45.2 - Renal Transporter Function and Chronic Kidney Disease: Utility of a Dual-Channel Microphysiological System
Saturday, April 2, 2022
1:35 PM – 2:00 PM
Room: 113 C - Pennsylvania Convention Center
Introduction: Recent advances in the development of novel testing systems that recapitulate the human microenvironment and microanatomy have advanced drug and chemical screening. Using microphysiological systems, investigators are able to consider the influence of fluid flow, cell-cell communication, extracellular matrix, and 3-dimensional organization in organs-on-a-chip and tissue-engineered organ constructs and microtissues. Advancement of this technology includes the robust characterization of transporter expression and function, often in concert with evaluation of drug metabolizing enzymes and regulatory factors. This session will highlight examples of microfluidic systems and novel tissue cultures that recapitulate human transporter function across a number of organ systems. Speakers will review the potential application of these model systems for drug development and toxicity screening.
