Presenting Author
School of Biomedical Science, the Chinese University of Hong Kong, Hong Kong
I graduated with BSc in Biological Science from the Hong Kong University of Science and Technology (HKUST). Currently continuing my studies in the School of Biomedical Sciences as a Ph.D. student. My research project involves the study of gastric dysrhythmia in a diabetic condition in zebrafish larvae. I have attained a YIA Poster Presentation Award (1st Runner Up) at the East Meets West Symposium 2021, 23rd Diabetes and Cardiovascular Risk Factors.
My research involves the characterization of gastrointestinal (GI) peristaltic movements in zebrafish larvae and compares new and validated diabetic zebrafish models of DM. Both induced and genetically modified DM models will be used and validated using Body Mass Index (BMI) analysis, Enzyme-linked immunosorbent assay (ELISA), and glucose assays.
I hypothesize that incretins and their receptors are responsible for contractile differences in control and DM models and that peristalsis and interstitial cells of Cajal (ICC) function may be restored in DM fish using incretin treatments.
Our preliminary studies indicate except for overfed models (ED – excess diet), there are significant differences in BMI while high-fat diet (HFD) models showed the highest area of adipose deposit in the GI. Motility analysis of untreated larvae showed that anterior regions of the GI tract had irregular waves; stronger spikes were seen in the mid-intestine and posterior region; however, recordings were contaminated with background noise.
I proposed to continue to develop and validate the normal and DM models; characterize GI peristalsis and differentiate between control and models with/without drug treatments.
Please feel free to contact me at 1155133573@link.cuhk.edu.hk for any interest in my research or possible collaborations.