390 - Radical SAM enzymology

Session Chair(s)

• Tadhg Begley

  Speaker
  Texas A&M University

The presentations in this session will cover many exciting developments in enzymology, including recently discovered enzymatic functions, evidence for trapping long-anticipated enzymatic intermediates, insight into how various cofactors can enable unique reactions, and cutting-edge experimental approaches enabling us to understand better how enzymes dynamically function. There’s still a whole lot to learn about how enzymes get their jobs done.

Who should attend: all who are fascinated by how enzymes can use some newly discovered tricks, handy cofactors and dynamic movements to carry out their chemistry.

Presentations:

• 9:15 AM – 9:45 AM

  Radical SAM Enzymes and the Unexplored Chemistry of RiPP Biosynthesis
  

  Presenting Author: Douglas Mitchell – University of Illinois Urbana-Champaign
• 9:45 AM – 10:15 AM

  The biosynthesis of lipoic acid: A saga of death, destruction, and rebirth
  

  Presenting Author: Squire Booker – Penn State University
• 10:15 AM – 10:45 AM

  Unraveling the secrets of radical SAM mechanisms
  

  Presenting Author: Joan Broderick – Montana State University
• 10:45 AM – 11:15 AM

  How do aerobic organisms solve the oxygen sensitivity problem of [4Fe-4S] in radical SAM enzymes?
  

  Presenting Author: Hening Lin – Howard Hughes Medical Institute; Cornell University