227 - Division for Drug Metabolism and Disposition - Bernard B. Brodie Award, Gillette Awards, and Junior Investigator Platform Session

Session Chair(s)

• Xiaobo Zhong

  Univ of Connecticut

Session Co-Chair(s)

• Joanne Wang

  University of Washington

This session will feature a lecture by the 2022 winner of the Bernard B. Brodie Award as well as talks from the authors of the two best papers of 2021 from the journal of Drug Metabolism and Disposition who received the James R. Gillette Awards in pharmacokinetics (transporters) and drug metabolizing enzymes. The session will also include abstract-based oral presentations from graduate students, post-bacs, and postdocs. Submit your abstract to the Drug Metabolism and Disposition topic categories below to be considered for the platform session.

Presentations:

• 8:00 AM – 8:05 AM

  Introduction of Brodie Award recipient by Dr. Zhong
• 8:05 AM – 8:40 AM

  Elucidating the Function of Intestinal CYP3A: A Journey of Discovery and Clinical Importance
  

  Speaker: Kenneth Thummel – Univ of Washington
• 8:40 AM – 8:42 AM

  Introduction of Gillette Award on Transporters by Dr. Wang
• 8:42 AM – 9:00 AM

  Predicting Maternal-fetal Disposition of Fentanyl following Intravenous and Epidural Administration using Physiologically-based Pharmacokinetic Modeling
  

  Speaker: Sara Shum – University of Washington
• 9:00 AM – 9:02 AM

  Introduction of Gillette Award on Drug Metabolism by Dr. Zhong
• 9:02 AM – 9:20 AM

  Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
  

  Speaker: Shida Qian
• 9:20 AM – 7:30 AM

  Proteomics-informed physiologically-based pharmacokinetic (PBPK) modeling revealed differential effects of UGT2B17 variability on the pharmacokinetics of diclofenac following intravenous and oral administration
  

  Presenting Author: Deepak Ahire – Washington State University
• 9:30 AM – 9:40 AM

  Physiologically Based Pharmacokinetic (PBPK) Modelling to Predict Breast Milk Exposure of Valproic Acid
  

  Presenting Author: Nina Nauwelaerts – KU Leuven
• 9:40 AM – 9:50 AM

  Characterization of a Cleavable Fusion of Human CYP24A1 with Adrenodoxin Reveals the Variable Role of Hydrophobics in Redox Partner Binding
  

  Presenting Author: Natalie Jay – University at Buffalo
• 9:50 AM – 10:00 AM

  Investigation of Diazepam Sequential Metabolism with Hepatocytes via a Microfluidic Device
  

  Presenting Author: Zeyuan Wang – Temple University