396 - Bringing the dead to life: pseudoenzymes

Session Chair(s)

• Anne-Claude Gingras

  Presenting Author
  Lunenfeld-Tanenbaum Research Institute, University of Toronto

In this session, we will focus on atypical signaling mechanisms, from the discovery of new catalysis within the kinome superfamily and noncanonical ubiquitination to the role of metals such as copper in signaling. We also discuss the emergence of pseudoenzymes: These allosteric signaling scaffolds are defined by their structural and sequence homology to canonical enzymes such as kinases and phosphatases, but they lack catalytic activity and remain relatively unexplored biologically and as potential drug targets. We also will discuss how improvements in phosphoproteomics, genetic screens, and affinity and proximity proteomics permit us to globally assess specific aspects of signal transduction and shine new lights on poorly characterized enzymes, scaffolds and substrates.

Who should attend: everyone who likes taking the road less traveled and those interested in good detective stories.

Presentations:

• 9:15 AM – 9:45 AM

  Catalytic degradation in pseudoenzymes
  

  Presenting Author: Patrick Eyers – University of Liverpool
• 9:45 AM – 10:15 AM

  Protein Tyrosine Pseudophosphatase Signalling Mechanisms
  

  Presenting Author: Hayley Sharpe – Babraham Institute
• 10:15 AM – 10:45 AM

  New light on an old problem — molecular basis for glycogen synthase activity regulation
  

  Speaker: Elton Zeqiraj – University of Leeds
• 10:45 AM – 11:15 AM

  Defining pseudoenzymes in glycosylation pathways
  

  Presenting Author: Natarajan Kannan – University of Georgia