96 - Breast Cancer Workshop: Therapeutic Resistance Pathways and Emerging Drug Targets for Breast Cancer

Session Chair(s)

• Dennis Jones

  Presenting Author
  Boston University

• Bethany Hannafon

  University of Oklahoma Health Sciences Center

Session

Description: The development of therapeutic resistance is one of the most significant clinical problems in the treatment of breast cancer. This session will explore current basic and translational research in the mechanisms associated with therapeutic resistance and will introduce emerging drug targets in the treatment of breast cancer. Attendees will hear from leaders in the breast cancer field about the genetic and cellular underpinnings of resistance to breast cancer therapies. The presentations in this session will illuminate strategies to maximize the potential of targeted therapies and immunotherapies for breast cancer treatment. This session will also focus on the role of cancer stem cells and dormant cancer cells in setting the stage for metastatic recurrence due to therapeutic resistance.

Presentations:

• 8:30 AM

  Chair - Welcome and Introductions
• 8:30 AM – 9:05 AM

  Activating Mutations in HER2 Confer Resistance to Therapy in Breast Cancer
  

  Speaker: Utthara Nayar – Johns Hopkins Bloomberg School of Public Health
• 9:05 AM – 9:40 AM

  Role of Cancer Stem Cells in Resistance to Treatment in Breast Cancer
  

  Speaker: Rumela Chakrabarti – University of Pennsylvania
• 9:40 AM – 10:15 AM

  Pathways Regulating the Survival and Recurrence of Residual Cancer Cells
  

  Speaker: James Alvarez – Fred Hutchinson Cancer Research Center
• 10:15 AM – 10:50 AM

  Heterogeneity of MHC-I and MHC-II Antigen Presentation in Immunotherapy Outcomes in Breast Cancer
  

  Speaker: Justin Balko – Vanderbilt University Medical Center
• 10:50 AM – 11:00 AM

  Questions and Answers