Presenting Author
Dongguk University, Republic of Korea
EDUCATION
• Yeungnam University (2005 – 2011)
School of Biotechnology, Major of Biotechnology
• Seoul National University (MS & Ph.D, 2012 – 2018)
College of Medicine, Department of Physiology
EXPERIENCES
• 2018.2 ~ 2019.2 Post.Doc (Department of Physiology, Seoul National University. College of medicine)
SPECIALIZED FIELDS AND TECHNIQUES
1) Patch clamp: Potassium channels (Kv, KATP, KCa, Kir, and K2P) recording in primary astrocyte, B cells, and cell line. TRP channels recording in cell lines. VRAC(volume regulated anion channels) recording in myoblast. NSC (nonselective cation channels) recording in primary vascular smooth muscle cells. SAC (stretch activated channels) recording in primary pulmonary smooth muscle cells.
2) Primary B cell isolation (Spleen, lymph node)
3) Primary astrocyte isolation
4) Primary glia cell isolation
5) Measuring intracellular [Ca2+] recording (Fura-2)
6) Cell culture: permanent cell lines, primary astrocyte
7) Immunohistochemistry
8) RT-PCR
9)Western blot
PUBLICATIONS
1. Diethylstilbestrol, a Novel ANO1 Inhibitor, Exerts an Anticancer Effect on Non-Small Cell Lung Cancer via Inhibition of ANO1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021.07
2. Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na+ Current Induction and hERG K+ Channel Inhibition. ANTIOXIDANTS. 2021.07
3. Higher expression of KCNK10 (TREK-2) K+ channels and their functional upregulation by lipopolysaccharide treatment in mouse peritoneal B1a cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2021.04
4. Thermosensitivity of the voltage-dependent activation of calcium homeostasis modulator 1 (calhm1) ion channel. Biochemical and Biophysical Research Communications. 2021
5. Nootkatol prevents ultraviolet radiation-induced photoaging via ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes. Korean Journal of Physiology and Pharmacology. 2021
6. Dual regulatory effects of PI(4,5)P2 on TREK-2 K+ channel through antagonizing interaction between the alkaline residues (K330 and R355-357) in the cytosolic C-terminal helix. The Korean Journal of Physiology & Pharmacology. 2020.11
7. The agonistic action of URO-K10 on Kv7.4 and 7.5 channels is attenuated by co-expression of KCNE4 ancillary subunit. The Korean Journal of Physiology & Pharmacology. 2020.11
8. Teaching cardiac excitation-contraction coupling using a mathematical computer simulation model of human ventricular myocytes. Advances in Physiology Education. 2020.09
9. Gardenia jasminoides extract and its constituent, genipin, inhibit activation of CD3/CD28 co-stimulated CD4(+)T cells via ORAI1 channel. KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY. 2020.07
10. Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells. The Korean Journal of Physiology & Pharmacology. 2020.07
11. Triple arginine residues in the proximal C-terminus of TREK K + channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate . American journal of physiology. Cell physiology. 2019.03
12. Temperature-dependent increase in the calcium sensitivity and acceleration of activation of ANO6 chloride channel variants. SCIENTIFIC REPORTS. 2019
13. Flos Magnoliae and its Constituent Linoleic Acid Suppress T Lymphocyte Activation via Store-Operated Calcium Entry. American Journal of Chinese Medicine. 2019
14. Dual action of the Gα q -PLCβ-PI(4,5)P 2 pathway on TRPC1/4 and TRPC1/5 heterotetramers. Scientific Reports. 2018.12
15. Mitochondrial dysfunction reduces the activity of KIR2.1 K+ channel in myoblasts via impaired oxidative phosphorylation. KOREAN JOURNAL OF PHYSIOLOGY PHARMACOLOGY. 2018.11
16. TMEM16F/ANO6, a Ca2+-activated anion channel, is negatively regulated by the actin cytoskeleton and intracellular MgATP. Biochemical and Biophysical Research Communications. 2018.09
17. Dual action of the G alpha(q)-PLC beta-PI(4,5) P-2 pathway on TRPC1/4 and TRPC1/5 heterotetramers. SCIENTIFIC REPORTS. 2018.08
18. Identification of critical amino acids in the proximal C-terminal of TREK-2 K+ channel for activation by acidic pH(i) and ATP-dependent inhibition. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2018.02
19. Differential modulation of TWIK-related K+ channel (TREK) and TWIK-related acid-sensitive K+ channel 2 (TASK2) activity by pyrazole compounds. EUROPEAN JOURNAL OF PHARMACOLOGY. 2016.11
20. Inhibition of TREK-2 K+ channels by PI(4,5)P-2: an intrinsic mode of regulation by intracellular ATP via phosphatidylinositol kinase. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2016.08
21. Investigation of critical amino acids in c-terminal regions for the complex sensitivity of TREK-2 K+ channel to membrane PIP2 and pH(i). FASEB JOURNAL. 2014.04
22. Differential pathways for calcium influx activated by concanavalin A and CD3 stimulation in Jurkat T cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2012.02