Track: ANATOMY
Track: BIOCHEMISTRY AND MOLECULAR BIOLOGY
Track: PATHOLOGY
Track: PHARMACOLOGY
Track: PHYSIOLOGY
What is the impact of changing physiological conditions or genetic modification on protein interactions, and what are the consequences of those changes on protein function? What are the compositions of those functional species? Which complex forms, is it stable and how strong are those interactions?
These represent fundamental questions at the heart of biochemical research and in this presentation, we will introduce mass photometry as an innovative, new technique that seeks to help address these. It complements the existing biophysical analysis toolkit, delivering a rapid, accurate mass measurement of single molecules in solution, in their native state without the need for labels. In a one assay format, it can be harnessed in multiple applications:
Confirm if a desired complex has formed, detect if it is stable and characterize its stoichiometry;
Calculate biomolecule-biomolecule binding affinities;
Identify the oligomeric states present in a sample and detect aggregate formation with high mass resolution, over a wide mass range
Determine functionalized ratios
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Booth 1537