Bacteria that chronically colonize the host must adapt to various forms of stress in the host environment. The molecular mechanisms bacteria use to sense and respond to these environmental signals are crucial for maintaining symbiotic associations with host cells. My laboratory uses chemical and biological tools to uncover new molecular mechanisms of bacterial adaptation to oxidative stress. In this talk, I will describe our recent discovery of a widely conserved transporter that enables microbial uptake of a diet-derived antioxidant from the host.
Support or Funding Information
This work was supported by NIH R35GM137952 and T32GM067543.
