323.3 - Brain Inhibitory GABAergic Function and Cognitive Deficits in Depression and During Aging: Mechanisms and Therapeutic Targeting
Monday, April 4, 2022
3:55 PM – 4:15 PM
Room: 113 A - Pennsylvania Convention Center
Introduction: This session will explore the role of inhibitory neurotransmission and specifically of molecularly defined GABA-A receptor subtypes in the response to chronic stress, which has been implicated in the development of depression. Speakers will present basic science and translational aspects linking different GABA-A receptor subtypes to depressive-like behaviors. A combination of pharmacological, biochemical, molecular modeling, medicinal chemistry, electrophysiological and behavioral approaches has been applied to elucidate the mechanisms behind the surprising observation that both positive and negative allosteric modulation of a5-containing GABA-A receptors exhibit fast antidepressant actions and the suitability of this receptor subtype as a drug target for a novel class of antidepressants will be discussed.
Etienne Sibille ( Campbell Family Mental Health Research Institute, University of Toronto and DAMONA Pharmaceuticals )
