – 2:00 PM
(489.8) Synthesis of the transmembrane domain of the accessory protein ORF7a of SARS-CoV-2 using solid phase peptide synthesis and analyzing the oligomerization state
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12:45 PM – 2:00 PM
(489.9) Metal Substrate Translocation and Transport Mechanism of the Sinorhizobium meliloti P1B-5-type ATPase Nia Revealed by In-vitro Transport Assays in Proteoliposomes
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12:45 PM – 2:00 PM
(490.1) Synergy of Nrf2-Activating Electrophiles in Combination with the Nrf2-Inhibitor KI696: A Model of Mechanistic Basis for Synergy
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12:45 PM – 2:00 PM
(490.2) STAT3 Nuclear Accumulation Due to Loss of RanBP2 May Contribute to Pathogenesis of Acute Necrotizing Encephalopathy
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12:45 PM – 2:00 PM
(490.3) Oxidative Stress Suppresses Nrf2 Protein Synthesis through Global Protein Synthesis Inhibition
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12:45 PM – 2:00 PM
(490.4) Ribosomal quality control in repeat-associated non-AUG translation of GC rich repeats (Board A101)
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12:45 PM – 2:00 PM
(490.5) Increased Oxidation From Glucose Limiting Conditions or SOD Deletions Result in Activation of No-Go Decay and Subsequent P-body Assembly
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12:45 PM – 2:00 PM
(490.6) A Directed Evolution Experiment to Improve Protein Splicing of Two Inteins From Haloquadratum walsbyi
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12:45 PM – 2:00 PM
(490.7) Exploring the Role of Arginine Methylation in the RNA Helicase, Ded1
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12:45 PM – 2:00 PM
(490.8) Dual Pathways for B. anthracis Asparaginyl-tRNA Formation
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12:45 PM – 2:00 PM
(490.9) RBM20 regulates muscle hypertrophy through titin and calcium signaling
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12:45 PM – 2:00 PM
(491.1) Transient local secondary structure in the intrinsically disordered C-term of the Albino3 insertase
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12:45 PM – 2:00 PM
(491.2) Using molecular modeling to identify potential anti-tubulin compounds
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12:45 PM – 2:00 PM
(491.3) Examining the Interaction Between Cas9 and Ku, and its Implications for Gene Editing
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12:45 PM – 2:00 PM
(491.4) Allosteric Regulation of Coregulator Recruitment in FXR
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12:45 PM – 2:00 PM
(491.5) Ligands Binding Peptidoglycan-Associated Lipoprotein as Biomarkers for Sepsis
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12:45 PM – 2:00 PM
(491.6) Elucidating the Effect of Point Mutations on Gamma B Crystallin Protein Interactions
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12:45 PM – 2:00 PM
(491.7) Determining Protein D Antibody Suppression by OMP26
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12:45 PM – 2:00 PM
(491.8) Probing the potential interactions between two protein vaccine candidates from Nontypeable Haemophilus influenzae
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12:45 PM – 2:00 PM
(491.9) Probing Pal-TolB Interactions Using Site-directed Mutagenesis
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12:45 PM – 2:00 PM
(492.2) Extending the Catalytic HECT Domain Boundaries for the HECT E3 Ubiquitin Ligase HACE1 Increases Solubility and Enzymatic Activity
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12:45 PM – 2:00 PM
(492.3) Detection of cofactor conformer exchange in the active sites of methyltransferases with vibrational spectroscopy
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12:45 PM – 2:00 PM
(492.4) New insights into regulation of P-Rex1 autoinhibition
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12:45 PM – 2:00 PM
(492.5) Characterization of the Structure, Stability, Bioactivity of Recombinant FGF19
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12:45 PM – 2:00 PM
(492.6) Methionine-aromatic Interaction as a Tool to Enhance Protein Stability
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12:45 PM – 2:00 PM
(492.7) Structural and Biophysical Mechanisms Driving Differential Hormone Response in Steroid Receptors
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12:45 PM – 2:00 PM
(492.8) 19F-NMR shows that active site aromatic residues in CYP121 of Mycobacterial tuberculosis play a dual role in substrate interaction and protein structure
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12:45 PM – 2:00 PM
(492.9) From Alignment Laser to 3D Structures: Determining Structures of GPCRs in a Compact X-ray Light Source
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12:45 PM – 2:00 PM
(493.1) Investigating the Roles of NAC and RAC in Suppressing Prion Formation in Saccharomyces cerevisiae
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12:45 PM – 2:00 PM
(493.2) A Yeast Model System to Study the Human Orthologs of the Ribosome-Associated Complex
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12:45 PM – 2:00 PM
(493.3) Role of HSP90 Family Molecular Chaperone in Regulating Chloroplast Protein Homeostasis and Plant Development in Arabidopsis
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12:45 PM – 2:00 PM
(493.4) Folding state as the Decision Maker in Detecting Misfolded Proteins by Hsp70
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12:45 PM – 2:00 PM
(493.5) Structural Elements of ‘Anti-prion J protein 1’ (Apj1) Required for Efficient Curing of the [PSI+] Prion by Hsp104 Overexpression
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12:45 PM – 2:00 PM
(493.6) Domain Analysis of Arabidopsis Thaliana Sis1 Orthologs in Yeast Prion Propagation
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12:45 PM – 2:00 PM
(493.7) Client Specificity of an ATP-independent Chaperone is Regulated by a Temperature Sensitive Switch
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12:45 PM – 2:00 PM
(494.1) The Regulation of Basal Autophagic Flux by an ATG13-ATG101 Complex
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12:45 PM – 2:00 PM
(494.2) A novel ClpX degron targets the E. coli antitoxin MqsA for degradation by ClpXP
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12:45 PM – 2:00 PM
(494.3) Elucidating the cellular mechanism of methionine toxicity
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12:45 PM – 2:00 PM
(494.4) Liver-Heart Microphysiological Organoid Model for the Study and Treatment of Cardiac Amyloidosis
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12:45 PM – 2:00 PM
(494.5) Optimization of a Chaperone Protein Disaggregase Complex for Neurodegenerative Disease
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12:45 PM – 2:00 PM
(494.6) Elucidating the mechanism of potentiated Hsp104 NBD2 variants against proteotoxicity
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12:45 PM – 2:00 PM
(494.7) The Role of Heat Shock Proteins in Amyloid Body Reversal
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12:45 PM – 2:00 PM
(495.1) Structure of a pathologic amyloid nucleus determined by rational genetic deconstruction of an intracellular nucleation barrier
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12:45 PM – 2:00 PM
(495.2) Increased Nuclear Localization of Engineered Hsp104 Variants Mitigates aS, FUS, and TDP-43 Toxicity in Yeast
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12:45 PM – 2:00 PM
(495.3) Exploring the Effect of RNA Binding on TDP-43 Liquid-Liquid Phase Separation
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12:45 PM – 2:00 PM
(495.4) Structural Investigation of a Putative Intrinsically Disordered Region Within Deleted in Colorectal Carcinoma That Regulates Protein Synthesis
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12:45 PM – 2:00 PM
(495.5) Enhanced Brain Retention of Aβ4-x Proteoforms and its Contribution to Amyloid Deposits in Alzheimer’s Disease
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12:45 PM – 2:00 PM
(495.6) The Extracellular Chaperone Clusterin in Aβ and Non-Aβ Cerebral Amyloidoses
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12:45 PM – 2:00 PM
(496.1) The 26S Proteasome Switches Between ATP-Dependent and Independent Mechanisms in Response to Substrate Ubiquitination
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12:45 PM – 2:00 PM
(496.2) Minimal mechanistic component of proteasome activation and prevention of impairment by pathological oligomers
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12:45 PM – 2:00 PM
(496.3) Altering the Stability of an Upstream Domain Affects the Proteasome’s Ability to Unfold a Downstream Domain
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12:45 PM – 2:00 PM
(496.4) Proteasome Localization is Regulated Through Mitochondrial Respiration and Kinase Signaling
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12:45 PM – 2:00 PM
(496.5) Proteasome Shuttle Factors Regulate the Relocalization of Proteasomes to Cytosolic Granules upon Specific Stress Conditions
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12:45 PM – 2:00 PM
(497.1) Expression, Characterization, and Analysis of Type II Metacaspases from the Fungus Schizophyllum commune
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12:45 PM – 2:00 PM
(497.2) Effects of macromolecular crowding on the enzyme kinetics and thermodynamics of glutamate dehydrogenase with the substrate norvaline
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12:45 PM – 2:00 PM
(497.3) Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen Clostridioides difficile
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12:45 PM – 2:00 PM
(497.4) Transformations of phosphonates by non-heme iron-dependent oxygenases
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12:45 PM – 2:00 PM
(497.5) Structural Enzymology of the Cysteine Tryptophylquinone (CTQ) Enzyme GoxA
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12:45 PM – 2:00 PM
(497.6) NMR-Guided Directed Evolution of a Kemp Eliminase
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12:45 PM – 2:00 PM
(497.7) Characterization of an S-adenosylmethionine Dependent X-Succinate Synthase Activating Enzyme
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12:45 PM – 2:00 PM
(497.8) Structural insight into key mevalonate pathway enzymes
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12:45 PM – 2:00 PM
(497.9) Elucidating The Nicotinic Acid Degradation Pathway In Bacillus niacini: Identification and Biochemical Characterization Of Proteins Of Unknown Function
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12:45 PM – 2:00 PM
(498.1) Effect of pH Dependent Substrate Inhibition on Glutamate Dehydrogenase Kinetics
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12:45 PM – 2:00 PM
(498.2) Mechanism of Inosine-Uridine Nucleoside Hydrolase (IU-NH) from Arabidopsis thaliana
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12:45 PM – 2:00 PM
(498.3) Effect of loop variants on enzymatic activity in acyl-protein thioesterases
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12:45 PM – 2:00 PM
(498.4) Exploring the novel mechanistic aspects of function of a hyperthermophile two-site exo-amylase-cum-glucanotransferase displaying substrate versatility
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12:45 PM – 2:00 PM
(498.5) Derivatives of 3,4-dihydroxyhydrocinnamic acid at the 6-position as mechanistic probes of L-DOPA dioxygenase
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12:45 PM – 2:00 PM
(498.6) Exploring The Promiscuity Potential Of 6-Hydroxynicotinate-3-Monooxygenase: Consequences To Catalysis Of Adding A Nitrogen At C5 Within The Substrate’s Aromatic Ring
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12:45 PM – 2:00 PM
(498.7) The Multiple Roles of the Active Site Loop of Watermelon Glyoxysomal Malate Dehydrogenase
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12:45 PM – 2:00 PM
(498.8) Enzymatic production of acetaldehyde using a Pseudomonas fluorescens mannitol-2-dehydrogenase mutant to regenerate NAD+
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12:45 PM – 2:00 PM
(498.9) Macromolecular Crowding Effects on Citrate Synthase Kinetics are Concentration-Dependent
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12:45 PM – 2:00 PM
(499.1) Conformational Dynamics Linking Kinase and Endonuclease Domains Explain the Divergent Function of IRE1 Paralogues
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12:45 PM – 2:00 PM
(499.2) Investigation of structural factors controlling loop dynamics in acyl protein thioesterases
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12:45 PM – 2:00 PM
(499.3) Evolution of enzymatic function through gene duplication in the metallocarboxypeptidase family
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12:45 PM – 2:00 PM
(499.4) The Effect of Mutations on Protein-Protein and Protein-Ligand Interactions for a 17β-Hydroxysteroid Dehydrogenase
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12:45 PM – 2:00 PM
(499.5) Allosteric networks regulate function in multi-enzyme complexes
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12:45 PM – 2:00 PM
(499.6) Malate Dehydrogenase-Citrate Synthase Multienzyme Complex Dynamics Is Affected By TCA Cycle Flux In Living Yeast Cells
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12:45 PM – 2:00 PM
(499.7) Visualizing the Gas Channel of a Monofunctional Carbon Monoxide Dehydrogenase
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12:45 PM – 2:00 PM
(499.8) Structural Remodelling of the Carbon-Phosphorus Enzymatic Machinery by a Dual ATP-Binding Cassette Module
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12:45 PM – 2:00 PM
(499.9) Functional Dynamics of Deubiquitinase A
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12:45 PM – 2:00 PM
(500.1) Molecular Basis for Antiviral Action of EDP-235: A Potent and Selective SARS-CoV-2 3CLpro Inhibitor for the Treatment of Covid 19
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12:45 PM – 2:00 PM
(500.2) Analysis of Swelling Capability and Efficacy of Gelatin-Based Antibiotic Eluting Hemostatic Agents
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12:45 PM – 2:00 PM
(500.3) Design and Evaluation of Cleavable CoQ-triphenylphosphonium Analogs
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12:45 PM – 2:00 PM
(500.4) Towards the Selection of Single-Stranded DNA Molecular Recognition Element Against Cyanotoxin L-BMAA
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12:45 PM – 2:00 PM
(500.5) Intracellular Delivery of Functional Proteins
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12:45 PM – 2:00 PM
(500.6) Studying the Impact of Annonaceous Acetogenin, A Prominent Component in Graviola Leaves, on the Growth of Glioblastoma Cancer Cells
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12:45 PM – 2:00 PM
(500.7) Development of DNA Aptamers Against Structural Proteins of SARS-CoV-2
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12:45 PM – 2:00 PM
(500.8) The minor groove topology of nucleic acid ligands plays a key role in nuclease resistance and targeting of HMGB1
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12:45 PM – 2:00 PM
(500.9) A Small-molecule Inhibitor VM17 Targeting a Transcriptional Regulator HlyU Attenuates the Virulence of Vibrio vulnificus
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12:45 PM – 2:00 PM
(501.1) A Flavonoid Compound 7, 4 Dihydroxy Flavone as a Potential Therapeutic for the Treatment and Management of EoE
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12:45 PM – 2:00 PM
(501.2) Ex vivo and In vivo Assays for Drug Discovery and Detection of Photoreceptor Survival Factors
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12:45 PM – 2:00 PM
(501.3) The effect of the linker in urea-based soluble epoxide hydrolase inhibitors’ on their blood-brain penetration ability and drug-like properties
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12:45 PM – 2:00 PM
(501.4) Virtual Screening Approach to Repurpose FDA-approved Drugs for Targeting Acid Ceramidase-1 in Pancreatic Cancer
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12:45 PM – 2:00 PM
(501.5) The neuroprotective effect of a novel 1,4-Dihydroquinazolin-3(2H)-yl benzamide derivative against chronic constriction injury-induced neuropathic pain in rats
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12:45 PM – 2:00 PM
(501.6) Characterization of Novel A3 Adenosine Receptor Allosteric Modulators
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12:45 PM – 2:00 PM
(502.1) Synthesis of Anthraquinone Derivatives for the Replacement of Cibacron Blue 3G-A
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12:45 PM – 2:00 PM
(502.2) Ligand Specificity in Progesterone Receptor
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12:45 PM – 2:00 PM
(502.3) Computational Approaches to Identify a Novel Binding Site on Estrogen Receptor α
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12:45 PM – 2:00 PM
(502.4) FXR ligand structure impact on FXR-DNA binding
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12:45 PM – 2:00 PM
(502.5) Development and Characterization of Novel LRH-1 Antagonist Using Structural and Computational Techniques
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12:45 PM – 2:00 PM
(502.6) The Selection of Novel Drugs for the Inhibition of Sterol Carrier Protein-2
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12:45 PM – 2:00 PM
(502.7) Characterization of Protein Tyrosine Phosphatase 1B activator peptides in cells
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12:45 PM – 2:00 PM
(502.8) α-hydroxytropolones Inhibit RNase H1 Noncompetitively Despite Binding in the Active Site
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12:45 PM – 2:00 PM
(503.1) Pharmacological Modulation of B16-F10 Murine Melanoma-Induced TAMs Functional Phenotype via Lipoprotein-Based Nanoparticles
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12:45 PM – 2:00 PM
(503.2) A Modular Approach Toward Controlling Stability of Oligonucleotide-Stabilized Lipid Micelles
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12:45 PM – 2:00 PM
(503.3) Effect of Viscosity on Fouling: Investigation into Pre-Treatment of Saliva Samples for a Point-of-care SARS-CoV-2 Device
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12:45 PM – 2:00 PM
(503.4) Novel HDL mimicking targeted drug delivery system for the treatment of Ewing Sarcoma
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12:45 PM – 2:00 PM
(503.5) Size Characterization of Graphene-coated Silver Nanoparticles for Drug Delivery System Design
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12:45 PM – 2:00 PM
(503.6) Gold Nanoparticles as a Drug Delivery Vehicle System Against ErbB2+ Breast Cancer
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12:45 PM – 2:00 PM
(503.7) Synthesis and Characterization of Biopolyol-based Waterborne Polyurethane Modified through Complexation with Chitosan
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12:45 PM – 2:00 PM
(503.8) Design and characterization of Eco-friendly composite for bone tissue engineeing
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12:45 PM – 2:00 PM
(504.1) Targeted Metabolomics Reveals Plasma Biomarkers and Metabolic Alterations of the Aging Process in Healthy Young and Older Adults
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12:45 PM – 2:00 PM
(504.2) LC/MS coupled to PODIUM establishes the amino acid metabolomes of Sorghum bicolor
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12:45 PM – 2:00 PM
(504.3) Lipidomics identifies novel circulating markers of CVD risk in African American and Caucasian women
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12:45 PM – 2:00 PM
(504.4) Changes to the Neurospora crassa metabolome as a result of defects in arginine catabolism
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12:45 PM – 2:00 PM
(504.5) Elucidating the Physiological Role of Guanidinium (Gdm+) in Bacteria
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12:45 PM – 2:00 PM
(504.6) Neucode Tags for Highly Multiplexed Metabolomics
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12:45 PM – 2:00 PM
(504.7) Loss of Pkm2 Alters Myocardial Metabolism and Increases Oxidative Stress After Infarction
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12:45 PM – 2:00 PM
(504.8) Metabolomics can spot the difference: Dried Blood Spot (DBS) coming of age in a metabolomics era
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12:45 PM – 2:00 PM
(504.9) Metabolomic Signatures of Ocean Acidification Stress in the Coral Acropora millepora
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12:45 PM – 2:00 PM
(505.1) Proper cell-to-cell communication relies on signal coordination, and signal coordination relies on transcription fidelity
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12:45 PM – 2:00 PM
(505.2) Proteins of the ubiquitin system in the Shoc2 - ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair (NSLAH) RASopathy
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12:45 PM – 2:00 PM
(505.3) Investigating the Effects of Vaping and Nicotine’s Block of Kir2.1 on Humerus and Digital Development in Embryonic Mice
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12:45 PM – 2:00 PM
(505.4) Differential Behavior of 4E-BP1 and 4E-BP2 Under ER Stress
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12:45 PM – 2:00 PM
(505.5) An siRNA library screen for endothelial PAR1-specific deubiquitinases regulating p38 MAPK inflammatory signaling
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12:45 PM – 2:00 PM
(505.6) Neuroimmunomodulatory balance between pro and anti-inflammatory cytokines regulate m-CoV induced alteration of gap junction protein Cx43
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12:45 PM – 2:00 PM
(505.7) Unconventional GPCR-PKA Signaling in the Hedgehog Pathway
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12:45 PM – 2:00 PM
(505.8) Mapping Allosteric Sites on Protein Kinases Critical in MAPK Signaling
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12:45 PM – 2:00 PM
(505.9) PLEKHA5 Regulates Mitotic Progression by Promoting APC/C Localization to Microtubules
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12:45 PM – 2:00 PM
(506.1) Membrane Targeting of Constitutively Active Gαq Regulates Inhibition by YM-254980
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12:45 PM – 2:00 PM
(506.2) Abscisic Acid Controlled Redox Proteome of Arabidopsis and its Regulation by Heterotrimeric G-proteins
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12:45 PM – 2:00 PM
(506.3) YM-254890 Promotes the Subcellular Redistribution of Gαq
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12:45 PM – 2:00 PM
(506.4) Biochemical Mechanisms that Control the Effects of RhoA Small GTPase Signaling on Synaptic Stability and Cognition
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12:45 PM – 2:00 PM
(506.5) Identification of Peptide Inhibitors of Gαs that Block its Effector Binding Site
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12:45 PM – 2:00 PM
(506.6) Optogenetic inhibition of subcellular GαqGTP signaling
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12:45 PM – 2:00 PM
(506.7) Identifying Vesicular Localization of the Rho GTPase RhoJ/TCL Through Colocalization with Rab Family GTPases
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12:45 PM – 2:00 PM
(506.8) An optogenetic GDI drives GPCR and Gα independent macrophage migration
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12:45 PM – 2:00 PM
(506.9) Role of the orphan receptors GPR21, GPR39, GPR82 and GPR6 in chronic inflammation in 3T3-L1 adipose model
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12:45 PM – 2:00 PM
(507.1) Development of Tumor-selective Transmembrane Peptides to Promote the Activity of the Receptor Protein Tyrosine Phosphatase J by Disrupting its Homodimerization
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12:45 PM – 2:00 PM
(507.2) Regulation of Mitogen-Activated Protein Kinase Hog1 Phosphorylation Induced by DNA Damage Agent in Saccharomyces cerevisiae
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12:45 PM – 2:00 PM
(507.3) Plant Phytochrome B Assembles an Asymmetric Dimer with Unique Signaling Potential
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12:45 PM – 2:00 PM
(507.4) Kinase Domain Autophosphorylation Rewires the Activity and Substrate Specificity of CK1 Enzymes
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12:45 PM – 2:00 PM
(507.5) Identification of protein interactors of BRAF via Chemical Induced Dimerization-BRAF and LC-MS/MS
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12:45 PM – 2:00 PM
(507.6) Analysis of Cancer-associated Mutations in the Novel PKC Theta
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12:45 PM – 2:00 PM
(507.7) TNK1 is a ubiquitin-sensing kinase that can be targeted to block tumor growth
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12:45 PM – 2:00 PM
(507.8) A 14-3-3-mediated mechanism of regulation for the ubiquitin-sensing kinase TNK1
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12:45 PM – 2:00 PM
(507.9) A mechanism of regulation for the ubiquitin-sensing kinase TNK1
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12:45 PM – 2:00 PM
(508.1) Increased Levels of Stress Induces a More Metastatic Phenotype in Human Melanoma Cells
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12:45 PM – 2:00 PM
(508.2) Transcriptional regulation of Rab21 GTPase in leukemia
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12:45 PM – 2:00 PM
(508.3) Effect of Knock-out of the a4 Isoform of Vacuolar H+-ATPase following CRISPR/Cas9 on Activation of Cathepsins in MDA-MB231 Breast Cancer Cell
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12:45 PM – 2:00 PM
(508.4) Deregulation of PiwiL1 and associated RNAs in cervical cancer: is HPV oncogene responsible?
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12:45 PM – 2:00 PM
(508.5) Investigating the Molecular and Phenotypic Differences in Pancreatic Neuroendocrine Tumor (PanNET) Cells with Functional Loss of Either ATRX or DAXX
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12:45 PM – 2:00 PM
(508.6) Differential Expression of Nuclear Body Component, Zc3h8, Disrupts DNA Double Strand Break Repair
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12:45 PM – 2:00 PM
(508.7) Anti-Tumor Effect of Embryonic Stem Cell Derived Exosomes in Triple Negative Breast Cancer: Potential Role of TCF7-E-Cadherin and VEGF
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12:45 PM – 2:00 PM
(509.1) Aryl hydrocarbon Receptor (AhR) Promotes Cell Growth, Induces Stemness Like Characteristics and Metastasis in Ovarian Cancer Cells via Activation of Akt, β-Catenin and EMT
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12:45 PM – 2:00 PM
(509.2) A Computational Method for the Visualization of Nitrated Hsp90 Distribution in 3D Culture Models
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12:45 PM – 2:00 PM
(509.3) GPR30: A potential therapeutic target in Triple-negative Inflammatory Breast Cancer
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12:45 PM – 2:00 PM
(509.4) Elucidating the Anticancer Mechanism of Arachidin-1 in Triple-Negative Breast Cancer Cells
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12:45 PM – 2:00 PM
(509.5) The Sulfiredoxin-Peroxiredoxin axis promotes urethane-induced lung adenocarcinoma through the regulation of the tumor microenvironment
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12:45 PM – 2:00 PM
(509.6) DNA Repair of Ovarian Cancer Cell Lines SKOV3 and OV90 Compared to Non-Transformed PBMC Cells
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12:45 PM – 2:00 PM
(509.7) Alisol B23-Acetate Targets SHH Signaling in MED12 Knockdown Breast Cancer Cells to Inhibit Oncogenesis
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12:45 PM – 2:00 PM
(509.8) Glycoalkaloid Solasonine Targets SHH Signaling to Block MED12 Mutant Breast Cancer Oncogenesis
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12:45 PM – 2:00 PM
(509.9) Role of SOX18 in Promoting Tumorigenesis in Pediatric Cancer Cell Lines
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12:45 PM – 2:00 PM
(510.1) Utilizing mpx:gfp transgenic zebrafish to assess eya3’s potential effects on neutrophils
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12:45 PM – 2:00 PM
(510.2) Insulin-like growth factor 1 induces a reparative neutrophil phenotype
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12:45 PM – 2:00 PM
(510.3) Targeting Hypoxia-Adenosinergic Signaling to Enable Effective Anti-Tumor Responses by Reprogramming the Immunosuppressive Tumor Microenvironment
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12:45 PM – 2:00 PM
(510.4) Aggregated Alpha-Synuclein Activates Pro-Inflammatory NFKB Signaling Pathways Through TLR-Dependent and Independent Mechanisms in Peripheral Monocytic Cells
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12:45 PM – 2:00 PM
(510.5) Dopamine D2-Like Receptor Signaling and Downregulation of Filamin-A May Drive the Association Between Neighborhood Socioeconomic Status and CCR2 Expression on Monocytes
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12:45 PM – 2:00 PM
(510.6) Effects of Dibutyltin Exposures on Translation Regulatory Factors eIF4E, eIF4B, and S6 in Human Immune Cells
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12:45 PM – 2:00 PM
(510.7) Effects of Poly-Substituted Pyrroles on Pro-Inflammatory Signaling in RAW264.7 Macrophages
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12:45 PM – 2:00 PM
(510.8) β-Adrenergic Receptor Signaling Reduces Pro-Inflammatory Signaling and Promotes the M2 Phenotype in the RAW264.7 Macrophage Cell Line
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12:45 PM – 2:00 PM
(510.9) Osmosensing by cytoplasmic biomolecular condensates of antiviral MxA GTPase
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12:45 PM – 2:00 PM
(511.1) Analysis of Domain Structure of the Bacterial Mating Protein ConB of Bacillus subtilis
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12:45 PM – 2:00 PM
(511.2) Role of ConE’s ATPase Motifs in Protein-Protein Interactions within the Conjugation Machinery of Bacillus subtilis
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12:45 PM – 2:00 PM
(511.3) Effects of T-2 Toxin on the Intestinal Cecum Microbiome of Broiler Chickens
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12:45 PM – 2:00 PM
(511.4) Characterizing F.nucleatum complement resistance
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12:45 PM – 2:00 PM
(511.5) Cellular localization, immunological function and biophysical characterization of Mycobacterium tuberculosis Methyltransferases
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12:45 PM – 2:00 PM
(511.6) Profiling Growth Patterns of Human Gut Microbes in Response to Preterm Human Milk and Formula
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12:45 PM – 2:00 PM
(512.1) Isolation of Multidrug Resistant Bacteria from the Lane College Soil
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12:45 PM – 2:00 PM
(512.2) Genesis of Antibiotic Resistance (AR) LXXXV: Turbulence Modeling(TM) of Hemodynamics in Simplified Severe Sepsis Protocol-2 (SSSP-2)-NCT01663701: Clinical Connotation of Monitoring ISP [BP(PP), MAP, CBF, ICP, CPPopt, Comatose GCS 3, and CCP] for Attenuation of IHM
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12:45 PM – 2:00 PM
(512.3) Genesis of Antibiotic Resistance (AR) LXXXVI: Turbulence Modeling(TM) of Hemodynamics in Simplified Severe Sepsis Protocol-2 (SSSP-2)-NCT01663701: Mechanism(s) of ISP Afloat Transient APG Thrust VKVS free shear flow augmented cerebral vessel collapse, GCS3, & IHM
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12:45 PM – 2:00 PM
(512.4) Elucidating the antibiotic sensing mechanism of VanB vancomycin-resistant Enterococci
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12:45 PM – 2:00 PM
(512.5) Genesis of Antibiotic Resistance (AR) LXXXVII: Turbulence Modeling(TM) of Hemodynamics in Simplified Severe Sepsis Protocol-2 (SSSP-2)-NCT01663701: Fluid bolus evoked fluid volume expansion Augmented APG, VSF, reprobate to inviscid fluid (Fluid Stalling, Re= ∞; viscosity=0) augment IHM
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12:45 PM – 2:00 PM
(512.6) Genesis of Antibiotic Resistance (AR) LXXXIX: Turbulence Modeling(TM) of Hemodynamics in Simplified Severe Sepsis Protocol-2 (SSSP-2)-NCT01663701: Global Alliance for an Integrated Data Base on Antibiotic(AR)/Antimicrobial(AMR) Susceptibility Test Interpretive Criteria (Breakpoints) (STIC), to mitigate AR Pandemic(ARP) in turn Fetter Modalities of Neuro(logy)) Psychiatry
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12:45 PM – 2:00 PM
(512.7) Metabolic Regulation of Quiescence and Antibiotic Tolerance in Uropathogenic Escherichia coli
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12:45 PM – 2:00 PM
(512.8) Identification Of Compounds In Melaleuca Alternifolia Oil With Bacteriostatic Activity In Salmonella Typhimurium
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12:45 PM – 2:00 PM
(513.1) Partially Conserved Motifs Support an Alternating Access Model for the Human Mitochondrial NAD+ Transporter
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12:45 PM – 2:00 PM
(513.2) Role of Mitochondrial TNAP in Thermogenesis and Obesity
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12:45 PM – 2:00 PM
(513.3) Mitochondrial Fission is Essential to Maintain Cristae Morphology and Bioenergetics
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12:45 PM – 2:00 PM
(513.4) Regulation of Adipocyte Metabolic Homeostasis by SR-BI and PCPE2
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12:45 PM – 2:00 PM
(513.5) Ketones Improve the Mitochondrial Coupling Efficiency of Brown Adipocytes
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12:45 PM – 2:00 PM
(513.6) Alanine Modulates Lactyl-CoA Abundance in HepG2 Cells
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12:45 PM – 2:00 PM
(513.7) Mitochondrial Calcium Transporters Regulate Autophagy
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12:45 PM – 2:00 PM
(513.8) Regulation of Mitochondrial Calcium Transport by Caloric Restriction in Rat Kidney
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12:45 PM – 2:00 PM
(514.1) Targeting GCN2 Regulation of Amino Acid Homeostasis in Prostate Cancer
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12:45 PM – 2:00 PM
(514.2) Uncovering the Conditionally Essential Roles of NAD Kinases in Human Cells
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12:45 PM – 2:00 PM
(514.3) Influence of High-Polyphenol Sorghum on Benzo[a]pyrene-Metabolizing Enzymes
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12:45 PM – 2:00 PM
(514.4) Aberrant glycogen accumulation alters gene expression and promotes lung tumor progression in vivo
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12:45 PM – 2:00 PM
(514.5) Enhanced Metabolism and Altered Paracrine Signaling in Glioblastoma Following Cytomegalovirus Infection
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12:45 PM – 2:00 PM
(514.6) Development of Cancer-on-a-chip Technology for the Study of Tumor Microenvironment and Metabolism
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12:45 PM – 2:00 PM
(514.7) Prognostic Potential of a PSAT1-Associated Gene Signature in Identifying High-Risk Patients in Early-Stage EGFR-Mutant Lung Cancer
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12:45 PM – 2:00 PM
(514.8) Pre-treatment with cinnamon extract alters MCF7 cell morphology and alters expression level of Akt1 signaling protein and SIRT1
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12:45 PM – 2:00 PM
(515.1) Exercise increases the expression of glucose transport and lipid metabolism genes at optimum level time point 6 hours post exercise in rat skeletal muscle
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12:45 PM – 2:00 PM
(515.2) Pharmacologic or Genetic PDE4 Inactivation Reduces Obesity and Improves Glucose Handling in Mice
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12:45 PM – 2:00 PM
(515.3) Distinct Properties of Adipose Stem Cell Subpopulations Determine Fat Depot-Specific Characteristics
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12:45 PM – 2:00 PM
(515.4) SARM1 NAD Hydrolase Deficiency Normalizes Fibrosis and Ameliorates Cardiac Dysfunction in Diabetic Hearts
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12:45 PM – 2:00 PM
(515.5) Integrated single cell RNA-seq and ATAC-seq of iPSC-derived kidney organoids reveals the complexity of TGFβ signalling to chromatin during the origin of fibroblasts
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12:45 PM – 2:00 PM
(515.6) Zebrafish model of in utero glucose exposure alters developmental programming that leads to life-long metabolic consequences
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12:45 PM – 2:00 PM
(515.7) Molecular and Functional Characterization of the Dual-Specificity Phosphodiesterase Type 10A in Human White Adipocytes
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12:45 PM – 2:00 PM
(515.8) Raman spectroscopy of the skin of an animal model of diet-induced obesity
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12:45 PM – 2:00 PM
(515.9) Identification of Adipose-Specific iNKT Cell Subpopulation through Single-Cell RNA Sequencing
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12:45 PM – 2:00 PM
(516.1) Host lipids required for Membrane protein matrix formation in new severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), ribonucleocapsid packaging and viral assembly
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12:45 PM – 2:00 PM
(516.2) Respiratory defects caused by mutations affecting the Endoplasmic Reticulum-Mitochondria Encounter Structure (ERMES) can be rescued by the deletion of COQ11
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12:45 PM – 2:00 PM
(516.3) Ca2+-activated Sphingomyelin Scrambling and Turnover Mediate ESCRT-independent Lysosomal Repair
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12:45 PM – 2:00 PM
(516.4) Lipid Expansion Microscopy
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12:45 PM – 2:00 PM
(516.5) Exploring the Dynamics and Regulatory Functions of Nuclear Lipids
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12:45 PM – 2:00 PM
(516.6) Formation of Nascent Lipid Droplets at Specialized ER subdomains
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12:45 PM – 2:00 PM
(516.7) Decreasing Phosphatidylcholine on the Lipid Droplet Surface Selectively Recruits Proteins with Amphipathic Alpha Helices
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12:45 PM – 2:00 PM
(516.8) Erythrocyte Fatty Acids and Association with Cardiometabolic Risk Factors in Free-Living Elderly
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12:45 PM – 2:00 PM
(516.9) Acute Manipulation of Outer Membrane Phospholipid Composition Directly Alters Mitochondrial Dynamics and Ultrastructure
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12:45 PM – 2:00 PM
(517.1) Anionic membrane phospholipids: A New Class of Chemokine-Binding Site Important for both Apoptotic Cell Clearance and Antibiotic Activity by Chemokines
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12:45 PM – 2:00 PM
(517.2) Itaconate is a negative regulator of hepatic lipid metabolism during sepsis
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12:45 PM – 2:00 PM
(517.3) Pro-survival lipid metabolism activates intracellular complement signaling to induce inflammasome-mediated tumor metastasis
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12:45 PM – 2:00 PM
(517.4) Enhanced expression of lectin-like oxidized LDL receptor-1 is implicated in the sodium arsenite-induced increase in foam cells from murine macrophages
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12:45 PM – 2:00 PM
(517.5) The TSPO ligand 3,17,19-androsten-5-triol attenuates NASH by increasing FXR expression and autophagy
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12:45 PM – 2:00 PM
(517.6) Carboxylesterase 1 (Ces1) Releases Oxylipins From Oxidized Triacylglycerols: Examination of Its Substrate Selectivity
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12:45 PM – 2:00 PM
(517.7) Effects of Omega-6 Fatty Acids on Interleukin-6, Phospholipase A2, and Prostaglandin-Endoperoxide Synthase 2 Gene Expression in Lipopolysaccharide-Challenged Murine Macrophages and Adipocytes
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12:45 PM – 2:00 PM
(517.8) Increased Endogenous Production of Pro-inflammatory Adipokines by 3T3-L1 Adipocytes Differentiated with Arachidonic Acid
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12:45 PM – 2:00 PM
(517.9) Novel Roles of FFAR4 in Macrophage Foam Cell Formation
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12:45 PM – 2:00 PM
(518.1) Investigating Variant Surface Glycoprotein Dynamics under Inhibition of Fatty Acid Synthesis
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12:45 PM – 2:00 PM
(518.2) Mechanisms of Substrate Selectivity and Transport by a Bacterial Methionine ABC Importer
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12:45 PM – 2:00 PM
(518.3) From Flat to Bulb - Novel Insights in Caveolae Membrane Curvature
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12:45 PM – 2:00 PM
(518.4) Dishevelled localization and function are differentially regulated by structurally distinct sterols
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12:45 PM – 2:00 PM
(518.5) Understanding the Lipid-dependent function of SARS-CoV-2 E Protein
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12:45 PM – 2:00 PM
(518.6) Role of ACAT1 in Atherosclerosis and Alzheimers Disease
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12:45 PM – 2:00 PM
(518.7) Interactions between the aNT Domains of Human V-ATPases and Phosphatidylinositol Phosphate Lipids
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12:45 PM – 2:00 PM
(518.8) Metallated Anticancer Peptides: An Expanded Mechanism that Encompasses Physical and Chemical Bilayer Disruption
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12:45 PM – 2:00 PM
(518.9) A Quantitative Native Mass Spectrometry Platform for Deconstructing Hierarchical Organization of Membrane Proteins and Lipids
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12:45 PM – 2:00 PM
(519.1) The Effect of Antibiotics on Outer Membrane Vesicle Production
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12:45 PM – 2:00 PM
(519.2) A Myosin Vb Splice Variant Regulates Coronavirus M Protein Trafficking in Polarized Epithelial Cells
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12:45 PM – 2:00 PM
(519.4) Triggering toxicity: How antibiotics can enhance the release of outer membrane vesicles from Escherichia coli during sepsis
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12:45 PM – 2:00 PM
(519.5) Auto-inhibitory interactions of Sec7, master regulator of the Golgi complex
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12:45 PM – 2:00 PM
(519.6) Filling in the GAPs- Mapping the Spatiotemporal Kinetics of Arf1 and its Regulators
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12:45 PM – 2:00 PM
(519.7) Structural basis for specific activation of the Rab11 GTPase by the TRAPPII complex
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12:45 PM – 2:00 PM
(519.8) Optimizing the production, purification, characterization of E. coli OMVs
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12:45 PM – 2:00 PM
(519.9) A phosphorylation network controls the stability of alpha-arrestins Aly1/Art6 and Aly2/Art3
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12:45 PM – 2:00 PM
(520.1) The sialyltransferase ST6Gal1 is upregulated in a cytokine-mediated manner during pancreatitis
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12:45 PM – 2:00 PM
(520.2) Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage
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12:45 PM – 2:00 PM
(520.3) Elucidating the Role of Glycogen in Glucose Transporter 1 Deficiency Syndrome
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12:45 PM – 2:00 PM
(520.4) Characterization of the DH475 cooperating antibody and its interaction with the HIV-1 spike
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12:45 PM – 2:00 PM
(520.5) Novel Affinity Chromatography Ligand Utilizing the Biological Interaction Between the N-linked glycans on Monoclonal Antibodies and the FcγIIIA Receptor
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12:45 PM – 2:00 PM
(520.6) O-GlcNAc characterization during Tribolium castaneum development
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12:45 PM – 2:00 PM
(520.7) Nematode hexosaminidases – a new biochemical tool for glycan analysis
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12:45 PM – 2:00 PM
(520.8) Identifying Mucus-Degrading Microbes Within the Human Gut Microbiota
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12:45 PM – 2:00 PM
(520.9) Understanding the Role of Cancer Glycosylation on Antibody Binding to MUC16
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12:45 PM – 2:00 PM
(521.1) Teaching Collaboration Skills to Undergraduate Biochemistry and Chemistry Students
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12:45 PM – 2:00 PM
(521.2) Pilot study of career development and personal values among Biochemistry students
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12:45 PM – 2:00 PM
(521.3) Connecting the Dots: Students’ Mental Organization and Storage of Biochemistry Visual Literacy Skills
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12:45 PM – 2:00 PM
(521.4) Metal Chelators Ethylenediaminetetraacetic acid (EDTA) and N,N,N′,N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine (TPEN) Interfere with Carbonic Anhydrase (CA) Activity in Wilbur-Anderson Assay (WAa)
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12:45 PM – 2:00 PM
(521.5) Communicating Science at 24 fps
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12:45 PM – 2:00 PM
(521.6) You gotta work, BASIL! Reimagining an established CURE to provide high-quality digital learning experiences that are intentionally equitable, inclusive and accessible for all students
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12:45 PM – 2:00 PM
(521.7) Developing Assessments to Gauge Biomolecular Visual Literacy: A 5 step approach to ensuring accuracy and reliability
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12:45 PM – 2:00 PM
(521.8) An Enhanced 1D Electrophoresis Simulation with Pedagogical Tools
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12:45 PM – 2:00 PM
(521.9) Identifying Student Misconceptions in Biomolecular Visualization in the Context of the BioMolViz Framework
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12:45 PM – 2:00 PM
(522.1) CRISPR-ethics in the Undergraduate Classroom using CCR5 Gene
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12:45 PM – 2:00 PM
(522.2) Anti-Covid Gene Therapy: Integration of Authentic Research into a Continuously Evolving Undergraduate Laboratory Course
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12:45 PM – 2:00 PM
(522.3) Characterizing Novel Kinases as an Authentic Research Experience in the Undergraduate Biochemistry Lab
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12:45 PM – 2:00 PM
(522.4) A Biochemistry Course Undergraduate Research Experience (CURE) on Crithidia fasciculata parasites
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12:45 PM – 2:00 PM
(522.5) The Genomics Education Partnership As A Model of Course-Based Undergraduate Experience (CURE) that Promotes Growth Mindset
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12:45 PM – 2:00 PM
(522.6) Adaptable online discussion format to increase student interest, peer interactions, and information literacy
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12:45 PM – 2:00 PM
(522.7) MDH protein interactions and phosphorylation: Engaging students with a novel scientific theme using CUREs.
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12:45 PM – 2:00 PM
(522.8) A CURE for Cloning: Implementing a Modular Approach to Cloning Recombinant Antibodies in an Undergraduate Teaching Lab
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12:45 PM – 2:00 PM
(522.9) Setting up the CURE: approaches to introducing scientific literature into course-based research projects studying Malate Dehydrogenase function in Trypanosoma brucei
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12:45 PM – 2:00 PM
(523.1) Ten Best Practices for Taking Experiential Learning Online
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12:45 PM – 2:00 PM
(523.2) The Nova Hydroculture Project: Bringing a Community of Science Technology, Engineering, Arts, and Math (STEAM) Learners Together to Grow a Unique Garden
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12:45 PM – 2:00 PM
(523.3) Doing Better: Addressing Community Educational Disparities through Student-Led Outreach
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12:45 PM – 2:00 PM
(523.4) Educational/Professional Partnership in the Development of a Novel Strain of S-11 Saccharomyces cerevisiae Brewing Yeast
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12:45 PM – 2:00 PM
(524.1) Targeted Cancer Immunotherapy by Nanoparticle T Cell Engagers
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12:45 PM – 2:00 PM
(524.2) Sex-Specific Arrhythmias Caused by Cardiac Sodium Channel Nav1.5 Mutation Alters Cardiomyocyte Metabolism
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12:45 PM – 2:00 PM
(524.3) Electronic Nicotine Delivery Systems Exhibit LowerToxicity Compared to Cigarettes: “The Replica Study Experience”
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12:45 PM – 2:00 PM
(524.4) Use of DNA Barcoding to Identify Species of Raw Ready-To-Eat Seafood Products Sold in Orange County, CA
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12:45 PM – 2:00 PM
(524.5) Comparative in vitro efficacy of a hyaluronic acid (HA) matrix ingredient containing HA, dermatan sulphate and collagen (Dermial®) versus pure HA from extraction or fermentation origin
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12:45 PM – 2:00 PM
(524.6) Naringenin antihypertensive power is mediated via abrogation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway
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12:45 PM – 2:00 PM
(524.7) Investigating Mitochondrial Dysfunction in Barth Syndrome
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12:45 PM – 2:00 PM
(524.8) Anti-S2 Protection in COVID-19 Infection and SARS-CoV-2 Spike Vaccination
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12:45 PM – 2:00 PM
(524.9) Developing a Pipeline for Personalized Diagnoses of Glut1 Deficiency Syndrome
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12:45 PM – 2:00 PM
(483.10) Unparalleled Approaches to Directly Visualize DNA-Binding Proteins and Biomolecular Condensates
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12:45 PM – 2:00 PM
(483.11) Extending the Applications of Telomere-Anchored PCR for Telomere Length Measurements
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12:45 PM – 2:00 PM
(483.12) Tau Mediated Coupling Interactions between Pol III Core DNA Synthesis and DnaB Helicase Unwinding
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12:45 PM – 2:00 PM
(484.10) Epigenomic mechanisms used by KrasG12D to regulate inflammatory gene clusters in epithelial pancreatic cancer cells, which are critical for reprogramming the tumor microenvironment
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12:45 PM – 2:00 PM
(484.11) A Novel Approach to Assess Podocyte Damage at Single Cell Level
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12:45 PM – 2:00 PM
(484.12) Control of Foxp3+ Treg Production, Stability and Function by the Nuclear Co-regulator, Sin3A
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12:45 PM – 2:00 PM
(484.13) Pharmacological reactivation of RBL2/p130 could be an effective antitumoral strategy for malignant pleural mesothelioma
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12:45 PM – 2:00 PM
(484.14) Aberrant Silencing of Ribosomal DNA Initiates a Global Stress Response that Promotes H3K9-mediated Adaptation
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12:45 PM – 2:00 PM
(484.15) Mechanisms of mitochondrial promoter recognition in humans and other mammalian species
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12:45 PM – 2:00 PM
(485.10) Overexpression of the Neurospora crassa Transcription Factor fsd-1 Inhibits Mating
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12:45 PM – 2:00 PM
(485.11) Investigating the Effect of PARP Mediated Compartments on Transcription Dynamics
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12:45 PM – 2:00 PM
(486.10) Fingerprinting Small Molecule Modulators of Nucleolar Biophysics
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12:45 PM – 2:00 PM
(486.11) A novel histogram based on the SEER database predicts overall survival in patients with high-grade cerebellar glioma
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12:45 PM – 2:00 PM
(486.12) Congested Heart Failure in Small Breeds Dogs
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12:45 PM – 2:00 PM
(486.13) PACER lncRNA Regulates COX-2 Expression in Lung Cancer Cell Lines
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12:45 PM – 2:00 PM
(486.14) Studies of the 5 Untranslated Region of sagA/Pel in Streptococcus pyogenes
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12:45 PM – 2:00 PM
(486.15) A genetic screen for proteins involved in Non-Stop mRNA decay in C. elegans
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12:45 PM – 2:00 PM
(486.16) Introns in yeast regulate translation to generate protein and cellular function
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12:45 PM – 2:00 PM
(489.10) A Role for Inositol Pyrophosphates in ER Protein Translocation?
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12:45 PM – 2:00 PM
(489.11) Biochemical analysis of human ERK2 mutants reveals important residues in MEK1-ERK2 binding and phosphorylation
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12:45 PM – 2:00 PM
(489.12) Expression and Purification of Human Circadian Protein hRORγ for Structural and Functional Studies
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12:45 PM – 2:00 PM
(489.13) Synthesis and Conformational Analysis of APP O-Glycopeptides Bearing the Tn Antigen
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12:45 PM – 2:00 PM
(489.14) Investigating the Interaction Interface between MEK and ERK Kinase
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12:45 PM – 2:00 PM
(489.15) Developing a recombinant expression system for human serine protease PRSS23
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12:45 PM – 2:00 PM
(489.16) Effect of Rosa canina Methanol Extract on Membrane Trafficking in Different Niemann-Pick C1 Phenotypes
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12:45 PM – 2:00 PM
(489.17) Targeting Translational Control in Cancer Using Small Molecule Activators of PP2A
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12:45 PM – 2:00 PM
(489.18) Profiling the ubiquitinated proteome in human cells
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12:45 PM – 2:00 PM
(489.19) A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase
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12:45 PM – 2:00 PM
(489.20) Identification of Eral1 Recognition Sequences for Unfolding and Degradation by Mitochondrial ClpXP
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12:45 PM – 2:00 PM
(489.21) Towards an understanding of S100A8 and S100A9 post-translational regulation
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12:45 PM – 2:00 PM
(489.22) Identification of protein targets for NADPH oxidase 5 mediated oxidative modification
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12:45 PM – 2:00 PM
(489.23) Structures, Mechanism, and Functional Relevance of Filament Formation by SgrAI
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12:45 PM – 2:00 PM
(489.24) Detection of the Pin1-ligand interactions using 19F NMR spectroscopy
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12:45 PM – 2:00 PM
(489.25) Highly conserved binding region of ACE2 as a receptor for SARS-CoV-2 between humans and Hippopotamus
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12:45 PM – 2:00 PM
(489.26) Tau Mutants Alter the Rheological Properties of Phase-Separated Tau Condensates
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12:45 PM – 2:00 PM
(489.27) Initial Characterization of the Extra Cytoplasmic Function Sigma Factor (FpvI) and Sigma Regulator (FpvR) Anti Sigma Domain Interaction in Pseudomonas aeruginosa
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12:45 PM – 2:00 PM
(490.10) The use of wet lab and computational docking experiments to elucidate idiosyncrasies associated with amino acid activation.
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12:45 PM – 2:00 PM
(490.11) Analysis of Global and Residue-Specific yB Crystallin Protein Dynamics via NMR Spectroscopy and Dynamic Light Scattering
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12:45 PM – 2:00 PM
(491.10) Conformational dynamics of SNARE recycling mediated by NSF
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12:45 PM – 2:00 PM
(491.11) Expression and Purification of Corticosterone Binding Globulin in E. coli for Quantification
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12:45 PM – 2:00 PM
(491.12) Analysis of Crassostrea Virginica Protein Metal Complexes after Exposure to Toxic Environmental Pollutant Cadmium
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12:45 PM – 2:00 PM
(491.13) Fullerenes Materials Contribute to Ordered Interfacial Cell Water Improving Cellular Electrodynamics and Oxidative Stress Management
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12:45 PM – 2:00 PM
(491.14) Inhibition of SUMO-mediated Protein-Protein Interactions in DNA Damage Repair
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12:45 PM – 2:00 PM
(491.15) MSL2 Localization to Histone Loci in Drosophila Species
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12:45 PM – 2:00 PM
(491.16) Investigating the interaction of E6/E6AP heterodimer with p53-DBD by fluorescence resonance energy transfer
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12:45 PM – 2:00 PM
(491.17) The Design of an Antagonist that Improves Cardiac Function through Ligand-Directed Signaling
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12:45 PM – 2:00 PM
(491.18) Chaperoning mechanism of innate immune receptor NOD2 by HSP70
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12:45 PM – 2:00 PM
(491.19) Proteins Interacting with S-Nitrosoglutathione reductase to Regulate Nitric Oxide Homeostasis
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12:45 PM – 2:00 PM
(491.20) Identification and Characterization of Novel Macromolecular Assemblies Responsible for Cell Adhesion
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12:45 PM – 2:00 PM
(492.10) Structural and computational investigation of MMP-3 affinity improvements with an engineered TIMP-1 inhibitor
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12:45 PM – 2:00 PM
(492.11) Biochemical Characterization of a Human Ribonucleotide Reductase (HsRNR) Variant Lacking Activity Regulation
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12:45 PM – 2:00 PM
(492.12) Structural Analysis of a Non-canonical Terpene Synthase
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12:45 PM – 2:00 PM
(492.13) Understanding the Structural Requirements for Hemolytic Protein Function
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12:45 PM – 2:00 PM
(492.14) Design and characterization of a FGF1-FGF21 chimeric protein with increased stability and enhanced antidiabetic activities
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12:45 PM – 2:00 PM
(492.15) Engineering a Better FLUture with Neuraminidase-Targeted Monoclonal Antibodies
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12:45 PM – 2:00 PM
(492.16) On the Flame: The Fab Fragment of Rheumatoid Arthritis
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12:45 PM – 2:00 PM
(492.17) Domain-swapped dimeric γ-crystallin: the missing link in the evolution of oligomeric β-crystallins
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12:45 PM – 2:00 PM
(492.18) Tryptophan Fluorescence as a Probe for Conformational Dynamics in Zinc Solute Binding Proteins
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12:45 PM – 2:00 PM
(497.10) Structural Investigation of Allosteric Regulation in Class III Ribonucleotide Reductases
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12:45 PM – 2:00 PM
(497.11) Salty Enzymes: Protein Splicing Dependence on Salt Concentrations
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12:45 PM – 2:00 PM
(497.12) Biochemical characterization of a new 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (HPPK) from Methanocaldococcus jannaschii
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12:45 PM – 2:00 PM
(497.13) A suicide diiron oxygenase in p-aminobenzoate biosynthesis in Chlamydia trachomatis
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12:45 PM – 2:00 PM
(497.14) Characterization of an Unusual Metalloenzyme Containing an [FeFe] Hydrogenase and a Rubrerythrin Domain
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12:45 PM – 2:00 PM
(497.15) The Investigation on the Effect Asn123Gly mutation in the Enzyme Pyrroline-5-Carboxylate Reductase
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12:45 PM – 2:00 PM
(497.16) Assembly-line catalysis in bifunctional terpene synthases: (+)-Copalyl diphosphate synthase from fungal Penicillium species
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12:45 PM – 2:00 PM
(497.17) Flavin binding affinity and initial kinetic characterization of DnmZ, a flavin-dependent N-oxygenase
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12:45 PM – 2:00 PM
(497.18) Molecular Basis for Regulation of Mammalian Fatty Acid Synthase
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12:45 PM – 2:00 PM
(498.10) Indole-3-glycerol phosphate synthase (IGPS) serving as a drug target in M. tuberculosis
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12:45 PM – 2:00 PM
(498.11) Elucidating the Kinetic Mechanism of Human METTL16
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12:45 PM – 2:00 PM
(498.12) Effects of Both Inherent Chemical Structure and Environment Conditions on the Enzyme-Small Molecule Relationship of a Non-Oxime Reactivator of Organophosphorus-Inhibited Human Acetylcholinesterase
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12:45 PM – 2:00 PM
(498.13) Insight into L-DOPA dioxygenase mechanism with 6-substituted L-DOPA derivatives
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12:45 PM – 2:00 PM
(499.10) Investigating Structural Features Utilized by Two-component Flavin-dependent Systems
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12:45 PM – 2:00 PM
(499.11) Differences in Conformational Dynamics Between a Viral Polyprotein and Its Processed Products in Functionally Relevant Regions Revealed by Solution-State NMR Spectroscopy
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12:45 PM – 2:00 PM
(499.12) Determination and Characterization of Genes that Encode the Nicotinate Dehydrogenase and 6-Hydroxynicotinate Dehydrogenase Complexes within the Nicotinic Acid Degradation Pathway by Bacillus Niacini
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12:45 PM – 2:00 PM
(499.13) Dynamic gating of substrate binding in β-amylase2 from Arabidopsis thaliana
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12:45 PM – 2:00 PM
(499.14) Determining Whether Tightness of Substrate Binding in the Active Site of a Dimeric Taurocyamine Kinase Plays a Role in Inducing Negative Cooperativity
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12:45 PM – 2:00 PM
(500.10) Structure-activity relationships for several series of fragment-based inhibitors that target Trichomonas vaginalis nucleoside ribohydrolase enzymes
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12:45 PM – 2:00 PM
(500.11) Crotonate sensitizes IAPi in the disruption of latent HIV by modulating the ncNF-κB signaling pathway at the step of p100 cleavage into p52
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12:45 PM – 2:00 PM
(500.12) Parasitology assays to assess Trichomonas vaginalis nucleoside ribohydrolase inhibitors
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12:45 PM – 2:00 PM
(500.13) Rac and Cdc42 Inhibitors in Rheumatoid Arthritis Therapy
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12:45 PM – 2:00 PM
(500.14) Vaccine Immunogenicity assay in bovines against fasciola hepatica
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12:45 PM – 2:00 PM
(500.15) Targeted Covalent Inhibition of Small CTD Phosphatase-1 to Promote the Degradation of REST Transcription Factor in Human Cells
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12:45 PM – 2:00 PM
(500.16) A New Method for Undruggable Targets: Amino Acids as Fragments of Inhibitors
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12:45 PM – 2:00 PM
(500.17) Alternative Approach to NADPH Oxidase Inhibition: Challenging Selectivity through Fragment Based Drug Design
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12:45 PM – 2:00 PM
(500.18) Portability of Small Molecule Binding Sites in Intrinsically Disordered Proteins
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12:45 PM – 2:00 PM
(505.10) The Effects of Disabled ARR1 Gene on C. Elegans Expression of Substance Preferences
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12:45 PM – 2:00 PM
(505.11) The scaffold protein Shoc2 controls ERK1/2-driven neural crest development by balancing the expression of extracellular matrix components
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12:45 PM – 2:00 PM
(505.12) Glutamine metabolism co-ordinates the cell-cycle with cell fate in stem cells
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12:45 PM – 2:00 PM
(505.13) Quantitative Mass Spectrometry Reveals a Proteome-wide Role for Cyclin A and Cks1 in Multisite, Non-Proline Directed Phosphorylation by CDK1
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12:45 PM – 2:00 PM
(505.14) Arg84/65 Within the αC-Helix of Erk1/2 is Pivotal for Blocking Autoactivation and Oncogenicity and Distinguishes MAP Kinases from Other EPKs
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12:45 PM – 2:00 PM
(505.15) DGKζ interacts with ERK3 and counteracts the promoting role of ERK3 in lung cancer migration
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12:45 PM – 2:00 PM
(505.16) Determining the role of the Ras family GTPase Rap1 in regulating mTORC2 activity and function in cell migration
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12:45 PM – 2:00 PM
(505.17) Kub5-Hera Deficiency Promotes R-Loop-Induced Genomic Instability and Carcinogenesis Following Whole-Body Exposure to Ionizing Radiation
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12:45 PM – 2:00 PM
(505.18) Understanding the Pro-Apoptotic Mechanisms of Bitter Local Anesthetics in Head and Neck Squamous Cell Carcinoma
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12:45 PM – 2:00 PM
(505.19) Characterization of RTK Tyrosine Phosphorylation in Response to Chemotherapy Drugs in Triple Negative Breast Cancer
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12:45 PM – 2:00 PM
(505.21) IGF2BP2 Promotes Cancer Progression by Degrading the RNA Transcript Encoding a v-ATPase Subunit
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12:45 PM – 2:00 PM
(505.22) RSK as a Therapeutic Target for ER+ Breast Cancer
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12:45 PM – 2:00 PM
(505.23) Expression of IDO1 is regulated via Ras signaling pathways
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12:45 PM – 2:00 PM
(505.24) Optogenetic Control of Phosphatase and Kinase Function
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12:45 PM – 2:00 PM
(505.25) Understanding the Role of the Peroxiredoxin Family in the Regulation of Ferroptosis in Colorectal Cancer
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12:45 PM – 2:00 PM
(505.26) Human transcription factor protein interaction networks
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12:45 PM – 2:00 PM
(505.27) Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells
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12:45 PM – 2:00 PM
(505.28) In-Vitro Combo Treatments of Human Melanoma (1205Lu) Cell line with Curcumin, Vitamins and Steroids
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12:45 PM – 2:00 PM
(505.29) Pigment epithelium-derived factor induced CRX alterations in the mouse retina
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12:45 PM – 2:00 PM
(505.30) Role of glucocorticoid-induced leucine zipper during type II macrophage differentiation induced by dexamethasone and IL-4
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12:45 PM – 2:00 PM
(505.31) Cyclin C Suppresses Pancreatic Intraepithelial Neoplasia and Neural Endocrine Neoplasia Progression in a Murine Kras Model
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12:45 PM – 2:00 PM
(507.10) TNK1 negatively regulates TBK1 at ubiquitin condensates
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12:45 PM – 2:00 PM
(507.11) A mechanism of TNK1 activation by C-terminal gene truncation in human lymphomas
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12:45 PM – 2:00 PM
(507.12) The Forgotten PKAs: New Insights Revealed by the First Crystal Structure of a PKA C Beta Splice Variant, Cβ4ab
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12:45 PM – 2:00 PM
(507.13) Phosphorylation-based regulation of mitochondrial metabolism
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12:45 PM – 2:00 PM
(507.14) Impact of Redox Modification on PKA Substrate Selection
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12:45 PM – 2:00 PM
(507.15) Elucidating the Mechanisms of CaMKII-CaMKAP Interactions
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12:45 PM – 2:00 PM
(509.10) Autophagy is Disrupted in the Livers of Obese Mice Exposed to Asparaginase
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12:45 PM – 2:00 PM
(509.11) The effect of the iron chelator Deferasirox in combination with Cisplatin chemotherapy against lung carcinoma
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12:45 PM – 2:00 PM
(509.12) Shugoshin-1 Depletion Reduces Tumor Growth in Triple-Negative Breast Cancer
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12:45 PM – 2:00 PM
(509.13) Yeast Bax Inhibitor (Bxi1p/Ybh3p) is a Calcium Channel in E. coli
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12:45 PM – 2:00 PM
(509.14) Inhibition of PLK-1 by using a Small Molecule Inhibitor HMN-214 is a Novel Therapeutic Approach for High-risk Neuroblastoma
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12:45 PM – 2:00 PM
(509.15) Synergistic Effects of Anti-Cancer Drug Administration on Acute Myeloid Leukemia
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12:45 PM – 2:00 PM
(509.16) Drug repurposing: A novel therapeutic approach for pancreatic cancer
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12:45 PM – 2:00 PM
(509.17) TFEB and TFE3 Depletion Increases Cancer Stem Cell Characteristics and EMT in Triple-Negative Breast Cancer
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12:45 PM – 2:00 PM
(510.10) Development of an in vitro bioassay to assess the regulation of immune genes in nontraditional model species
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12:45 PM – 2:00 PM
(510.11) Interleukin 21-induced Mitochondrial Dysfunction Drives Regulatory T Cell Inflammatory Response during Intestinal Inflammation
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12:45 PM – 2:00 PM
(510.12) Patient-specific Autoantigen Sample Preparation and Analysis Using the Reversible Protein Tag ProMTag
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12:45 PM – 2:00 PM
(510.13) Loss of Autotaxin inhibits Toll-like receptor4-mediated immune mechanisms and promote spontaneous colitis in Il10-ko mice
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12:45 PM – 2:00 PM
(510.14) T cell differentiation and lineage choice are determined by the TCR
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12:45 PM – 2:00 PM
(515.10) The Minichromosome Maintainance Complex is Up-regulated in the Placentas of Low-Insulin Sensitive Mothers in the First Trimester of Pregnancy
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12:45 PM – 2:00 PM
(515.11) Carotenoids in Orange Carrots Mitigate Against Non-alcoholic Fatty Liver Disease Progression
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12:45 PM – 2:00 PM
(515.12) Deletion of the Vitamin D Receptor in Skeletal Muscle is Associated with Improved Glucose Tolerance and Reduced Muscle Function
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12:45 PM – 2:00 PM
(515.14) Dysregulation of Angiopoietin-like Proteins is a Potential Link Between Vitamin D Deficiency and Dyslipidemia
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12:45 PM – 2:00 PM
(515.15) Infantile Neurodegeneration results from Mutants of 17β-Hydroxysteroid Dehydrogenase Type 10 rather than Aβ-Binding Alcohol Dehydrogenase
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12:45 PM – 2:00 PM
(516.10) Trabecular Meshwork Cholesterol Levels Regulate Actin Polymerization and Tunneling Nanotubes
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12:45 PM – 2:00 PM
(516.11) The Role of Endothelial PARs in Modulating Insulin Signaling
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12:45 PM – 2:00 PM
(516.12) The pathological progression of repetitive and mild traumatic brain injury in mice
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12:45 PM – 2:00 PM
(516.13) Antioxidant Effects of Guishe Extract from Agave lechuguilla on Kidney Mitochondria from Stz-Induced Diabetic Male Rats
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12:45 PM – 2:00 PM
(516.14) Investigating the tryptophan-metabolizing enzyme AFMID (arylformamidase) in colon cancer
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12:45 PM – 2:00 PM
(517.10) Antimicrobial Triclosan (TCS) Increases Production of Interleukin 1 beta (IL-1β) in Human Immune Cells
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12:45 PM – 2:00 PM
(519.10) DMT1-mediated endosome-mitochondria interactions regulates iron homeostasis and mitochondrial metabolism
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12:45 PM – 2:00 PM
(519.11) Delivering MicroRNA-137 to the Brain via Nanoparticles
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12:45 PM – 2:00 PM
(519.12) The role of FIP200 in Phagophore formation during Autophagy
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12:45 PM – 2:00 PM
(519.13) Membrane Protein Comparison Between Cell Membranes and ExtracellularVvesicle Membranes of S. pneumoniae Provide Insights into Extracellular Vesicle Formation and Shedding
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12:45 PM – 2:00 PM
(520.10) Longitudinal profiling of the Plasma Glycome from Normal and Alzheimer’s Disease individuals
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12:45 PM – 2:00 PM
(520.11) Fungal polysaccharides are altered by lyophilization resulting in decreased antibody binding
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12:45 PM – 2:00 PM
(520.12) High-throughput Assay and In Vivo Screen Identify α-2,3-sialylation of CD98 by ST3GAL1 and ST3GAL2 as Essential to Melanoma Survival
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12:45 PM – 2:00 PM
(521.10) Teaching Biomolecular Visualization Literacy: Guidelines for Developing Assessments, Images and Rubrics Aligned with the BioMolViz Framework
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12:45 PM – 2:00 PM
(521.11) The CRISPR in the Classroom Network: A Support System for Instructors to Bring Gene Editing Technology to the Undergraduate Classroom
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12:45 PM – 2:00 PM
(521.12) Building a Distributed Research Network for Undergraduate Opportunities in Molecular Biochemistry
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12:45 PM – 2:00 PM
(521.13) Journal Club 3.0: An Effective Method of Training High School Students to Understand and Present Relevant Academic Research Papers
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12:45 PM – 2:00 PM
(521.14) Fundamentals of Biochemistry, a free and new LibreText book for Undergraduate Courses
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12:45 PM – 2:00 PM
(521.15) Flexible design can help overcome barriers identified when implementing a Course-based Undergraduate Research Experience (CURE)
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12:45 PM – 2:00 PM
(521.16) Engaging biochemistry students virtually utilizing problem-based learning and at home lab activities
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12:45 PM – 2:00 PM
(521.17) Addressing persistence and retention of chemistry and biochemistry majors with engagement seminars beyond the first year
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12:45 PM – 2:00 PM
(521.18) Creation of Three-Dimensional Pedagogical Models of Genetic Mutations
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12:45 PM – 2:00 PM
(521.19) Integrated Math And Science Scholars (iMASS)- Community and collaboration creating opportunities for STEM students
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12:45 PM – 2:00 PM
(522.10) External Collaboration Results in Student Learning Gains and Positive STEM Attitudes in CUREs
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12:45 PM – 2:00 PM
(524.10) BRD4-MK2 signaling: target for Crohn’s Disease-associated fibrosis
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12:45 PM – 2:00 PM
(524.11) 4-Aminopyridine promotes cutaneous reinnervation and accelerates wound healing
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12:45 PM – 2:00 PM
(524.12) Structural Landscape of SARS-CoV-2 entry & activation of spike glycoprotein & potential interventions
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