Introduction: Acute infection and inflammation transiently suppress hepatic drug metabolism. This session will discuss clinical cases supporting altered pharmacokinetics of small molecules and biologics following SARS-CoV-2 infection or immunization and examine the mechanisms of interactions between the innate immune response and small molecule and biologic metabolism following SARS-CoV-2 infection or immunization. Understanding the impact of emerging infections and vaccine technologies on drug metabolism will help mitigate drug toxicity and improve drug and vaccine safety and effectiveness.
