119 - Atypical signaling mechanisms

Session Chair(s)

• Patrick Eyers

  Presenting Author
  University of Liverpool

In this session, we will focus on atypical signaling mechanisms, from the discovery of new catalysis within the kinome superfamily and noncanonical ubiquitination to the role of metals such as copper in signaling. We also discuss the emergence of pseudoenzymes: These allosteric signaling scaffolds are defined by their structural and sequence homology to canonical enzymes such as kinases and phosphatases, but they lack catalytic activity and remain relatively unexplored biologically and as potential drug targets. We also will discuss how improvements in phosphoproteomics, genetic screens, and affinity and proximity proteomics permit us to globally assess specific aspects of signal transduction and shine new lights on poorly characterized enzymes, scaffolds and substrates. Who should attend: everyone who likes taking the road less traveled and those interested in good detective stories.

Presentations:

• 9:30 AM – 10:00 AM

  Structural and mechanistic basis for protein glutamylation by the kinase fold
  

  Presenting Author: Vincent Tagliabracci – University of Texas, Southwestern
• 10:00 AM – 10:30 AM

  Structural basis for signaling by the HER3 pseudokinase receptor
  

  Presenting Author: Natalia Jura – University of California
• 10:30 AM – 11:00 AM

  Tracing copper utilization by kinase signal transduction pathways: Implications for cancer cell processes
  

  Presenting Author: Donita Brady – University of Pennsylvania
• 11:00 AM – 11:30 AM

  Beyond Lysine Ubiquitination
  

  Presenting Author: Satpal Virdee – University of Dundee