Professor
Beijing Normal University, China (People's Republic)
Biography
M.Phil. and Ph.D. in pharmacology, University of Cambridge, 1986, 1989;
Postdoctoral positions, Dept. Pharmacology, Yale Univ. School of Medicine, and Dept. of Surgery, Harvard Medical School and Beth Isreal Hospital, 1990-1994;
Associate Professor, National Laboratory of Biotechnology, China Agricultural Univ, 1994-1998;
Professor in Cell Biology, Beijing Normal University, 1998- present.
A Short-Term Fellowship from The HFSP, 1996.
The China Ministry of Education Trans-Century Talent Programme, 1998.
Young Scientist Merrit Award, NSFC, 1998.
A Special Stipend from The Chinese State Council, 1999.
Editorial boards: Prog Physiol Sci, Biophysics Reports (Associate Editor), Pancreapedia.
Formerly Council Member, Chinese Society for Cell Biology, Chinese Biophysical Society.
Past President, Chinese Commission for Photobiology (a section of The Chinese Biophysical Society).
Undergraduate course (Nationally Acclaimed Course):
Human and Animal Physiology
(Text used: Walter F. Boron, Emile Boulpaep, Medical Physiology, 3Rd Ed; Guyton and Hall Textbook of Medical Physiology, 14Th Ed.).
Research Interests
1/ Cytosolic calcium oscillations
2/ Molecular basis of exocytosis
3/ Singlet oxygen as a signaling molecule
4/ Modulation of synaptic transmission by toosendanin
5/ Contact regulation between neighbouring cell types
Recruitments for MPhil and PhD students:
071009 Cell Biology Programme – 05 Signalling in secretory cells
FOR OVERSEAS STUDENTS:
PLEASE SEND
1/ OFFICIAL TRANSCRIPTS OF UNDERGRADUATE AND GRADUATE ACADEMIC SCORES,
2/ OFFICIAL REFERENCES FOR BOTH UNDERGRADUATE AND POSTGRDUATE EDUCATION,
3/ CERTIFICATES FOR ENGLISH LEVEL.
Representative Publications
Li Y, Cui ZJ (2022) Photodynamic activation of the cholecystokinin 1 receptor with tagged genetically encoded protein photosensitizers: Optimizing the tagging patterns. Photochem Photobiol www.doi.org/10.1111/php.13611
Zhang SJ, Li ZH, Zhang YD, Chen J, Li Y, Wu FQ, Wang W, Cui ZJ, Chen GQ (2021) Ketone body 3-hydroxybutyrate ameliorates atherosclerosis via receptor Gpr109a-mediated calcium influx. Adv Sci 2021: 2003410.
Li Y, Cui ZJ (2020) Photodynamic activation of cholecystokinin 1 receptor with different genetically encoded protein photosensitizers and at varied subcellular sites. Biomolecules 10: 1423.
Li Y, Cui ZJ (2020) NanoLuc bioluminescence-driven photodynamic activation of cholecystokinin 1 receptor with genetically encoded protein photosensitiser miniSOG. Intl J Mol Sci 21: 3763.
Tang WZ, Cui ZJ (2020) Permanent photodynamic activation of the cholecystokinin 2 receptor. Biomolecules 10: 236.
Liu JS, Cui ZJ (2019) Pancreatic stellate cells serve as a brake mechanism on pancreatic acinar cell calcium signaling modulated by methionine sulfoxide reductase expression. Cells 8: 109.
Guo HY, Cui ZJ (2019) Extracellular histones activate TLR9 to induce calcium oscillations in rat pancreatic acinar tumor cell AR4-2J. Cells 8: 3.
Jiang WY, Li Y, Li ZY, Cui ZJ (2018) Permanent photodynamic cholecystokinin 1 receptor activation – dimer-to-monomer conversion. Cell Mol Neurobiol 38: 1283-1292.
Jiang HN, Li Y, Jiang WY, Cui ZJ (2018) Cholecystokinin 1 receptor - a unique G protein-coupled receptor activated by singlet oxygen (GPCR-ABSO). Front Physiol 9: 497.
Jiang HN, Li Y, Cui ZJ (2017) Photodynamic physiology - photonanomanipulations in cellular physiologywith protein photosensitisers. Front Physiol 8: 191.
Li ZY, Jiang WY, Cui ZJ (2015) An essential role forNAD(P)H oxidase 2 inUVA-induced calcium oscillations in mast cells. Photochem Photobiol Sci 14: 414-428.
Liang HY, Song ZM, Cui ZJ (2013) Lasting inhibition of receptor-mediated calcium oscillations in pancreaticacini by neutrophil respiratory burst - a novel mechanism for secretoryblockade in acute pancreatitis? BiochemBiophys Res Commun 437: 361-367.
Cui ZJ, Han ZQ, Li ZY (2012) Modulating protein acvitity and cellular function by methionine residue oxidation. Amino Acids 43: 505-517.
Jia YH, Cui ZJ (2011) Tri-phasic modulation of ACh- and NE-maintained calcium plateau by high potassium in isolated mouse submandibular granular convoluted tubular cells. Arch Oral Biol 56: 1347-1355.
Fang XF, Cui ZJ (2011) The anti-botulism triterpenoid toosendanin elicits calcium increase and exocytosis in rat sensory neurons. Cell Mol Neurobiol 31: 1151-1162.
Duan YJ, Liang HY, Jin WJ, Cui ZJ (2011) Substance P conjugated to CdTe quantum dot triggers cytosolic calcium oscillations and induces QD internalization in the pancreatic carcinoma cell line AR4-2J. Analyt Bioanalyt Chem 400: 2995-3003.
Chen BD, Guan DD, Cui ZJ, Wang X & Shen X (2010) Thioredoxin 1 downregulates MCP-1 secretion and expression in human endothelial cells by suppressing nuclear translocation of activator protein 1 and redox factor-1. Am J Physiol Cell Physiol 298: C1170-C1179.
Wang BJ, Liang HY & Cui ZJ (2009) Duck pancreatic acinar cell as a unique model for independent cholinergic stimulation-secretion coupling. Cell Mol Neurobiol 29: 747-756.
Zhou YD, Fang XF & Cui ZJ (2009) UVA induced calcium oscillations in rat mast cells. Cell Calcium 45: 18-28. (Yan Dong Zhou: https://profiles.psu.edu/profiles/display/73800983)
Hu F, Sun WW, Zhao XT, Cui ZJ & Yang WX (2008) TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization. Biochem Biophys Res Commun 369: 989-993.
Wang BJ & Cui ZJ (2007) How does cholecystokinin stimulate exocrine pancreatic secretion? From birds, rodents, to humans. Am J Physiol 292: R666-R678.
Ma CY & Cui ZJ (2004) Selective use of a reserved mechanism for inducing calcium oscillations. Cell Signal 16: 1435-1440.
Xiao R & Cui ZJ (2004) Mutual dependence of VIP/PACAP and CCK receptor signaling for a physiological role in duck exocrine pancreatic secretion. Am J Physiol 286: R189-R198. (Rui Xiao: http://aging.ufl.edu/profile/rui-xiao-ph-d/)
Cui ZJ, Zhou YD, Satoh Y & Habara Y (2003) A physiological role for protoporphyrin IX photodynamic action in the rat Harderian gland? Act Physiol Scand 179: 149-154.
An YP, Xiao R, Cui H & Cui ZJ (2003) Selective activation by photodynamic action of cholecystokinin receptor in the freshly isolated rat pancreatic acini. Br J Pharmacol 139: 872-880.
Recent Grants from NSFC:
1/ 2010-2012, Cytosolic calcium oscillations in rat mast cells.
2/ 2013-2016, Neutrophil regulation of calcium signalling in pancreatic acini.
3/ 2017-2020, Protein photosensitizer photodynamic regulation of GPCR.
4/ 2021-2023, G Protein Coupled Receptor Activated By Singlet Oxygen (GPCR-ABSO): Fundamental characteristics.
Grant from MOST:
5/ 2011-2015, Spatial and Temporal Regulation of Cell Calcium Signal.